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1. 发明申请

US20060241302A1 Morpholine derivatives 失效
标题翻译：吗啉衍生物
公开(公告)号：US20060241302A1
公开(公告)日：2006-10-26
申请号：US10561838
申请日：2004-06-29
申请人： Hideki Kubota , Takanori Yasukouchi , Satoru Miyauchi , Kayoko Motoki , Masanori Saito , Hitoshi Iimori
发明人： Hideki Kubota , Takanori Yasukouchi , Satoru Miyauchi , Kayoko Motoki , Masanori Saito , Hitoshi Iimori
IPC分类号： C07D403/02 , C07D401/02 , C07D213/02
CPC分类号： C07D213/30 , C07C317/14 , C07C2601/14
摘要： Provided is a compound capable of inhibiting production or secretion of β amyloid protein. A compound represented by the following formula (1): (wherein, R1 represents a heterocyclic group which may have a substituent, R2 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R3 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R4 represents a hydrogen atom or a C1-6 alkyl group, and X represents —S—, —SO— or —SO2—); an N-oxide or S-oxide thereof; a salt thereof; or a solvate thereof; and a medicament containing any of them.
摘要翻译：提供能够抑制β淀粉样蛋白的产生或分泌的化合物。由下式（1）表示的化合物：其中R 1表示可以具有取代基的杂环基，R 2表示可以具有可以具有取代基的取代基或杂环基，R 3表示可以具有取代基的环状烃基或可以具有取代基的杂环基，R 4，表示氢原子或C 1-6烷基，X表示-S - ， - SO-或-SO 2 - ）。其N-氧化物或S-氧化物; 其盐; 或其溶剂合物; 和含有它们中任何一种的药物。

2. 发明授权

US07932271B2 Heterocyclic methyl sulfone derivative 失效
标题翻译：杂环甲基砜衍生物
公开(公告)号：US07932271B2
公开(公告)日：2011-04-26
申请号：US10561838
申请日：2004-06-29
申请人： Hideki Kubota , Takanori Yasukouchi , Satoru Miyauchi , Kayoko Motoki , Masanori Saito , Hitoshi Iimori
发明人： Hideki Kubota , Takanori Yasukouchi , Satoru Miyauchi , Kayoko Motoki , Masanori Saito , Hitoshi Iimori
IPC分类号： A61K31/44 , C07D401/00 , C07D213/72 , C07D213/00
CPC分类号： C07D213/30 , C07C317/14 , C07C2601/14
摘要： Provided is a compound capable of inhibiting production or secretion of β amyloid protein.A compound represented by the following formula (1): (wherein, R1 represents a heterocyclic group which may have a substituent, R2 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R3 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R4 represents a hydrogen atom or a C1-6 alkyl group, and X represents —S—, —SO— or —SO2—); an N-oxide or S-oxide thereof; a salt thereof; or a solvate thereof; and a medicament containing any of them.
摘要翻译：本发明提供能够抑制β-葡聚糖的生成或分泌的化合物。淀粉样蛋白。由下式（1）表示的化合物：其中，R 1表示可以具有取代基的杂环基，R 2表示可以具有取代基的环状烃基或可以具有取代基的杂环基，R 3表示环状可以具有取代基的烃基或可以具有取代基的杂环基，R4表示氢原子或C1-6烷基，X表示-S-，-SO-或-SO2-）; 其N-氧化物或S-氧化物; 其盐; 或其溶剂合物; 和含有它们中任何一种的药物。

