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1. 发明授权

US09295640B2 Pharmaceutical composition for treating cancer using carbonate apatite nanoparticles 有权
标题翻译：使用碳酸盐磷灰石纳米颗粒治疗癌症的药物组合物
公开(公告)号：US09295640B2
公开(公告)日：2016-03-29
申请号：US14010878
申请日：2013-08-27
申请人： Hirofumi Yamamoto , Toshihiro Akaike , Masaki Mori , Yuichiro Doki , Xin Wu , IJUNKAI
发明人： Hirofumi Yamamoto , Hiroyuki Nakanishi , Toshihiro Akaike , Masaki Mori , Yuichiro Doki , Xin Wu
IPC分类号： A61K48/00 , C12N15/11 , C07H21/02 , C07H21/04 , A61K9/00 , A61K9/51
CPC分类号： A61K9/0019 , A61K9/5115 , C12N15/111 , C12N2320/32
摘要： A principal object of the present invention is to provide a pharmaceutical composition that can produce a high antitumor effect by efficiently delivering a drug with antitumor activity to tumor tissues with the aid of carbonate apatite nanoparticles. The present invention provides a pharmaceutical composition including carbonate apatite nanoparticles with an average particle size of at most 50 nm containing a drug with antitumor activity and a pharmacologically acceptable solvent in which the carbonate apatite nanoparticles containing the drug are dispersed.
摘要翻译：本发明的主要目的是提供一种药物组合物，其可以借助于碳酸盐磷灰石纳米颗粒，有效地向肿瘤组织递送具有抗肿瘤活性的药物，从而产生高抗肿瘤效果。本发明提供一种药物组合物，其包含平均粒径为50nm以下的碳酸磷灰石纳米粒子，其含有具有抗肿瘤活性的药物和药物可接受的溶剂，其中分散有所述药物的碳酸盐磷灰石纳米颗粒。

2. 发明授权

US08852941B2 Method for producing induced pluripotent stem cells 有权
标题翻译：诱导多能干细胞的制备方法
公开(公告)号：US08852941B2
公开(公告)日：2014-10-07
申请号：US13579314
申请日：2011-02-18
申请人： Masaki Mori , Hideshi Ishii , Norikatsu Miyoshi , Yuichiro Doki , Masahiro Tanemura , Kenichi Nagai , Hiromitsu Hoshino , Yoshiaki Omura , Naotsugu Haraguchi , Susumu Miyazaki
发明人： Masaki Mori , Hideshi Ishii , Norikatsu Miyoshi , Yuichiro Doki , Masahiro Tanemura , Kenichi Nagai , Hiromitsu Hoshino , Yoshiaki Omura , Naotsugu Haraguchi , Susumu Miyazaki
IPC分类号： C12N5/07 , C12N15/00 , G01N33/50 , C12N5/074
CPC分类号： C12N5/0696 , C12N2501/65 , C12N2506/1307 , C12N2506/1384 , G01N33/5008
摘要： A major object of the present invention is to provide a method for producing induced pluripotent stem cells with low tumorigenesis potential and high induction efficiency.The invention provides a method for producing induced pluripotent stem cells comprising the step of introducing one or more nucleic acids that facilitate expression of at least one gene selected from the group consisting of NANOG, SOX2, OCT3/4, KLF4, LIN28, and c-MYC into somatic cells.
摘要翻译：本发明的主要目的是提供一种具有低致瘤潜力和诱导效率高的诱导多能干细胞的方法。本发明提供一种产生诱导多能干细胞的方法，包括引入一种或多种促进至少一种选自NANOG，SOX2，OCT3 / 4，KLF4，LIN28和c- MYC进入体细胞。

