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1. 发明授权

US09587222B2 Three-dimensional tissue structure 有权
标题翻译：三维组织结构
公开(公告)号：US09587222B2
公开(公告)日：2017-03-07
申请号：US10567728
申请日：2004-02-02
申请人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shigeru Miyagawa
发明人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shigeru Miyagawa
IPC分类号： C12N15/00 , C12N5/00 , C12N5/02 , C12N5/071 , C12N5/077 , A61L27/38 , A61K35/34 , A61K35/12
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34 , A61L27/3804 , A61L27/3834 , A61L27/3839 , A61L27/3895 , A61L2430/20 , C12N5/0068 , C12N5/0657 , C12N2506/02 , C12N2506/1392 , C12N2513/00 , C12N2523/00 , C12N2533/40 , C12N2539/10
摘要： The present invention provides a prosthetic tissue or sheet capable of withstanding implantation operations, which can be used in actual operation and can be produced by culture. The present invention also provides a novel therapy which can substitute for cell therapy. Particularly, the present invention provides a method for producing a prosthetic tissue comprising a cell derived from a part other than myocardium and capable of withstanding implantation operation. The above-described objects of the present invention were partially achieved by finding that by culturing cells under specific culture conditions, the cells are unexpectedly organized into a tissue, and the resultant prosthetic tissue is capable of being detached from culture dishes. The present invention also provides a three-dimensional structure applicable to heart, comprising a cell derived from a part other than the myocardium of an adult.
摘要翻译：本发明提供能够承受植入操作的假体组织或片材，其可以在实际操作中使用并且可以通过培养产生。本发明还提供了可代替细胞治疗的新型治疗方法。特别地，本发明提供了一种用于制造假体组织的方法，所述假体组织包含源于除了心肌之外的部分的细胞并且能够承受植入操作。通过发现通过在特定培养条件下培养细胞，细胞意外地组织成组织，并且所得到的假体组织能够从培养皿中分离，部分实现了本发明的上述目的。本发明还提供了适用于心脏的三维结构，其包含源自成人心肌之外的部分的细胞。

2. 发明申请

US20070244568A1 Decellularized Tissue and Method of Preparing the Same 审中-公开
标题翻译：脱细胞组织及其制备方法
公开(公告)号：US20070244568A1
公开(公告)日：2007-10-18
申请号：US10584740
申请日：2004-12-24
申请人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shigeru Miyagawa , Shigemitau Iwai , Takeyoshi Ota , Jun Miyake , Masayuki Hara , Masakazu Furuta , Eiichiro Uchimura
发明人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shigeru Miyagawa , Shigemitau Iwai , Takeyoshi Ota , Jun Miyake , Masayuki Hara , Masakazu Furuta , Eiichiro Uchimura
IPC分类号： A61F2/02
CPC分类号： A61L27/3683 , A61L27/3604
摘要： Decellularization of tissue by means of an amphipathic solvent a well-established practice. However, situations exist where the provision of enhanced decellularization is preferred. There is a demand for treating methods for coping with such situations. Thus, it is intended to provide a method for enhancing decellularization. The method comprises not only the immersing of a tissue in a solution containing an amphiphilic molecule in non-micellar form (for example, 1,2-epoxide polymer) but also performing a radical reaction (for example, treatment selected from the group consisting of exposure to gamma-ray irradiation, ultraviolet irradiation, a free radical supply source, ultrasonication, electron beam irradiation, and X-ray irradiation).
摘要翻译：通过两性溶剂去除细胞组织，这是一个很好的做法。然而，存在提供增强脱细胞化优先的情况。需要处理这种情况的方法。因此，旨在提供一种增强脱细胞化的方法。该方法不仅包括将组织浸入含有非胶束形式的两亲分子（例如1,2-环氧化物聚合物）的溶液中，而且还进行自由基反应（例如，选自由暴露于γ射线照射，紫外线照射，自由基供应源，超声波处理，电子束照射和X射线照射）。