3. 发明申请

US20100168136A1 ALKYLSULFONE DERIVATIVES 审中-公开
标题翻译：碱性衍生物
公开(公告)号：US20100168136A1
公开(公告)日：2010-07-01
申请号：US12722282
申请日：2010-03-11
申请人： Hitoshi Iimori , Hideki Kubota , Satoru Miyauchi , Kayoko Motoki
发明人： Hitoshi Iimori , Hideki Kubota , Satoru Miyauchi , Kayoko Motoki
IPC分类号： C07D213/81 , A61K31/519 , A61K31/437 , A61P25/28 , A61P25/00 , C07D213/79 , C07D487/04 , C07D471/04 , C07D213/72 , C07D213/28 , A61K31/443
CPC分类号： C07D213/48 , C07D213/61 , C07D213/73 , C07D213/74 , C07D213/77 , C07D213/79 , C07D213/81 , C07D471/04
摘要： A compound having activity to inhibit production and/or secretion of β-amyloid protein, and is useful for prevention and/or treatment of various diseases associated with abnormal production and/or secretion of β-amyloid protein, the compound represented by the general formula (I): [wherein, R1 represents a C1-C6 alkyl group which may have 1 to 6 halogen atoms as substituent groups, a C2-C6 alkenyl group which may have 1 to 6 halogen atoms as substituent groups, or a C3-C7 cycloalkyl group which may have 1 to 6 halogen atoms as substituent groups; R2 represents a 6-membered nitrogen-containing monocyclic aromatic heterocyclic group having 1 to 3 substituent groups, or a 9- or 10-membered nitrogen-containing bicyclic heterocyclic group having 1 to 4 substituent groups; Z1, Z2 and Z3 each independently represent a hydrogen atom, a halogen atom or a cyano group; and n represents 0, 1 or 2], salts thereof, or solvates thereof.
摘要翻译：具有抑制β-淀粉样蛋白的生成和/或分泌活性的化合物，可用于预防和/或治疗与淀粉样蛋白异常产生和/或分泌相关的各种疾病，所述化合物由通式（I）：[其中，R 1表示可以具有1〜6个卤素原子作为取代基的C 1〜C 6烷基，可以具有1〜6个卤素原子作为取代基的C 2〜C 6烯基或C 3 可以具有1至6个卤素原子作为取代基的-C 7环烷基; R2表示具有1〜3个取代基的6元含氮单环芳族杂环基或具有1〜4个取代基的9元或10元含氮双环杂环基; Z 1，Z 2和Z 3各自独立地表示氢原子，卤素原子或氰基; 和n表示0,1或2]，其盐或溶剂化物。

4. 发明授权

US07399775B2 β-amyloid protein production/secretion inhibitor 失效
标题翻译： β-淀粉样蛋白生成/分泌抑制剂
公开(公告)号：US07399775B2
公开(公告)日：2008-07-15
申请号：US10500156
申请日：2002-12-27
申请人： Takanori Yasukouchi , Masayuki Ito , Hideki Kubota , Satoru Miyauchi , Masanori Saito
发明人： Takanori Yasukouchi , Masayuki Ito , Hideki Kubota , Satoru Miyauchi , Masanori Saito
IPC分类号： A61K31/44 , C07D211/70
CPC分类号： C07D213/34 , C07D207/325 , C07D211/24 , C07D211/54 , C07D213/61 , C07D213/65 , C07D213/71 , C07D213/74 , C07D213/82 , C07D215/12 , C07D215/36 , C07D233/64 , C07D233/68 , C07D233/84 , C07D235/06 , C07D235/28 , C07D239/26 , C07D239/38 , C07D257/04 , C07D263/22 , C07D263/32 , C07D277/26 , C07D277/36 , C07D277/76 , C07D295/096 , C07D307/10 , C07D307/38 , C07D309/08 , C07D311/56 , C07D333/18 , C07D335/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06
摘要： Provided are novel compounds having an inhibitory activity against production or secretion of β-amyloid protein. They embrace compounds represented by the following formula (1): and capable of being replaced with a variety of substituents; and salts thereof, and solvates of any one of them.
摘要翻译：提供了对β-淀粉样蛋白的产生或分泌具有抑制活性的新化合物。它们包括由下式（1）表示的化合物：并且能够被各种取代基取代; 及其盐，以及它们中任何一种的溶剂合物。

5. 发明申请

US20070293495A1 BETA-AMYLOID PROTEIN PRODUCTION/SECRETION INHIBITORS 审中-公开
标题翻译： BETA-AMYLOID蛋白生产/分泌抑制剂
公开(公告)号：US20070293495A1
公开(公告)日：2007-12-20
申请号：US11829533
申请日：2007-07-27
申请人： Takanori YASUKOUCHI , Masayuki Ito , Hideki Kubota , Satoru Miyauchi , Masanori Saito
发明人： Takanori YASUKOUCHI , Masayuki Ito , Hideki Kubota , Satoru Miyauchi , Masanori Saito
IPC分类号： C07D239/24 , A61K31/10 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/496 , A61K31/505 , A61K31/5377 , C07D241/04 , C07D413/00 , C07D401/14 , C07D401/02 , A61P25/00 , A61P25/28 , C07C317/10 , C07D211/00 , C07D213/61 , C07D213/62 , C07D239/02
CPC分类号： C07D213/34 , C07D207/325 , C07D211/24 , C07D211/54 , C07D213/61 , C07D213/65 , C07D213/71 , C07D213/74 , C07D213/82 , C07D215/12 , C07D215/36 , C07D233/64 , C07D233/68 , C07D233/84 , C07D235/06 , C07D235/28 , C07D239/26 , C07D239/38 , C07D257/04 , C07D263/22 , C07D263/32 , C07D277/26 , C07D277/36 , C07D277/76 , C07D295/096 , C07D307/10 , C07D307/38 , C07D309/08 , C07D311/56 , C07D333/18 , C07D335/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06
摘要： Provided are novel compounds having an inhibitory activity against production or secretion of β-amyloid protein. They embrace compounds represented by the following formula (1): and capable of being replaced with a variety of substituents; and salts thereof, and solvates of any one of them.
摘要翻译：提供了对β-淀粉样蛋白的产生或分泌具有抑制活性的新化合物。它们包括由下式（1）表示的化合物：并且能够被各种取代基取代; 及其盐，以及它们中任何一种的溶剂合物。

