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1. 发明授权

US07691979B2 Anti-metastin antibody and its use 有权
标题翻译：抗转移抗体及其用途
公开(公告)号：US07691979B2
公开(公告)日：2010-04-06
申请号：US11498439
申请日：2006-08-02
申请人： Hirokazu Matsumoto , Yasuko Horikoshi , Chieko Kitada , Tetsuya Ohtaki
发明人： Hirokazu Matsumoto , Yasuko Horikoshi , Chieko Kitada , Tetsuya Ohtaki
IPC分类号： C07K16/00
CPC分类号： G01N33/689 , C07K16/18 , G01N33/6857 , G01N2800/368
摘要： The present invention aims at providing an antibody, by which metastin or its derivative can be quantified specifically with a high sensitivity, a method of detecting/quantifying metastin or its derivative using the antibody, and a diagnostic agent (e.g., a diagnostic for pregnancy) the same. Specifically, an antibody capable of specifically reacting with a partial peptide at the N-terminus or C-terminus of a polypeptide having the amino acid sequence represented by SEQ ID NO: 1 or its derivative, and a method of detecting/quantifying metastin or its derivative using the antibody as well as a diagnostic agent using the same.
摘要翻译：本发明的目的在于提供抗体，通过该抗体可以以高灵敏度特异性地定量分析蛋白或其衍生物，使用抗体检测/定量分析蛋白或其衍生物的方法，以及诊断剂（例如，怀孕诊断）一样。具体而言，能够与具有SEQ ID NO：1所示的氨基酸序列的多肽的N末端或C末端的部分肽特异性反应的抗体或其衍生物，以及检测/定量分析的方法衍生物以及使用该抗体的诊断剂。

2. 发明授权

US07173112B2 Antibody to GALP and uses thereof 失效
标题翻译： GALP抗体及其用途
公开(公告)号：US07173112B2
公开(公告)日：2007-02-06
申请号：US10490917
申请日：2002-09-25
申请人： Hirokazu Matsumoto , Yasuko Horikoshi , Chieko Kitada , Tetsuya Ohtaki
发明人： Hirokazu Matsumoto , Yasuko Horikoshi , Chieko Kitada , Tetsuya Ohtaki
IPC分类号： C07K16/00
CPC分类号： C07K16/26 , A61K2039/505 , G01N33/74
摘要： The present invention intends to provide a novel monoclonal antibody having a binding specificity to GALP or its derivative, which is useful in developing therapeutic agents, preventive agents or diagnostic agent for diseases associated with GALP or its derivative, and a method of quantifying GALP using the antibody. More specifically, the present invention provides an antibody specifically reacting with a partial peptide in the C-terminal region of a polypeptide having the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or its derivative, and a method of quantifying GALP or its derivative.
摘要翻译：本发明旨在提供具有对GALP或其衍生物的结合特异性的新型单克隆抗体，其可用于开发与GALP或其衍生物相关的疾病的治疗剂，预防剂或诊断剂，以及使用抗体。更具体地，本发明提供了具有与SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3所示的氨基酸序列的多肽的C-末端区域中的部分肽特异性反应的抗体，或其衍生物，以及量化GALP或其衍生物的方法。

3. 发明申请

US20060275286A1 Antibody and use of the same 有权
标题翻译：抗体和使用相同
公开(公告)号：US20060275286A1
公开(公告)日：2006-12-07
申请号：US11498439
申请日：2006-08-02
申请人： Hirokazu Matsumoto , Yasuko Horikoshi , Chieko Kitada , Tetsuya Ohtaki
发明人： Hirokazu Matsumoto , Yasuko Horikoshi , Chieko Kitada , Tetsuya Ohtaki
IPC分类号： A61K39/395 , G01N33/53 , C12P21/04 , C12N5/06 , C07K16/26
CPC分类号： G01N33/689 , C07K16/18 , G01N33/6857 , G01N2800/368
摘要： The present invention aims at providing an antibody, by which metastin or its derivative can be quantified specifically with a high sensitivity, a method of detecting/quantifying metastin or its derivative using the antibody, and a diagnostic agent (e.g., a diagnostic for pregnancy) the same. Specifically, an antibody capable of specifically reacting with a partial peptide at the N-terminus or C-terminus of a polypeptide having the amino acid sequence represented by SEQ ID NO: 1 or its derivative, and a method of detecting/quantifying metastin or its derivative using the antibody as well as a diagnostic agent using the same.
摘要翻译：本发明的目的在于提供抗体，通过该抗体可以以高灵敏度特异性地定量分析蛋白或其衍生物，使用抗体检测/定量分析蛋白或其衍生物的方法，以及诊断剂（例如，怀孕诊断）一样。具体而言，能够与具有SEQ ID NO：1所示的氨基酸序列的多肽的N末端或C末端的部分肽特异性反应的抗体或其衍生物，以及检测/定量分析的方法衍生物以及使用该抗体的诊断剂。

