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1. 发明申请

US20100016263A1 9, 10-SECOPREGNANE DERIVATIVE AND PHARMACEUTICAL 有权
标题翻译： 9，10-SECOPREGNANE DERIVATIVE AND PHARMACEUTICAL
公开(公告)号：US20100016263A1
公开(公告)日：2010-01-21
申请号：US12302975
申请日：2007-06-01
申请人： Hiroki Fujieda , Hironori Otsu , Shoji Yasufuku , Masaaki Shirai
发明人： Hiroki Fujieda , Hironori Otsu , Shoji Yasufuku , Masaaki Shirai
IPC分类号： A61K31/593 , C07C401/00 , A61P17/00
CPC分类号： C07C401/00
摘要： A main object of the invention is to provide a novel useful vitamin D3 derivative, which has an excellent vitamin D3 activity and, as compared with conventional vitamin D3 derivatives, has a relatively small amount of influence on the systemic calcium metabolism. The invention includes a 9,10-secopregnane derivative of the following general formula [1] and a pharmaceutical composition containing it as active ingredient. In the general formula [1], the following partial structure between the 16-position and the 17-position means a single bond or a double bond: Y is a single bond, an alkylene, an alkenylene or phenylene; R1 and R2 are the same or different, each represents hydrogen, an alkyl or a cycloalkyl; or R1 and R2, taken together with the adjacent carbon atom, form a cycloalkyl; R3 is hydrogen or methyl; Z is hydrogen, hydroxy or —NR11R12.
摘要翻译：本发明的主要目的是提供一种具有优异维生素D3活性的新型有用的维生素D3衍生物，与常规维生素D3衍生物相比，对全身钙代谢的影响相对较小。本发明包括以下通式[1]的9,10-仲孕烷衍生物和含有它作为活性成分的药物组合物。在通式[1]中，16位和17位之间的以下部分结构是指单键或双键：Y为单键，亚烷基，亚烯基或亚苯基; R1和R2相同或不同，各自表示氢，烷基或环烷基; 或R 1和R 2与相邻碳原子一起形成环烷基; R3是氢或甲基; Z是氢，羟基或-NR 11 R 12。

2. 发明授权

US08796246B2 9, 10-secopregnane derivative and pharmaceutical 有权
标题翻译： 9,10-孕代衍生物和药物
公开(公告)号：US08796246B2
公开(公告)日：2014-08-05
申请号：US12302975
申请日：2007-06-01
申请人： Hiroki Fujieda , Hironori Otsu , Shoji Yasufuku , Masaaki Shirai
发明人： Hiroki Fujieda , Hironori Otsu , Shoji Yasufuku , Masaaki Shirai
IPC分类号： A61K31/593 , C07C401/00
CPC分类号： C07C401/00
摘要： A main object of the invention is to provide a novel useful vitamin D3 derivative, which has an excellent vitamin D3 activity and, as compared with conventional vitamin D3 derivatives, has a relatively small amount of influence on the systemic calcium metabolism. The invention includes a 9,10-secopregnane derivative of the following general formula [1] and a pharmaceutical composition containing it as active ingredient. In the general formula [1], the following partial structure between the 16-position and the 17-position means a single bond or a double bond: Y is a single bond, an alkylene, an alkenylene or phenylene; R1 and R2 are the same or different, each represents hydrogen, an alkyl or a cycloalkyl; or R1 and R2, taken together with the adjacent carbon atom, form a cycloalkyl; R3 is hydrogen or methyl; Z is hydrogen, hydroxy or —NR11R12.
摘要翻译：本发明的主要目的是提供一种具有优异维生素D3活性的新型有用的维生素D3衍生物，与常规维生素D3衍生物相比，对全身钙代谢的影响相对较小。本发明包括以下通式[1]的9,10-仲孕烷衍生物和含有它作为活性成分的药物组合物。在通式[1]中，16位和17位之间的以下部分结构是指单键或双键：Y为单键，亚烷基，亚烯基或亚苯基; R1和R2相同或不同，各自表示氢，烷基或环烷基; 或R 1和R 2与相邻碳原子一起形成环烷基; R3是氢或甲基; Z是氢，羟基或-NR 11 R 12。

3. 发明授权

US5997736A Method of biologically removing nitrogen and system therefor 有权
公开(公告)号：US5997736A
公开(公告)日：1999-12-07
申请号：US161458
申请日：1998-09-28
申请人： Tatsuo Sumino , Nobuko Hashimoto , Hiroki Nakamura , Kazuhiko Noto , Takako Ogasawara , Masaaki Shirai , Hiroyoshi Emori , Masataka Kasai
发明人： Tatsuo Sumino , Nobuko Hashimoto , Hiroki Nakamura , Kazuhiko Noto , Takako Ogasawara , Masaaki Shirai , Hiroyoshi Emori , Masataka Kasai
IPC分类号： C02F3/12 , C02F3/30 , C02F3/34 , C02F3/06
CPC分类号： C02F3/087 , C02F3/302 , C02F3/34 , C02F3/085 , Y02W10/15 , Y10S210/903
摘要： In a method of biologically removing nitrogen and a system therefor according to the present invention, by utilizing the characteristics of AH bacteria as being nitrifying bacteria of nitrous acid type for displaying high activity at the high concentration of ammonium nitrogen and the characteristics of AL bacteria as being nitrifying bacteria of nitrous acid type for displaying high activity at the low concentration of the ammonium nitrogen, in the nitrifying process, operations capable of obtaining the maximum nitrifying speed in accordance with the concentration of the ammonium nitrogen can be performed, and the nitrifying reaction of nitrous acid type for producing nitrous acid as being an intermediate oxide material of the ammonium nitrogen can be performed.