6. 发明申请

US20050234109A1 Beta-amyloid protein production. secretion inhibitor 失效
标题翻译： β-淀粉样蛋白生产。分泌抑制剂
公开(公告)号：US20050234109A1
公开(公告)日：2005-10-20
申请号：US10500156
申请日：2002-12-27
申请人： Takanori Yasukouchi , Masayuki Ito , Hideki Kubota , Satoru Miyauchi , Masanori Saito
发明人： Takanori Yasukouchi , Masayuki Ito , Hideki Kubota , Satoru Miyauchi , Masanori Saito
IPC分类号： C07C311/28 , C07C317/14 , C07C317/18 , C07C317/20 , C07C317/22 , C07C317/44 , C07C323/65 , C07D207/32 , C07D207/325 , C07D211/24 , C07D211/54 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/71 , C07D213/74 , C07D213/82 , C07D215/12 , C07D215/36 , C07D233/54 , C07D233/68 , C07D233/84 , C07D235/06 , C07D235/28 , C07D239/26 , C07D239/38 , C07D257/04 , C07D263/22 , C07D263/32 , C07D277/26 , C07D277/36 , C07D277/76 , C07D295/096 , C07D307/10 , C07D307/38 , C07D309/08 , C07D311/56 , C07D333/18 , C07D335/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , A61K31/44 , A61K31/165 , A61K31/40 , C07C317/32 , C07C323/29
CPC分类号： C07D213/34 , C07D207/325 , C07D211/24 , C07D211/54 , C07D213/61 , C07D213/65 , C07D213/71 , C07D213/74 , C07D213/82 , C07D215/12 , C07D215/36 , C07D233/64 , C07D233/68 , C07D233/84 , C07D235/06 , C07D235/28 , C07D239/26 , C07D239/38 , C07D257/04 , C07D263/22 , C07D263/32 , C07D277/26 , C07D277/36 , C07D277/76 , C07D295/096 , C07D307/10 , C07D307/38 , C07D309/08 , C07D311/56 , C07D333/18 , C07D335/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06
摘要： Provided are novel compounds having an inhibitory activity against production or secretion of β-amyloid protein. They embrace compounds represented by the following formula (1): and capable of being replaced with a variety of substituents; and salts thereof, and solvates of any one of them.
摘要翻译：提供了对β-淀粉样蛋白的产生或分泌具有抑制活性的新化合物。它们包括由下式（1）表示的化合物：并且能够被各种取代基取代; 及其盐，以及它们中任何一种的溶剂合物。

7. 发明授权

US08114886B2 Pyridylmethylsulfone derivative 有权
标题翻译：吡啶基甲基砜衍生物
公开(公告)号：US08114886B2
公开(公告)日：2012-02-14
申请号：US11910500
申请日：2006-04-07
申请人： Satoru Miyauchi , Hideki Kubota , Kayoko Motoki , Masayuki Ito
发明人： Satoru Miyauchi , Hideki Kubota , Kayoko Motoki , Masayuki Ito
IPC分类号： A01N43/40 , A01N43/42 , A61K31/435 , A61K31/44
CPC分类号： C07D213/79 , C07D213/51 , C07D213/61 , C07D213/81 , C07D401/06 , C07D405/12
摘要： The present invention relates to a novel compound having an effect of inhibiting production/secretion of β-amyloid protein. The present invention provides a compound represented by the general formula (1): or a salt thereof, or a solvate of the compound or the salt; and a medicament comprising thereof.
摘要翻译：本发明涉及具有抑制β-淀粉样蛋白生产/分泌作用的新型化合物。本发明提供由通式（1）表示的化合物或其盐或化合物或其盐的溶剂合物; 和包含其的药物。

8. 发明申请

US20090149439A1 PYRIDYLMETHYSULFONE DERIVATIVE 有权
标题翻译：吡啶衍生物衍生物
公开(公告)号：US20090149439A1
公开(公告)日：2009-06-11
申请号：US11910500
申请日：2006-04-07
申请人： Satoru Miyauchi , Hideki Kubota , Kayoko Motoki , Masayuki Ito
发明人： Satoru Miyauchi , Hideki Kubota , Kayoko Motoki , Masayuki Ito
IPC分类号： A61K31/4427 , C07D213/61 , A61K31/44 , C07D213/81 , A61P25/28 , C07D401/12 , A61K31/444 , A61K31/5377 , C07D413/06
CPC分类号： C07D213/79 , C07D213/51 , C07D213/61 , C07D213/81 , C07D401/06 , C07D405/12
摘要： The present invention relates to a novel compound having an effect of inhibiting production/secretion of β-amyloid protein. The present invention provides a compound represented by the general formula (1): or a salt thereof, or a solvate of the compound or the salt; and a medicament comprising thereof.
摘要翻译：本发明涉及具有抑制β-淀粉样蛋白生产/分泌作用的新型化合物。本发明提供由通式（1）表示的化合物或其盐或化合物或其盐的溶剂合物; 和包含其的药物。

