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1. 发明授权

US07820636B2 Sugar intake promoters 有权
标题翻译：糖摄入促进剂
公开(公告)号：US07820636B2
公开(公告)日：2010-10-26
申请号：US10474721
申请日：2002-03-20
申请人： Hiromichi Okuda , Chie Morimoto , Kenji Kameda , Fumiki Harano
发明人： Hiromichi Okuda , Chie Morimoto , Kenji Kameda , Fumiki Harano
IPC分类号： A61K31/7076 , A61K31/522 , A61K31/52
CPC分类号： A61Q7/00 , A61K8/4953 , A61K8/606 , A61K31/52 , A61K31/675 , A61Q19/00 , A61Q19/02 , A61Q19/08
摘要： An object of the invention is to provide a substance that activates saccharide uptake in epidermal cells and is thus expected to be effective in promoting skin cell neogenesis and metabolism. The invention provides a promoter for saccharide uptake in epidermal keratinocytes which comprises a purine base or a salt thereof as an active ingredient. The present invention further provides a method of promoting saccharide uptake in epidermal keratinocytes, comprising applying a purine base or a salt thereof to the skin.
摘要翻译：本发明的一个目的是提供一种激活表皮细胞中的糖吸收的物质，因此预期其有效促进皮肤细胞新生和代谢。本发明提供了包含嘌呤碱或其盐作为活性成分的表皮角化细胞中糖摄取的启动子。本发明还提供一种促进表皮角质形成细胞中的糖摄取的方法，包括将嘌呤碱或其盐施用于皮肤。

2. 发明授权

US09125928B2 Agent for suppressing the formation of abnormal skin cells caused by exposure to light 有权
标题翻译：用于抑制由暴露于光引起的异常皮肤细胞形成的药剂
公开(公告)号：US09125928B2
公开(公告)日：2015-09-08
申请号：US13703671
申请日：2011-06-24
申请人： Mitsuaki Kawamura , Shigeo Shinohara , Fumiki Harano , Akihiro Aoki , Eri Ueno
发明人： Mitsuaki Kawamura , Shigeo Shinohara , Fumiki Harano , Akihiro Aoki , Eri Ueno
IPC分类号： A01N43/04 , A61K31/70 , A61K31/7076 , A61K9/00 , A61K47/10
CPC分类号： A61K31/7076 , A61K9/0014 , A61K47/10
摘要： An object of the present invention is to provide an agent for suppressing the formation of skin cells induced by exposure to light such as ultraviolet light. The object is achieved by using a purine nucleic acid for suppressing the formation of abnormal skin cells caused by exposure to light.
摘要翻译：本发明的目的是提供一种用于抑制由诸如紫外线的光照射而诱导的皮肤细胞形成的药剂。该目的通过使用嘌呤核酸来抑制由于暴露于光而引起的异常皮肤细胞的形成来实现。

3. 发明申请

US20110224163A1 GEL COMPOSITION FOR EXTERNAL APPLICATION CONTAINING AN ADENINE COMPOUND (As Amended) 有权
标题翻译：含有ADENINE化合物的外部应用的凝胶组合物（如修改）
公开(公告)号：US20110224163A1
公开(公告)日：2011-09-15
申请号：US12672254
申请日：2008-08-04
申请人： Misato Nakajo , Fumiki Harano , Kosaburo Wakamatsu , Kazuhiro Yagyu
发明人： Misato Nakajo , Fumiki Harano , Kosaburo Wakamatsu , Kazuhiro Yagyu
IPC分类号： A61K8/60 , A61Q19/08
CPC分类号： A61K8/0208 , A61K8/0212 , A61K8/60 , A61K8/606 , A61K9/0014 , A61K9/7007 , A61K31/52 , A61K31/7076 , A61K47/10 , A61K47/183 , A61K47/36 , A61K2800/88 , A61Q19/00 , A61Q19/08
摘要： An object of the present invention is to provide a composition for external application that is applied to a part of the skin to more effectively elicit the useful effects of an adenine compound such as adenine, adenosine, and a phosphoric ester of adenosine, and that has long-lasting effects and enhanced skin-moisturizing effects. A gel composition for external application containing an adenine compound such as adenine, adenosine, and a phosphoric ester of adenosine is prepared by using agar as a gelling agent. The gel composition is further prepared in the form of a sheet-like adhesive patch. The gel composition in the form of a sheet-like adhesive patch is kept immersed in an aqueous solution containing the adenine compound.
摘要翻译：本发明的目的是提供一种外用组合物，其用于一部分皮肤，以更有效地引发腺嘌呤化合物如腺嘌呤，腺苷和腺苷磷酸酯的有效作用，并且具有持久的效果和增强的皮肤保湿效果。通过使用琼脂作为胶凝剂制备含有腺嘌呤化合物如腺嘌呤，腺苷和腺苷磷酸酯的外用凝胶组合物。凝胶组合物进一步以片状粘合剂贴剂的形式制备。将片状粘贴剂形式的凝胶组合物浸渍在含有腺嘌呤化合物的水溶液中。

