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1. 发明授权

US5563138A Benzoheterocyclic compounds 失效
标题翻译：苯并杂环化合物
公开(公告)号：US5563138A
公开(公告)日：1996-10-08
申请号：US179239
申请日：1988-04-08
申请人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
发明人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
IPC分类号： C07D215/56 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/54 , A61K31/55 , A61P31/04 , C07C25/02 , C07C25/13 , C07C63/04 , C07C63/06 , C07C63/70 , C07C69/716 , C07C69/738 , C07C205/11 , C07C205/12 , C07C211/47 , C07C211/52 , C07C229/30 , C07C229/34 , C07C321/16 , C07C323/29 , C07D207/09 , C07D207/14 , C07D215/22 , C07D241/04 , C07D295/04 , C07D295/16 , C07D319/06 , C07D401/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/04 , C07D487/04 , C07D491/04 , C07D498/04 , C07D498/06 , C07F5/04
CPC分类号： C07D491/04 , C07D215/56 , C07D401/04 , C07D405/12 , C07D409/04 , C07D487/04
摘要： Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is cyclopropyl which may have 1 to 3 substituents of alkyl and halogen; phenyl which may be substituted by 1 to 3 substituents of alkoxy, halogen and OH; alkyl which may be substituted by halogen, alkanoyloxy or OH; alkenyl; or thienyl, R.sup.2 is 5- to 9-membered saturated or unsaturated heterocyclic ring which may be sustituted, R.sup.3 is alkyl, R is H or alkyl, and X is halogen, and pharmaceutically acceptable salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.
摘要翻译：具有下式的新型4-氧代喹啉-3-羧酸化合物：其中R 1是可以具有1至3个烷基和卤素取代基的环丙基; 可被1至3个烷氧基，卤素和OH取代基取代的苯基; 可被卤素，烷酰氧基或OH取代的烷基; 烯基; 或噻吩基，R 2为可被取代的5-至9-元饱和或不饱和杂环，R 3为烷基，R为H或烷基，X为卤素及其药学上可接受的盐，所述化合物具有优异的抗微生物活性，因此可用作抗微生物剂，以及含有所述化合物作为活性成分的药物组合物。

2. 发明授权

US5495020A Benzoheterocyclic compounds 失效
标题翻译：苯并杂环化合物
公开(公告)号：US5495020A
公开(公告)日：1996-02-27
申请号：US562034
申请日：1990-08-02
申请人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
发明人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
IPC分类号： C07D215/56 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/54 , A61K31/55 , A61P31/04 , C07C25/02 , C07C25/13 , C07C63/04 , C07C63/06 , C07C63/70 , C07C69/716 , C07C69/738 , C07C205/11 , C07C205/12 , C07C211/47 , C07C211/52 , C07C229/30 , C07C229/34 , C07C321/16 , C07C323/29 , C07D207/09 , C07D207/14 , C07D215/22 , C07D241/04 , C07D295/04 , C07D295/16 , C07D319/06 , C07D401/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/04 , C07D487/04 , C07D491/04 , C07D498/04 , C07D498/06 , C07F5/04
CPC分类号： C07D491/04 , C07D215/56 , C07D401/04 , C07D405/12 , C07D409/04 , C07D487/04
摘要： Useful as intermediates for antimicrobacterial agents are compounds of the formulas ##STR1## wherein R.sup.1A is a cyclopropyl which may be substituted by 1 to 3 substituents selected from the group consisting of a C.sub.1 -C.sub.6 alkyl and a halogen atom; a phenyl which may be substituted by 1 to 3 substituents selected from the group consisting of a C.sub.1 -C.sub.6 alkoxy, a halogen atom and hydroxy on the phenyl group; a C.sub.1 -C.sub.6 alkyl which may be substituted by a halogen atom, a C.sub.1 -C.sub.6 alkanoyloxy or hydroxy; a C.sub.2 -C.sub.6 alkenyl; or thienyl,R.sup.3A is a C.sub.1 -C.sub.6 alkyl group, or a halogen atom,R.sup.4 is a C.sub.1 -C.sub.6 alkyl group,R.sup.14 is a hydrogen atom, a lower alkyl group, or a group of the formula ##STR2## R.sup.31 is hydrogen or a C.sub.1 -C.sub.6 alkyl group, and X and X.sup.4 are halogen atoms, and salts thereof.
摘要翻译：作为抗微生物剂的中间体有用的是下式的化合物：其中R 1A是可以被1-3个选自C1-C6烷基和卤素原子的取代基取代的环丙基; 可以被1-3个选自C1-C6烷氧基，卤素原子和苯基上的羟基的取代基取代的苯基; 可被卤素原子取代的C1-C6烷基，C1-C6烷酰氧基或羟基; C 2 -C 6烯基; 或噻吩基，R 3A为C1-C6烷基或卤素原子，R4为C1-C6烷基，R14为氢原子，低级烷基或式为R3的基团为氢或 C 1 -C 6烷基，X和X 4为卤素原子，及其盐。

