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1. 发明授权

US07544665B2 Synthesis using peptide intermediate fragments 失效
标题翻译：使用肽中间体片段进行合成
公开(公告)号：US07544665B2
公开(公告)日：2009-06-09
申请号：US11322394
申请日：2005-12-30
申请人： Hiralal N. Khatri , Yeun-Kwei Han , David A. Johnston , L. Mark Hodges
发明人： Hiralal N. Khatri , Yeun-Kwei Han , David A. Johnston , L. Mark Hodges
IPC分类号： A61K38/00 , C07K1/02
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Methods for the solid phase synthesis of T-1249 peptides and peptide intermediates, in particular methods involving synthesizing T-1249 peptide intermediates at low loading factors to produce products having excellent purity and yield.
摘要翻译： T-1249肽和肽中间体的固相合成方法，特别是涉及在低负载因子下合成T-1249肽中间体以产生具有优异纯度和产率的产物的方法。

2. 发明授权

US06743927B2 Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one 有权
公开(公告)号：US06743927B2
公开(公告)日：2004-06-01
申请号：US10364547
申请日：2003-02-10
申请人： Michael P. Fleming , Yeun-Kwei Han , Lewis M. Hodges , David A. Johnston , Roger P. Micheli , Kurt Puentener , Chris R. Roberts , Michelangelo Scalone , Mark A. Schwindt , Robert J. Topping
发明人： Michael P. Fleming , Yeun-Kwei Han , Lewis M. Hodges , David A. Johnston , Roger P. Micheli , Kurt Puentener , Chris R. Roberts , Michelangelo Scalone , Mark A. Schwindt , Robert J. Topping
IPC分类号： C07D30932
CPC分类号： C07F3/02 , C07B2200/07 , C07C67/30 , C07C67/31 , C07D305/12 , C07D309/32 , C07C69/716 , C07C69/675
摘要： The present invention relates to a novel process for producing a &dgr;-lactone of the formula: using an acyl halide of the formula: wherein R1, R2 R3 and X are described herein, as well as novel intermediates. In particular, the present invention relates to a process for enantioselectively producing the (R)-&dgr;-lactone.

3. 发明授权

US06818789B2 Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one 有权
标题翻译： 3,6-二烷基-5,6-二氢-4-羟基 - 吡喃-2-酮的合成
公开(公告)号：US06818789B2
公开(公告)日：2004-11-16
申请号：US10364692
申请日：2003-02-10
申请人： Michael P. Fleming , Yeun-Kwei Han , Lewis M. Hodges , David A. Johnston , Roger P. Micheli , Kurt Puentener , Chris R. Roberts , Michelangelo Scalone , Mark A. Schwindt , Robert J. Topping
发明人： Michael P. Fleming , Yeun-Kwei Han , Lewis M. Hodges , David A. Johnston , Roger P. Micheli , Kurt Puentener , Chris R. Roberts , Michelangelo Scalone , Mark A. Schwindt , Robert J. Topping
IPC分类号： C07C6966
CPC分类号： C07F3/02 , C07B2200/07 , C07C67/30 , C07C67/31 , C07D305/12 , C07D309/32 , C07C69/716 , C07C69/675
摘要： The present invention relates to a novel process for producing a &dgr;-lactone of the formula: using an acyl halide of the formula: wherein R1, R2 R3 and X are described herein, as well as novel intermediates. In particular, the present invention relates to a process for enantioselectively producing the (R)-&dgr;-lactone.
摘要翻译：本发明涉及用于制备下式的δ-内酯的新方法：使用下式的酰卤：其中R 1，R 2，R 3和X在本文中描述，以及新颖的中间体。特别地，本发明涉及对映选择性地制备（R） - 内酯的方法。