4. 发明申请

US20070280979A1 Solid Oil-In-Water Emulsion 有权
标题翻译：固体油包水乳液
公开(公告)号：US20070280979A1
公开(公告)日：2007-12-06
申请号：US11722965
申请日：2005-12-12
申请人： Shigeo Shinohara , Fumiki Harano , Shinji Tsujimoto , Isamu Saeki
发明人： Shigeo Shinohara , Fumiki Harano , Shinji Tsujimoto , Isamu Saeki
IPC分类号： A61K8/06 , A61K31/7076 , A61Q1/06 , B01F3/08 , A61Q99/00 , A61K47/00
CPC分类号： A61Q1/06 , A61K8/0229 , A61K8/06 , A61K8/062 , A61K8/345 , A61K8/39 , A61K8/55 , A61K8/606 , A61K8/67 , A61K8/92 , A61Q19/00 , A61Q19/02 , A61Q19/08
摘要： The present invention aims to provide solid compositions comprising an oil-in-water emulsion that have sufficient hardness and good feel when used, and can sufficiently exhibit the physiological functions of an electrolyte. A solid composition is obtained by preparing an oil-in-water emulsion by combining a solid oil (A), a liquid oil (B), a surfactant (C), a polyhydric alcohol (D), an electrolyte (E), and water (F).
摘要翻译：本发明旨在提供一种固体组合物，其包含在使用时具有足够的硬度和良好的手感的水包油乳液，并且可充分发挥电解质的生理功能。固体组合物通过将固体油（A），液体油（B），表面活性剂（C），多元醇（D），电解质（E）和水（F）。

5. 发明授权

US09597266B2 Gel composition for external application containing an adenine compound 有权
公开(公告)号：US09597266B2
公开(公告)日：2017-03-21
申请号：US12672254
申请日：2008-08-04
申请人： Misato Nakajo , Fumiki Harano , Kosaburo Wakamatsu , Kazuhiro Yagyu
发明人： Misato Nakajo , Fumiki Harano , Kosaburo Wakamatsu , Kazuhiro Yagyu
IPC分类号： A61K8/02 , A61K31/7076 , A61K9/00 , A61K47/36 , A61K8/60 , A61K9/70 , A61K31/52 , A61K47/10 , A61K47/18 , A61Q19/00 , A61Q19/08
CPC分类号： A61K8/0208 , A61K8/0212 , A61K8/60 , A61K8/606 , A61K9/0014 , A61K9/7007 , A61K31/52 , A61K31/7076 , A61K47/10 , A61K47/183 , A61K47/36 , A61K2800/88 , A61Q19/00 , A61Q19/08
摘要： An object of the present invention is to provide a composition for external application that is applied to a part of the skin to more effectively elicit the useful effects of an adenine compound such as adenine, adenosine, and a phosphoric ester of adenosine, and that has long-lasting effects and enhanced skin-moisturizing effects. A gel composition for external application containing an adenine compound such as adenine, adenosine, and a phosphoric ester of adenosine is prepared by using agar as a gelling agent. The gel composition is further prepared in the form of a sheet-like adhesive patch. The gel composition in the form of a sheet-like adhesive patch is kept immersed in an aqueous solution containing the adenine compound.

