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1. 发明授权

US08722663B2 Di-substituted pyridine derivatives as anticancers 失效
标题翻译：二取代吡啶衍生物作为抗癌剂
公开(公告)号：US08722663B2
公开(公告)日：2014-05-13
申请号：US13318053
申请日：2011-01-28
申请人： Hideki Takasu , Shigekazu Fujita , Shinya Ohtsuka , Toshiyuki Hirose , Yosuke Sato , Satoshi Yamada , Keisuke Miyajima , Koji Sakai , Yutaka Kojima , Kazuo Sekiguchi , Yasuo Yanagihara , Takashi Suzuki , Hideo Tanaka , Kazuhisa Sugiyama , Mitsuhiro Okuno , Takumi Sumida
发明人： Hideki Takasu , Shigekazu Fujita , Shinya Ohtsuka , Toshiyuki Hirose , Yosuke Sato , Satoshi Yamada , Keisuke Miyajima , Koji Sakai , Yutaka Kojima , Kazuo Sekiguchi , Yasuo Yanagihara , Takashi Suzuki , Hideo Tanaka , Kazuhisa Sugiyama , Mitsuhiro Okuno , Takumi Sumida
IPC分类号： A61K31/44 , A61K31/4439 , A61K31/4545 , A61K31/4725 , A61K31/443 , A61K31/496 , A61K31/551 , A61K31/553 , C07D213/69 , C07D401/12 , C07D405/12 , C07D413/12
CPC分类号： C07D213/69 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is —NH-G2-, —N(lower alkyl)-G2-, —NH—CH2-G2-, —N(lower alkyl)-CH2-G2- or —CH2-G2-, [wherein G2 binds to R2, G2-R2 is bond-R2, phenylene-G3-R2, phenylene-G4-O—R2, phenylene-G5-NH—R2, phenylene-G6-N(lower alkyl)-R2 or quinolinediyl-O—R2, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G3-R2 is —O-lower alkylene-R2 or the like; G4-O— is lower alkylene-O— or the like; G5 is lower alkylene; G6 is lower alkylene].
摘要翻译：本发明提供具有优异抗肿瘤效果的新型化合物。本发明的化合物由以下通式（1）表示，其中R 1和R 2是芳基等; A是低级亚烷基; 环X是任选取代的亚芳基; E是键或低级亚烯基; 环Y是含有一个或多个氮原子的任选取代的杂环亚烷基，其中一个氮原子连接到相邻的羰基上; G是-NH-G2-，-N（低级烷基）-G2-，-NH-CH2-G2-，-N（低级烷基）-CH2-G2-或-CH2-G2-，其中G2与R2结合，G2-R2是键-R2，亚苯基-G3-R2，亚苯基-G4-O-R2，亚苯基-G5-NH-R2，亚苯基-G6-N（低级烷基）-R2或喹啉二基-O-R2，所述含亚苯基的亚苯基任选被一个或多个取代基取代; G3-R2是-O-低级亚烷基-R2等; G4-O-是低级亚烷基-O-等; G5为低级亚烷基; G6为低级亚烷基]。

