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1. 发明授权

US07189415B2 Rapidly disintegrable pharmaceutical composition 失效
标题翻译：快速分解的药物组合物
公开(公告)号：US07189415B2
公开(公告)日：2007-03-13
申请号：US10998659
申请日：2004-11-30
申请人： Hirokazu Takagi , Atsushi Kajiyama , Masahiro Yanagisawa
发明人： Hirokazu Takagi , Atsushi Kajiyama , Masahiro Yanagisawa
IPC分类号： A61K9/14 , A61K9/20 , A61K9/26 , A61K9/48 , A61K9/66
CPC分类号： A61K9/2009 , A61K9/1617 , A61K9/1652 , A61K9/2018 , A61K9/2022 , A61K9/2054
摘要： The present invention relates to a pharmaceutical composition useful for rapid disintegration, which comprises a sparingly soluble medicament held on a gel-forming water-soluble polymer as a solid dispersion, wherein it contains a salt substance that comprises an alkali and a weak or strong acid and has an endothermic standard enthalpy of solution or heat of solution. Since rapid disintegration of the pharmaceutical composition of the present invention and rapid dissolution of the medicament contained in the preparation can be made in the digestive tracts pH-independently, good bioavailability can be attained.
摘要翻译：本发明涉及用于快速崩解的药物组合物，其包含保持在形成凝胶的水溶性聚合物作为固体分散体的微溶性药物，其中其含有包含碱和弱或强酸的盐物质并且具有吸热标准溶液溶液或溶液热。由于本发明的药物组合物的快速崩解和制剂中包含的药物的快速溶解可以在消费道中独立地进行，可以获得良好的生物利用度。

2. 发明申请

US20050095289A1 Rapidly disintegrable pharmaceutical composition 失效
标题翻译：快速分解的药物组合物
公开(公告)号：US20050095289A1
公开(公告)日：2005-05-05
申请号：US10998659
申请日：2004-11-30
申请人： Hirokazu Takagi , Atsushi Kajiyama , Masahiro Yanagisawa
发明人： Hirokazu Takagi , Atsushi Kajiyama , Masahiro Yanagisawa
IPC分类号： A61K9/16 , A61K9/20 , A61K9/14
CPC分类号： A61K9/2009 , A61K9/1617 , A61K9/1652 , A61K9/2018 , A61K9/2022 , A61K9/2054
摘要： The present invention relates to a pharmaceutical composition useful for rapid disintegration, which comprises a sparingly soluble medicament held on a gel-forming water-soluble polymer as a solid dispersion, wherein it contains a salt substance that comprises an alkali and a weak or strong acid and has an endothermic standard enthalpy of solution or heat of solution. Since rapid disintegration of the pharmaceutical composition of the present invention and rapid dissolution of the medicament contained in the preparation can be made in the digestive tracts pH-independently, good bioavailability can be attained.
摘要翻译：本发明涉及用于快速崩解的药物组合物，其包含保持在形成凝胶的水溶性聚合物作为固体分散体的微溶性药物，其中其含有包含碱和弱或强酸的盐物质并且具有吸热标准溶液溶液或溶液热。由于本发明的药物组合物的快速崩解和制剂中包含的药物的快速溶解可以在消费道中独立地进行，可以获得良好的生物利用度。

3. 发明申请

US20070014856A1 Rapidly disintegrable pharmaceutical composition 审中-公开
公开(公告)号：US20070014856A1
公开(公告)日：2007-01-18
申请号：US11522977
申请日：2006-09-19
申请人： Hirokazu Takagi , Atsushi Kajiyama , Masahiro Yanagisawa
发明人： Hirokazu Takagi , Atsushi Kajiyama , Masahiro Yanagisawa
IPC分类号： A61K31/55 , A61K9/20
CPC分类号： A61K9/2009 , A61K9/1617 , A61K9/1652 , A61K9/2018 , A61K9/2022 , A61K9/2054
摘要： The present invention relates to a pharmaceutical composition useful for rapid disintegration, which comprises a sparingly soluble medicament held on a gel-forming water-soluble polymer as a solid dispersion, wherein it contains a salt substance that comprises an alkali and a weak or strong acid and has an endothermic standard enthalpy of solution or heat of solution. Since rapid disintegration of the pharmaceutical composition of the present invention and rapid dissolution of the medicament contained in the preparation can be made in the digestive tracts pH-independently, good bioavailability can be attained.

