专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07964744B2 Method for producing a ruthenium complex 有权
标题翻译：钌络合物的制造方法
公开(公告)号：US07964744B2
公开(公告)日：2011-06-21
申请号：US12540794
申请日：2009-08-13
申请人： Hideki Nara , Noboru Sayo , Takahiro Fujiwara
发明人： Hideki Nara , Noboru Sayo , Takahiro Fujiwara
IPC分类号： C07F15/00
CPC分类号： C07F15/0053
摘要： Provided is a method for producing a ruthenium complex comprises the step of reacting a ruthenium compound represented by general formula (1): [RuX(L)(PP)]X (1), wherein Ru represents a ruthenium atom; X represents a halogen atom; L represents an arene; and PP represents an optically active bisphosphine, with a carboxylate salt represented by general formula (2): R1CO2M (2), wherein M represents a monovalent cation; and R1 represents a group selected from the group consisting of alkyl groups, haloalkyl groups, phenyl groups optionally having a substituent(s), 1-aminoalkyl groups and 1-amino-1-phenylalkyl groups, to produce a ruthenium complex represented by general formula (3): Ru(OCOR1)2(PP) (3), wherein R1 represents the group selected from the group consisting of alkyl groups, haloalkyl groups, phenyl groups optionally having a substituent(s), 1-aminoalkyl groups and 1-amino-1-phenylalkyl groups; and PP represents the optically active bisphosphine.
摘要翻译：提供一种制备钌络合物的方法，包括使通式（1）表示的钌化合物：[RuX（L）（PP）] X（1），其中Ru表示钌原子; X表示卤原子; L代表芳烃; 和PP代表光学活性双膦，与通式（2）表示的羧酸盐：R1CO2M（2），其中M表示一价阳离子; 并且R 1表示选自烷基，卤代烷基，任选具有取代基的苯基，1-氨基烷基和1-氨基-1-苯基烷基的基团，以制备由通式（3）：Ru（OCOR1）2（PP）（3），其中R1表示选自烷基，卤代烷基，任选具有取代基的苯基，1-氨基烷基和1- 氨基-1-苯基烷基; PP代表光学活性双膦。

2. 发明申请

US20100076210A1 METHOD FOR PRODUCING A RUTHENIUM COMPLEX 有权
标题翻译：生产金属复合材料的方法
公开(公告)号：US20100076210A1
公开(公告)日：2010-03-25
申请号：US12540794
申请日：2009-08-13
申请人： Hideki Nara , Noboru Sayo , Takahiro Fujiwara
发明人： Hideki Nara , Noboru Sayo , Takahiro Fujiwara
IPC分类号： C07F15/00
CPC分类号： C07F15/0053
摘要： Provided is a method for producing a ruthenium complex comprises the step of reacting a ruthenium compound represented by general formula (1): [RuX(L)(PP)]X (1), wherein Ru represents a ruthenium atom; X represents a halogen atom; L represents an arene; and PP represents an optically active bisphosphine, with a carboxylate salt represented by general formula (2): R1CO2M (2), wherein M represents a monovalent cation; and R1 represents a group selected from the group consisting of alkyl groups, haloalkyl groups, phenyl groups optionally having a substituent(s), 1-aminoalkyl groups and 1-amino-1-phenylalkyl groups, to produce a ruthenium complex represented by general formula (3): Ru(OCOR1)2(PP) (3), wherein R1 represents the group selected from the group consisting of alkyl groups, haloalkyl groups, phenyl groups optionally having a substituent(s), 1-aminoalkyl groups and 1-amino-1-phenylalkyl groups; and PP represents the optically active bisphosphine.
摘要翻译：提供一种制备钌络合物的方法，包括使通式（1）表示的钌化合物：[RuX（L）（PP）] X（1），其中Ru表示钌原子; X表示卤原子; L代表芳烃; 和PP代表光学活性双膦，与通式（2）表示的羧酸盐：R1CO2M（2），其中M表示一价阳离子; 并且R 1表示选自烷基，卤代烷基，任选具有取代基的苯基，1-氨基烷基和1-氨基-1-苯基烷基的基团，以制备由通式（3）：Ru（OCOR1）2（PP）（3），其中R1表示选自烷基，卤代烷基，任选具有取代基的苯基，1-氨基烷基和1- 氨基-1-苯基烷基; PP代表光学活性双膦。