4. 发明授权

US07112662B2 Anti-metasin antibodies and their methods of use 有权
标题翻译：抗metasin抗体及其使用方法
公开(公告)号：US07112662B2
公开(公告)日：2006-09-26
申请号：US10490125
申请日：2002-09-18
申请人： Hirokazu Matsumoto , Yasuko Horikoshi , Chieko Kitada , Tetsuya Ohtaki
发明人： Hirokazu Matsumoto , Yasuko Horikoshi , Chieko Kitada , Tetsuya Ohtaki
IPC分类号： C07K16/00
CPC分类号： G01N33/689 , C07K16/18 , G01N33/6857 , G01N2800/368
摘要： The present invention aims at providing an antibody, by which metastin or its derivative can be quantified specifically with a high sensitivity, a method of detecting/quantifying metastin or its derivative using the antibody, and a diagnostic agent (e.g., a diagnostic for pregnancy) the same.Specifically, an antibody capable of specifically reacting with a partial peptide at the N-terminus or C-terminus of a polypeptide having the amino acid sequence represented by SEQ ID NO: 1 or its derivative, and a method of detecting/quantifying metastin or its derivative using the antibody as well as a diagnostic agent using the same.
摘要翻译：本发明的目的在于提供抗体，通过该抗体可以以高灵敏度特异性地定量分析蛋白或其衍生物，使用抗体检测/定量分析蛋白或其衍生物的方法，以及诊断剂（例如，怀孕诊断）一样。具体而言，能够与具有SEQ ID NO：1所示的氨基酸序列的多肽的N末端或C末端的部分肽特异性反应的抗体或其衍生物，以及检测/定量分析的方法衍生物以及使用该抗体的诊断剂。

5. 发明申请

US20090318365A1 METASTIN DERIVATIVES AND USE THEREOF 审中-公开
标题翻译：分子衍生物及其用途
公开(公告)号：US20090318365A1
公开(公告)日：2009-12-24
申请号：US12455563
申请日：2009-06-02
申请人： Chieko Kitada , Taiji Asami , Naoko Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
发明人： Chieko Kitada , Taiji Asami , Naoko Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
IPC分类号： A61K38/08 , C07K7/06
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a metastin derivative in which the amino acids comprising metastin were modified by alternative chemical substituents resulting in metastin derivatives, having excellent blood stability and exhibiting cancer metastasis inhibiting action or cancer growth inhibiting action.
摘要翻译：本发明提供了一种转氨酶衍生物，其中包含转氨酶的氨基酸被替代的化学取代基修饰，导致转氨酶衍生物，具有优异的血液稳定性和显示出癌转移抑制作用或癌生长抑制作用。

6. 发明申请

US20060287227A1 Gonadal function improving agents 有权
标题翻译：性腺功能改善剂
公开(公告)号：US20060287227A1
公开(公告)日：2006-12-21
申请号：US10547974
申请日：2004-03-11
申请人： Tetsuya Ohtaki , Hisanori Matsui , Hirokazu Matsumoto , Chieko Kitada
发明人： Tetsuya Ohtaki , Hisanori Matsui , Hirokazu Matsumoto , Chieko Kitada
IPC分类号： A61K48/00 , A61K38/24
CPC分类号： G01N33/689 , A61K31/00 , A61K31/7088 , A61K38/1709
摘要： Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.
摘要翻译：促甲状腺激素分泌抑制剂，雌激素分泌促进剂，性激素分泌抑制剂等的促性腺激素分泌抑制剂，促性腺激素分泌促进剂，性激素分泌抑制剂等的优良性腺功能改善剂，排卵诱导剂或促进剂，促性腺激素分泌促进剂，并且可以用作预防/治疗无菌，激素敏感性癌症，子宫内膜异位症等的药剂.MCastin及其受体可用于筛选这些药物。