4. 发明授权

US6033569A Method of biologically removing nitrogen and system therefor 有权
标题翻译：生物除氮方法及其系统
公开(公告)号：US6033569A
公开(公告)日：2000-03-07
申请号：US205107
申请日：1998-12-03
申请人： Tatsuo Sumino , Nobuko Hashimoto , Hiroki Nakamura , Kazuhiko Noto , Takako Ogasawara , Masaaki Shirai , Hiroyoshi Emori , Masataka Kasai
发明人： Tatsuo Sumino , Nobuko Hashimoto , Hiroki Nakamura , Kazuhiko Noto , Takako Ogasawara , Masaaki Shirai , Hiroyoshi Emori , Masataka Kasai
IPC分类号： C02F3/12 , C02F3/30 , C02F3/34
CPC分类号： C02F3/087 , C02F3/302 , C02F3/34 , C02F3/085 , Y02W10/15 , Y10S210/903
摘要： In a method of biologically removing nitrogen and a system therefor according to the present invention, by utilizing the characteristics of AH bacteria as being nitrifying bacteria of nitrous acid type for displaying high activity at the high concentration of ammonium nitrogen and the characteristics of AL bacteria as being nitrifying bacteria of nitrous acid type for displaying high activity at the low concentration of the ammonium nitrogen, in the nitrifying process, operations capable of obtaining the maximum nitrifying speed in accordance with the concentration of the ammonium nitrogen can be performed, and the nitrifying reaction of nitrous acid type for producing nitrous acid as being an intermediate oxide material of the ammonium nitrogen can be performed.
摘要翻译：在根据本发明的生物去除氮的方法及其系统中，通过利用AH细菌的特征作为在高浓度铵态氮下显示高活性的亚硝酸硝化细菌和AL细菌的特性作为在硝化过程中，可以进行亚硝酸类硝化细菌在氮浓度低的显示高活性的硝化细菌，能够根据铵氮的浓度获得最大硝化速度的操作，硝化反应的亚硝酸型，用于生产亚硝酸作为铵氮的中间体氧化物材料。

5. 发明授权

US5876603A Method of biologically removing nitrogen and system therefor 失效
公开(公告)号：US5876603A
公开(公告)日：1999-03-02
申请号：US682019
申请日：1996-07-16
申请人： Tatsuo Sumino , Nobuko Hashimoto , Hiroki Nakamura , Kazuhiko Noto , Takako Ogasawara , Masaaki Shirai , Hiroyoshi Emori , Masataka Kasai
发明人： Tatsuo Sumino , Nobuko Hashimoto , Hiroki Nakamura , Kazuhiko Noto , Takako Ogasawara , Masaaki Shirai , Hiroyoshi Emori , Masataka Kasai
IPC分类号： C02F3/12 , C02F3/30 , C02F3/34
CPC分类号： C02F3/087 , C02F3/302 , C02F3/34 , C02F3/085 , Y02W10/15 , Y10S210/903
摘要： In a method of biologically removing nitrogen and a system therefor according to the present invention, by utilizing the characteristics of AH bacteria as being nitrifying bacteria of nitrous acid type for displaying high activity at the high concentration of ammonium nitrogen and the characteristics of AL bacteria as being nitrifying bacteria of nitrous acid type for displaying high activity at the low concentration of the ammonium nitrogen, in the nitrifying process, operations capable of obtaining the maximum nitrifying speed in accordance with the concentration of the ammonium nitrogen can be performed, and the nitrifying reaction of nitrous acid type for producing nitrous acid as being an intermediate oxide material of the ammonium nitrogen can be performed.

6. 发明授权

US5849180A Method of biologically removing nitrogen and system therefor 失效
公开(公告)号：US5849180A
公开(公告)日：1998-12-15
申请号：US46618
申请日：1998-03-24
申请人： Tatsuo Sumino , Nobuko Hashimoto , Hiroki Nakamura , Kazuhiko Noto , Takako Ogasawara , Masaaki Shirai , Hiroyoshi Emori , Masataka Kasai
发明人： Tatsuo Sumino , Nobuko Hashimoto , Hiroki Nakamura , Kazuhiko Noto , Takako Ogasawara , Masaaki Shirai , Hiroyoshi Emori , Masataka Kasai
IPC分类号： C02F3/12 , C02F3/30 , C02F3/34
CPC分类号： C02F3/087 , C02F3/302 , C02F3/34 , C02F3/085 , Y02W10/15 , Y10S210/903
摘要： In a method of biologically removing nitrogen and a system therefor according to the present invention, by utilizing the characteristics of AH bacteria as being nitrifying bacteria of nitrous acid type for displaying high activity at the high concentration of ammonium nitrogen and the characteristics of AL bacteria as being nitrifying bacteria of nitrous acid type for displaying high activity at the low concentration of the ammonium nitrogen, in the nitrifying process, operations capable of obtaining the maximum nitrifying speed in accordance with the concentration of the ammonium nitrogen can be performed, and the nitrifying reaction of nitrous acid type for producing nitrous acid as being an intermediate oxide material of the ammonium nitrogen can be performed.

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