3. 发明申请

US20070060772A1 Phosphines, transition metal complexes containing the same as the ligand, and process for production of optically active carboxylic acids 有权
公开(公告)号：US20070060772A1
公开(公告)日：2007-03-15
申请号：US11540166
申请日：2006-09-29
申请人： Akira Amano , Daisuke Igarashi , Noboru Sayo
发明人： Akira Amano , Daisuke Igarashi , Noboru Sayo
IPC分类号： C07B53/00 , C07F15/00
CPC分类号： C07F9/5027 , C07B2200/07 , C07C51/36 , C07F9/65517 , C07F15/004 , C07F15/0053 , C07F15/0066 , C07F15/008 , C07F15/045 , C07C53/128
摘要： [PROBLEMS] To provide a method by which desired optically active carboxylic acids may be prepared from a carboxylic acid having a carbon-carbon double bond through asymmetric hydrogenation with a catalyst consisting of a transition metal complex containing a water-soluble ligand and which permits easy separation of the used catalyst from the product by liquid-liquid separation alone and enables the recovery of an expensive transition metal and the reuse of the catalyst. [MEANS FOR SOLVING PROBLEMS] Phosphines represented by the general formula (1): wherein X1 is oxygen or methylene; X2 is methylene, ethylene, trimethylene, 1,2-dimethylethylene, isopropylidene, or difluoromethylene; A is a Group IA alkali metal of the periodic table, hydrogen, or an ammonium ion; and a, b, c and d are each an integer of 0 or 1, with the proviso that the cases wherein the sum of a, b, c, and d is 0 are excepted.

4. 发明授权

US06492545B2 Process for producing optically active alcohol 有权
标题翻译：光学活性醇的制造方法
公开(公告)号：US06492545B2
公开(公告)日：2002-12-10
申请号：US09909803
申请日：2001-07-23
申请人： Takao Saito , Tohru Yokozawa , Kazuhiko Matsumura , Noboru Sayo
发明人： Takao Saito , Tohru Yokozawa , Kazuhiko Matsumura , Noboru Sayo
IPC分类号： C07C6966
CPC分类号： C07C67/31 , C07B2200/07 , Y02P20/55 , C07C69/675
摘要： A novel process in which an optically active alcohol compound having a desired absolute configuration and a high optical purity can be obtained by asymmetrically hydrogenating a &bgr;-keto acid compound through a simple operation. An optically active alcohol represented by general formula (III) as defined is obtained by asymmetrically hydrogenating a &bgr;-keto ester compound represented by general formula (I) as defined in the presence of at least one ruthenium complex having as a ligand an optically active tertiary diphosphine compound represented by general formula (II) as defined.
摘要翻译：通过简单的操作通过不对称氢化β-酮酸化合物，可以获得具有所需绝对构型和高光学纯度的光学活性醇化合物的新方法。由通式（III）表示的光学活性醇通过不对称氢化由通式（I）表示的β-酮酯化合物获得，如在至少一种具有光学活性第三级如通式（Ⅱ）所示的二膦化合物。

5. 发明授权

US06313317B1 Ruthenium-phosphine complex and method for producing the same 有权
标题翻译：钌膦络合物及其制备方法
公开(公告)号：US06313317B1
公开(公告)日：2001-11-06
申请号：US09273260
申请日：1999-03-22
申请人： Noboru Sayo , Takao Saito , Tohru Yokozawa
发明人： Noboru Sayo , Takao Saito , Tohru Yokozawa
IPC分类号： C07F930
CPC分类号： B01J31/2457 , B01J31/2295 , B01J2231/643 , B01J2231/645 , B01J2531/821 , C07B53/00 , C07C67/31 , C07F15/0053 , C07C69/675
摘要： Disclosed is a ruthenium-phosphine complex usable as the catalyst giving a high enantiomer excess in an asymmetric reaction and a method for producing the complex. The ruthenium-phosphine complex is represented by formula (1): [{(RuX(L)}2(&mgr;-X)3]−[R22NH2]+ (1) wherein R2 represents hydrogen, alkyl, cycloalkyl or benzyl and L represents a diphosphine ligand represented by formula (2): wherein R1 represents an optionally substituted phenyl group and X represents a halogen atom. The method for preparing a ruthenium-phosphine complex represented by formula (1) is characterized in that a ruthenium complex represented by the formula [RuX(arene)(L)]X and an ammonium salt represented by the formula R22NH.HX are reacted with each other.
摘要翻译：公开了可用作在不对称反应中给出高对映体过量的催化剂的钌膦络合物和制备该络合物的方法。钌膦配合物由式（1）表示：其中R2表示氢，烷基，环烷基或苄基，L表示由式（2）表示的二膦配体：其中R1表示任选取代的苯基，X表示卤素原子。由式（1）表示的钌 - 膦配合物的制备方法的特征在于，由式[RuX（芳烃）（L）] X表示的钌络合物和由式R22NH.HX表示的铵盐与彼此。