7. 发明申请

US20120015868A1 Metastin derivatives and use thereof 有权
标题翻译： Metastin衍生物及其用途
公开(公告)号：US20120015868A1
公开(公告)日：2012-01-19
申请号：US13135230
申请日：2011-06-29
申请人： Chieko Kitada , Taiji Asami , Naoko Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
发明人： Chieko Kitada , Taiji Asami , Naoko Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
IPC分类号： A61K38/08 , A61P3/10 , A61P25/28 , A61P15/00 , A61P35/00 , A61P25/00 , A61P3/04 , A61P13/00 , C07K7/06 , A61P9/10
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a metastin derivative in which the amino acids comprising metastin were modified by alternative chemical substituents resulting in metastin derivitives, having excellent blood stability and exhibiting cancer metastasis inhibiting action or cancer growth inhibiting action.
摘要翻译：本发明提供了一种转氨酶衍生物，其中包含转氨酶的氨基酸被替代的化学取代基修饰，导致转移衍生物，具有优异的血液稳定性和显示出癌转移抑制作用或癌生长抑制作用。

8. 发明授权

US07754220B2 Methods of inhibiting secretion of follicle-stimulating hormone and testosterone 有权
标题翻译：抑制促卵泡激素和睾丸激素分泌的方法
公开(公告)号：US07754220B2
公开(公告)日：2010-07-13
申请号：US10547974
申请日：2004-03-11
申请人： Tetsuya Ohtaki , Hisanori Matsui , Hirokazu Matsumoto , Chieko Kitada
发明人： Tetsuya Ohtaki , Hisanori Matsui , Hirokazu Matsumoto , Chieko Kitada
IPC分类号： A61K38/16 , A61K38/17
CPC分类号： G01N33/689 , A61K31/00 , A61K31/7088 , A61K38/1709
摘要： Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.
摘要翻译：促甲状腺激素分泌抑制剂，雌激素分泌促进剂，性激素分泌抑制剂等的促性腺激素分泌抑制剂，促性腺激素分泌促进剂，性激素分泌抑制剂等的优良性腺功能改善剂，排卵诱导剂或促进剂，促性腺激素分泌促进剂，并且可以用作预防/治疗无菌，激素敏感性癌症，子宫内膜异位症等的药剂.MCastin及其受体可用于筛选这些药物。

9. 发明申请

US20060241051A1 Metastin derivatives and use thereof 审中-公开
公开(公告)号：US20060241051A1
公开(公告)日：2006-10-26
申请号：US10540494
申请日：2003-12-26
申请人： Chieko Kitada , Taiji Asami , Naoki Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
发明人： Chieko Kitada , Taiji Asami , Naoki Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
IPC分类号： A61K38/10 , C07K7/08
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a metastin derivative in which the amino acids comprising metastin were modified by alternative chemical substituents resulting in metastin derivitives, having excellent blood stability and exhibiting cancer metastasis inhibiting action or cancer growth inhibiting action.

10. 发明授权

US07662380B2 ZAQ ligand-1 antibodies and uses thereof 失效
标题翻译： ZAQ配体-1抗体及其用途
公开(公告)号：US07662380B2
公开(公告)日：2010-02-16
申请号：US10542664
申请日：2004-01-21
申请人： Hirokazu Matsumoto , Yasuko Horikoshi , Yasushi Masuda , Tetsuya Ohtaki
发明人： Hirokazu Matsumoto , Yasuko Horikoshi , Yasushi Masuda , Tetsuya Ohtaki
IPC分类号： A61K39/395 , C12N5/12
CPC分类号： C07K16/18 , A61K2039/505
摘要： The antibody of the present invention has an extremely high binding ability to human ZAQL-1, can neutralize the activity of human ZAQL-1, and inhibits the action of human ZAQL-1. Therefore, the antibody is useful as a preventive or therapeutic agent or a diagnostic agent for, e.g., digestive diseases, diseases associated with angiogenesis, diseases relating to pregnancy, eating disorders, sleeping disorders, seasonal depression, reproductive dysfunction, endocrine diseases, senile dementia, Alzheimer's disease, various disorders caused by aging, cerebral circulatory disorders, head trauma, spinal injury, epilepsy, anxiety, depression, manic depression, schizophrenia, alcoholism, Parkinson's disease, hypertension, arteriosclerosis, arrhythmia, premenstral syndrome, glaucoma, cancer, AIDS, diabetes, etc.
摘要翻译：本发明的抗体对人ZAQL-1具有极高的结合能力，可以中和人ZAQL-1的活性，并抑制人ZAQL-1的作用。因此，抗体可用作预防或治疗剂或诊断剂，例如消化系统疾病，与血管发生相关的疾病，与怀孕有关的疾病，进食障碍，睡眠障碍，季节性抑郁症，生殖功能障碍，内分泌疾病，老年性痴呆阿尔茨海默氏病，衰老引起的各种疾病，脑循环障碍，头部创伤，脊髓损伤，癫痫，焦虑，抑郁，躁狂抑郁，精神分裂症，酒精中毒，帕金森病，高血压，动脉硬化，心律失常，前期综合征，青光眼，癌症，AIDS ，糖尿病等

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