3. 发明授权

US5723648A Intermediates for anti-microbial benzoheterocyclic compounds 失效
标题翻译：抗微生物苯并杂环化合物的中间体
公开(公告)号：US5723648A
公开(公告)日：1998-03-03
申请号：US676034
申请日：1996-07-05
申请人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
发明人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
IPC分类号： C07D215/56 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/54 , A61K31/55 , A61P31/04 , C07C25/02 , C07C25/13 , C07C63/04 , C07C63/06 , C07C63/70 , C07C69/716 , C07C69/738 , C07C205/11 , C07C205/12 , C07C211/47 , C07C211/52 , C07C229/30 , C07C229/34 , C07C321/16 , C07C323/29 , C07D207/09 , C07D207/14 , C07D215/22 , C07D241/04 , C07D295/04 , C07D295/16 , C07D319/06 , C07D401/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/04 , C07D487/04 , C07D491/04 , C07D498/04 , C07D498/06 , C07F5/04 , C07C69/66
CPC分类号： C07D491/04 , C07D215/56 , C07D401/04 , C07D405/12 , C07D409/04 , C07D487/04
摘要： Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is cyclopropyl which may have 1 to 3 substituents of alkyl and halogen; phenyl which may be substituted by 1 to 3 substituents of alkoxy, halogen and OH; alkyl which may be substituted by halogen, alkanoyloxy or OH; alkenyl; or thienyl, R.sup.2 is 5- to 9-membered saturated or unsaturated heterocyclic ring which may be sustituted, R.sup.3 is alkyl, R is H or alkyl, and X is halogen, and pharmaceutically acceptable salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.
摘要翻译：具有下式的新型4-氧代喹啉-3-羧酸化合物：其中R 1是可以具有1至3个烷基和卤素取代基的环丙基; 可被1至3个烷氧基，卤素和OH取代基取代的苯基; 可被卤素，烷酰氧基或OH取代的烷基; 烯基; 或噻吩基，R 2为可被取代的5-至9-元饱和或不饱和杂环，R 3为烷基，R为H或烷基，X为卤素及其药学上可接受的盐，所述化合物具有优异的抗微生物活性，因此可用作抗微生物剂，以及含有所述化合物作为活性成分的药物组合物。

4. 发明授权

US5591744A Benzoheterocyclic compounds 失效
标题翻译：苯并杂环化合物
公开(公告)号：US5591744A
公开(公告)日：1997-01-07
申请号：US179300
申请日：1988-04-08
申请人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
发明人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
IPC分类号： C07D215/56 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/54 , A61K31/55 , A61P31/04 , C07C25/02 , C07C25/13 , C07C63/04 , C07C63/06 , C07C63/70 , C07C69/716 , C07C69/738 , C07C205/11 , C07C205/12 , C07C211/47 , C07C211/52 , C07C229/30 , C07C229/34 , C07C321/16 , C07C323/29 , C07D207/09 , C07D207/14 , C07D215/22 , C07D241/04 , C07D295/04 , C07D295/16 , C07D319/06 , C07D401/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/04 , C07D487/04 , C07D491/04 , C07D498/04 , C07D498/06 , C07F5/04
CPC分类号： C07D491/04 , C07D215/56 , C07D401/04 , C07D405/12 , C07D409/04 , C07D487/04
摘要： Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is cyclopropyl which may have 1 to 3 substituents of alkyl and halogen; phenyl which may be substituted by 1 to 3 substituents of alkoxy, halogen and OH; alkyl which may be substituted by halogen, alkanoyloxy or OH; alkenyl; or thienyl, R.sup.2 is 5- to 9-membered saturated or unsaturated heterocyclic ring which may be sustituted, R.sup.3 is alkyl or halogen, R.sup.4 is alkyl or halogen, R is H or alkyl, R.sup.1 and R.sup.3 may be taken together to form ##STR2## wherein R.sup.31 is H or alkyl, and X is halogen, provided that R.sup.3 and R.sup.4 are not simultaneously halogen, and salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.
摘要翻译：具有下式的新型4-氧代喹啉-3-羧酸化合物：其中R 1是可以具有1至3个烷基和卤素取代基的环丙基; 可被1至3个烷氧基，卤素和OH取代基取代的苯基; 可被卤素，烷酰氧基或OH取代的烷基; 烯基; 或噻吩基，R 2是可以被取代的5-至9-元饱和或不饱和杂环，R 3是烷基或卤素，R 4是烷基或卤素，R是H或烷基，R 1和R 3可以一起形成其中R31为H或烷基，X为卤素，条件是R3和R4不同时为卤素，其盐，所述化合物具有优异的抗微生物活性，因此可用作抗微生物剂，以及含有所述化合物的药物组合物活性成分。

