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1. 发明授权

US5939552A Process for preparing optically active mevalonolactone compounds 失效
标题翻译：光学活性甲羟戊酸内酯化合物的制备方法
公开(公告)号：US5939552A
公开(公告)日：1999-08-17
申请号：US700396
申请日：1996-08-22
申请人： Hirokazu Ikeda , Tatsushi Murakami , Hiroo Matsumoto , Yoshio Ohara , Hiroyasu Kanda
发明人： Hirokazu Ikeda , Tatsushi Murakami , Hiroo Matsumoto , Yoshio Ohara , Hiroyasu Kanda
IPC分类号： B01D15/18 , B01D15/38 , C07C59/01 , C07D215/14 , C07D405/06 , C07D215/00
CPC分类号： B01D15/3833 , B01D15/185 , B01J20/262 , B01J20/265 , B01J20/285 , B01J20/3272 , B01J20/328 , C07C59/01 , C07D215/14 , C07D405/06
摘要： The process for preparing mevalonolactone compounds is carried out by means of batch system chromatography or a simulated moving bed chromatographic process using columns filled with an optical resolution filler comprising a polysaccharide derivative. The simulated moving bed chromatographic process comprises forming a circulation flow circuit comprising a plurality of columns endlessly connected in series; enforcing a fluid to flow through the circuit in one direction; providing the column series alternately with an inlet port through which the fluid is introduced into the column in the flow direction and with an outlet port, through which the fluid is taken out; intermittently shifting activation of the inlet port and the outlet port in the direction of the fluid flow; introducing a solution containing a racemic mevalonolactone compound and an eluent through an inlet port into the circuit; and simultaneously taking out a solution rich in the weakly adsorbable substance and a solution rich in the strongly adsorbable and desorbed substance through the outlet port.
摘要翻译： PCT No.PCT / JP95 / 00251 Sec。 371日期：1996年8月22日 102（e）日期1996年8月22日PCT提交1995年2月22日PCT公布。公开号WO95 / 23125 日期1995年8月31日制备甲羟戊酸内酯化合物的方法通过间歇系统色谱法或使用填充有包含多糖衍生物的光学拆分填料的柱的模拟移动床层析法进行。模拟移动床层析方法包括形成循环流动回路，其包括多个串联连续的列; 强制流体在一个方向流过电路; 提供柱系列与入口端口交替流动，流体通过该入口沿流动方向引入塔中，并具有出口，通过该出口端口取出流体; 在流体流动的方向上间歇地移动入口和出口的活化; 将含有外消旋甲羟戊酸内酯化合物和洗脱液的溶液通过入口引入电路; 并通过出口同时取出富含弱吸附物质的溶液和富含强吸附和解吸物质的溶液。

2. 发明授权

US5587467A Separating agent for optical isomers and process for producing the same 失效
标题翻译：光学异构体分离剂及其制备方法
公开(公告)号：US5587467A
公开(公告)日：1996-12-24
申请号：US374530
申请日：1995-01-11
申请人： Tatsushi Murakami , Akito Ichida
发明人： Tatsushi Murakami , Akito Ichida
IPC分类号： B01J20/291 , B01J20/281 , B01J20/283 , B01J20/32 , C07B57/00 , C08B37/00 , G01N30/88 , C08B3/12 , B01J20/10 , C08B3/30 , C08B15/10 , C08B31/04
CPC分类号： C07B57/00 , B01J20/103 , B01J20/24 , B01J20/28004 , B01J20/28078 , B01J20/286 , B01J20/29 , B01J20/3092 , B01J20/3204 , B01J20/3219 , B01J20/3257 , B01J20/3259 , B01J20/3261 , B01J20/3274 , B01J20/3282 , B01J2220/54 , B01J2220/58
摘要： Polysaccharide derivative molecules are crosslinked exclusively among themselves on a support such as silica gel with the use of a polyfunctional crosslinking agent to immobilize the polysaccharide derivative on the support. The separating agent for optical isomers produced by the method has a high solvent resistance and, therefore, is most suitable as a separating agent for optical resolution.
摘要翻译： PCT No.PCT / JP94 / 00992 Sec。 371 1995年1月11日第 102（e）1995年1月11日，PCT PCT 1994年6月21日PCT公布。出版物WO95 / 00463 日期1995年1月5日多糖衍生物分子在载体如硅胶上独自交联，使用多官能交联剂将多糖衍生物固定在载体上。通过该方法制造的光学异构体分离剂具有高耐溶剂性，因此最适合作为光学拆分的分离剂。