3. 发明申请

US20070092492A1 Three-dimentional tissue structure 有权
标题翻译：三维组织结构
公开(公告)号：US20070092492A1
公开(公告)日：2007-04-26
申请号：US10567728
申请日：2004-02-02
申请人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shigeru Miyagawa
发明人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shigeru Miyagawa
IPC分类号： A61K35/34 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0658 , A61K35/12 , A61K35/34 , A61L27/3804 , A61L27/3834 , A61L27/3839 , A61L27/3895 , A61L2430/20 , C12N5/0068 , C12N5/0657 , C12N2506/02 , C12N2506/1392 , C12N2513/00 , C12N2523/00 , C12N2533/40 , C12N2539/10
摘要： The present invention provides a prosthetic tissue or sheet capable of withstanding implantation operations, which can be used in actual operation and can be produced by culture. The present invention also provides a novel therapy which can substitute for cell therapy. Particularly, the present invention provides a method for producing a prosthetic tissue comprising a cell derived from a part other than myocardium and capable of withstanding implantation operation. The above-described objects of the present invention were partially achieved by finding that by culturing cells under specific culture conditions, the cells are unexpectedly organized into a tissue, and the resultant prosthetic tissue is capable of being detached from culture dishes. The present invention also provides a three-dimensional structure applicable to heart, comprising a cell derived from a part other than the myocardium of an adult.
摘要翻译：本发明提供能够承受植入操作的假体组织或片材，其可以在实际操作中使用并且可以通过培养产生。本发明还提供了可代替细胞治疗的新型治疗方法。特别地，本发明提供了一种用于制造假体组织的方法，所述假体组织包含源于除了心肌之外的部分的细胞并且能够承受植入操作。通过发现通过在特定培养条件下培养细胞，细胞意外地组织成组织，并且所得到的假体组织能够从培养皿中分离，部分实现了本发明的上述目的。本发明还提供了适用于心脏的三维结构，其包含源自成人心肌之外的部分的细胞。

4. 发明申请

US20060018941A1 System and method for injecting liquid drug containing biological material 审中-公开
标题翻译：用于注射含药物的生物材料的系统和方法
公开(公告)号：US20060018941A1
公开(公告)日：2006-01-26
申请号：US10954639
申请日：2004-09-30
申请人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shin Kawamata , Shigeru Miyagawa , Emi Maeno , Yoshiho Toyota , Shinji Ozawa
发明人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shin Kawamata , Shigeru Miyagawa , Emi Maeno , Yoshiho Toyota , Shinji Ozawa
IPC分类号： A61F13/00
CPC分类号： A61M5/1456 , A61M5/14566 , A61M5/14593 , A61M5/482 , A61M5/488 , A61M2005/14513 , C12M35/00
摘要： A method for injecting a liquid drug containing a biological material is provided, which comprises the step of injecting the liquid drug containing the biological material contained in an injector into a subject at a predetermined range of velocity.
摘要翻译：提供了一种用于注射含有生物材料的液体药物的方法，其包括将包含在注射器中的生物材料的液体药物以预定的速度范围注射到受试者中的步骤。

5. 发明申请

US20050070874A1 System and method for injecting liquid drug containing biological material 审中-公开
标题翻译：用于注射含药物的生物材料的系统和方法
公开(公告)号：US20050070874A1
公开(公告)日：2005-03-31
申请号：US10675254
申请日：2003-09-30
申请人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shin Kawamata , Shigeru Miyagawa , Emi Maeno , Yoshiho Toyota , Shinji Ozawa
发明人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shin Kawamata , Shigeru Miyagawa , Emi Maeno , Yoshiho Toyota , Shinji Ozawa
IPC分类号： A61M5/145 , A61M5/315 , A61M5/48 , C12M3/00 , C12N5/00 , A61F13/00 , A61M31/00
CPC分类号： A61M5/1456 , A61M5/14566 , A61M5/14593 , A61M5/482 , A61M5/488 , A61M2005/14513 , C12M35/00
摘要： A method for injecting a liquid drug containing a biological material is provided, which comprises the step of injecting the liquid drug containing the biological material contained in an injector into a subject at a predetermined range of velocity.
摘要翻译：提供了一种用于注射含有生物材料的液体药物的方法，其包括将包含在注射器中的生物材料的液体药物以预定的速度范围注射到受试者中的步骤。