5. 发明授权

US5811576A Intermediates for anti-microbial quinolone carboxylic acids 失效
标题翻译：抗微生物喹诺酮羧酸的中间体
公开(公告)号：US5811576A
公开(公告)日：1998-09-22
申请号：US922108
申请日：1997-09-03
申请人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
发明人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
IPC分类号： C07D215/56 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/54 , A61K31/55 , A61P31/04 , C07C25/02 , C07C25/13 , C07C63/04 , C07C63/06 , C07C63/70 , C07C69/716 , C07C69/738 , C07C205/11 , C07C205/12 , C07C211/47 , C07C211/52 , C07C229/30 , C07C229/34 , C07C321/16 , C07C323/29 , C07D207/09 , C07D207/14 , C07D215/22 , C07D241/04 , C07D295/04 , C07D295/16 , C07D319/06 , C07D401/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/04 , C07D487/04 , C07D491/04 , C07D498/04 , C07D498/06 , C07F5/04
CPC分类号： C07D491/04 , C07D215/56 , C07D401/04 , C07D405/12 , C07D409/04 , C07D487/04
摘要： Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is cyclopropyl which may have 1 to 3 substituents of alkyl and halogen; phenyl which may be substituted by 1 to 3 substituents of alkoxy, halogen and OH; alkyl which may be substituted by halogen, alkanoyloxy or OH; alkenyl; or thienyl, R.sup.2 is 5- to 9-membered saturated or unsaturated heterocyclic ring which may be substituted, R.sup.3 is alkyl, R is H or alkyl, and X is halogen, and pharmaceutically acceptable salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.
摘要翻译：具有下式的新型4-氧代喹啉-3-羧酸化合物：其中R 1是可以具有1至3个烷基和卤素取代基的环丙基; 可被1至3个烷氧基，卤素和OH取代基取代的苯基; 可被卤素，烷酰氧基或OH取代的烷基; 烯基; 或噻吩基，R 2为可被取代的5至9元饱和或不饱和杂环，R 3为烷基，R为H或烷基，X为卤素及其药学上可接受的盐，所述化合物具有优异的抗微生物活性，因此可用作抗微生物剂，以及含有所述化合物作为活性成分的药物组合物。

6. 发明授权

US5290934A Benzoheterocyclic compounds 失效
标题翻译：苯并杂环化合物
公开(公告)号：US5290934A
公开(公告)日：1994-03-01
申请号：US711273
申请日：1991-06-04
申请人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
发明人： Hiraki Ueda , Hisashi Miyamoto , Hiroshi Yamashita , Hitoshi Tone
IPC分类号： C07D215/56 , C07D401/04 , C07D405/12 , C07D409/04 , C07D487/04 , C07D491/04 , C07D498/06 , C07D215/283
CPC分类号： C07D215/56 , C07D401/04 , C07D405/12 , C07D409/04 , C07D487/04 , C07D491/04
摘要： Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is cyclopropyl which may have 1 to 3 substituents of alkyl and halogen; phenyl which may be substituted by 1 to 3 substituents of alkoxy, halogen and OH; alkyl which may be substituted by halogen, alkanoyloxy or OH; alkenyl; or thienyl, R.sup.2 is 5- to 9-membered saturated or unsaturated heterocyclic ring which may be substituted, R.sup.3 is alkyl, R is H or alkyl, and X is halogen, and pharmaceutically acceptable salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.
摘要翻译：具有下式的新型4-氧代喹啉-3-羧酸化合物：其中R 1是可以具有1至3个烷基和卤素取代基的环丙基; 可被1至3个烷氧基，卤素和OH取代基取代的苯基; 可被卤素，烷酰氧基或OH取代的烷基; 烯基; 或噻吩基，R 2为可被取代的5至9元饱和或不饱和杂环，R 3为烷基，R为H或烷基，X为卤素及其药学上可接受的盐，所述化合物具有优异的抗微生物活性，因此可用作抗微生物剂，以及含有所述化合物作为活性成分的药物组合物。