6. 发明授权

US6040465A Process for producing optically active .beta.-lactones 失效
标题翻译：光学活性β-内酯的制备方法
公开(公告)号：US6040465A
公开(公告)日：2000-03-21
申请号：US265371
申请日：1999-03-10
申请人： Sotaro Miyano , Tetsutaro Hattori , Osamu Uesugi , Yasufumi Tamai , Noboru Sayo
发明人： Sotaro Miyano , Tetsutaro Hattori , Osamu Uesugi , Yasufumi Tamai , Noboru Sayo
IPC分类号： B01J31/22 , C07D305/12 , B01J20/00
CPC分类号： C07D305/12
摘要： Disclosed is a process for producing an optically active .beta.-lactone represented by the general formula (I): ##STR1## wherein R.sup.1 represents an alkyl group having 1-9 carbon atoms which can be branched or a cycloalkyl group having 5-7 carbon atoms. The process comprises reacting an aldehyde represented by the general formula (II):R.sup.1 CHO (II)wherein R.sup.1 is the same as defined above, with a ketene represented by the general formula (III):CH.sub.2 .dbd.C.dbd.O (III)in the presence of a bissulfonamide/aluminum complex represented by the general formula (IV): ##STR2## wherein Ar represents 2,4,6-(R.sup.2).sub.3 C.sub.6 H.sub.2 (wherein R.sup.2 represents an alkyl group having 2-4 carbon atoms), Et represents an ethyl group and Ph represents a phenyl group.
摘要翻译：公开了由通式（I）表示的光学活性β-内酯的制备方法：其中R1表示可以是支链或具有5-7个碳原子的环烷基的具有1-9个碳原子的烷基。该方法包括使由通式（II）表示的醛：其中R 1与上述定义相同的R 1 CHO（II）与通式（III）表示的乙烯酮：CH 2 = C = O（III）由通式（IV）表示的双磺酰胺/铝络合物的存在：其中Ar表示2,4,6-（R2）3C6H2（其中R2表示具有2-4个碳原子的烷基），Et表示乙基， Ph表示苯基。

7. 发明授权

US5922918A Method for making an optically active diphosphine ligand 失效
标题翻译：制备光学活性二膦配体的方法
公开(公告)号：US5922918A
公开(公告)日：1999-07-13
申请号：US957020
申请日：1997-10-24
申请人： Xiaoyaong Zhang , Noboru Sayo
发明人： Xiaoyaong Zhang , Noboru Sayo
IPC分类号： C07F9/32 , C07F9/50 , C07F9/53
CPC分类号： C07F9/509 , C07F9/5325 , C07B2200/07
摘要： The present invention provides a method for making compound (1) by reacting compound (2) with phosphine oxide (3) in the presence of a transition metal/phosphine complex and optionally reducing the reaction product: ##STR1## where n represents 0 or 1; the double line having a continuous line and a dotted line represents a double bond or a single bond such that the ring having the double line forms a naphthalene ring or an octahydronaphthalene ring with an adjacent benzene ring; Tf represents a trifluoromethanesulfonyl group; and Ar represents a phenyl group, a substituted phenyl group or a naphthyl group. The present invention provides an economical way to produce compound (1) as a ligand of a complex useful as a catalyst for a variety of asymmetric synthesis reactions.
摘要翻译：本发明提供了在过渡金属/膦配合物存在下使化合物（2）与氧化膦（3）反应制备化合物（1）的方法，任选地还原反应产物：其中n表示0或1; 具有连续线和虚线的双线表示双键或单键，使得具有双线的环形成具有相邻苯环的萘环或八氢萘环; Tf表示三氟甲磺酰基; Ar表示苯基，取代苯基或萘基。本发明提供了一种生产化合物（1）作为可用作各种不对称合成反应的催化剂的络合物的配体的经济方法。

