专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08084476B2 Substituted methyl aryl or heteroaryl amide compounds 有权
标题翻译：取代的甲基芳基或杂芳基酰胺化合物
公开(公告)号：US08084476B2
公开(公告)日：2011-12-27
申请号：US12368778
申请日：2009-02-10
申请人： Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
发明人： Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
IPC分类号： A61K31/44 , C07D211/72
CPC分类号： C07D213/74 , C07C235/42 , C07C235/46 , C07C2601/08 , C07C2601/14 , C07D213/65 , C07D213/82 , C07D213/89
摘要： This invention provides a compound of the formula (I): wherein X represents a carbon atom or the like: Y represents imino, or the like: R1 represents an alkyl group having from 1 to 6 carbon atoms or the like: R2 and R3 independently represents a hydrogen atom or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）的化合物：其中X表示碳原子等：Y表示亚氨基等：R 1表示具有1至6个碳原子的烷基等：R 2和R 3独立地表示氢原子等。这些化合物可用于治疗由前列腺素介导的疾病状况，例如哺乳动物中的疼痛等。本发明还提供了包含上述化合物的药物组合物。

2. 发明申请

US20090163558A1 Substituted Methyl Aryl or Heteroaryl Amide Compounds 有权
标题翻译：取代的甲基芳基或杂芳基酰胺化合物
公开(公告)号：US20090163558A1
公开(公告)日：2009-06-25
申请号：US12368778
申请日：2009-02-10
申请人： Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
发明人： Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
IPC分类号： A61K31/44 , C07D213/56
CPC分类号： C07D213/74 , C07C235/42 , C07C235/46 , C07C2601/08 , C07C2601/14 , C07D213/65 , C07D213/82 , C07D213/89
摘要： This invention provides a compound of the formula (I): wherein X represents a carbon atom or the like: Y represents imino, or the like: R1 represents an alkyl group having from 1 to 6 carbon atoms or the like: R2 and R3 independently represents a hydrogen atom or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）的化合物：其中X表示碳原子等：Y表示亚氨基等：R 1表示具有1至6个碳原子的烷基等：R 2和R 3独立地表示氢原子等。这些化合物可用于治疗由前列腺素介导的疾病状况，例如哺乳动物中的疼痛等。本发明还提供了包含上述化合物的药物组合物。

3. 发明授权

US07534914B2 Substituted methyl aryl or heteroaryl amide compounds 失效
标题翻译：取代的甲基芳基或杂芳基酰胺化合物
公开(公告)号：US07534914B2
公开(公告)日：2009-05-19
申请号：US11118497
申请日：2005-04-29
申请人： Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
发明人： Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
IPC分类号： C07C229/00
CPC分类号： C07D213/74 , C07C235/42 , C07C235/46 , C07C2601/08 , C07C2601/14 , C07D213/65 , C07D213/82 , C07D213/89
摘要： This invention provides a compound of the formula (I): wherein X represents a carbon atom or the like: Y represents imino, or the like: R1 represents an alkyl group having from 1 to 6 carbon atoms or the like: R2 and R3 independently represents a hydrogen atom or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）的化合物：其中X表示碳原子等：Y表示亚氨基等：R 1表示具有1至6个碳原子的烷基等：R 2和R 3独立地表示氢原子等。这些化合物可用于治疗由前列腺素介导的疾病状况，例如哺乳动物中的疼痛等。本发明还提供了包含上述化合物的药物组合物。

4. 发明申请

US20050267170A1 Substituted methyl aryl or heteroaryl amide compounds 失效
标题翻译：取代的甲基芳基或杂芳基酰胺化合物
公开(公告)号：US20050267170A1
公开(公告)日：2005-12-01
申请号：US11118497
申请日：2005-04-29
申请人： Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
发明人： Hiroki Koike , Kana Kon-i , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
IPC分类号： A61K31/195 , A61K31/455 , C07C235/42 , C07C235/46 , C07C235/70 , C07D213/56 , C07D213/65 , C07D213/74 , C07D213/82 , C07D213/89
CPC分类号： C07D213/74 , C07C235/42 , C07C235/46 , C07C2601/08 , C07C2601/14 , C07D213/65 , C07D213/82 , C07D213/89
摘要： This invention provides a compound of the formula (I): wherein X represents a carbon atom or the like: Y represents imino, or the like: R1 represents an alkyl group having from 1 to 6 carbon atoms or the like: R2 and R3 independently represents a hydrogen atom or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）的化合物：其中X表示碳原子等：Y表示亚氨基等：R 1表示具有1至6个碳原子的烷基 R 2，R 3和R 3独立地表示氢原子等。这些化合物可用于治疗由前列腺素介导的疾病状况，例如哺乳动物中的疼痛等。本发明还提供了包含上述化合物的药物组合物。