2. 发明申请

US20120283242A1 DI - SUBSTITUTED PYRIDINE DERIVATIVES AS ANTICANCERS 失效
标题翻译： DI - 取代的吡啶衍生物作为反应物
公开(公告)号：US20120283242A1
公开(公告)日：2012-11-08
申请号：US13318053
申请日：2011-01-28
申请人： Hideki Takasu , Shigekazu Fujita , Shinya Ohtsuka , Toshiyuki Hirose , Yosuke Sato , Satoshi Yamada , Keisuke Miyajima , Koji Sakai , Yutaka Kojima , Kazuo Sekiguchi , Yasuo Yanagihara , Takashi Suzuki , Hideo Tanaka , Kazuhisa Sugiyama , Mitsuhiro Okuno , Takumi Sumida
发明人： Hideki Takasu , Shigekazu Fujita , Shinya Ohtsuka , Toshiyuki Hirose , Yosuke Sato , Satoshi Yamada , Keisuke Miyajima , Koji Sakai , Yutaka Kojima , Kazuo Sekiguchi , Yasuo Yanagihara , Takashi Suzuki , Hideo Tanaka , Kazuhisa Sugiyama , Mitsuhiro Okuno , Takumi Sumida
IPC分类号： A61K31/496 , C07D401/14 , C07D405/14 , A61K31/551 , A61P35/00 , A61K31/4545 , C07D413/14 , C07D413/12 , A61K31/553 , C07D401/12 , C07D417/14
CPC分类号： C07D213/69 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is —NH-G2-, —N(lower alkyl)-G2-, —NH—CH2-G2-, —N(lower alkyl)-CH2-G2- or —CH2-G2-, [wherein G2 binds to R2, G2-R2 is bond-R2, phenylene-G3-R2, phenylene-G4-O—R2, phenylene-G5-NH—R2, phenylene-G6-N(lower alkyl)-R2 or quinolinediyl-O—R2, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G3-R2 is —O-lower alkylene-R2 or the like; G4-O— is lower alkylene-O— or the like; G5 is lower alkylene; G6 is lower alkylene].
摘要翻译：本发明提供具有优异抗肿瘤效果的新型化合物。本发明的化合物由以下通式（1）表示，其中R 1和R 2是芳基等; A是低级亚烷基; 环X是任选取代的亚芳基; E是键或低级亚烯基; 环Y是含有一个或多个氮原子的任选取代的杂环亚烷基，其中一个氮原子连接到相邻的羰基上; G是-NH-G2-，-N（低级烷基）-G2-，-NH-CH2-G2-，-N（低级烷基）-CH2-G2-或-CH2-G2-，其中G2与R2结合，G2-R2是键-R2，亚苯基-G3-R2，亚苯基-G4-O-R2，亚苯基-G5-NH-R2，亚苯基-G6-N（低级烷基）-R2或喹啉二基-O-R2，所述含亚苯基的亚苯基任选被一个或多个取代基取代; G3-R2是-O-低级亚烷基-R2等; G4-O-是低级亚烷基-O-等; G5为低级亚烷基; G6为低级亚烷基]。

3. 发明申请

US20080315066A1 Poly 4-Methyl-1-Pentene Resin Composition, Film and Mold for Production of Sealed Electronic Element Product 审中-公开
标题翻译：聚4-甲基-1-戊烯树脂组合物，用于生产密封电子元件产品的膜和模具
公开(公告)号：US20080315066A1
公开(公告)日：2008-12-25
申请号：US11658992
申请日：2005-07-28
申请人： Tooru Tanaka , Toshiyuki Hirose
发明人： Tooru Tanaka , Toshiyuki Hirose
IPC分类号： B28B7/34 , C08F10/14 , C08L23/00
CPC分类号： C08J5/18 , C08J2323/20 , C08L23/20 , C08L23/24 , H01C17/02 , H01G2/103 , H05K3/4611 , C08L2666/02
摘要： A poly 4-methyl-1-pentene resin composition which includes a polymer containing 80% by mass or more of 4-methyl-1-pentene in which the resin composition has a melting point of 170 to 240° C. and a semicrystallization time of 70 to 220 seconds. Also provided are a release film having good releasibility, a mold for production of a sealed electronic element product having excellent heat resistance and releasibility and an LED mold, which are obtained by molding the resin composition.
摘要翻译：聚4-甲基-1-戊烯树脂组合物，其包含含有80质量％以上的4-甲基-1-戊烯的聚合物，其中树脂组合物的熔点为170〜240℃，半结晶时间 70到220秒。还提供了具有良好剥离性的脱模膜，用于生产具有优异的耐热性和可剥离性的密封电子元件产品的模具和通过模制树脂组合物而获得的LED模具。

4. 发明申请

US20080304393A1 Resin Composition And Use Thereof 审中-公开
标题翻译：树脂组合物及其用途
公开(公告)号：US20080304393A1
公开(公告)日：2008-12-11
申请号：US11631950
申请日：2005-07-01
申请人： Atsushi Shibuya , Toshiyuki Hirose
发明人： Atsushi Shibuya , Toshiyuki Hirose
IPC分类号： G11B7/00 , C08K5/3435
CPC分类号： C08K5/3435 , C08K5/0008 , C08K5/49 , C08L23/0823 , G02B1/04 , G11B2007/0006
摘要： Provided is a resin composition suitable for an optical element in which the moldability, thermal resistance, mechanical strength, and low birefringence are not impaired, the deterioration is hardly generated although the laser light nearby the UV is used, change in the optical properties during the use are extremely small, particularly the light transmittance is maintained high, and a foreign substance is hardly deposited on a surface of the molded product such as an optical element, also provided is an optical element obtained by molding the resin composition, and an optical pickup device using the optical element. The thermoplastic resin composition contains the polymer having a specific structure and two kinds of specific optical stabilizers in a specific mass ratio among a hindered amine light stabilizer having the molecular weight of 400 to 5,000; the optical element is obtained by molding the thermoplastic resin composition; and the optical pickup device includes the optical element.
摘要翻译：本发明提供一种适用于不损害成型性，耐热性，机械强度，低双折射性的光学元件的树脂组合物，尽管使用了UV附近的激光，但几乎不发生劣化，使用非常小，特别是透光率保持较高，并且异物难以沉积在诸如光学元件的成型产品的表面上，还提供了通过模制树脂组合物获得的光学元件和光学拾取器装置使用光学元件。热塑性树脂组合物含有具有特定结构的聚合物和两种具有分子量为400至5,000的受阻胺光稳定剂之间的比质量比的特定光学稳定剂; 光学元件通过模制热塑性树脂组合物而获得; 并且光学拾取装置包括光学元件。