3. 发明申请

US20070227957A1 Separating agent for optical isomers and separation column for optical isomers 有权
标题翻译：光学异构体分离剂和旋光异构体分离柱
公开(公告)号：US20070227957A1
公开(公告)日：2007-10-04
申请号：US11806033
申请日：2007-05-29
申请人： Tatsushi Murakami , Akihiro Nakanishi , Dieter Lubda , Michael Schulte
发明人： Tatsushi Murakami , Akihiro Nakanishi , Dieter Lubda , Michael Schulte
IPC分类号： B01D15/08
CPC分类号： G01N30/52 , B01J20/286 , B01J20/29 , B01J20/3272 , G01N2030/528
摘要： This invention provides a separating agent for optical isomers, which has high asymmetry recognition ability and can be used particularly at a high flow rate when used for the separation of the optical isomers, and a separation column for optical isomers having the same. This invention provides: a separating agent for optical isomers which is used for separation of optical isomers in a sample comprising the optical isomers, which is comprising a monolithic inorganic type carrier having a meso pore formed on an inner wall surface of a specific macropore, and a polysaccharide or a polysaccharide derivative supported on the monolithic inorganic type carrier, wherein the meso pore has a pore size of 6 to 100 nm; and a separation column for optical isomers in which the separating agent for optical isomers is held in a column tube.
摘要翻译：本发明提供了一种光学异构体分离剂，其具有高不对称识别能力，特别是在用于分离光学异构体时可以以高流速使用，以及具有该光学异构体的旋光异构体分离柱。本发明提供了一种用于光学异构体分离剂，其用于在包含光学异构体的样品中分离光学异构体，其包含在特定大孔的内壁表面上形成的具有中孔的单片无机型载体，以及支撑在单片无机载体上的多糖或多糖衍生物，其中内孔的孔径为6〜100nm; 和用于光学异构体分离剂保持在柱管中的光学异构体分离柱。

4. 发明申请

US20070163961A1 Separating agent for enantiomeric isomer 审中-公开
标题翻译：对映异构体分离剂
公开(公告)号：US20070163961A1
公开(公告)日：2007-07-19
申请号：US10589527
申请日：2005-03-03
申请人： Yasuhiro Kagamihara , Tatsushi Murakami
发明人： Yasuhiro Kagamihara , Tatsushi Murakami
IPC分类号： B01D15/08
CPC分类号： B01J20/29 , B01J20/28004 , B01J20/28057 , B01J20/286 , B01J20/3272 , B01J20/328 , G01N2030/027 , G01N2030/8836 , G01N2030/8877
摘要： The present invention provides a separating agent for enantiomeric isomers which exhibits stable separating performance, high optical resolving power, and sufficient solvent resistance at the same time. The separating agent for enantiomeric isomers includes an optically active polymer compound such as cellulose or amylose carried on a carrier such as silica gel through chemical bonding and has a specific surface area of 10 to 150 m2/g and an average particle size of 1 to 100 μm.
摘要翻译：本发明提供了一种对映体异构体的分离剂，其同时具有稳定的分离性能，高分辨能力和耐溶剂性。用于对映异构体的分离剂包括通过化学键合在诸如硅胶的载体上承载的纤维素或直链淀粉的光学活性聚合物化合物，其比表面积为10至150m 2 / g，平均粒径为1〜100μm。

5. 发明授权

US08883001B2 Separating agent for optical isomers and separation column for optical isomers 有权
公开(公告)号：US08883001B2
公开(公告)日：2014-11-11
申请号：US11806033
申请日：2007-05-29
申请人： Tatsushi Murakami , Akihiro Nakanishi , Dieter Lubda , Michael Schulte
发明人： Tatsushi Murakami , Akihiro Nakanishi , Dieter Lubda , Michael Schulte
IPC分类号： B01J20/29 , G01N30/52 , B01J20/32 , B01J20/286
CPC分类号： G01N30/52 , B01J20/286 , B01J20/29 , B01J20/3272 , G01N2030/528
摘要： This invention provides a separating agent for optical isomers, which has high asymmetry recognition ability and can be used particularly at a high flow rate when used for the separation of the optical isomers, and a separation column for optical isomers having the same. This invention provides: a separating agent for optical isomers which is used for separation of optical isomers in a sample comprising the optical isomers, which is comprising a monolithic inorganic type carrier having a meso pore formed on an inner wall surface of a specific macropore, and a polysaccharide or a polysaccharide derivative supported on the monolithic inorganic type carrier, wherein the meso pore has a pore size of 6 to 100 nm; and a separation column for optical isomers in which the separating agent for optical isomers is held in a column tube.

