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1. 发明授权

US09795932B2 Porous hollow fiber membrane and a porous hollow fiber membrane for the treatment of a protein-containing liquid 有权
公开(公告)号：US09795932B2
公开(公告)日：2017-10-24
申请号：US13142125
申请日：2009-12-24
申请人： Hideyuki Yokota , Noriaki Kato , Hirofumi Ogawa , Junsuke Morita
发明人： Hideyuki Yokota , Noriaki Kato , Hirofumi Ogawa , Junsuke Morita
IPC分类号： B01D69/08 , B01D71/68 , B01D69/02
CPC分类号： B01D71/68 , B01D69/02 , B01D69/08 , B01D69/081 , B01D69/087 , B01D2239/1233 , B01D2239/1258 , B01D2325/02 , B01D2325/021 , B01D2325/022 , B01D2325/023 , B01D2325/20
摘要： The purpose of the present invention is to provide a porous hollow fiber membrane that can efficiently separate and remove the substances to be removed such as small-particle virus contained in a solution and, at the same time, useful recovering substances such as protein can be efficiently permeated and the decrease of its transmission rate with elapse of time is small. The porous hollow fiber membrane of the present invention is characterized in that the filtration downstream surface thereof has dot-shaped or slit-shaped pores, the filtration upstream surface thereof is a network structure or a fine particle aggregate structure, the central region of the membrane is composed of a substantially homogeneous structure, the membrane wall is composed of a structure having substantially no macrovoids, the permeability for pure water is 10 to 300 L/(h·m2·bar) and the permeability for a 0.1% by weight solution of bovine γ-globulin is 30 to 100% of the permeability for pure water. Also, the hollow fiber membrane is characterized in that the permeability for a 0.1% by weight solution of bovine γ-globulin in a 20 mmol/L phosphate buffer is 30 to 100% of the permeability for a 0.1% by weight solution of bovine γ-globulin in a 20 mmol/L phosphate-buffered physiological saline solution.

2. 发明授权

US08881915B2 Polymeric porous hollow fiber membrane 有权
标题翻译：聚合多孔中空纤维膜
公开(公告)号：US08881915B2
公开(公告)日：2014-11-11
申请号：US12298456
申请日：2007-04-25
申请人： Hideyuki Yokota , Noriaki Kato , Hirofumi Ogawa , Junsuke Morita
发明人： Hideyuki Yokota , Noriaki Kato , Hirofumi Ogawa , Junsuke Morita
IPC分类号： B01D39/16 , B01D63/02 , B01D63/06 , B01D69/08 , D01F1/08 , B32B3/12 , B01D71/68 , B01D71/44 , B01D69/02
CPC分类号： B01D69/087 , B01D69/02 , B01D69/08 , B01D71/44 , B01D71/68 , B01D2325/022 , B01D2325/36 , B01D2325/38 , Y10T428/249921 , Y10T428/249978 , Y10T428/249979 , Y10T428/24998 , Y10T428/2975
摘要： PURPOSE: To provide a polymeric porous hollow fiber membrane which exhibits excellent fractionation performance and excellent permeability in treatment of a variety of aqueous fluids and also shows sufficient strength when incorporated into a module or used to treat a fluid, and which is excellent in aging stability in these performances and characteristics and is also excellent in membrane performance recoverability by washing, and which is especially suitable for treatment of a polyphenol-containing beverage and is expected to effectively harmonize the flavor of such a beverage.SOLUTION: A polymeric porous hollow fiber membrane of the present invention is characterized in that (a) the hollow fiber membrane has skin layers on its inner and outer surfaces; (b) the diameters of the pores in the inner surface are smaller than the diameters of the pores in the outer surface; (c) the porosity tends to increase from the inner surface toward the outer surface, and then tends to decrease from at least one portion having a maximum porosity, of the wall section of the membrane, toward the outer surface; and (d) the hollow fiber membrane satisfies a relationship of 2 [%]≦DR≦20 [%], wherein the critical diameter of a fine particle to be removed, found by a fine particle-passing test, is φmax [μm]; the diameter of the pores in the inner surface is dIS [μm]; and the proportion of the pores with dIS exceeding φmax is DR [%]. This polymeric porous hollow fiber membrane is also characterized in that the adsorption of polyphenol per a surface area of 1 m2 defined by the inner and outer surfaces of the membrane is from 50 to 500 mg.
摘要翻译：目的：提供一种聚合多孔中空纤维膜，其在各种水性流体的处理中表现出优异的分级性能和优异的渗透性，并且当结合到模块中或用于处理流体时也显示出足够的强度，并且其老化稳定性优异在这些性能和特性中，通过洗涤也具有优异的膜性能可回收性，并且其特别适用于处理含多酚饮料，并且预期能有效地协调这种饮料的风味。解决方案：本发明的聚合物多孔中空纤维膜的特征在于：（a）中空纤维膜在其内表面和外表面上具有表皮层; （b）内表面的孔的直径小于外表面的孔的直径; （c）孔隙率从内表面朝向外表面增加，然后趋向于从膜的壁部的最大孔隙率的至少一部分朝向外表面减小; 和（d）中空纤维膜满足2 [％]＆nlE; DR＆nlE; 20 [％]的关系，其中通过细粒通过试验发现的要除去的微粒的临界直径为最大 [μm]; 内表面孔的直径为dIS [μm]。 dIS超过最大孔的比例为DR [％]。该聚合物多孔中空纤维膜的特征还在于，由膜的内表面和外表面限定的1m 2表面积的多酚的吸附量为50〜500mg。