5. 发明申请

US20070249792A1 Olefin-Based Polymers and Uses Thereof 有权
标题翻译：基于烯烃的聚合物及其用途
公开(公告)号：US20070249792A1
公开(公告)日：2007-10-25
申请号：US11628640
申请日：2005-06-09
申请人： Nobuo Kawahara , Shinichi Kojoh , Shingo Matsuo , Hideyuki Kaneko , Tomoaki Matsugi , Norio Kashiwa , Munehito Funaya , Naritoshi Hirota , Tooru Tanaka , Toshiyuki Hirose , Nobuhisa Mikawa , Kouichi Kizu , Keiji Okada
发明人： Nobuo Kawahara , Shinichi Kojoh , Shingo Matsuo , Hideyuki Kaneko , Tomoaki Matsugi , Norio Kashiwa , Munehito Funaya , Naritoshi Hirota , Tooru Tanaka , Toshiyuki Hirose , Nobuhisa Mikawa , Kouichi Kizu , Keiji Okada
IPC分类号： C08F10/14 , B65D1/09
CPC分类号： C08F210/14 , C08F110/14 , D01F6/04 , D01F6/30 , C08F2500/15 , C08F2500/17 , C08F2500/03 , C08F210/16 , C08F210/06
摘要： A novel olefin-based polymer has excellent thermal resistance, as well as excellent balance among various properties. The olefin-based polymer is an olefin-based polymer comprising 50 to 100% by weight of a constituent unit derived from 4-methyl-1-pentene, and 0 to 50% by weight of a constituent unit derived from at least one olefin selected from olefins having 2 to 20 carbon atoms except 4-methyl-1-pentene, and having the following properties: i) the diad isotacticity is 70% or greater, ii) the ratio (Mw/Mn) of the weight average molecular weight (Mw) to the number average molecular weight (Mn) as measured by gel permeation chromatography (GPC) is in the range of 1.0 to 3.5, and iii) the intrinsic viscosity [η] is 0.5 (dl/g) or greater.
摘要翻译：一种新型的烯烃基聚合物具有优异的耐热性，以及各种性能之间的良好平衡。所述烯烃类聚合物是含有50〜100重量％的来自4-甲基-1-戊烯的构成单元和0〜50重量％的来源于所选择的至少一种烯烃的构成单元的烯烃系聚合物来自具有2-甲基-1-戊烯的碳原子数为2〜20的烯烃，具有以下性质：i）二单体全同立构规整度为70％以上，ii）重均分子量（Mw / Mn） Mw）与通过凝胶渗透色谱法（GPC）测定的数均分子量（Mn）的比例在1.0〜3.5的范围内，和iii）特性粘度η为0.5（dl / g）以上。

6. 发明申请

US20070155903A1 Method for producing resin composition 有权
标题翻译：树脂组合物的制造方法
公开(公告)号：US20070155903A1
公开(公告)日：2007-07-05
申请号：US11660307
申请日：2005-08-29
申请人： Kazuyoshi Kaneko , Toshiyuki Hirose
发明人： Kazuyoshi Kaneko , Toshiyuki Hirose
IPC分类号： C08F8/00
CPC分类号： C08J3/005 , C08J2345/00 , C08J2365/00 , C08K5/14 , C08L45/00 , C08L65/00 , C08L2666/02
摘要： Provided is a method for producing a resin composition by melt-kneading a cyclic olefin polymer (A) having a glass transition temperature of from 60 to 200° C. and a flexible polymer (B) having a glass transition temperature of 0° C. or lower, wherein a part of the cyclic olefin polymer (A) is previously melt-kneaded with the flexible polymer (B) and a radical initiator (C) and then the remaining cyclic olefin polymer (A) is added thereto and melt-kneaded. The cyclic olefin polymer (A) is divided into two portions and added separately at two times, and accordingly, the mixture having a crosslinked structure may be diluted with the cyclic olefin polymer (A) not having a crosslinked structure, and the increase in the melt viscosity of the resin composition may be thereby prevented. A composition having good abrasion resistance and good melt shapability can be obtained.
摘要翻译：提供一种通过熔融捏合玻璃化转变温度为60-200℃的环烯烃聚合物（A）和玻璃化转变温度为0℃的柔性聚合物（B）来制备树脂组合物的方法。或更低，其中一部分环烯烃聚合物（A）预先与柔性聚合物（B）熔融捏合和自由基引发剂（C），然后向其中加入剩余的环状烯烃聚合物（A）并熔融捏合。环状烯烃聚合物（A）分成两部分，分两次加入，因此可以用不具有交联结构的环状烯烃聚合物（A）稀释交联结构的混合物，因此可以防止树脂组合物的熔融粘度。可以获得具有良好的耐磨性和良好的熔融成形性的组合物。