6. 发明申请

US20060252981A1 Biocompatible implant and use of the same 审中-公开
标题翻译：生物相容性植入物及其使用
公开(公告)号：US20060252981A1
公开(公告)日：2006-11-09
申请号：US10537678
申请日：2003-12-05
申请人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shigemitsu Iwai , Koichiro Hirakawa
发明人： Hikaru Matsuda , Yoshiki Sawa , Satoshi Taketani , Shigemitsu Iwai , Koichiro Hirakawa
IPC分类号： A61F2/02 , C12N5/08
CPC分类号： B32B7/02 , A61F2/142 , A61L31/00 , B32B1/08 , B32B5/02 , B32B5/024 , B32B5/026 , B32B5/18 , B32B5/26 , B32B27/28 , B32B2305/186 , B32B2305/188 , B32B2305/38 , B32B2307/7163 , B32B2307/7242 , B32B2535/00 , B32B2597/00
摘要： The present invention provides an implant capable of being cellularized in treatment of an injured organ or tissue in organisms. The present inventors found that a biocompatible implant comprising a biological molecule and a support is capable of being cellularized. The implant can be used instead of conventional implants which essentially comprise cells. The present invention provides a biocompatible implant comprising A) a biological molecule and B) a support. The present invention also provides A) a first layer having a rough surface, B) a rough surface; B) a second layer having a strength which allows the support to resist in vivo shock. The first layer is attached to the second layer via at least one point.
摘要翻译：本发明提供能够在生物体内损伤的器官或组织的治疗中被细胞化的植入物。本发明人发现包含生物分子和载体的生物相容性植入物能够被细胞化。可以使用植入物代替基本上包含细胞的常规植入物。本发明提供一种生物相容性植入物，其包含A）生物分子和B）支持物。本发明还提供了A）具有粗糙表面的第一层，B）粗糙表面; B）具有允许支持体抵抗体内冲击的强度的第二层。第一层通过至少一个点连接到第二层。

7. 发明申请

US20050256588A1 Decellularized tissue 审中-公开
标题翻译：脱细胞组织
公开(公告)号：US20050256588A1
公开(公告)日：2005-11-17
申请号：US10519814
申请日：2003-06-27
申请人： Yoshiki Sawa , Satoshi Taketani , Shigemitsu Iwai , Hikaru Matsuda , Masayuki Hara , Eiichiro Uchimura , Jun Miyake
发明人： Yoshiki Sawa , Satoshi Taketani , Shigemitsu Iwai , Hikaru Matsuda , Masayuki Hara , Eiichiro Uchimura , Jun Miyake
IPC分类号： A61K35/12 , A61L27/00 , A61L27/36 , A61L27/38 , C12N5/071 , A61F2/02
CPC分类号： C12N5/0697 , A61K35/12 , A61L27/3604 , A61L27/3683 , A61L27/3687 , A61L27/3695 , A61L27/3804 , A61L2430/40 , C12N5/0691
摘要： An objective of the present invention is to overcome a problem that there is an inverse relationship between the decellularization rate and the strength of tissue. This problem was solved by immersing tissue in a solution containing a non-micellar amphipathic molecule (e.g., a 1,2-epoxide polymer). Thus, the present invention provides decellularized tissue, in which the cell survival rate of the tissue is less than a level at which calcification or an immune reaction is elicited in an organism and the tissue damage rate of the tissue is suppressed to a level which permits clinical applications. Tissue prepared by the above-described treatment preferably retains a certain level of tissue strength. Further, the tissue of the present invention has an effect of performing cell replacement.
摘要翻译：本发明的目的是克服脱细胞率与组织强度之间存在反比关系的问题。通过将组织浸入含有非胶束两亲性分子（例如1,2-环氧化物聚合物）的溶液中来解决该问题。因此，本发明提供脱细胞组织，其中组织的细胞存活率小于在生物体中引起钙化或免疫反应的水平，并且组织的组织损伤率被抑制到允许临床应用。通过上述处理制备的组织优选保持一定水平的组织强度。此外，本发明的组织具有进行细胞置换的效果。

8. 发明申请

US20060259056A1 Surgical holder for a blood vessel 审中-公开
标题翻译：血管外科手术夹
公开(公告)号：US20060259056A1
公开(公告)日：2006-11-16
申请号：US10550819
申请日：2004-03-23
申请人： Go Watanabe , Yoshiki Sawa , Satoshi Taketani
发明人： Go Watanabe , Yoshiki Sawa , Satoshi Taketani
IPC分类号： A61B17/32
CPC分类号： A61B17/02 , A61B17/0218 , A61B2017/00243 , A61B2017/00778 , A61B2017/00902 , A61B2017/2808
摘要： A surgical holder comprises a grasping member for grasping a tissue, a manipulation member for manipulating the grasping member, and a connection portion with one end connected to the manipulation member, wherein: the grasping member includes a first grasping plate, and a second grasping plate provided so as to oppose the first grasping plate in a movable manner so that they are able to become closer to each other or more distranced from each other; a first grasping portion which can grasp a part of a tissue between the first grasping plate and the second grasping plate, and an opening which can expose another part of the tissue are provided in one end portion of the grasping member; and a second grasping portion which can form a tissue grasping space between the first grasping plate and the second grasping plate is provided in another end portion of the grasping member.
摘要翻译：手术夹具包括用于抓握组织的把持构件，用于操纵抓握构件的操作构件和连接到操作构件的一端的连接部，其中：抓握构件包括第一抓握板和第二抓握板设置成能够以可移动的方式与第一把持板相对，使得它们能够彼此变得更靠近或更多地彼此分离; 能够抓住第一把持板和第二抓握板之间的组织的一部分的第一抓取部，以及能够使另一部分组织露出的开口设置在抓持部件的一个端部; 并且在所述把持部件的另一端部设置能够在所述第一把持板和所述第二抓持板之间形成组织夹持空间的第二抓取部。