4. 发明授权

US06858749B2 Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one 有权
标题翻译： 3,6-二烷基-5,6-二氢-4-羟基 - 吡喃-2-酮的合成
公开(公告)号：US06858749B2
公开(公告)日：2005-02-22
申请号：US10364536
申请日：2003-02-10
申请人： Michael P. Fleming , Yeun-Kwei Han , Lewis M. Hodges , David A. Johnston , Roger P. Micheli , Kurt Puentener , Chris R. Roberts , Michelangelo Scalone , Mark A. Schwindt , Robert J. Topping
发明人： Michael P. Fleming , Yeun-Kwei Han , Lewis M. Hodges , David A. Johnston , Roger P. Micheli , Kurt Puentener , Chris R. Roberts , Michelangelo Scalone , Mark A. Schwindt , Robert J. Topping
IPC分类号： C07B61/00 , C07C67/30 , C07C67/31 , C07D305/12 , C07D309/32 , C07F3/02 , C07C69/66
CPC分类号： C07F3/02 , C07B2200/07 , C07C67/30 , C07C67/31 , C07D305/12 , C07D309/32 , C07C69/716 , C07C69/675
摘要： The present invention relates to a novel process for producing a δ-lactone of the formula: using an acyl halide of the formula: wherein R1, R2 R3 and X are described herein, as well as novel intermediates. In particular, the present invention relates to a process for enantioselectively producing the (R)-δ-lactone.
摘要翻译：本发明涉及用于制备下式的δ-内酯的新方法：使用下式的酰卤：其中R 1，R 2，R 3和X在本文中描述，以及新颖的中间体。特别地，本发明涉及对映选择性地制备（R） - 内酯的方法。

5. 发明授权

US06545165B1 Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one 有权
标题翻译： 3,6-二烷基-5,6-二氢-4-羟基 - 吡喃-2-酮的合成
公开(公告)号：US06545165B1
公开(公告)日：2003-04-08
申请号：US09668834
申请日：2000-09-22
申请人： Michael P. Fleming , Yeun-Kwei Han , Lewis M. Hodges , David A. Johnston , Roger P. Micheli , Kurt Puentener , Chris R. Roberts , Michelangelo Scalone , Mark A. Schwindt , Robert J. Topping
发明人： Michael P. Fleming , Yeun-Kwei Han , Lewis M. Hodges , David A. Johnston , Roger P. Micheli , Kurt Puentener , Chris R. Roberts , Michelangelo Scalone , Mark A. Schwindt , Robert J. Topping
IPC分类号： C07D30932
CPC分类号： C07F3/02 , C07B2200/07 , C07C67/30 , C07C67/31 , C07D305/12 , C07D309/32 , C07C69/716 , C07C69/675
摘要： The present invention relates to a novel process for producing a &dgr;-lactone of the formula: using an acyl halide of the formula: wherein R1, R2 R3 and X are described herein, as well as novel intermediates. In particular, the present invention relates to a process for enantioselectively producing the (R)-&dgr;-lactone.
摘要翻译：本发明涉及用于制备下式的δ-内酯的新方法：使用下式的酰卤：其中R1，R2 R3和X如本文所述，以及新的中间体。特别地，本发明涉及对映选择性地制备（R） - 内酯的方法。

6. 发明授权

US07384939B2 Process for preparation of pyridine derivatives of NK-1 receptor antagonist 有权
标题翻译：制备NK-1受体拮抗剂吡啶衍生物的方法
公开(公告)号：US07384939B2
公开(公告)日：2008-06-10
申请号：US11175799
申请日：2005-07-05
申请人： Peter J. Harrington , David A. Johnston , L. Mark Hodges
发明人： Peter J. Harrington , David A. Johnston , L. Mark Hodges
IPC分类号： A61K31/54 , A61K31/497 , A61K31/66 , C07D279/10 , C07D401/00
CPC分类号： C07D213/127 , C07D213/81 , C07D213/82 , C07D213/85 , C07D401/04 , C07D417/04
摘要： The present invention provides a process for preparing a pyridine compound of the formula: wherein R1, R2, R3 and a are those defined herein.
摘要翻译：本发明提供下式的吡啶化合物的制备方法：其中R 1，R 2，R 3和A是定义的这里。