3. 发明授权

US08759099B2 Pancreatic islet separation method, and protective solution for protecting pancreatic islet tissue 有权
标题翻译：胰岛分离法，保护胰岛组织保护液
公开(公告)号：US08759099B2
公开(公告)日：2014-06-24
申请号：US13808390
申请日：2011-07-13
申请人： Masahiro Tanemura , Yoshiki Sawa , Akira Myoui , Toshinori Ito , Masaki Mori , Yuichiro Doki
发明人： Masahiro Tanemura , Yoshiki Sawa , Akira Myoui , Toshinori Ito , Masaki Mori , Yuichiro Doki
IPC分类号： C12N5/00
CPC分类号： C12N5/0676 , C12N2501/734
摘要： The disclosed islet isolation method comprises: an injection step of injecting a preservation solution into the pancreatic duct of an excised pancreas; a preservation step of immersing the pancreas into an immersion fluid for preservation; a digestion step of breaking down the pancreas to provide pancreatic tissue; and a purification step of immersing the pancreatic tissue in a purification solution to provide islets. The digestion step consists of: an enzyme injection step of injecting an enzyme solution containing a digestion enzyme into the pancreas; a digestion initiation step of activating the digestion enzyme; a digestion termination step of inactivating the digestion enzyme; and a collection step of collecting the broken-down pancreatic tissue. The islet isolation method is characterized in that, by adding a neutrophil elastase inhibitor to the system before the digestion initiation step, the neutrophil elastase inhibitor is present inside the pancreas at the time point of starting the digestion initiation step. By using the above method and a protective solution which can be used in the method, islets having a size and shape suitable for transplantation can be obtained in high yields.
摘要翻译：公开的胰岛分离方法包括：将保存液注入切除胰腺胰管的注射步骤; 将胰脏浸入用于保存的浸液中的保存步骤; 消化胰腺胰腺组织消化步骤; 以及将胰组织浸入净化溶液中以提供胰岛的纯化步骤。消化步骤包括：将含有消化酶的酶溶液注入胰腺的酶注射步骤; 活化消化酶的消化引发步骤; 消化终止步骤，使消化酶失活; 以及收集分解的胰组织的收集步骤。胰岛分离方法的特征在于，通过在消化引发步骤之前向系统中加入嗜中性粒细胞弹性蛋白酶抑制剂，在开始消化起始步骤的时间点，存在嗜中性粒细胞弹性蛋白酶抑制剂在胰腺内。通过使用上述方法和可用于该方法的保护溶液，可以高产率获得具有适合于移植的尺寸和形状的胰岛。

4. 发明申请

US20130065243A1 METHOD FOR PRODUCING INDUCED PLURIPOTENT STEM CELLS 有权
标题翻译：生产诱导型脑干细胞的方法
公开(公告)号：US20130065243A1
公开(公告)日：2013-03-14
申请号：US13579314
申请日：2011-02-18
申请人： Masaki Mori , Hideshi Ishii , Norikatsu Miyoshi , Yuichiro Doki , Masahiro Tanemura , Kenichi Nagai , Hiromitsu Hoshino , Yoshiaki Omura , Naotsugu Haraguchi , Susumu Miyazaki
发明人： Masaki Mori , Hideshi Ishii , Norikatsu Miyoshi , Yuichiro Doki , Masahiro Tanemura , Kenichi Nagai , Hiromitsu Hoshino , Yoshiaki Omura , Naotsugu Haraguchi , Susumu Miyazaki
IPC分类号： C12N5/071 , C12Q1/68 , C07H21/02 , C07H21/04 , C12N15/85 , C12N5/10
CPC分类号： C12N5/0696 , C12N2501/65 , C12N2506/1307 , C12N2506/1384 , G01N33/5008
摘要： A major object of the present invention is to provide a method for producing induced pluripotent stem cells with low tumorigenesis potential and high induction efficiency.The invention provides a method for producing induced pluripotent stem cells comprising the step of introducing one or more nucleic acids that facilitate expression of at least one gene selected from the group consisting of NANOG, SOX2, OCT3/4, KLF4, LIN28, and c-MYC into somatic cells.
摘要翻译：本发明的主要目的是提供一种具有低致瘤潜力和诱导效率高的诱导性多能干细胞的方法。本发明提供一种产生诱导多能干细胞的方法，包括引入一种或多种促进至少一种选自NANOG，SOX2，OCT3 / 4，KLF4，LIN28和c- MYC进入体细胞。