6. 发明授权

US5772876A Separating agent 失效
标题翻译：分离剂
公开(公告)号：US5772876A
公开(公告)日：1998-06-30
申请号：US933920
申请日：1997-09-22
申请人： Tatsushi Murakami
发明人： Tatsushi Murakami
IPC分类号： B01J20/32 , B01D15/08
CPC分类号： B01J20/286 , B01J20/28004 , B01J20/28078 , B01J20/285 , B01J20/29 , B01J20/3092 , B01J20/3204 , B01J20/321 , B01J20/3274 , B01J2220/54
摘要： A separating agent which comprises a polysaccharide derivative having an Mw/Mn (wherein Mw and Mn represent the weight-average molecular weight calculated as polystyrene and the number-average molecular weight calculated as polystyrene, respectively), which indicates the extent of molecular weight distribution, of 1 to 3. When liquid chromatography is effected using this separating agent as a column packing, the base line is highly steady, various types of solvents can be used as the eluent, and low-molecular polysaccharide derivatives are not eluted.
摘要翻译：一种分散剂，其包含Mw / Mn（其中Mw和Mn分别代表以聚苯乙烯计算的重均分子量和分别为聚苯乙烯计算的数均分子量）的多糖衍生物，其表示分子量分布的程度为1〜3。使用该分离剂作为柱填充液进行液相色谱分析时，基线高度稳定，可以使用各种溶剂作为洗脱液，低分子多糖衍生物不洗脱。

7. 发明授权

US08883002B2 Separating agent for optical isomers and separation column for optical isomers 有权
标题翻译：光学异构体分离剂和旋光异构体分离柱
公开(公告)号：US08883002B2
公开(公告)日：2014-11-11
申请号：US12979031
申请日：2010-12-27
申请人： Tatsushi Murakami , Akihiro Nakanishi , Dieter Lubda , Michael Schulte
发明人： Tatsushi Murakami , Akihiro Nakanishi , Dieter Lubda , Michael Schulte
IPC分类号： B01J20/29 , G01N30/52 , B01J20/32 , B01J20/286
CPC分类号： G01N30/52 , B01J20/286 , B01J20/29 , B01J20/3272 , G01N2030/528
摘要： This invention provides a separating agent for optical isomers, which has high asymmetry recognition ability and can be used particularly at a high flow rate when used for the separation of the optical isomers, and a separation column for optical isomers having the same. This invention provides: a separating agent for optical isomers which is used for separation of optical isomers in a sample comprising the optical isomers, which is comprising a monolithic inorganic type carrier having a meso pore formed on an inner wall surface of a specific macropore, and a polysaccharide or a polysaccharide derivative supported on the monolithic inorganic type carrier, wherein the meso pore has a pore size of 6 to 100 nm; and a separation column for optical isomers in which the separating agent for optical isomers is held in a column tube.
摘要翻译：本发明提供了一种光学异构体分离剂，其具有高不对称识别能力，特别是在用于分离光学异构体时可以以高流速使用，以及具有该光学异构体的旋光异构体分离柱。本发明提供了一种用于光学异构体分离剂，其用于在包含光学异构体的样品中分离光学异构体，其包含在特定大孔的内壁表面上形成的具有中孔的单片无机型载体，以及支撑在单片无机载体上的多糖或多糖衍生物，其中内孔的孔径为6〜100nm; 和用于光学异构体分离剂保持在柱管中的光学异构体分离柱。

8. 发明授权

US5734043A Separating agent for optical isomers 失效
标题翻译：光学异构体分离剂
公开(公告)号：US5734043A
公开(公告)日：1998-03-31
申请号：US582987
申请日：1995-12-29
申请人： Tatsushi Murakami , Nanami Nishida
发明人： Tatsushi Murakami , Nanami Nishida
IPC分类号： B01J20/291 , B01J20/32 , C07B57/00 , C07C29/94 , C07C33/18 , G01N30/88 , C08B3/00 , C08B30/00
CPC分类号： B01J20/287 , B01J20/28004 , B01J20/28085 , B01J20/29 , B01J20/3204 , B01J20/3219 , B01J20/3274 , C07B57/00 , B01J2220/4825 , B01J2220/54 , B01J2220/58
摘要： A separating agent which, when used as the packing material for reverse-phase liquid chromatography, has excellent baseline stability in the mobile phase and an increased number of steps of the detected peak in the measurement is provided. The agent comprises a polysaccharide derivative supported on a silica gel having surface silanol groups treated with a silylating agent having an aralkyl group.
摘要翻译： PCT No.PCT / JP95 / 00844 Sec。 371 1995年12月29日第 102（e）日期1995年12月29日PCT提交1995年4月27日PCT公布。公开号WO95 / 31420 PCT 日期1995年11月23日一种用作反相液相色谱的包装材料的分离剂在流动相中具有优异的基线稳定性，并且提供了测量中检测到的峰的增加的步骤数。该试剂包括负载在具有用具有芳烷基的甲硅烷基化剂处理的表面硅烷醇基团的硅胶上的多糖衍生物。

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