3. 发明申请

US20110259816A1 POROUS HOLLOW FIBER MEMBRANE AND A POROUS HOLLOW FIBER MEMBRANE FOR THE TREATMENT OF A PROTEIN-CONTAINING LIQUID 有权
标题翻译：多孔中空纤维膜和多孔中空纤维膜用于处理含蛋白质的液体
公开(公告)号：US20110259816A1
公开(公告)日：2011-10-27
申请号：US13142125
申请日：2009-12-24
申请人： Hideyuki Yokota , Noriaki Kato , Hirofumi Ogawa , Junsuke Morita
发明人： Hideyuki Yokota , Noriaki Kato , Hirofumi Ogawa , Junsuke Morita
IPC分类号： B01D69/08
CPC分类号： B01D71/68 , B01D69/02 , B01D69/08 , B01D69/081 , B01D69/087 , B01D2239/1233 , B01D2239/1258 , B01D2325/02 , B01D2325/021 , B01D2325/022 , B01D2325/023 , B01D2325/20
摘要： The purpose of the present invention is to provide a porous hollow fiber membrane that can efficiently separate and remove the substances to be removed such as small-particle virus contained in a solution and, at the same time, useful recovering substances such as protein can be efficiently permeated and the decrease of its transmission rate with elapse of time is small. The porous hollow fiber membrane of the present invention is characterized in that the filtration downstream surface thereof has dot-shaped or slit-shaped pores, the filtration upstream surface thereof is a network structure or a fine particle aggregate structure, the central region of the membrane is composed of a substantially homogeneous structure, the membrane wall is composed of a structure having substantially no macrovoids, the permeability for pure water is 10 to 300 L/(h·m2·bar) and the permeability for a 0.1% by weight solution of bovine γ-globulin is 30 to 100% of the permeability for pure water. Also, the hollow fiber membrane is characterized in that the permeability for a 0.1% by weight solution of bovine γ-globulin in a 20 mmol/L phosphate buffer is 30 to 100% of the permeability for a 0.1% by weight solution of bovine γ-globulin in a 20 mmol/L phosphate-buffered physiological saline solution.
摘要翻译：本发明的目的是提供一种多孔中空纤维膜，其能够有效地分离除去溶解物中所含的小粒子病毒等被除去物质，并且同时可用于回收物质如蛋白质可以是有效渗透，随着时间的流逝，传播速率的下降也很小。本发明的多孔中空纤维膜的特征在于，其过滤下游表面具有点状或狭缝状的孔，其过滤上游面为网状结构或细颗粒聚集体结构，膜的中心区域由基本上均匀的结构构成，膜壁由基本上没有大孔的结构构成，纯水的渗透性为10〜300L /（h·m 2·bar），并且0.1重量％的牛γ-球蛋白是纯水的渗透性的30〜100％。此外，中空纤维膜的特征在于，0.1％重量的牛γ-球蛋白溶液在20mmol / L磷酸盐缓冲液中的渗透性为0.1％（重量）牛γ溶液的渗透性的30〜100％ - 球蛋白在20 mmol / L磷酸盐缓冲生理盐水溶液中。