8. 发明授权

US5631397A Process for producing optically active diaminohexanone derivative 失效
标题翻译：光学活性二氨基己酮衍生物的制备方法
公开(公告)号：US5631397A
公开(公告)日：1997-05-20
申请号：US470466
申请日：1995-06-06
申请人： Tetsuro Yamasaki , Hidenori Kumobayashi , Noboru Sayo , Toshiyuki Murayama , Noboru Sano , Takero Ishizaki
发明人： Tetsuro Yamasaki , Hidenori Kumobayashi , Noboru Sayo , Toshiyuki Murayama , Noboru Sano , Takero Ishizaki
IPC分类号： B01J31/22 , B01J31/24 , C07B61/00 , C07C215/28 , C07C221/00 , C07C225/16 , C07C231/12 , C07C231/18 , C07C233/36 , C07C233/43 , C07C233/78 , C07C269/06 , C07C271/20
CPC分类号： C07C221/00 , C07C231/12 , C07C231/18 , C07C233/36 , C07C233/78 , C07C269/06 , C07C271/20
摘要： Disclosed herein is a process for producing a (2S,5S)-2,5-diamino-1,6-diphenyl-3-hexanone derivative represented by the formula (1): ##STR1## wherein R.sup.1 means a lower alkylcarbonyl group, a halogen-substituted lower alkylcarbonyl group, an arylcarbonyl group or a lower alkoxycarbonyl group, and R.sup.2 and R.sup.3 are identical with or different from each other and denote individually an aryl group or an alkoxy-substituted aryl group, which comprises subjecting a (2S)-2,5-diamino-1,6-diphenyl-4-hexen-3-one derivative represented by the formula (2): ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 have the same meaning as defined above, to a hydrogenation reaction in the presence of a transition metal-containing catalyst.
摘要翻译：本文公开了一种制备由式（1）表示的（2S，5S）-2,5-二氨基-1,6-二苯基-3-己酮衍生物的方法：其中R1表示低级烷基羰基基团，卤素取代的低级烷基羰基，芳基羰基或低级烷氧基羰基，R 2和R 3彼此相同或不同，分别表示芳基或烷氧基取代的芳基，其包括使（ 2S）-2,5-二氨基-1,6-二苯基-4-己烯-3-酮衍生物：其中R1，R2和R3具有与上述相同的含义。在含过渡金属的催化剂存在下进行氢化反应。

9. 发明授权

US5502221A Process for producing cyclohexylbutyric acid derivative 失效
公开(公告)号：US5502221A
公开(公告)日：1996-03-26
申请号：US437074
申请日：1995-05-05
申请人： Noboru Sayo , Noboru Sano , Hidenori Kumobayashi
发明人： Noboru Sayo , Noboru Sano , Hidenori Kumobayashi
IPC分类号： C07C69/675 , C07C227/32 , C07C229/28 , C07C247/12 , C07D303/48 , C07D303/38
CPC分类号： C07C227/32 , C07C229/28 , C07C247/12 , C07C69/675 , C07D303/48 , C07C2101/14
摘要： A process for for producing a (2R,3S)-cyclohexylnorstatine or a salt thereof is disclosed, which comprises the steps of: enantioselectively hydrogenating a 4-cyclohexyl-2-halogeno-3-oxobutyric acid ester in the presence of a ruthenium-phosphine complex to produce a 4-cyclohexyl-2-halogeno-(3R)-hydroxybutyric acid ester (2); epoxidizing the compound (2) in the presence of a base to produce a 4-cyclohexyl-(2S,3R)-epoxybutyric acid ester (3); reacting the compound (3) with a lower trialkylsilyl azide in the presence of a Lewis acid to produce a (3S)-azide-4-cyclohexyl-(2S)-substituted butyric acid ester (4); subjecting the compound (4) to hydrogenolysis to produce a (2S,3S)-cyclohexylnorstatine derivative (5); and inverting the configuration at the 2-position of the compound (5).

10. 发明授权

US4981992A Process for preparing optically active 3-hydroxybutanoic acid 失效
标题翻译：制备光学活性3-羟基丁酸的方法
公开(公告)号：US4981992A
公开(公告)日：1991-01-01
申请号：US435877
申请日：1989-11-14
申请人： Noboru Sayo , Takao Saito , Yoshiki Okeda , Hiroyuki Nagashima , Hidonori Kumobayashi
发明人： Noboru Sayo , Takao Saito , Yoshiki Okeda , Hiroyuki Nagashima , Hidonori Kumobayashi
IPC分类号： B01J31/24 , C07B53/00 , C07B61/00 , C07C231/18 , C07C233/47 , C07C233/83 , C07C235/52 , C07C269/06 , C07C271/22 , C07D205/08
CPC分类号： C07C231/18 , C07C233/47 , C07C233/83 , C07C269/06 , C07C271/22 , C07D205/08 , Y02P20/55
摘要： A process for preparing an optically active 3-hydroxybutanoic acid represented by formula (I): ##STR1## wherein: R.sup.1 represents a protective group of carboxylic acid, andR.sup.2 represents a hydrogen atom; a lower alkyl group which may be substituted with a halogen atom; a lower alkoxy group; a phenyl group which may be substituted with a lower alkyl group or a lower alkoxy group; or a benzyloxy group which may be substituted with a lower alkyl group or a lower alkoxy group,is disclosed, comprising asymmetrically hydrogenating a 3-oxobutanoic acid ester represented by formula (II): ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, in the presence of a ruthenium-optically active phosphine complex as a catalyst. The compound of formula (I) which is useful for synthesizing a 4-acetoxyazetidin-2-one derivative, a useful intermediate for obtaining penem antibiotics, can be prepared economically.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式