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1. 发明授权

US5461051A Tetracyclic compounds having anti-allergic and anti-asthmatic activities and their use 失效
标题翻译：具有抗过敏和抗哮喘活性的四环化合物及其用途
公开(公告)号：US5461051A
公开(公告)日：1995-10-24
申请号：US267274
申请日：1994-06-28
申请人： Hiroshi Fukumi , Toshiaki Sakamoto , Mitsuo Sugiyama , Yoshio Iizuka , Takeshi Yamaguchi
发明人： Hiroshi Fukumi , Toshiaki Sakamoto , Mitsuo Sugiyama , Yoshio Iizuka , Takeshi Yamaguchi
IPC分类号： C07D213/06 , C07D213/60 , C07D223/14 , C07D241/42 , C07D471/14 , C07D487/04 , A61K31/55
CPC分类号： C07D471/14 , C07D487/04 , Y10S514/826
摘要： Compounds of formula (I): ##STR1## in which: Q is nitrogen or .dbd.CH--; R.sup.1 and R.sup.2 are hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl or halogen; and R.sup.3 is a substituted alkyl groups, or a pharmaceutically acceptable salt thereof have valuable anti-allergic and anti-asthmatic activities. The compounds are prepared by reacting a corresponding compound where R.sup.3 is replaced by a hydrogen atom with a compound to introduce the group R.sup.3.
摘要翻译：式（I）的化合物：其中：Q是氮或= CH-; R1和R2是氢，烷基，烷氧基，羟基，三氟甲基或卤素; 并且R 3是取代的烷基，或其药学上可接受的盐具有有价值的抗过敏和抗哮喘活性。通过使其中R3被氢原子代替的相应化合物与化合物反应以引入基团R3来制备化合物。

2. 发明授权

US5407933A Nitrogen-containing tetracyclic compounds having anti-allergic and anti-asthmatic activities and their use 失效
标题翻译：具有抗过敏和抗哮喘活性的含氮四环化合物及其用途
公开(公告)号：US5407933A
公开(公告)日：1995-04-18
申请号：US291347
申请日：1994-08-16
申请人： Hiroshi Fukumi , Toshiaki Sakamoto , Mitsuo Sugiyama , Yoshio Iizuka , Takeshi Yamaguchi
发明人： Hiroshi Fukumi , Toshiaki Sakamoto , Mitsuo Sugiyama , Yoshio Iizuka , Takeshi Yamaguchi
IPC分类号： A61K31/55 , C07D487/04 , C07D487/14
CPC分类号： C07D487/04 , C07D487/14
摘要： Compounds of formula (I): ##STR1## [wherein: A-- B is .dbd.C.dbd.CH--or a nitrogen atom; R.sup.1 is hydrogen, alkyl, aryl or aralkyl; and Z is alkylene] and pharmaceutically acceptable salts thereof are useful in the treatment and prevention of allergies and asthma.
摘要翻译：式（I）化合物：其中：A-B为= C = CH-或氮原子; R1是氢，烷基，芳基或芳烷基; 和Z是亚烷基]及其药学上可接受的盐可用于治疗和预防过敏和哮喘。

3. 发明授权

US5294623A (Benzhydryloxyethylpiperidyl) aliphatic acid derivatives and their use in the treatment of allergies and asthma 失效
标题翻译：（二苯甲氧基乙基哌啶基）脂肪酸衍生物及其在治疗过敏和哮喘中的应用
公开(公告)号：US5294623A
公开(公告)日：1994-03-15
申请号：US995547
申请日：1992-12-22
申请人： Hiroshi Fukumi , Toshiaki Sakamoto , Mitsuo Sugiyama , Yoshio Iizuka , Takeshi Yamaguchi
发明人： Hiroshi Fukumi , Toshiaki Sakamoto , Mitsuo Sugiyama , Yoshio Iizuka , Takeshi Yamaguchi
IPC分类号： A61K31/445 , A61K31/452 , A61P11/00 , A61P11/08 , A61P37/08 , A61P43/00 , C07D211/34 , A01N41/02 , C07D211/18
CPC分类号： C07D211/34
摘要： Compounds of formula (I): ##STR1## in which: R.sup.1 and R.sup.2 are independently alkyl, alkoxy, trifluoromethyl, nitro or halogen; A is an aliphatic hydrocarbon group having from 2 to 8 carbon atoms whose chain contains at least 2 carbon atoms in a linear chain between the piperidine group and --COOH, said group optionally being unsaturated; and m and n are independently 0, 1, 2 or 3; and pharmaceutically acceptable salts and esters thereof have been found to have valuable anti-histamine properties without the usual side effects of anti-histamines. Methods of preparing the compounds are also provided.
摘要翻译：式（I）化合物：其中：R 1和R 2独立地是烷基，烷氧基，三氟甲基，硝基或卤素; A是具有2至8个碳原子的脂族烃基，其链在哌啶基和-COOH之间的直链中含有至少2个碳原子，所述基团任选是不饱和的; m和n分别为0,1,2或3; 已经发现其药学上可接受的盐和酯具有有价值的抗组胺性质而没有抗组氨胺的常见副作用。还提供了制备化合物的方法。