7. 发明授权

US07314905B2 Drawn film and process for producing the same 有权
标题翻译：制作电影和制作过程
公开(公告)号：US07314905B2
公开(公告)日：2008-01-01
申请号：US10521189
申请日：2004-03-26
申请人： Shigetoshi Nishijima , Shinichi Imuta , Toshiyuki Hirose
发明人： Shigetoshi Nishijima , Shinichi Imuta , Toshiyuki Hirose
IPC分类号： C08F10/14 , B32B27/32 , B32B11/08 , B65B33/00
CPC分类号： C08J5/18 , B29C33/68 , B29K2023/00 , B32B27/32 , C08J2323/02 , H05K3/4611 , Y10S428/91 , Y10T428/31913 , Y10T428/31938
摘要： A film that has high rigidity and high heat resistance and good releasability from a roughened copper foil surface, which is subjected to surface oxidization or etching treatment with acid, such as a black oxidized copper foil surface and that is suitable as a release film for producing an MLB; and a process for producing the same. A drawn film having a layer (A) which comprises a copolymer that is made from 4-methyl-1-pentene and ethylene or an α-olefin, except 4-methyl-1-pentene, having 3 to 20 carbon atoms and that comprises 80% or more by mole of 4-methyl-1-pentene, the thermal coefficient of contraction of the film being 20% or more in the film-drawn direction, or the peel area of the film being 50% or more when the film, together with a copper foil surface subjected to roughening treatment, is subjected to heating and pressing treatment. This film is suitable for producing an MLB and has good releasability from the roughened copper foil surface, for example, a black oxidized copper foil surface.
摘要翻译：具有高刚性和高耐热性以及从被粗糙化的铜箔表面剥离的良好剥离性的薄膜，其经过表面氧化或酸蚀刻处理，例如黑色氧化铜箔表面，并且适合作为用于生产一个MLB; 及其制造方法。具有层（A）的拉伸膜，其包含由4-甲基-1-戊烯和乙烯或除了4-甲基-1-戊烯以外的具有3-20个碳原子的α-烯烃的共聚物，其包含 80％以上的4-甲基-1-戊烯，膜的热收缩率为20％以上，膜的剥离面积为50％以上时，膜的收缩率为50％以上与经受粗糙化处理的铜箔表面一起进行加热和压制处理。该膜适用于生产MLB，并且具有从粗糙化的铜箔表面，例如黑色氧化铜箔表面的良好的剥离性。

8. 发明申请

US20060261988A1 CHARACTER STRING RETRIEVING CIRCUIT AND CHARACTER STRING RETRIEVING METHOD 失效
标题翻译：字符串检索电路和字符串检索方法
公开(公告)号：US20060261988A1
公开(公告)日：2006-11-23
申请号：US11383308
申请日：2006-05-15
申请人： Toshiyuki Hirose
发明人： Toshiyuki Hirose
IPC分类号： H03M7/00
CPC分类号： H03M7/3086
摘要： A character string retrieving circuit includes a delay circuit (10) for delaying a match/no match signal created in each clock period to indicate whether or not a character matched with a retrieval target exists in a dictionary by one clock period, creating circuits (2 (i), 3 (i), 5 (i) and 6 (i)) for creating in advance signals of two kinds of a signal (ps1 [i]) to assume that a character matched with a retrieval target exists in a dictionary in the clock period and a signal (ps0 [i]) to assume that a character matched with a retrieval target does not exist in a dictionary in the clock period as signals to predict retrieved results in a certain clock period later and a selecting circuit (4) (i) for selecting a signal with a correct assumption from the signals of 2 kinds in accordance with the match/no match signal delayed by the delay circuit (10), wherein a signal selected by the selecting circuit (4) (i) is used in the next clock period. Thus, in the character string retrieving circuit provided within a data compressing circuit using the LZ77 method, faster character string retrieval can be realized based on pipeline processing.
摘要翻译：字符串检索电路包括延迟电路（10），用于延迟在每个时钟周期中产生的匹配/不匹配信号，以指示在字典中与检索对象匹配的字符是否存在一个时钟周期，产生电路（2 （i），3（i），5（i）和6（i）），用于提前产生两种信号（ps 1 [i]）的信号，以假设与检索目标匹配的字符存在于字典在时钟周期中，以及信号（ps 0 [i]），以假设与检索对象匹配的字符在时钟周期中不存在于字典中，作为预测的信号在特定时钟周期内检索到的结果，以及选择电路（4）（i），用于根据由延迟电路（10）延迟的匹配/不匹配信号从2种信号中选择具有正确假设的信号，其中由选择电路（4）选择的信号，（i）在下一个时钟周期使用。因此，在使用LZ77方法的数据压缩电路内提供的字符串检索电路中，可以基于流水线处理来实现更快的字符串检索。