9. 发明申请

US20070140914A1 Reagent-introducing medical device configured to create laminar flow and rotating flow 审中-公开
标题翻译：试剂引入医疗装置，其构造成产生层流和旋转流
公开(公告)号：US20070140914A1
公开(公告)日：2007-06-21
申请号：US11314493
申请日：2005-12-21
申请人： Yoshiki Sawa , Satoshi Taketani , Yoshiho Toyota , Shinji Ozawa , Nobuyoshi Watanabe
发明人： Yoshiki Sawa , Satoshi Taketani , Yoshiho Toyota , Shinji Ozawa , Nobuyoshi Watanabe
IPC分类号： B01L3/02
CPC分类号： A61M25/1002 , A61M25/0026 , A61M25/0084
摘要： The invention provides a reagent-introducing medical device that can guide a reagent into a reagent injector while maintaining all biological materials contained in the reagent in a healthy state. In an embodiment of the reagent-introducing medical device, an apparatus body (12) comprises a channel (77, 78, 80, 50e) through which a reagent flows, as well as a reagent inlet (76) and outlet (21), and further comprises a first control mechanism (58, 64) for controlling the flow of the reagent to create a laminar reagent flow in the channel (77, 78, 80, 50e) and a second control mechanism (70) for further controlling the laminar reagent flow in the channel to create a rotational reagent flow.
摘要翻译：本发明提供了一种试剂导入医疗装置，其能够将试剂引导到试剂注射器中，同时将包含在试剂中的所有生物材料保持在健康状态。在试剂导入医疗装置的一个实施方案中，装置主体（12）包括试剂流过的通道（77,78,80,450e）以及试剂入口（76）和出口（21），，还包括用于控制所述试剂的流动以在所述通道（77,78,80,450e）中产生层流试剂流的第一控制机构（58,64）和用于进一步控制的第二控制机构（70）通道中的层流试剂流动以产生旋转试剂流。

10. 发明申请

US20060025720A1 Medicinal-liquid injection apparatus 失效
标题翻译：药液注射装置
公开(公告)号：US20060025720A1
公开(公告)日：2006-02-02
申请号：US11242482
申请日：2005-10-03
申请人： Yoshiki Sawa , Satoshi Taketani , Shinji Ozawa , Manabu Shimogami
发明人： Yoshiki Sawa , Satoshi Taketani , Shinji Ozawa , Manabu Shimogami
IPC分类号： A61M5/178
CPC分类号： A61M25/0084 , A61B2090/0801 , A61M2025/009 , A61M2025/0096
摘要： It is a purpose to provide a medicinal-liquid injection apparatus in which a needle-like tubular member is smoothly movable in a lumen without damaging an inner circumferential surface of the lumen. It includes that the needle-like tubular member having an acuminate needle portion as a free end portion thereof, in which a medicinal liquid can flow, is inserted in the lumen of a tubular main body insertable in a body of a living being, and a protection member having a flexible portion provided in a state such that the protection member is movable together with the needle-like tubular member and such that the flexible portion is interposed between an inner circumferential surface of the lumen and a tip of the needle portion of the needle-like tubular member.
摘要翻译：提供一种药液注射装置，其中针状管状构件能够在内腔中平稳移动而不损坏内腔的内周表面。它包括具有药液可以流动的其自由端部的渐尖针部分的针状管状部件插入可插入生物体的管状主体的内腔中，并且保护构件具有设置在使得保护构件能够与针状管状构件一起移动的状态的柔性部分，并且使得柔性部分插入在内腔的内周表面和针管部分的尖端之间针状管状构件。

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