4. 发明授权

US5476848A 14B(R) isomers of novel tetracyclic compounds having anti-allergic and anti-asthmatic activities, and their use 失效
标题翻译：具有抗过敏和抗哮喘活性的新型四环化合物的14B（R）异构体及其用途
公开(公告)号：US5476848A
公开(公告)日：1995-12-19
申请号：US197208
申请日：1994-02-16
申请人： Hiroshi Fukumi , Toshiaki Sakamoto , Mitsuo Sugiyama , Yoshio Iizuka , Takeshi Yamaguchi
发明人： Hiroshi Fukumi , Toshiaki Sakamoto , Mitsuo Sugiyama , Yoshio Iizuka , Takeshi Yamaguchi
IPC分类号： C07D471/14 , C07D487/04 , C07D487/14 , A61K31/55
CPC分类号： C07D471/14 , C07D487/04 , C07D487/14
摘要： An optically active compound of formula (I): ##STR1## in which R.sup.3 represents groups of formula --A--COOR.sup.4, whereinA represents alkylene groups having 3 or 5 carbon atoms andR.sup.4 represents hydrogen or an alkyl group having 1 to 4 carbon atoms; or a pharmaceutically acceptable salt thereof.
摘要翻译：式（I）的光学活性化合物：其中R 3表示式-A-COOR 4的基团，其中A表示具有3或5个碳原子的亚烷基，R 4表示氢或具有1至 4个碳原子; 或其药学上可接受的盐。

5. 发明授权

US5362725A Tetracyclic compounds having anti-allergic and anti-asthmatic activities and their use 失效
标题翻译：具有抗过敏和抗哮喘活性的四环化合物及其用途
公开(公告)号：US5362725A
公开(公告)日：1994-11-08
申请号：US962037
申请日：1992-10-15
申请人： Hiroshi Fukumi , Toshiaki Sakamoto , Mitsuo Sugiyama , Yoshio Iizuka , Takeshi Yamaguchi
发明人： Hiroshi Fukumi , Toshiaki Sakamoto , Mitsuo Sugiyama , Yoshio Iizuka , Takeshi Yamaguchi
IPC分类号： C07D213/06 , C07D213/60 , C07D223/14 , C07D241/42 , C07D471/14 , C07D487/04 , A61K31/55
CPC分类号： C07D471/14 , C07D487/04 , Y10S514/826
摘要： Compounds of formula (I): ##STR1## in which: Q is nitrogen or .dbd.CH--; R.sup.1 and R.sup.2 are hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl or halogen; and R.sup.3 is a substituted alkyl groups or a pharmaceutically acceptable salt thereof have valuable anti-allergic and anti-asthmatic activities. The compounds are prepared by reacting a corresponding compound where R.sup.3 is replaced by a hydrogen atom with a compound to introduce the group R.sup.3.
摘要翻译：式（I）的化合物：其中：Q是氮或= CH-; R1和R2是氢，烷基，烷氧基，羟基，三氟甲基或卤素; 并且R 3是取代的烷基或其药学上可接受的盐具有有价值的抗过敏和抗哮喘活性。通过使其中R3被氢原子代替的相应化合物与化合物反应以引入基团R3来制备化合物。