4. 发明授权

US08225941B2 Hollow fiber membrane for treating liquids 有权
标题翻译：用于处理液体的中空纤维膜
公开(公告)号：US08225941B2
公开(公告)日：2012-07-24
申请号：US12682814
申请日：2008-10-16
申请人： Hirofumi Ogawa , Noriaki Kato , Hideyuki Yokota , Junsuke Morita
发明人： Hirofumi Ogawa , Noriaki Kato , Hideyuki Yokota , Junsuke Morita
IPC分类号： B01D33/21 , B01D39/00 , B01D39/14 , B01D70/28
CPC分类号： C02F1/444 , B01D69/02 , B01D69/081 , B01D2325/022 , B01D2325/04
摘要： The present invention provides a hollow fiber membrane for treating liquids. When used for a hollow fiber membrane module for refining a fermented liquid such as beer or wine, the hollow fiber membrane exhibits a high filtration performance per unit area thereof, with reduced clogging of the membrane. The membrane performance is sufficiently recovered by washing.The present invention is a hollow fiber membrane for treating liquids, wherein a ratio of Flux 120 to Flux 30 is 0.45 or higher when filtration is performed by supplying a solution having a turbidity of 20 NTU into a hollow fiber membrane having an internal diameter of 500 to 1500 μm and a membrane thickness of 100 to 500 μm with a transmembrane pressure of 1.5 bar, the Flux 30 being flux 30 minutes after the start of the filtration, the Flux 120 being flux 120 minutes after the start of the filtration.
摘要翻译：本发明提供一种用于处理液体的中空纤维膜。当用于中空纤维膜组件用于精炼啤酒或葡萄酒等发酵液时，中空纤维膜的单位面积显示出高的过滤性能，同时膜的堵塞减少。通过洗涤充分回收膜性能。本发明是用于处理液体的中空纤维膜，其中当通过将具有20NTU的浊度的溶液供应到内径为500的中空纤维膜中时，通量120与通量30的比例为0.45或更高至1500微米，膜厚为100至500微米，跨膜压力为1.5巴，Flux 30在开始过滤后30分钟通入，Flux 120在开始过滤120分钟后通入。

5. 发明申请

US20100219122A1 HOLLOW FIBER MEMBRANE FOR TREATING LIQUIDS 有权
标题翻译：中空纤维膜用于处理液体
公开(公告)号：US20100219122A1
公开(公告)日：2010-09-02
申请号：US12682814
申请日：2008-10-16
申请人： Hirofumi Ogawa , Noriaki Kato , Hideyuki Yokota , Junsuke Morita
发明人： Hirofumi Ogawa , Noriaki Kato , Hideyuki Yokota , Junsuke Morita
IPC分类号： B01D69/08
CPC分类号： C02F1/444 , B01D69/02 , B01D69/081 , B01D2325/022 , B01D2325/04
摘要： The present invention provides a hollow fiber membrane for treating liquids. When used for a hollow fiber membrane module for refining a fermented liquid such as beer or wine, the hollow fiber membrane exhibits a high filtration performance per unit area thereof, with reduced clogging of the membrane. The membrane performance is sufficiently recovered by washing.The present invention is a hollow fiber membrane for treating liquids, wherein a ratio of Flux 120 to Flux 30 is 0.45 or higher when filtration is performed by supplying a solution having a turbidity of 20 NTU into a hollow fiber membrane having an internal diameter of 500 to 1500 μm and a membrane thickness of 100 to 500 μm with a transmembrane pressure of 1.5 bar, the Flux 30 being flux 30 minutes after the start of the filtration, the Flux 120 being flux 120 minutes after the start of the filtration.
摘要翻译：本发明提供一种用于处理液体的中空纤维膜。当用于中空纤维膜组件用于精炼啤酒或葡萄酒等发酵液时，中空纤维膜的单位面积显示出高的过滤性能，同时膜的堵塞减少。通过洗涤充分回收膜性能。本发明是用于处理液体的中空纤维膜，其中当通过将具有20NTU的浊度的溶液供应到内径为500的中空纤维膜中时，通量120与通量30的比例为0.45或更高至1500微米，膜厚为100至500微米，跨膜压力为1.5巴，Flux 30在开始过滤后30分钟通入，Flux 120在开始过滤120分钟后通入。