7. 发明授权

US4755513A Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds 失效
标题翻译：抗菌性1-取代苯基-4-氧代喹啉-3-羧酸化合物
公开(公告)号：US4755513A
公开(公告)日：1988-07-05
申请号：US766337
申请日：1985-08-16
申请人： Hitoshi Tone , Hisashi Miyamoto , Hiraki Ueda , Kazuyuki Nakagawa
发明人： Hitoshi Tone , Hisashi Miyamoto , Hiraki Ueda , Kazuyuki Nakagawa
IPC分类号： C07D215/56 , C07D487/04 , A61K31/495 , C07D401/04
CPC分类号： C07D487/04 , C07D215/56
摘要： Novel 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen atom or an alkyl having 1 to 2 carbon atoms, R.sup.2 is hydrogen atom or fluorine atom, and R.sup.3 is hydroxy, fluorine atom or an alkanoyloxy having 1 to 6 carbon atoms, and a pharmaceutically acceptable salt thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition comprising as an active ingredient said 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds or a pharmaceutically acceptable salt thereof in admixture with a pharmaceutically acceptable diluent or carrier.
摘要翻译：新颖的1-取代的苯基-4-氧代喹啉-3-羧酸化合物，其结构式如下：其中R 1是氢原子或具有1至2个碳原子的烷基，R 2是氢原子或氟原子，R 3是羟基，氟原子或具有1至6个碳原子的烷酰氧基及其药学上可接受的盐，所述化合物具有优异的抗微生物活性，因此可用作抗微生物剂，以及药物组合物，其包含作为活性成分的所述1-取代苯基-4 - 氧喹啉-3-羧酸化合物或其药学上可接受的盐与药学上可接受的稀释剂或载体混合。

8. 发明授权

US4684648A Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds and compositions thereof 失效
标题翻译：抗菌剂1-取代苯基-4-氧代喹啉-3-羧酸化合物及其组合物
公开(公告)号：US4684648A
公开(公告)日：1987-08-04
申请号：US770080
申请日：1985-08-28
申请人： Hitoshi Tone , Hisashi Miyamoto , Hiraki Ueda , Kazuyuki Nakagawa
发明人： Hitoshi Tone , Hisashi Miyamoto , Hiraki Ueda , Kazuyuki Nakagawa
IPC分类号： C07D215/56 , C07D487/04 , A61K31/40 , A61K31/47 , C07D401/14
CPC分类号： C07D487/04 , C07D215/56
摘要： Novel 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R is hydrogen atom or fluorine atom, R.degree. is hydroxy, fluorine atom or an alkanoyloxy having 1 to 6 carbon atoms, and X.sup.1 is hydrogen atom or fluorine atom, and a pharmaceutically acceptable salt thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition comprising as an active ingredient said 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds or a pharmaceutically acceptable salt thereof in admixture with a pharmaceutically acceptable diluent or carrier.
摘要翻译：新颖的1-取代的苯基-4-氧代喹啉-3-羧酸化合物，其结构式如下：其中R是氢原子或氟原子，R是羟基，氟原子或具有1至6个碳原子的烷酰氧基，X1 所述化合物具有优异的抗微生物活性，因此可用作抗微生物剂，以及包含作为活性成分的所述1-取代苯基-4-氧代喹啉-3-酮的药物组合物，羧酸化合物或其药学上可接受的盐与药学上可接受的稀释剂或载体混合。