9. 发明授权

US06342549B1 Cycloolefin resin pellets and a process for producing a molded product thereof 失效
标题翻译：环状烯烃树脂粒料及其成型体的制造方法
公开(公告)号：US06342549B1
公开(公告)日：2002-01-29
申请号：US08583461
申请日：1996-01-05
申请人： Toshiyuki Hirose , Yohzoh Yamamoto , Toshio Kimura , Shinji Osato
发明人： Toshiyuki Hirose , Yohzoh Yamamoto , Toshio Kimura , Shinji Osato
IPC分类号： C08K513
CPC分类号： C08K5/0016 , C08K5/005 , C08L45/00
摘要： Cycloolefin resin pellets of the present invention comprises a cycloolefin resin pellet and a powdery coating material and/or a liquid coating material, the melting point or the glass transition point of the coating material being 200° C. or lower, and the coating material being adhered onto the surface of the cycloolefin resin pellets, so that the molded product thereof is excellent in transparency.
摘要翻译：本发明的环烯烃树脂颗粒包含环烯烃树脂颗粒和粉末涂料和/或液体涂料，涂料的熔点或玻璃化转变点为200℃以下，涂料为粘附到环烯树脂颗粒的表面上，使得其模塑产品具有优异的透明度。

10. 发明授权

US5818652A Device for reproducing a recording medium having plural recording areas 失效
标题翻译：用于再现具有多个记录区域的记录介质的装置
公开(公告)号：US5818652A
公开(公告)日：1998-10-06
申请号：US666779
申请日：1996-06-19
申请人： Shinya Ozaki , Hiroshi Ishibashi , Toshiyuki Hirose
发明人： Shinya Ozaki , Hiroshi Ishibashi , Toshiyuki Hirose
IPC分类号： G11B15/06 , G11B15/18 , G11B15/467 , G11B15/52 , G11B20/10 , G11B20/12 , G11B20/18 , G11B27/10 , G11B27/30 , G11B5/02 , G11B5/09
CPC分类号： G11B20/1806 , G11B15/1816 , G11B15/52 , G11B20/1208 , G11B27/107 , G11B27/3027 , G11B27/3063 , G11B15/06 , G11B15/4678 , G11B20/10 , G11B2220/90 , G11B2220/913
摘要： A data reproducing apparatus in which the identification information recorded in multiplicity on a recording track can be reliably reproduced assuring stable data reproduction including a decoder 61 to decode the area IDs supplied from an 8/10 demodulation circuit 43 and to supply each decoded area ID to counters C0 to C15, a system controller 70 to find the number of times of occurrences of coincidences of the area IDs of areas other than the end of data (EOD) area and, based on the frequency of detection of the occurrences of the area IDs by the counters C0 to C15, detects the area IDs of the (EOD) area. Finally, the system controller 70 controls the running of a magnetic tape 31 based on the detected area IDs.
摘要翻译：一种数据再现装置，其中可以可靠地再现记录在记录轨道上的多重性的识别信息，从而确保包括解码器61的稳定的数据再现，以对从8/10解调电路43提供的区域ID进行解码，并将每个解码区域ID提供给计数器C0至C15，系统控制器70，用于查找除数据结束（EOD）区域之外的区域的区域ID的重合出现次数，并且基于区域ID的出现次数通过计数器C0〜C15检测（EOD）区域的区域ID。最后，系统控制器70基于检测到的区域ID来控制磁带31的运行。

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