5. 发明申请

US20130177986A1 PANCREATIC ISLET SEPARATION METHOD, AND PROTECTIVE SOLUTION FOR PROTECTING PANCREATIC ISLET TISSUE 有权
标题翻译：胰岛分离方法和保护胰腺组织的保护性解决方案
公开(公告)号：US20130177986A1
公开(公告)日：2013-07-11
申请号：US13808390
申请日：2011-07-13
申请人： Masahiro Tanemura , Yoshiki Sawa , Akira Myouri , Toshinori Ito , Masaki Mori , Yuichiro Doki
发明人： Masahiro Tanemura , Yoshiki Sawa , Akira Myouri , Toshinori Ito , Masaki Mori , Yuichiro Doki
IPC分类号： C12N5/071
CPC分类号： C12N5/0676 , C12N2501/734
摘要： The disclosed islet isolation method comprises: an injection step of injecting a preservation solution into the pancreatic duct of an excised pancreas; a preservation step of immersing the pancreas into an immersion fluid for preservation; a digestion step of breaking down the pancreas to provide pancreatic tissue; and a purification step of immersing the pancreatic tissue in a purification solution to provide islets. The digestion step consists of: an enzyme injection step of injecting an enzyme solution containing a digestion enzyme into the pancreas; a digestion initiation step of activating the digestion enzyme; a digestion termination step of inactivating the digestion enzyme; and a collection step of collecting the broken-down pancreatic tissue. The islet isolation method is characterized in that, by adding a neutrophil elastase inhibitor to the system before the digestion initiation step, the neutrophil elastase inhibitor is present inside the pancreas at the time point of starting the digestion initiation step. By using the above method and a protective solution which can be used in the method, islets having a size and shape suitable for transplantation can be obtained in high yields.
摘要翻译：公开的胰岛分离方法包括：将保存液注入切除胰腺胰管的注射步骤; 将胰脏浸入用于保存的浸液中的保存步骤; 消化胰腺胰腺组织消化步骤; 以及将胰组织浸入净化溶液中以提供胰岛的纯化步骤。消化步骤包括：将含有消化酶的酶溶液注入胰腺的酶注射步骤; 活化消化酶的消化引发步骤; 消化终止步骤，使消化酶失活; 以及收集分解的胰组织的收集步骤。胰岛分离方法的特征在于，通过在消化引发步骤之前向系统中加入嗜中性粒细胞弹性蛋白酶抑制剂，在开始消化起始步骤的时间点，存在嗜中性粒细胞弹性蛋白酶抑制剂在胰腺内。通过使用上述方法和可用于该方法的保护溶液，可以高产率获得具有适合于移植的尺寸和形状的胰岛。

6. 发明授权

US09089550B2 Combined islet transplantation using pancreatic islets and adipose tissue derived stem cells 有权
标题翻译：结合胰岛移植使用胰岛和脂肪组织来源的干细胞
公开(公告)号：US09089550B2
公开(公告)日：2015-07-28
申请号：US13814489
申请日：2011-08-05
申请人： Masahiro Tanemura , Yoshiaki Omura , Hiroaki Nagano , Masaki Mori , Yuichiro Doki , Toshinori Ito
发明人： Masahiro Tanemura , Yoshiaki Omura , Hiroaki Nagano , Masaki Mori , Yuichiro Doki , Toshinori Ito
IPC分类号： A61K35/39 , C12N5/071 , A61K35/28
CPC分类号： A61K35/39 , A61K35/28 , C12N5/0676 , C12N2502/1382 , A61K2300/00
摘要： An object of the present invention is to provide a pancreatic islet transplantation technique that enables increase of graft survival rate of pancreatic islets after pancreatic islet transplantation, to maintain survival of pancreatic islets, and to reduce the number of transplanted pancreatic islets required for normalizing blood glucose level. When performing pancreatic islet transplantation, by transplanting pancreatic islets and adipose tissue-derived stem cells together, it is possible to significantly improve graft survival rate of transplanted pancreatic islets, and reduce by half the number of transplanted pancreatic islets required for normalizing blood glucose level.
摘要翻译：本发明的目的是提供胰岛移植技术，其能够增加胰岛移植后胰岛的移植物存活率，保持胰岛的存活，并减少使血糖正常化所需的移植胰岛数量水平。当进行胰岛移植时，通过将胰岛和脂肪组织衍生的干细胞移植到一起，可以显着提高移植胰岛的移植物存活率，并减少标准化血糖水平所需的移植胰岛数量的一半。