6. 发明申请

US20100279972A1 COMPOSITION FOR EXTERNAL APPLICATION 有权
标题翻译：外部应用的组成
公开(公告)号：US20100279972A1
公开(公告)日：2010-11-04
申请号：US12812402
申请日：2009-01-08
申请人： Kosaburo Wakamatsu , Shigeo Shinohara , Masahiko Tanaka , Fumiki Harano , Akihiro Aoki , Osamu Takasu
发明人： Kosaburo Wakamatsu , Shigeo Shinohara , Masahiko Tanaka , Fumiki Harano , Akihiro Aoki , Osamu Takasu
IPC分类号： A61K8/60 , A61Q19/02 , A61Q19/08 , A61Q19/00
CPC分类号： A61Q19/08 , A61K8/60 , A61K8/606 , A61Q1/08 , A61Q1/10 , A61Q19/00 , A61Q19/02 , A61Q19/10
摘要： A composition for external use capable of more efficiently deriving the effect of purine substances (and/or salts thereof) including (A) sugar; and (B) at least one member selected from the group consisting of purine substances and salts thereof.
摘要翻译：一种外用组合物，能够更有效地获得包含（A）糖的嘌呤物质（和/或其盐）的作用; 和（B）选自嘌呤物质及其盐中的至少一种。

7. 发明申请

US20080095567A1 Bar-Like Cosmetic Delivering Container 失效
标题翻译：酒吧般的化妆品运输集装箱
公开(公告)号：US20080095567A1
公开(公告)日：2008-04-24
申请号：US10584836
申请日：2005-02-17
申请人： Fumiki Harano , Yoshiyuki Murata
发明人： Fumiki Harano , Yoshiyuki Murata
IPC分类号： B43K21/02 , B43K21/00
CPC分类号： A45D40/12 , A45D40/06 , A45D2200/051
摘要： Provided is a bar-like cosmetic delivering container which is internally sealed and suppresses the cosmetic from forming a play due to negative pressure and prevents the lipstick from contacting the inner surface of a lid sleeve body. The bar-like cosmetic delivering container adapted to project and retract the cosmetic by relative rotation between a receiving sleeve body and an outer sleeve body, wherein a lid sleeve body is provided with a sealing sleeve body adapted to fit on the outer sleeve body, thereby sealing the interior of the container. This ensures that even when the lid sleeve body is opened to release the sealing sleeve body, the receiving sleeve body alone is not internally subjected to negative pressure, preventing the lipstick from floating up or forming a play. Further, since the lid sleeve body and the outer sleeve body are fitted together by the sealing sleeve body, relative rotation between the lid sleeve body and the outer sleeve body does not deliver or screw out the lipstick in the container, never causing the lipstick to contact the top surface of the lid sleeve body.
摘要翻译：提供一种内部密封的棒状化妆品输送容器，并且抑制化妆品由于负压而形成打击，并防止口红与盖套筒体的内表面接触。所述棒状化妆品输送容器适于通过接受套筒主体和外套筒本体之间的相对旋转而投射和缩回化妆品，其中盖套筒主体设置有适于装配在外套筒主体上的密封套筒体，由此密封容器的内部。这确保了即使当打开盖套筒体以释放密封套筒体时，接收套筒本体也不会内部受到负压，从而防止唇膏浮起或形成打印。此外，由于盖套筒主体和外套筒主体通过密封套筒本体装配在一起，所以盖套筒主体和外套筒本体之间的相对旋转不会将口红传递或拧出容器中的口红，从而不会使口红接触盖套体的顶面。

8. 发明授权

US09084904B2 Composition for external application 有权
标题翻译：组合外部应用
公开(公告)号：US09084904B2
公开(公告)日：2015-07-21
申请号：US12812402
申请日：2009-01-08
申请人： Kosaburo Wakamatsu , Shigeo Shinohara , Masahiko Tanaka , Fumiki Harano , Akihiro Aoki , Osamu Takasu
发明人： Kosaburo Wakamatsu , Shigeo Shinohara , Masahiko Tanaka , Fumiki Harano , Akihiro Aoki , Osamu Takasu
IPC分类号： A01N43/04 , A61K31/70 , A61K31/715 , A61Q19/08 , A61K8/60 , A61Q19/00 , A61Q19/02 , A61Q1/08 , A61Q1/10 , A61Q19/10
CPC分类号： A61Q19/08 , A61K8/60 , A61K8/606 , A61Q1/08 , A61Q1/10 , A61Q19/00 , A61Q19/02 , A61Q19/10
摘要： A composition for external use capable of more efficiently deriving the effect of purine substances (and/or salts thereof) including (A) sugar; and (B) at least one member selected from the group consisting of purine substances and salts thereof.
摘要翻译：一种外用组合物，能够更有效地获得包含（A）糖的嘌呤物质（和/或其盐）的作用; 和（B）选自嘌呤物质及其盐中的至少一种。