4. 发明授权

US06899899B2 Rapidly disintegrable pharmaceutical composition 失效
公开(公告)号：US06899899B2
公开(公告)日：2005-05-31
申请号：US10190568
申请日：2002-07-09
申请人： Hirokazu Takagi , Atsushi Kajiyama , Masahiro Yanagisawa
发明人： Hirokazu Takagi , Atsushi Kajiyama , Masahiro Yanagisawa
IPC分类号： A61K9/16 , A61K9/20 , A61K9/14 , A61K9/48
CPC分类号： A61K9/2009 , A61K9/1617 , A61K9/1652 , A61K9/2018 , A61K9/2022 , A61K9/2054
摘要： The present invention relates to a pharmaceutical composition useful for rapid disintegration, which comprises a sparingly soluble medicament held on a gel-forming water-soluble polymer as a solid dispersion, wherein it contains a salt substance that comprises an alkali and a weak or strong acid and has an endothermic standard enthalpy of solution or heat of solution. Since rapid disintegration of the pharmaceutical composition of the present invention and rapid dissolution of the medicament contained in the preparation can be made in the digestive tracts pH-independently, good bioavailability can be attained.

5. 发明申请

US20050100598A1 Quick disintegrating tablet in buccal cavity and production process thereof 审中-公开
标题翻译：颊腔快速崩解片及其制作方法
公开(公告)号：US20050100598A1
公开(公告)日：2005-05-12
申请号：US10961875
申请日：2004-10-07
申请人： Takao Mizumoto , Yoshinori Masuda , Atsushi Kajiyama , Masahiro Yanagisawa , Janaki Ram Nyshadham
发明人： Takao Mizumoto , Yoshinori Masuda , Atsushi Kajiyama , Masahiro Yanagisawa , Janaki Ram Nyshadham
IPC分类号： A61K9/00 , A61K9/20 , A61K47/26 , A61K47/36 , H04L12/44 , H04L29/06 , H04L29/08
CPC分类号： H04L12/44 , A61K9/0056 , A61K9/2018 , A61K9/2095 , H04L29/06 , H04L67/12 , H04L67/26 , H04L69/08 , H04L69/329
摘要： The present invention relates to a quick disintegrating tablet in buccal cavity, comprising: a mixture, comprising a drug, a sugar (A), and an amorphous sugar (B), and after it is forming a tablet, it is humidified and dried. In particularly, the present invention relates to a quick disintegrating tablet in buccal cavity comprising: a mixture; comprising a drug, a sugar (A), and an amorphous sugar (B) which an amorphous-forming sugar in crystalline state is dissolved in a medicinally permitted solvent, the amorphous sugar is obtained from this solution by removing the solvent, and after it is forming a tablet, and it is humidified and dried. The tablet in the present invention is to provide stability against moisture at preserved, because the amorphous sugar changed to the crystalline state in a nonreversible reaction after it is humidified and dried in a manufacturing process. The tablet in the present invention is to further provide a design for the pharmaceutical preparation with respect to the stability of a drug, because the tablet is manufactured by one kind of a sugar and an amorphous sugar. Furthermore, the tablet in the present invention is to provide a production process by utilizing a common granulating machine and by utilizing a common tablet machine.
摘要翻译：本发明涉及颊腔中的快速崩解片，其包含：包含药物，糖（A）和无定形糖（B）的混合物，在形成片剂之后，将其加湿干燥。特别地，本发明涉及颊腔中的快速崩解片剂，其包含：混合物; 包含药物，糖（A）和无定形糖（B），其中结晶状态的无定形形成糖溶解在药物允许溶剂中，通过除去溶剂从该溶液获得无定形糖，之后正在形成片剂，并且被加湿和干燥。本发明中的片剂是为了提供在保存的水分中的稳定性，因为无定形糖在制造过程中被加湿干燥后，在不可逆反应中变为结晶状态。本发明的片剂是为了进一步提供关于药物的稳定性的药物制剂的设计，因为片剂由一种糖和无定形糖制造。此外，本发明中的片剂是通过利用普通的造粒机和利用普通的压片机来提供制造方法。