6. 发明申请

US20090110900A1 POLYMERIC POROUS HOLLOW FIBER MEMBRANE 有权
标题翻译：聚合多孔中空纤维膜
公开(公告)号：US20090110900A1
公开(公告)日：2009-04-30
申请号：US12298456
申请日：2007-04-25
申请人： Hideyuki Yokota , Noriaki Kato , Hirofumi Ogawa , Junsuke Morita
发明人： Hideyuki Yokota , Noriaki Kato , Hirofumi Ogawa , Junsuke Morita
IPC分类号： B32B3/26 , B32B5/24
CPC分类号： B01D69/087 , B01D69/02 , B01D69/08 , B01D71/44 , B01D71/68 , B01D2325/022 , B01D2325/36 , B01D2325/38 , Y10T428/249921 , Y10T428/249978 , Y10T428/249979 , Y10T428/24998 , Y10T428/2975
摘要： Purpose: To provide a polymeric porous hollow fiber membrane which exhibits excellent fractionation performance and excellent permeability in treatment of a variety of aqueous fluids and also shows sufficient strength when incorporated into a module or used to treat a fluid, and which is excellent in aging stability in these performances and characteristics and is also excellent in membrane performance recoverability by washing, and which is especially suitable for treatment of a polyphenol-containing beverage and is expected to effectively harmonize the flavor of such a beverage. Solution: A polymeric porous hollow fiber membrane of the present invention is characterized in that (a) the hollow fiber membrane has skin layers on its inner and outer surfaces; (b) the diameters of the pores in the inner surface are smaller than the diameters of the pores in the outer surface; (c) the porosity tends to increase from the inner surface toward the outer surface, and then tends to decrease from at least one portion having a maximum porosity, of the wall section of the membrane, toward the outer surface; and (d) the hollow fiber membrane satisfies a relationship of 2 [%]≦DR≦20 [%], wherein the critical diameter of a fine particle to be removed, found by a fine particle-passing test, is φmax [μm]; the diameter of the pores in the inner surface is dIS [μm]; and the proportion of the pores with dIS exceeding φmax is DR [%] This polymeric porous hollow fiber membrane is also characterized in that the adsorption of polyphenol per a surface area of 1 m2 defined by the inner and outer surfaces of the membrane is from 50 to 500 mg.
摘要翻译：目的：提供一种聚合多孔中空纤维膜，其在各种水性流体的处理中表现出优异的分级性能和优异的渗透性，并且当结合到模块中或用于处理流体时也显示出足够的强度，并且其老化稳定性优异在这些性能和特性中，通过洗涤也具有优异的膜性能可回收性，并且其特别适用于处理含多酚饮料，并且预期能有效地协调这种饮料的风味。解决方案：本发明的聚合物多孔中空纤维膜的特征在于，（a）中空纤维膜在其内表面和外表面上具有表皮层; （b）内表面的孔的直径小于外表面的孔的直径; （c）孔隙率从内表面朝向外表面增加，然后趋向于从膜的壁部的最大孔隙率的至少一部分朝向外表面减小; 和（d）中空纤维膜满足2 [％] <= DR <= 20 [％]的关系，其中通过微粒通过试验发现的要除去的微粒的临界直径为phimax [ 妈妈] 内表面的孔的直径为dIS [mum]; 并且dIS超过phimax的孔的比例为DR [％]。该聚合物多孔中空纤维膜的特征还在于，由膜的内表面和外表面限定的表面积为1m 2的多酚的吸附量为50 至500mg。