9. 发明授权

US08492353B2 Antiaging composition 有权
标题翻译：抗衰老成分
公开(公告)号：US08492353B2
公开(公告)日：2013-07-23
申请号：US10523605
申请日：2003-08-01
申请人： Kosaburo Wakamatsu , Fumiki Harano , Takashige Koba , Shigeo Shinohara
发明人： Kosaburo Wakamatsu , Fumiki Harano , Takashige Koba , Shigeo Shinohara
IPC分类号： A61K31/70 , A61K31/34 , A61K8/02
CPC分类号： A61Q19/02 , A61K8/606 , A61K8/676 , A61K31/375 , A61K31/7076 , A61Q19/08 , A61K2300/00
摘要： The present invention provides an antiaging composition capable of efficiently retarding skin aging skin aging, particularly, alleviating skin pigmentation. The present invention also provides a method for potentiating the antiaging action of ascorbic acids. The invention provides an antiaging composition containing at least one member selected from the group consisting of ascorbic acid, a derivative of ascorbic acid, and a salt thereof (A), and a purine nucleic acid-related substance (B). The invention provides a method for potentiating the antiaging action of such component (A) by the combined use of at least one member selected from the group consisting of ascorbic acid, a derivative of ascorbic acid, and a salt thereof (A), with a purine nucleic acid-related substance (B).
摘要翻译：本发明提供一种抗衰老组合物，其能够有效地延缓皮肤老化的皮肤老化，特别是减轻皮肤色素沉着。本发明还提供了一种增强抗坏血酸抗衰老作用的方法。本发明提供含有选自抗坏血酸，抗坏血酸的衍生物及其盐（A）和嘌呤核酸相关物质（B）中的至少一种的抗衰老组合物。本发明提供了一种通过组合使用选自抗坏血酸，抗坏血酸衍生物及其盐（A）中的至少一种的组分（A）来增强这种组分（A）的抗衰老作用的方法，嘌呤核酸相关物质（B）。

10. 发明授权

US07553101B2 Bar-like cosmetic delivering container 失效
标题翻译：酒吧式化妆品送货箱
公开(公告)号：US07553101B2
公开(公告)日：2009-06-30
申请号：US10584836
申请日：2005-02-17
申请人： Fumiki Harano , Yoshiyuki Murata
发明人： Fumiki Harano , Yoshiyuki Murata
IPC分类号： A65D40/04
CPC分类号： A45D40/12 , A45D40/06 , A45D2200/051
摘要： Provided is a bar-like cosmetic delivering container which is internally sealed and suppresses the cosmetic from forming a play due to negative pressure and prevents the lipstick from contacting the inner surface of a lid sleeve body. The bar-like cosmetic delivering container adapted to project and retract the cosmetic by relative rotation between a receiving sleeve body and an outer sleeve body, wherein a lid sleeve body is provided with a sealing sleeve body adapted to fit on the outer sleeve body, thereby sealing the interior of the container. This ensures that even when the lid sleeve body is opened to release the sealing sleeve body, the receiving sleeve body alone is not internally subjected to negative pressure, preventing the lipstick from floating up or forming a play. Further, since the lid sleeve body and the outer sleeve body are fitted together by the sealing sleeve body, relative rotation between the lid sleeve body and the outer sleeve body does not deliver or screw out the lipstick in the container, never causing the lipstick to contact the top surface of the lid sleeve body.
摘要翻译：提供一种内部密封的棒状化妆品输送容器，并且抑制化妆品由于负压而形成打击，并防止口红与盖套筒体的内表面接触。所述棒状化妆品输送容器适于通过接受套筒主体和外套筒本体之间的相对旋转而投射和缩回化妆品，其中盖套筒主体设置有适于装配在外套筒主体上的密封套筒体，由此密封容器的内部。这确保了即使当打开盖套筒体以释放密封套筒体时，接收套筒本体也不会内部受到负压，从而防止唇膏浮起或形成打印。此外，由于盖套筒主体和外套筒主体通过密封套筒本体装配在一起，所以盖套筒主体和外套筒本体之间的相对旋转不会将口红传递或拧出容器中的口红，从而不会使口红接触盖套体的顶面。

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