9. 发明授权

US4786649A Antimicrobial 1-thienyl-4-oxoquinoline-3-carboxylic acids 失效
标题翻译：抗微生物1-噻吩基-4-氧代喹啉-3-羧酸
公开(公告)号：US4786649A
公开(公告)日：1988-11-22
申请号：US929847
申请日：1986-11-13
申请人： Hiraki Ueda , Hisashi Miyamoto
发明人： Hiraki Ueda , Hisashi Miyamoto
IPC分类号： C07D333/00 , A61K31/47 , A61P31/04 , C07D401/14 , C07D409/14
CPC分类号： C07D409/14
摘要： Novel 1-thienyl-4-oxoquinoline-3-carboxylic acid compounds of the formula ##STR1## wherein R.sup.1 is an amino (lower) alkyl, R.sup.2 is thienyl, and X is a halogen atom, and a pharmaceutically acceptable salt thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition comprising as an active ingredient said 1-thienyl-4-oxoquinoline-3-carboxylic acid compounds or a pharmaceutically acceptable salt thereof in admixture with a pharmaceutically acceptable diluent or carrier.
摘要翻译：新颖的下式的1-噻吩基-4-氧代喹啉-3-羧酸化合物，其中R 1是氨基（低级）烷基，R 2是噻吩基，X是卤素原子及其可药用盐，所述化合物具有优异的抗微生物活性，因此可用作抗微生物剂，以及药物组合物，其包含作为活性成分的所述1-噻吩基-4-氧代喹啉-3-羧酸化合物或其药学上可接受的盐与药学上可接受的稀释剂或载体

10. 发明授权

US4880806A 1-Cyclopropyl-6-fl uoro-7-piperazinyl-1,4-Dihydro-4-oxo-quinoline-3-carboxylic acid derivatives 失效
标题翻译： 1-环丙基-6-氟-7-哌嗪基-1,4-二氢-4-氧代 - 喹啉-3-羧酸衍生物
公开(公告)号：US4880806A
公开(公告)日：1989-11-14
申请号：US76890
申请日：1987-07-23
申请人： Hiraki Ueda , Hisashi Miyamoto , Shinji Aki , Tatsuya Otsuka
发明人： Hiraki Ueda , Hisashi Miyamoto , Shinji Aki , Tatsuya Otsuka
IPC分类号： C07D215/56 , C07D401/04 , C07D405/12 , C07D487/04
CPC分类号： C07D215/56 , C07D401/04 , C07D405/12 , C07D487/04
摘要： Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.2 is a heterocyclic group: ##STR2## in which R.sup.A is H, C.sub.1 -C.sub.6 alkyl or phenyl (C.sub.1 -C.sub.6) alkyl, R.sup.B is 2-oxo-1,3-dioxolenemethyl substituted by C.sub.1 -C.sub.6 alkyl, or C.sub.3 -C.sub.8 cycloalkyl, R.sup.C is H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxycarbonyl, or phenyl(C.sub.1 -C.sub.6)alkyl, R.sup.D is H or C.sub.1 -C.sub.6 alkyl, R.sup.G is C.sub.1 -C.sub.6 alkyl, and R.sup.H is C.sub.1 -C.sub.6 alkyl, phenyl(C.sub.1 -C.sub.6)alkyl, or C.sub.1 C.sub.6 alkanoyl, and R.sup.3 is C.sub.1 -C.sub.6 alkyl, or R.sup.3 is C.sub.1 -C.sub.6 alkyl having 1 to 3 substituents selected from OH, C.sub.1 -C.sub.6 alkoxy and halogen when R.sup.2 is ##STR3## or a salt thereof, said compounds having excellent antimicrobial activity and being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.
摘要翻译：新颖的下式的4-氧代喹啉-3-羧酸化合物：其中R 2是杂环基：其中RA是H，C 1 -C 6烷基或苯基（C 1 -C 6） C6）烷基，RB是被C1-C6烷基或C3-C8环烷基取代的2-氧代-1,3-二氧杂环戊烯甲基，RC是H，C1-C6烷基，C1-C6烷氧基羰基或苯基（C1-C6）烷基，RD为H或C1-C6烷基，RG为C1-C6烷基，RH为C1-C6烷基，苯基（C1-C6）烷基或C1C6烷酰基，R3为C1-C6烷基，R3为C1- 当R2为1或3个选自OH，C1-C6烷氧基和卤素的取代基时，具有1至3个取代基的C6烷基或其盐，所述具有优异抗微生物活性并可用作抗微生物剂的化合物和含有所述化合物的药物组合物活性成分。

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