6. 发明授权

US06589554B1 Tablets quickly disintegrating in the oral cavity and process for producing the same 失效
标题翻译：片剂在口腔中迅速崩解，并制备其
公开(公告)号：US06589554B1
公开(公告)日：2003-07-08
申请号：US09646249
申请日：2000-09-14
申请人： Takao Mizumoto , Yoshinori Masuda , Atsushi Kajiyama , Masahiro Yanagisawa , Janaki Ram Nyshadham
发明人： Takao Mizumoto , Yoshinori Masuda , Atsushi Kajiyama , Masahiro Yanagisawa , Janaki Ram Nyshadham
IPC分类号： A61K920
CPC分类号： H04L12/44 , A61K9/0056 , A61K9/2018 , A61K9/2095 , H04L29/06 , H04L67/12 , H04L67/26 , H04L69/08 , H04L69/329
摘要： The present invention relates to a quick disintegrating tablet in buccal cavity, comprising: a mixture, comprising a drug, a sugar (A), and an amorphous sugar (B), and after it is forming a tablet, it is humidified and dried. In particularly, the present invention relates to a quick disintegrating tablet in buccal cavity comprising: a mixture; comprising a drug, a sugar (A), and an amorphous sugar (B) which an amorphous-forming sugar in crystalline state is dissolved in a medicinally permitted solvent, the amorphous sugar is obtained from this solution by removing the solvent, and after it is forming a tablet, and it is humidified and dried. The tablet in the present invention is to provide stability against moisture at preserved, because the amorphous sugar changed to the crystalline state in a nonreversible reaction after it is humidified and dried in a manufacturing process. The tablet in the present invention is to further provide a design for the pharmaceutical preparation with respect to the stability of a drug, because the tablet is manufactured by one kind of a sugar and an amorphous sugar. Furthermore, the tablet in the present invention is to provide a production process by utilizing a common granulating machine and by utilizing a common tablet machine.
摘要翻译：本发明涉及颊腔中的快速崩解片，其包含：包含药物，糖（A）和无定形糖（B）的混合物，在形成片剂之后，将其加湿干燥。特别地，本发明涉及颊腔中的快速崩解片剂，其包含：混合物; 包含药物，糖（A）和无定形糖（B），其中结晶状态的无定形形成糖溶解在药物允许溶剂中，通过除去溶剂从该溶液获得无定形糖，之后是形成片剂，并且其被加湿和干燥。本发明的片剂是为了在保存的时候提供对水分的稳定性，因为无定形糖在制造过程中被加湿干燥后在非可逆反应中变为结晶状态。本发明的片剂是为了进一步提供关于药物的稳定性的药物制剂的设计，因为片剂由一种糖和无定形糖制造。此外，本发明中的片剂是通过利用普通的造粒机和利用普通的压片机来提供制造方法。

7. 发明授权

US06803054B2 Technical field 失效
标题翻译：技术领域
公开(公告)号：US06803054B2
公开(公告)日：2004-10-12
申请号：US10453422
申请日：2003-06-02
申请人： Takao Mizumoto , Yoshinori Masuda , Atsushi Kajiyama , Masahiro Yanagisawa , Janaki Ram Nyshadham
发明人： Takao Mizumoto , Yoshinori Masuda , Atsushi Kajiyama , Masahiro Yanagisawa , Janaki Ram Nyshadham
IPC分类号： A61K920
CPC分类号： H04L12/44 , A61K9/0056 , A61K9/2018 , A61K9/2095 , H04L29/06 , H04L67/12 , H04L67/26 , H04L69/08 , H04L69/329
摘要： The present invention relates to a quick disintegrating tablet in buccal cavity, comprising: a mixture, comprising a drug, a sugar (A), and an amorphous sugar (B), and after it is forming a tablet, it is humidified and dried. In particularly, the present invention relates to a quick disintegrating tablet in buccal cavity comprising: a mixture; comprising a drug, a sugar (A), and an amorphous sugar (B) which an amorphous-forming sugar in crystalline state is dissolved in a medicinally permitted solvent, the amorphous sugar is obtained from this solution by removing the solvent, and after it is forming a tablet, and it is humidified and dried. The tablet in the present invention is to provide stability against moisture at preserved, because the amorphous sugar changed to the crystalline state in a nonreversible reaction after it is humidified and dried in a manufacturing process. The tablet in the present invention is to further provide a design for the pharmaceutical preparation with respect to the stability of a drug, because the tablet is manufactured by one kind of a sugar and an amorphous sugar. Furthermore, the tablet in the present invention is to provide a production process by utilizing a common granulating machine and by utilizing a common tablet machine.
摘要翻译：本发明涉及颊腔中的快速崩解片，其包含：包含药物，糖（A）和无定形糖（B）的混合物，在形成片剂之后，将其加湿干燥。特别地，本发明涉及颊腔中的快速崩解片剂，其包含：混合物; 包含药物，糖（A）和无定形糖（B），其中结晶状态的无定形形成糖溶解在药物允许溶剂中，通过除去溶剂从该溶液获得无定形糖，之后是形成片剂并且被加湿和干燥。本发明的片剂是为了在保存的时候提供对水分的稳定性，因为无定形糖在制造过程中被加湿干燥后在非可逆反应中变为结晶状态。本发明的片剂是为了进一步提供关于药物的稳定性的药物制剂的设计，因为片剂由一种糖和无定形糖制造。此外，本发明中的片剂是通过利用普通的造粒机和利用普通的压片机来提供制造方法。