7. 发明申请

US20090272686A1 BLOOD PURIFIER 审中-公开
标题翻译：血液净化器
公开(公告)号：US20090272686A1
公开(公告)日：2009-11-05
申请号：US11910627
申请日：2006-04-03
申请人： Kimihiro Mabuchi , Hideyuki Yokota , Katsuaki Kuze , Noriko Monden , Noriaki Kato , Makoto Ohno , Mitsuru Suzuki
发明人： Kimihiro Mabuchi , Hideyuki Yokota , Katsuaki Kuze , Noriko Monden , Noriaki Kato , Makoto Ohno , Mitsuru Suzuki
IPC分类号： B01D69/08
CPC分类号： B01D69/02 , A61M1/16 , A61M2209/06 , B01D67/0011 , B01D67/009 , B01D69/08 , B01D71/44 , B01D71/68 , B01D2325/20 , B01D2325/28 , C02F1/44 , C02F2103/026
摘要： [Purpose] To provide a blood purifier which has high levels of blood compatibility, performance-retaining property when in contact with blood, and safety, and which shows an excellent water permeability-exhibiting rate after a priming treatment and has high reliability in long-term storage.[Solution] A blood purifier assembled using a polyvinyl pyrrolidone-containing polysulfone-based permselective hollow fiber membrane bundle, characterized in that the amount of polyvinyl pyrrolidone which elutes from the hollow fiber membrane bundle is 10 ppm or less, the amounts of hydrogen peroxide which elute from extracts from all the sites of the hollow fiber membrane bundle are 5 ppm or less, when the hollow fiber membrane bundle is divided into 10 portions in the lengthwise direction to test the sites of all the 10 portions according to the method regulated in the Approval Standard for Dialysis-Type Artificial Kidney Apparatus, and the water permeability of the blood purifier found at a point of time when 10 minutes has passed since the priming treatment of the blood purifier is 90% or more of the water permeability of the same found at a point of time when 24 hours has passed since the priming treatment thereof.
摘要翻译： [目的]提供一种具有高血液相容性，与血液接触时的性能保持性和安全性的血液净化器，并且在预处理后显示出优异的透水性，并且在长期使用中具有高可靠性，长期存储。 [解决方案]使用含聚乙烯吡咯烷酮的聚砜系渗透性中空纤维膜束组装的血液净化器，其特征在于，从中空纤维膜束洗出的聚乙烯吡咯烷酮的量为10ppm以下，过氧化氢的量从中空纤维膜束的所有位置的提取物中洗脱出的浓度为5ppm以下，将中空纤维膜束沿长度方向分割成10份，按照本发明的方法透析型人造肾器的认可标准和自血液净化器起动处理10分钟后发现的血液净化器的透水性为同一发现的透水性的90％以上在自启动处理24小时后的时间点。

8. 发明申请

US20080044643A1 Polysulfone Type Selectively Permeable Hollow Fiber Membrane Module and Process for Manufacturing the Same 有权
标题翻译：聚砜型选择性渗透中空纤维膜模块及其制造方法
公开(公告)号：US20080044643A1
公开(公告)日：2008-02-21
申请号：US11573333
申请日：2005-08-09
申请人： Hideyuki Yokota , Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
发明人： Hideyuki Yokota , Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
IPC分类号： C08J7/18 , B32B5/14
CPC分类号： B01D63/021 , A61M2209/06 , B01D65/022 , B01D65/10 , B01D67/009 , B01D67/0095 , B01D69/02 , B01D69/08 , B01D71/68 , B01D2313/23 , B01D2321/346 , B01D2323/34 , B01D2325/022 , Y10T428/249958
摘要： The invention relates to a hollow fiber membrane module comprising polysulfone type selectively permeable hollow fiber membranes which contain a polysulfone-based resin and a hydrophilic polymer as main components, wherein (A) the content of the hydrophilic polymer in the uppermost layer of the inner surface of the hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the proximate layer of the inner surface of the membrane, and (B) the content of the hydrophilic polymer in the uppermost layer of the outer surface of the hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the uppermost layer of the inner surface of the membrane. The hollow fiber membrane module is exposed to a radioactive ray, on condition that the oxygen concentration of an ambient atmosphere around the hollow fiber membrane is from 0.001 to 0.1%, and that the moisture content of the hollow fiber membrane to the weight thereof is from 0.2 to 7 mass %.
摘要翻译：本发明涉及一种包含聚砜型选择性渗透性中空纤维膜的中空纤维膜组件，其包含聚砜基树脂和亲水性聚合物作为主要成分，其中（A）亲水性聚合物在内表面最上层中的含量的中空纤维膜的至少比膜的内表面的邻近层中的亲水性聚合物的含量大至少1.1倍，（B）亲水性聚合物在外表面的最上层中的含量中空纤维膜比膜的内表面的最上层中的亲水性聚合物的含量大至少1.1倍。中空纤维膜组件暴露于放射线，条件是中空纤维膜周围的环境气氛的氧浓度为0.001〜0.1％，中空纤维膜的水分含量为 0.2〜7质量％。