5. 发明申请

US20050250818A1 Ortho substituted aryl or heteroaryl amide compounds 审中-公开
标题翻译：正构取代的芳基或杂芳基酰胺化合物
公开(公告)号：US20050250818A1
公开(公告)日：2005-11-10
申请号：US11118646
申请日：2005-04-29
申请人： Hiroki Koike , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
发明人： Hiroki Koike , Yukari Matsumoto , Kazunari Nakao , Yoshiyuki Okumura , Tatsuya Yamagishi
IPC分类号： A61K31/195 , A61K31/4415 , C07C235/60 , C07C255/54 , C07D213/61 , C07D213/82 , C07D213/89 , C07D261/08 , C07D307/12 , C07D307/42 , C07D309/06
CPC分类号： C07D261/08 , C07C235/60 , C07C255/54 , C07C2601/04 , C07C2601/14 , C07D213/61 , C07D213/82 , C07D213/89 , C07D307/12 , C07D307/42 , C07D309/06 , C07D405/12
摘要： This invention provides a compound of the formula (I): wherein X represents a carbon atom or the like: Y represents imino, or the like: Z represents a hydrogen atom or the like: R1 represents an alkyl group having from 1 to 6 carbon atoms or the like: R2 and R3 independently represents a hydrogen atom or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）的化合物：其中X表示碳原子等：Y表示亚氨基等; Z表示氢原子等：R 1表示具有1至6个碳原子的烷基等：R 2和R 3独立地表示氢原子等。这些化合物可用于治疗由前列腺素介导的疾病状况，例如哺乳动物中的疼痛等。本发明还提供了包含上述化合物的药物组合物。

6. 发明授权

US07238714B2 Aryl or heteroaryl amide compounds 有权
标题翻译：芳基或杂芳基酰胺化合物
公开(公告)号：US07238714B2
公开(公告)日：2007-07-03
申请号：US10932463
申请日：2004-09-02
申请人： Kazunari Nakao , Seiji Nukui , Yoshiyuki Okumura , Tatsuya Yamagishi
发明人： Kazunari Nakao , Seiji Nukui , Yoshiyuki Okumura , Tatsuya Yamagishi
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07C233/87 , C04B35/632 , C07C235/60 , C07C255/57 , C07D213/643 , C07D213/65 , C07D213/82 , C07D257/04 , C07D401/12 , C07D417/12
摘要： This invention provides a compound of the formula (I): wherein A represents a phenyl group or the like: B represents an aryl or the like: E represents a 1,4-phenylene group; R1 and R2 independently represent a hydrogen atom or the like: R3 and R4 independently represent a hydrogen atom or the like: R5 represents —CO2H or the like: R6 represents an alkyl group having from 1 to 6 carbon atoms or the like: X represents a methylene group or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）的化合物：其中A表示苯基等：B表示芳基等：E表示1,4-亚苯基; R 1和R 2独立地表示氢原子等：R 3和R 4独立地表示氢原子，氢原子等：R 5表示-CO 2 H等：R 6表示具有1至6个碳原子的烷基原子等：X表示亚甲基等。这些化合物可用于治疗由前列腺素介导的疾病状况，例如哺乳动物中的疼痛等。本发明还提供了包含上述化合物的药物组合物。

7. 发明申请

US20050065188A1 Aryl or heteroaryl amide compounds 有权
标题翻译：芳基或杂芳基酰胺化合物
公开(公告)号：US20050065188A1
公开(公告)日：2005-03-24
申请号：US10932463
申请日：2004-09-02
申请人： Kazunari Nakao , Seiji Nukui , Yoshiyuki Okumura , Tatsuya Yamagishi
发明人： Kazunari Nakao , Seiji Nukui , Yoshiyuki Okumura , Tatsuya Yamagishi
IPC分类号： A61P29/00 , C07C233/87 , C07C235/60 , C07C255/57 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/82 , C07D257/04 , C07D401/12 , C07D417/12 , A61K31/4439 , A61K31/18 , A61K31/195 , A61K31/198 , A61K31/355
CPC分类号： C07C233/87 , C04B35/632 , C07C235/60 , C07C255/57 , C07D213/643 , C07D213/65 , C07D213/82 , C07D257/04 , C07D401/12 , C07D417/12
摘要： This invention provides a compound of the formula (I): wherein A represents a phenyl group or the like: B represents an aryl or the like: E represents a 1,4-phenylene group; R1 and R2 independently represent a hydrogen atom or the like: R3 and R4 independently represent a hydrogen atom or the like: R5 represents —CO2H or the like: R6 represents an alkyl group having from 1 to 6 carbon atoms or the like: X represents a methylene group or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）的化合物：其中A表示苯基等：B表示芳基等：E表示1,4-亚苯基; R 1和R 2独立地表示氢原子等：R 3和R 4独立地表示氢原子等：R 5表示-CO 2 H等：R 6 >表示具有1〜6个碳原子的烷基等：X表示亚甲基等。这些化合物可用于治疗由前列腺素介导的疾病状况，例如哺乳动物中的疼痛等。本发明还提供了包含上述化合物的药物组合物。