6. 发明授权

US5470851A Thiazolidinecarboxylic acid amide derivatives and their therapeutic uses 失效
标题翻译：噻唑烷羧酸酰胺衍生物及其治疗用途
公开(公告)号：US5470851A
公开(公告)日：1995-11-28
申请号：US129774
申请日：1993-09-30
申请人： Hiroshi Fukumi , Toshiaki Sakamoto , Mitsuo Sugiyama , Takeshi Yamaguchi , Takeshi Oshima , Fumitoshi Asai , Yasuteru Iijima
发明人： Hiroshi Fukumi , Toshiaki Sakamoto , Mitsuo Sugiyama , Takeshi Yamaguchi , Takeshi Oshima , Fumitoshi Asai , Yasuteru Iijima
IPC分类号： C07D417/04 , C07D417/14 , C07D471/14 , C07D487/04 , C07D487/14 , A61K31/55
CPC分类号： C07D417/04 , C07D417/14 , C07D471/14 , C07D487/04 , C07D487/14
摘要： Thiazolidinecarboxylic acid amides having combined antiallergic and antiasthmatic activities with an antagonist activity against platelet Activating Factor and having the following general formula (I) ##STR1##
摘要翻译：具有抗血小板活化因子拮抗活性和具有下列通式（I）的组合抗过敏和抗哮喘活性的噻唑烷羧酸酰胺具有下列通式（I）：（VI）（VI）（六）

7. 发明授权

US5616579A Anti-ulcer pyridyloxy derivatives, their preparation and uses 失效
标题翻译：抗溃疡吡啶氧基衍生物，其制备及用途
公开(公告)号：US5616579A
公开(公告)日：1997-04-01
申请号：US35081
申请日：1993-03-22
申请人： Hiroshi Fukumi , Mitsuo Sugiyama , Keiichi Tabata , Koichi Kojima
发明人： Hiroshi Fukumi , Mitsuo Sugiyama , Keiichi Tabata , Koichi Kojima
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/495 , A61K31/505 , A61P1/04 , C07D213/64 , C07D213/70 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D401/00 , A61K31/54 , C07D409/00
CPC分类号： C07D213/64 , A61K31/44 , A61K31/495 , C07D213/70 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/10 , C07D417/12
摘要： Compounds of formula (I): ##STR1## [wherein: R.sup.1 is a cyclic amino group, or a dialkylamino group; R.sup.2 a group of formula --NHCHR.sup.3 R.sup.4 wherein R.sup.3 and R.sup.4 are each alkyl aryl or aralkyl, or together form a cycloalkyl group, or R.sup.2 is an aromatic heterocyclic group, or a group of formula --B--S(O).sub.m --R.sup.5 wherein R.sup.5 is a substituted alkyl group, or an aromatic heterocyclic group; B is an alkylene or alkylidene group; m is 0, 1 or 2; A is a group of formula --CH.dbd.CH-- or --(CH.sub.2).sub.n --, where n is 1, 2 or 3]; and salts thereof have valuable anti-ulcer activity.
摘要翻译：式（I）的化合物：其中：R1是环状氨基或二烷基氨基; R 2是式-NHCHR 3 R 4的基团，其中R 3和R 4各自是烷基芳基或芳烷基，或一起形成环烷基，或R 2是芳族杂环基，或式-BS（O）m -R 5基团，其中R 5是取代的烷基或芳族杂环基; B是亚烷基或亚烷基; m为0,1或2; A是式-CH = CH-或 - （CH 2）n - ，其中n是1,2或3]的基团; 其盐具有有价值的抗溃疡活性。

8. 发明授权

US5443561A Fuel vapor discharge limiting device for fuel tank 失效
标题翻译：燃油箱燃油蒸汽排放限制装置
公开(公告)号：US5443561A
公开(公告)日：1995-08-22
申请号：US213970
申请日：1994-03-16
申请人： Yoshiyasu Sakata , Mitsuo Sugiyama
发明人： Yoshiyasu Sakata , Mitsuo Sugiyama
IPC分类号： B60K15/077 , B60K15/035 , F02M37/00 , F16K24/04 , F16K31/18
CPC分类号： B60K15/03519 , F16K24/044 , Y10T137/0874 , Y10T137/3099 , Y10T137/86324
摘要： A fuel vapor discharge limiting device for limiting communication between a fuel tank and a fuel vapor discharge pipe for discharging a fuel vapor in the fuel tank. The fuel vapor discharge limiting device includes a first float valve for cutting off the communication between the fuel tank and the fuel vapor discharge pipe when a liquid level in the fuel tank rises near a predetermined full level; a relief valve for allowing the communication between the fuel tank and the fuel vapor discharge pipe when an internal pressure in the fuel tank becomes not less than a predetermined value; and a second float valve for blocking the communication allowed by the relief valve when the liquid level in the fuel tank abnormally rises over the predetermined full level. Accordingly, oversupply of liquid fuel to the fuel tank can be prevented, and the internal pressure in the fuel tank can be maintained always within a predetermined permissible range. Furthermore, discharge of the liquid fuel to the fuel vapor discharge pipe can be prevented.
摘要翻译：一种燃料蒸汽排放限制装置，用于限制燃料箱和用于排出燃料箱中的燃料蒸汽的燃料蒸汽排放管之间的连通。燃料蒸气排出限制装置包括：第一浮阀，用于当燃料箱中的液位升高到预定的全部水平时，切断燃料箱与燃料蒸汽排放管之间的连通; 当燃料箱中的内部压力变得不小于预定值时，用于允许燃料箱和燃料蒸汽排出管之间的连通的安全阀; 以及第二浮阀，用于当燃料箱中的液位异常上升超过预定的全部水平时，阻止安全阀所允许的连通。因此，可以防止液体燃料向燃料箱供过量供给，并且能够将燃料箱内的内部压力始终保持在规定的容许范围内。此外，可以防止液体燃料排出到燃料蒸汽排放管。