9. 发明授权

US06943549B2 Method for processing magnetic resonance imaging image information and magnetic resonance imaging system 失效
标题翻译：磁共振成像图像信息和磁共振成像系统的处理方法
公开(公告)号：US06943549B2
公开(公告)日：2005-09-13
申请号：US10679343
申请日：2003-10-07
申请人： Masahiko Matsuo , Hideo Eda , Satoru Miyauchi
发明人： Masahiko Matsuo , Hideo Eda , Satoru Miyauchi
IPC分类号： G01R33/32 , A61B5/055 , G01R33/54 , G01R33/56 , G06T1/00 , G01V3/00 , G06K9/36
CPC分类号： G01R33/56 , G01R33/5608
摘要： A method for processing magnetic resonance imaging image information is characterized by that a magnetic resonance spectral intensity value is measured at each of a plurality of measuring points that are arranged at predetermined intervals along a lengthwise direction, a crosswise direction and a height direction on an object to be measured and several kinds of magnetic resonance imaging image information as a set of the magnetic resonance spectral intensity values measured at the measuring point are obtained by a plurality of different spectral intensity measuring methods with respect to the object to be measured, a magnetic resonance spectral intensity value at the predetermined position is obtained directly or indirectly from a measured results of the magnetic resonance spectral intensity values that is included in the magnetic resonance imaging image information and the predetermined position is set to be identical for all of the several varieties of magnetic resonance imaging image information with respect to each of the magnetic resonance imaging image information, and new image information at the predetermined position is derived by linear calculation between the spectral intensity values.
摘要翻译：一种用于处理磁共振成像图像信息的方法的特征在于，在沿着物体上的长度方向，横向和高度方向以预定间隔布置的多个测量点中的每一个测量点处测量磁共振光谱强度值通过针对被测量物体的多种不同的光谱强度测定方法得到测定点上测定的磁共振光谱强度值的集合的多种磁共振成像图像信息，磁共振从包含在磁共振成像图像信息中的磁共振光谱强度值的测量结果直接或间接获得预定位置处的光谱强度值，并且将预定位置设置为对于所有几种磁性共振成像图像关于每个磁共振成像图像信息的e信息和在预定位置处的新图像信息通过光谱强度值之间的线性计算导出。

10. 发明授权

US06184388B2 Substituted aminocycloalkylpyrrolidine derivatives and cis-substituted aminocycloalkylpyrrolidine derivatives 失效
标题翻译：取代的氨基环烷基吡咯烷衍生物和顺式取代的氨基环烷基吡咯烷衍生物
公开(公告)号：US06184388B2
公开(公告)日：2001-02-06
申请号：US09397515
申请日：1999-09-17
申请人： Makoto Takemura , Youichi Kimura , Hisashi Takahashi , Kenichi Kimura , Satoru Miyauchi , Hitoshi Ohki , Kazuyuki Sugita , Rie Miyauchi
发明人： Makoto Takemura , Youichi Kimura , Hisashi Takahashi , Kenichi Kimura , Satoru Miyauchi , Hitoshi Ohki , Kazuyuki Sugita , Rie Miyauchi
IPC分类号： C07D20708
CPC分类号： C07D401/04 , C07D207/273 , C07D498/04
摘要： An antimicrobial drug having excellent antimicrobial activity and high safety is disclosed, which comprises as an active ingredient, a quinolone derivative having a substituted aminocycloalkylpyrrolidine as a substituent and which is further substituted with various substituents, represented by formula (I), its salts and hydrates thereof: wherein Q is represented by formula (II) or (IV). Also disclosed is a quinolone derivative where R4 and the substituent on the pyrrolidine ring of the following formula: are located at the cis-configuration; and Q is represented by the formula:
摘要翻译：公开了具有优异的抗微生物活性和高安全性的抗微生物药物，其包含作为活性成分的具有取代的氨基环烷基吡咯烷作为取代基的喹诺酮衍生物，并且还被式（I）表示的各种取代基，其盐和水合物其中Q由式（II）或（IV）表示。还公开了喹诺酮衍生物，其中R4和下式的吡咯烷环上的取代基位于顺式构型; Q由下式表示：

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