8. 发明授权

US07001917B2 Pyrazole compounds as anti-inflammatory and analgesic agents 失效
标题翻译：吡唑化合物作为抗炎和止痛剂
公开(公告)号：US07001917B2
公开(公告)日：2006-02-21
申请号：US10409881
申请日：2003-04-09
申请人： Misato Hirano , Kazunari Nakao , Seiji Nukui , Tatsuya Yamagishi
发明人： Misato Hirano , Kazunari Nakao , Seiji Nukui , Tatsuya Yamagishi
IPC分类号： A61K31/415 , C07D231/10 , A61P29/00
CPC分类号： C07D231/12 , C07D231/16 , C07D231/38 , C07D401/04 , C07D401/12 , C07D403/12 , C07D417/04 , C07D417/12 , C07D521/00
摘要： This invention provides a compound of the formula (I): wherein: R1 represents a hydrogen atom, an alkyl group, etc.; R2 represents a hydrogen atom, a halogen atom, etc.; R3 represents an alkyl group, etc.; R4 represents an aryl group, etc.; A represents an aryl1, etc; B represents an alkylene etc.; X represents NH, etc.; or a pharmaceutically acceptable ester of such compound, and pharmaceutically acceptable salts thereof. These compounds are useful for the treatment of medical conditions mediated by prostaglandin such as pain, fever or inflammation, etc. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供了式（

9. 发明授权

US06956050B2 Imidazole compounds as anti-inflammatory and analgesic agents 失效
标题翻译：咪唑化合物作为抗炎镇痛剂
公开(公告)号：US06956050B2
公开(公告)日：2005-10-18
申请号：US10409836
申请日：2003-04-09
申请人： Misato Hirano , Satoru Iguchi , Kazunari Nakao , Tatsuya Yamagishi
发明人： Misato Hirano , Satoru Iguchi , Kazunari Nakao , Tatsuya Yamagishi
IPC分类号： C07D233/60 , A61K31/4164 , A61K31/4439 , A61P1/04 , A61P3/10 , A61P5/00 , A61P7/02 , A61P7/04 , A61P9/00 , A61P11/06 , A61P13/12 , A61P15/08 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P25/06 , A61P25/20 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/12 , A61P31/16 , A61P35/00 , A61P35/04 , A61P37/02 , A61P37/08 , A61P43/00 , C07D233/54 , C07D233/61 , C07D233/88 , C07D235/08 , C07D401/04 , C07D401/12 , C07D417/04 , C07D521/00 , A61K31/4178 , C07D233/64
CPC分类号： C07D233/64 , C07D233/88 , C07D235/08 , C07D401/12 , C07D521/00
摘要： This invention provides a compound of the formula (I): wherein: R1 represents a hydrogen atom, an alkyl group, etc.; R2 represents a hydrogen atom, a halogen atom, etc.; R3 represents a hydrogen atom, an alkyl group, etc.; R4 represents an aryl group, etc.; A represents an aryl1, etc; B represents an alkylene etc.; X represents NH, etc.; or a pharmaceutically acceptable ester of such compound, and pharmaceutically acceptable salts thereof. These compounds are useful for the treatment of medical conditions mediated by prostaglamndin such as pain, fever or inflammation, etc. This invention also provides a pharmaceutical composition comprising the above compound.
摘要翻译：本发明提供式（I）的化合物：其中：R 1表示氢原子，烷基等; R 2表示氢原子，卤素原子等; R 3表示氢原子，烷基等; R 4表示芳基等; A表示芳基等; B表示亚烷基等。 X表示NH等。或这种化合物的药学上可接受的酯及其药学上可接受的盐。这些化合物可用于治疗由前列腺素介导的医学病症如疼痛，发热或炎症等。本发明还提供包含上述化合物的药物组合物。

10. 发明申请

US20070219237A1 Chromane Derivatives 审中-公开
标题翻译：色原衍生物
公开(公告)号：US20070219237A1
公开(公告)日：2007-09-20
申请号：US11687781
申请日：2007-03-19
申请人： Yukari Matsumoto , Hirohisa Shimokawa , Tatsuya Yamagishi
发明人： Yukari Matsumoto , Hirohisa Shimokawa , Tatsuya Yamagishi
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1, R2, R3, R4, R5, R6, R7, R8 A and B are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the method of treatment and the use, comprising such compounds for the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), laryngopharyngeal reflux disease, peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-erosive reflux disease (NERD), visceral pain, cancer, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中：R 1，R 2，R 3， R 4，R 5，R 6，R 7，R 8， A和B各自如本文所述或其药学上可接受的盐，以及含有这些化合物的组合物及其治疗和使用方法，其包含用于治疗由酸泵拮抗活性介导的病症的化合物，所述活性例如但不限于，胃肠疾病，胃食管疾病，胃食管反流病（GERD），咽喉反流病，消化性溃疡，胃溃疡，十二指肠溃疡，NSAID诱发的溃疡，胃炎，幽门螺杆菌感染，消化不良，功能性消化不良，佐林格 - 埃里森综合征，非侵蚀性反流病（NERD），内脏痛，癌症，胃灼热，恶心，食管炎，吞咽困难，过度激活，气道障碍或哮喘。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式