7. 发明申请

US20130171114A1 ISLETS OF LANGERHANS TRANSPLANT USING ISLETS OF LANGERHANS AND ADIPOSE TISSUE DERIVED STEM CELLS 有权
标题翻译：使用兰格兰和ADIPOSE组织衍生的干细胞分离的兰格兰运输途径
公开(公告)号：US20130171114A1
公开(公告)日：2013-07-04
申请号：US13814489
申请日：2011-08-05
申请人： Masahiro Tanemura , Yoshiaki Omura , Hiroaki Nagano , Masaki Mori , Yuichiro Doki , Toshinori Ito
发明人： Masahiro Tanemura , Yoshiaki Omura , Hiroaki Nagano , Masaki Mori , Yuichiro Doki , Toshinori Ito
IPC分类号： A61K35/39
CPC分类号： A61K35/39 , A61K35/28 , C12N5/0676 , C12N2502/1382 , A61K2300/00
摘要： An object of the present invention is to provide a pancreatic islet transplantation technique that enables increase of graft survival rate of pancreatic islets after pancreatic islet transplantation, to maintain survival of pancreatic islets, and to reduce the number of transplanted pancreatic islets required for normalizing blood glucose level. When performing pancreatic islet transplantation, by transplanting pancreatic islets and adipose tissue-derived stem cells together, it is possible to significantly improve graft survival rate of transplanted pancreatic islets, and reduce by half the number of transplanted pancreatic islets required for normalizing blood glucose level.
摘要翻译：本发明的目的是提供胰岛移植技术，其能够增加胰岛移植后胰岛的移植物存活率，保持胰岛的存活，并减少使血糖正常化所需的移植胰岛数量水平。当进行胰岛移植时，通过将胰岛和脂肪组织衍生的干细胞移植到一起，可以显着提高移植胰岛的移植物存活率，并减少标准化血糖水平所需的移植胰岛数量的一半。

8. 发明授权

US10150966B2 RNA sequence having anti-tumour activity 有权
公开(公告)号：US10150966B2
公开(公告)日：2018-12-11
申请号：US15123623
申请日：2015-03-04
申请人： Hirofumi Yamamoto , Masaki Mori
发明人： Hirofumi Yamamoto , Masaki Mori , Yuichiro Doki
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04 , C12N15/113 , A61K47/02 , A61K9/00 , A61K9/51
摘要： Provided is a novel useful microRNA having improved anti-tumor activity, obtained by introducing a variation in a microRNA which is present in-vivo and which exhibits an anti-tumor effect. This microRNA containing a base sequence (SEQ ID NO: 1) obtained by varying a predetermined region of the base sequence of miR-29b is able to exhibit a particularly outstanding anti-tumor effect.

9. 发明授权

US09889155B2 Enhancer of anti-tumor effect of anti-cancer agent 有权
公开(公告)号：US09889155B2
公开(公告)日：2018-02-13
申请号：US15119862
申请日：2015-02-20
申请人： Hirofumi Yamamoto , Masaki Mori
发明人： Hirofumi Yamamoto , Masaki Mori , Yuichiro Doki , Xin Wu
IPC分类号： A61K33/06 , A61K31/513 , A61K33/24 , A61K31/555 , A61K31/337 , A61K31/704
CPC分类号： A61K33/06 , A61K31/337 , A61K31/513 , A61K31/555 , A61K31/704 , A61K33/24 , A61K2300/00
摘要： An object of the present invention is to provide an agent that potentiates the antitumor effect of an anticancer agent by allowing efficient accumulation of the anticancer agent in tumor tissue. The administration of carbonate apatite with the anticancer agent allows efficient accumulation of the anticancer agent in the tumor tissue to dramatically potentiate the antitumor effect of the anticancer agent.

10. 发明授权

US10214743B2 Colorectal cancer drug, and method for predicting prognosis of colorectal cancer patient 有权
公开(公告)号：US10214743B2
公开(公告)日：2019-02-26
申请号：US15123621
申请日：2015-03-04
申请人： Hirofumi Yamamoto , Masaki Mori
发明人： Hirofumi Yamamoto , Masaki Mori , Yuichiro Doki , Junichi Nishimura
IPC分类号： A61K31/7088 , C12N15/11 , C12N15/113 , A61K47/02 , A61K31/7105 , C12Q1/6886 , A61K47/48 , A61K9/00 , A61K9/51
摘要： The purpose of the present invention is to provide a colorectal cancer drug that uses microRNA exhibiting outstanding effectiveness in colorectal cancer patients, particularly colorectal cancer patients having a mutated KRAS gene. miR4689 and/or miR4685-3p can suppress the growth of colorectal cancer cells, particularly colorectal cancer cells having a mutated KRAS gene, and thus exhibit an effective antitumor effect.

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