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    • 1. 发明申请
    • THERAPEUTIC AGENT (Y-39983) FOR CORNEAL ENDOTHELIAL DYSFUNCTION
    • 治疗药物(Y-39983)用于角膜内膜功能障碍
    • US20120288482A1
    • 2012-11-15
    • US13519682
    • 2010-12-28
    • Hiroaki TakahashiYuji SakamotoTetsuo KidaTakeshi Tarui
    • Hiroaki TakahashiYuji SakamotoTetsuo KidaTakeshi Tarui
    • A61K31/437A61K35/44A61P27/02
    • A61K31/437A61K9/0048A61K9/08C12N5/0621C12N2501/999
    • The present invention aims to provide a means for effectively and conveniently treating diseases wherein corneal endothelial cells poor in proliferative capacity in vivo are damaged. The present invention provides a therapeutic agent for corneal endothelial dysfunction containing (R)-(+)-N-(1H-pyrrolo [2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide or a pharmacologically acceptable salt thereof (compound (Ia)) as active ingredient, an agent for promoting adhesion of corneal endothelial cells, containing compound (Ia), a culture medium for corneal endothelial cells, containing the agent for promoting adhesion, an implant for corneal endothelial keratoplasty, containing corneal endothelial cells, scaffold and compound (Ia), and a production method of a corneal endothelial preparation, including a step of cultivating corneal endothelial cells using the culture medium.
    • 本发明旨在提供一种有效且方便地治疗疾病的手段,其中体内增殖能力差的角膜内皮细胞被破坏。 本发明提供了含有(R) - (+) - N-(1H-吡咯并[2,3-b]吡啶-4-基)-4-(1-氨基乙基)苯甲酰胺的角膜内皮功能障碍的治疗剂 -3983>或其药理学上可接受的盐(化合物(Ia))作为活性成分,用于促进角膜内皮细胞粘附的试剂,含有化合物(Ia),用于角膜内皮细胞的培养基,其含有促进粘附的试剂, 用于角膜内皮角膜移植术的植入物,其包含角膜内皮细胞,支架和化合物(Ia),以及角膜内皮制剂的制备方法,包括使用培养基培养角膜内皮细胞的步骤。