7. 发明授权

US07439222B2 Process and systems for peptide synthesis 有权
标题翻译：肽合成的方法和系统
公开(公告)号：US07439222B2
公开(公告)日：2008-10-21
申请号：US11021952
申请日：2004-12-23
申请人： Martin R. Guinn , Lewis M. Hodges , David A. Johnston , Hendrick Moorlag , Mark A. Schwindt
发明人： Martin R. Guinn , Lewis M. Hodges , David A. Johnston , Hendrick Moorlag , Mark A. Schwindt
IPC分类号： A01N37/18 , A61K38/00
CPC分类号： C07K1/04 , C07K1/026 , Y02P20/55
摘要： The invention provides methods of synthesizing peptides, involving the steps of providing a composition including a peptide fragment, wherein the peptide fragment has at least one amino acid residue and includes a base-sensitive, N-terminal protecting group; removing the base-sensitive, N-terminal protecting group from the peptide fragment using a deprotection reagent that includes a base, whereby an N-terminal functionality on the peptide fragment is deprotected; removing the base from the composition to provide a residual base content of more than 100 ppm; causing a reactive peptide fragment having a reactive C-terminus and a base-sensitive N-terminal protecting group to react with the deprotected N-terminal functionality of the peptide fragment under conditions such that the reactive peptide fragment is added to the peptide fragment; and optionally repeating the deprotection and coupling steps until a desired peptide is obtained. Also provided are methods of synthesizing peptides, wherein base is removed from the composition to a point where the composition would provide a positive chloranil test. Also provided are methods of synthesizing peptides, wherein coupling is performed in basic reaction mixtures.
摘要翻译：本发明提供了合成肽的方法，包括提供包含肽片段的组合物的步骤，其中肽片段具有至少一个氨基酸残基并且包括碱敏感的N-末端保护基; 使用包含碱的去保护试剂从肽片段中除去碱敏感的N-末端保护基，从而将肽片段上的N-末端官能团去保护; 从组合物中除去碱以提供大于100ppm的残留碱含量; 使得具有反应性C末端和碱敏感性N末端保护基团的反应性肽片段与肽片段的去保护的N末端官能团反应，使得将反应性肽片段加入到肽片段中; 并任选地重复脱保护和偶联步骤，直至获得所需的肽。还提供了合成肽的方法，其中将碱从组合物中除去至组合物将提供正氯醌测试的程度。还提供了合成肽的方法，其中在碱性反应混合物中进行偶联。

8. 发明授权

US5781776A Industrial controller permitting program editing during program execution 失效
标题翻译：工业控制器允许在程序执行期间编辑程序
公开(公告)号：US5781776A
公开(公告)日：1998-07-14
申请号：US551441
申请日：1995-11-01
申请人： David A. Johnston , Charles M. Rischar , Ronald E. Schultz , Otomar Schmidt
发明人： David A. Johnston , Charles M. Rischar , Ronald E. Schultz , Otomar Schmidt
IPC分类号： G06F9/445 , G06F9/44
CPC分类号： G05B19/056 , G06F8/67 , G05B2219/13153
摘要： A method of editing a real-time control program as it controls equipment is provided in which the editing occurs in a second area of memory and integrated into the pre-existing program by means of conditional jump instructions concatenated to that edited material. The pre-existing program is uninterrupted by the editing process except for a change of single instructions which do not affect the results of the execution but redirect the execution thread of that control program to be conditionally connected to the edited material. This single writing of single instructions, which do not affect execution results, precludes the possibility of the controller executing partially edited programs. The jump instructions are conditional on a test edit pointer to allow instantaneous implementation of the edits and a simple return to unedited instructions simply by changing the state of the flag.
摘要翻译：提供了一种在控制设备时编辑实时控制程序的方法，其中编辑发生在存储器的第二区域中，并通过连接到编辑的材料的条件跳转指令将其集成到预先存在的程序中。编辑过程中不存在预先存在的程序，除了改变不影响执行结果的单个指令，而是将控制程序的执行线程重定向到有条件地连接到编辑的材料。单个指令的单写不影响执行结果，排除了控制器执行部分编辑程序的可能性。跳转指令以测试编辑指针为条件，以允许即时实现编辑，并简单地通过更改标志的状态简单地返回到未编辑的指令。