9. 发明授权

US06974156B2 Fuel tank structure 失效
标题翻译：油箱结构
公开(公告)号：US06974156B2
公开(公告)日：2005-12-13
申请号：US10391229
申请日：2003-03-18
申请人： Masami Kosuge , Mitsuo Sugiyama , Mitsuru Sayama , Morio Kuroki , Nagatsugu Mukaibo , Hiroshi Ogasa
发明人： Masami Kosuge , Mitsuo Sugiyama , Mitsuru Sayama , Morio Kuroki , Nagatsugu Mukaibo , Hiroshi Ogasa
IPC分类号： B60K15/03 , B60K15/07 , B60P3/22
CPC分类号： B60K15/07 , B60K15/03006 , B60K2015/03164 , B60K2015/0638 , F17C11/005
摘要： A fuel tank structure for a vehicle using gaseous fuel, has a plurality of cylindrical tank main bodies communicating from one another. The plurality of cylindrical tank main bodies are disposed at a fuel tank mount portion in a state of being adjoined from one another.
摘要翻译：用于使用气体燃料的车辆的燃料箱结构具有彼此连通的多个圆筒形罐主体。多个圆柱形罐主体以彼此相邻的状态设置在燃料箱安装部。

10. 发明授权

US4898862A 1,2,4-triazinone derivatives, their preparation and use 失效
标题翻译： 1,2,4-三嗪酮衍生物，其制备和用途
公开(公告)号：US4898862A
公开(公告)日：1990-02-06
申请号：US26290
申请日：1987-03-16
申请人： Yasuhiro Morisawa , Mitsuru Kataoka , Mitsuo Sugiyama , Fujio Saito , Hiroyuki Koike , Takeshi Oshima , Yasuo Simoji , Hitoshi Nagahori
发明人： Yasuhiro Morisawa , Mitsuru Kataoka , Mitsuo Sugiyama , Fujio Saito , Hiroyuki Koike , Takeshi Oshima , Yasuo Simoji , Hitoshi Nagahori
IPC分类号： C07D253/06 , C07D401/12 , C07D403/12
CPC分类号： C07D253/06 , C07D401/12 , C07D403/12
摘要： Compounds of formula (I): ##STR1## (in which: R.sup.1 is hydrogen or alkl; R.sup.2 is a variety of groups or atoms; R.sup.3 is optionally substituted hydroxy or --(NH).sub.n --NR.sup.5 R.sup.6, wherein R.sup.5 and R.sup.6 are a variety of groups or atoms, preferably alkyl substituted by heterocyclic, and n is 0 or 1; Q is oxygen or sulfur; and A is a C.sub.1 -C.sub.6 alkylene group) have valuable cardiotionic activity and may be used for the treatment of cardiac disorders. They may be prepared from corresponding compounds containing a benzene ring with a group --QH at the 1-position and a group --CO--CHR.sup.1 --NH--COOR.sup.7 at the 4-position by ring closure and introduction of the group of formula --A--CO--R.sup.3 in any order.
摘要翻译：式（I）化合物：其中：R 1是氢或烷基; R 2是各种基团或基团; R 3是任选取代的羟基或 - （NH）n -NR 5 R 6，其中R 5和R 6 是各种基团或原子，优选被杂环取代的烷基，n为0或1; Q为氧或硫; A为C1-C6亚烷基）具有有价值的心血管活性，可用于治疗心脏疾病它们可以由相应的化合物制备，所述化合物含有1-环基团-QH的苯环和通过闭环在4-位上的-CO-CHR1-NH-COOR7基团，并引入式-A- CO-R3以任何顺序。

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