9. 发明申请

US20120305472A1 POROUS HOLLOW FIBER MEMBRANE FOR TREATMENT OF PROTEIN-CONTAINING LIQUID 有权
标题翻译：用于处理含蛋白质液体的多孔中空纤维膜
公开(公告)号：US20120305472A1
公开(公告)日：2012-12-06
申请号：US13578416
申请日：2011-03-08
申请人： Hideyuki Yokota , Toru Uenishi , Hirofumi Ogawa , Satoru Ashitaka , Noriko Monden
发明人： Hideyuki Yokota , Toru Uenishi , Hirofumi Ogawa , Satoru Ashitaka , Noriko Monden
IPC分类号： B01D71/68 , B01D63/02
CPC分类号： B01D69/02 , B01D69/08 , B01D69/087 , B01D71/44 , B01D71/68 , B01D2325/026 , B01D2325/20 , B01D2325/28 , B01D2325/36
摘要： An object of the present invention is to provide a porous hollow fiber membrane for the treatment of a protein-containing liquid where the substances to be removed such as small-sized virus contained in a solution can be efficiently separated and removed and, at the same time, useful substances to be recovered such as protein can be efficiently permeated and the decrease in the permeation characteristics thereof with elapse of time is small. The porous hollow fiber membrane for the treatment of a protein-containing liquid of the present invention is characterized in that the membrane comprises a hydrophobic polymer and a hydrophilic polymer, its permeability for pure water is 10 to 300 L/(h·m2·bar) and, when a 0.5% immunoglobulin solution is subjected to filtration at a constant pressure of 1.0 bar for 60 minutes in dead-end filtration mode, its filtration time and accumulated amount of recovered filtrate are substantially in a linear relation.
摘要翻译：本发明的目的是提供一种用于处理含蛋白质液体的多孔中空纤维膜，其中可以有效地分离和除去溶液中所含的小尺寸病毒等待除去的物质，同时可以有效地渗透有效回收的物质如蛋白质，并且随着时间的流逝，其渗透特性的降低也很小。用于处理本发明的含蛋白质的液体的多孔中空纤维膜的特征在于，所述膜包含疏水性聚合物和亲水性聚合物，其纯水的渗透性为10〜300L /（h·m········· ），并且当在死端过滤模式中将0.5％免疫球蛋白溶液在1.0巴的恒定压力下过滤60分钟时，其过滤时间和回收滤液的累积量基本上呈线性关系。

10. 发明授权

US09492794B2 Porous hollow fiber membrane for treatment of protein-containing liquid 有权
标题翻译：用于处理含蛋白质液体的多孔中空纤维膜
公开(公告)号：US09492794B2
公开(公告)日：2016-11-15
申请号：US13578416
申请日：2011-03-08
申请人： Hideyuki Yokota , Toru Uenishi , Hirofumi Ogawa , Satoru Ashitaka , Noriko Monden
发明人： Hideyuki Yokota , Toru Uenishi , Hirofumi Ogawa , Satoru Ashitaka , Noriko Monden
IPC分类号： B01D69/02 , B01D69/08 , B01D71/44 , B01D71/68
CPC分类号： B01D69/02 , B01D69/08 , B01D69/087 , B01D71/44 , B01D71/68 , B01D2325/026 , B01D2325/20 , B01D2325/28 , B01D2325/36
摘要： An object of the present invention is to provide a porous hollow fiber membrane for the treatment of a protein-containing liquid where the substances to be removed such as small-sized virus contained in a solution can be efficiently separated and removed and, at the same time, useful substances to be recovered such as protein can be efficiently permeated and the decrease in the permeation characteristics thereof with elapse of time is small. The porous hollow fiber membrane for the treatment of a protein-containing liquid of the present invention is characterized in that the membrane comprises a hydrophobic polymer and a hydrophilic polymer, its permeability for pure water is 10 to 300 L/(h·m2·bar) and, when a 0.5% immunoglobulin solution is subjected to filtration at a constant pressure of 1.0 bar for 60 minutes in dead-end filtration mode, its filtration time and accumulated amount of recovered filtrate are substantially in a linear relation.
摘要翻译：本发明的目的是提供一种用于处理含蛋白质液体的多孔中空纤维膜，其中可以有效地分离和除去溶液中所含的小尺寸病毒等待除去的物质，同时可以有效地渗透有效回收的物质如蛋白质，并且随着时间的流逝，其渗透特性的降低也很小。用于处理本发明的含蛋白质的液体的多孔中空纤维膜的特征在于，所述膜包含疏水性聚合物和亲水性聚合物，其纯水的渗透性为10〜300L /（h·m········· ），并且当在死端过滤模式中将0.5％免疫球蛋白溶液在1.0巴的恒定压力下过滤60分钟时，其过滤时间和回收滤液的累积量基本上呈线性关系。

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