9. 发明授权

US4638452A Programmable controller with dynamically altered programmable real time interrupt interval 失效
标题翻译：可编程控制器，具有动态改变的可编程实时中断间隔
公开(公告)号：US4638452A
公开(公告)日：1987-01-20
申请号：US584128
申请日：1984-02-27
申请人： Ronald E. Schultz , Otomar Schmidt , David A. Johnston
发明人： Ronald E. Schultz , Otomar Schmidt , David A. Johnston
IPC分类号： G05B19/05 , G06F15/18
CPC分类号： G05B19/05 , G05B2219/13001 , G05B2219/15052 , G05B2219/15079 , G05B2219/15081
摘要： A programmable controller includes a main processor which executes a user control program. The main processor is interrupted by a support processor which operates as a real time clock. The interval between interrupts is determined by instructions within the user control program and may be dynamically altered when required. The main processor executes a user created interrupt routine when each interrupt occurs.
摘要翻译：可编程控制器包括执行用户控制程序的主处理器。主处理器被作为实时时钟操作的支持处理器中断。中断之间的间隔由用户控制程序内的指令确定，并且可以在需要时动态地改变。当每个中断发生时，主处理器执行用户创建的中断程序。

10. 发明授权

US08566561B2 Method to separate and persist static and dynamic portions of a control application 有权
标题翻译：分离和维护控件应用程序的静态和动态部分的方法
公开(公告)号：US08566561B2
公开(公告)日：2013-10-22
申请号：US12780308
申请日：2010-05-14
申请人： Charles M. Rischar , David A. Johnston , Bruce J. Moore , Eugene M. Liberman , Kenwood H. Hall
发明人： Charles M. Rischar , David A. Johnston , Bruce J. Moore , Eugene M. Liberman , Kenwood H. Hall
IPC分类号： G06F12/00
CPC分类号： G05B19/042 , G05B2219/24137 , G05B2219/24139
摘要： The subject matter disclosed herein describes a method of allocating and persisting memory in an industrial controller without requiring a battery backup or a large capacitive storage system. Each data object is identified as static or dynamic. Static objects are further classified by whether frequent access of that data object is required. Each of the data objects is stored in non-volatile memory. The dynamic data objects and static data objects requiring frequent access are stored in volatile memory. A record of static data objects is maintained in non-volatile memory and a record of dynamic data objects is maintained in volatile memory. Upon power loss, the present value of each dynamic data object is copied to non-volatile memory. When power is restored, the values of both the dynamic data objects and the static data objects that require frequent access at run-time are copied from non-volatile memory to volatile memory.
摘要翻译：本文公开的主题描述了在工业控制器中分配和持久存储器而不需要电池备份或大型电容性存储系统的方法。每个数据对象被标识为静态或动态。通过是否需要频繁访问该数据对象来进一步分类静态对象。每个数据对象都存储在非易失性存储器中。需要频繁访问的动态数据对象和静态数据对象存储在易失性存储器中。静态数据对象的记录保存在非易失性存储器中，动态数据对象的记录保存在易失性存储器中。在断电时，将每个动态数据对象的当前值复制到非易失性存储器。当恢复供电时，在运行时需要频繁访问的动态数据对象和静态数据对象的值将从非易失性存储器复制到易失性存储器。

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