8. 发明授权

US4772475A Controlled-release multiple units pharmaceutical formulation 失效
标题翻译：控制释放多单位药物制剂
公开(公告)号：US4772475A
公开(公告)日：1988-09-20
申请号：US833961
申请日：1986-02-27
申请人： Muneo Fukui , Kouji Tomuro , Shigeru Masuyama , Atsushi Kajiyama , Tamio Hikosaka , Masayoshi Aruga , Saburo Higuchi , Yoshiaki Soeishi
发明人： Muneo Fukui , Kouji Tomuro , Shigeru Masuyama , Atsushi Kajiyama , Tamio Hikosaka , Masayoshi Aruga , Saburo Higuchi , Yoshiaki Soeishi
IPC分类号： A61K9/16 , A61K9/20 , A61K9/22 , A61K9/26 , A61K9/52
CPC分类号： A61K9/2077 , A61K9/1635 , A61K9/1652
摘要： A pharmaceutical controlled-release individual unit or multiple units formulation in which the individual unit comprises a granulation product obtained by adding a release controlling agent to a mixture of a physiologically active substance and units-forming substance(s) and granulating and resultant mixture, said granulation product (granules) being substantially not disintegrated but gradually releasing the physiologically active substance in the gastrointestinal tract.

9. 发明授权

US5028664A Drug-release controlling coating material for long acting formulations 失效
标题翻译：用于长效制剂的药物释放控制涂料
公开(公告)号：US5028664A
公开(公告)日：1991-07-02
申请号：US490831
申请日：1990-03-08
申请人： Tadayoshi Ohmura , Muneo Fukui , Hiroshi Sugiura , Satoru Yoneya , Toshiharu Hosono , Atsushi Kajiyama
发明人： Tadayoshi Ohmura , Muneo Fukui , Hiroshi Sugiura , Satoru Yoneya , Toshiharu Hosono , Atsushi Kajiyama
IPC分类号： A61K31/18 , A61K9/22 , A61K9/32 , A61K9/50 , A61K9/52 , A61K9/58 , A61K31/455 , A61K47/32 , A61P9/12 , A61P25/02
CPC分类号： A61K9/5078 , A61K9/5026
摘要： A coating material for controlling drug release, useful for long acting formulations--e.g. for once-a-day administration, and to a long acting granular composition comprising a drug (especially one conventionally difficult to prepare in long acting form) coated with the coating material. This composition may be mixed with other granular drug formulations. The drug-release controlling coating material comprising, in a specific ration, one specific water-insoluble and low water-permeability polymers and two materials differing from each other in the pH-dependency of their solubility (pH-dependent polymer-materials).

10. 发明授权

US5258186A Drug release controlling coating material for long acting formulations 失效
标题翻译：用于长效制剂的药物释放控制涂料
公开(公告)号：US5258186A
公开(公告)日：1993-11-02
申请号：US885910
申请日：1992-05-18
申请人： Tadayoshi Ohmura , Muneo Fukui , Hiroshi Sugiura , Satoru Yoneya , Toshiharu Hosono , Atsushi Kajiyama
发明人： Tadayoshi Ohmura , Muneo Fukui , Hiroshi Sugiura , Satoru Yoneya , Toshiharu Hosono , Atsushi Kajiyama
IPC分类号： A61K9/50 , A61K9/16
CPC分类号： A61K9/5026 , A61K9/5078
摘要： A coating material for controlling drug release, useful for long acting formulations--e.g. for once-a-day administration, and to a long acting granular composition comprising a drug (especially one conventionally difficult to prepare in long acting form) coated with the coating material. This composition may be mixed with other granular drug formulations. The drug-release controlling coating material comprising, in a specific ratio, one specific water-insoluble and low water-permeability polymers and two materials differing from each other in the pH-dependency of their solubility (pH-dependent polymer-materials).
摘要翻译：用于控制药物释放的涂料，可用于长效制剂 - 例如，以及长效粒状组合物，其包含涂覆有涂层材料的药物（特别是通常难以制备的长效型）。该组合物可与其它颗粒药物制剂混合。所述药物释放控制涂层材料以其特定比例包含一种特定的水不溶性和低透水性聚合物，以及两者在溶解度（pH依赖性聚合物材料）的pH依赖性方面彼此不同。

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