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1. 发明申请

US20130165626A1 ANTIFREEZE PROTEIN 审中-公开
标题翻译：抗体蛋白
公开(公告)号：US20130165626A1
公开(公告)日：2013-06-27
申请号：US13643811
申请日：2011-04-28
申请人： Joichi Fukuoka , Hidehisa Kawahara , Hideaki Kegasa , Naoki Arai , Jun Tomono , Shinichi Yokota
发明人： Joichi Fukuoka , Hidehisa Kawahara , Hideaki Kegasa , Naoki Arai , Jun Tomono , Shinichi Yokota
IPC分类号： C07K14/415 , C07K16/16 , A23L3/3472 , A61K8/64 , A61Q19/00 , C07K7/00 , C09K3/18
CPC分类号： A61K8/645 , A23J3/14 , A23V2002/00 , A61K2800/52 , A61Q19/00 , C09K3/185 , A23V2200/206 , A23V2250/548
摘要： An objective of the present invention is to provide an antifreeze protein which is capable of being efficiently produced on an industrial level at low cost and which is safe and has an excellent antifreezing activity for use on a practical level. Also, an objective of the present invention is to provide a polypeptide that corresponds to the active part of the antifreeze protein; a composition, a food, a biological sample protectant and a cosmetic containing the antifreeze protein or the polypeptide; and an antibody that specifically reacts with the antifreeze protein or the polypeptide. The antifreeze protein according to the present invention is characterized in being derived from a plant and having a specific amino acid sequence or being a plant seed protein.
摘要翻译：本发明的目的是提供一种能够在工业上以低成本有效地生产并且在实用水平上安全且具有优异的防冻活性的防冻蛋白。此外，本发明的目的是提供对应于抗冻蛋白的活性部分的多肽; 组合物，食品，生物样品保护剂和含有防冻蛋白或多肽的化妆品; 以及与抗冻蛋白或多肽特异性反应的抗体。根据本发明的抗冻蛋白的特征在于衍生自植物并具有特定氨基酸序列或植物种子蛋白。

2. 发明申请

US20120136138A1 ICE-CRYSTAL GROWTH INHIBITING SUBSTANCE 审中-公开
标题翻译：冰晶生长抑制物质
公开(公告)号：US20120136138A1
公开(公告)日：2012-05-31
申请号：US13377405
申请日：2010-05-27
申请人： Hideaki Kegasa , Naoki Arai , Jun Tomono , Shinichi Yokota , Hidehisa Kawahara
发明人： Hideaki Kegasa , Naoki Arai , Jun Tomono , Shinichi Yokota , Hidehisa Kawahara
IPC分类号： C07K14/415 , C07K1/34
CPC分类号： C07K14/415 , A23L3/3472 , A23L3/3526 , A23L3/36 , A23L33/18 , A61K8/645 , A61Q19/00
摘要： An objective to be achieved by the present invention is to provide an ice-crystal growth inhibiting substance which has an excellent ice-crystal growth inhibiting activity suitable for practical use and which can be produced easily, efficiently and economically in safe steps usable in food production. Another objective of the present invention is to provide a method for producing the ice-crystal growth inhibiting substance, a polypeptide which is an active part of the ice-crystal growth inhibiting substance, as well as an ice-crystal growth inhibiting substance composition, a food, a biological sample protectant and a cosmetic each containing the ice-crystal growth inhibiting substance or the polypeptide. The ice-crystal growth inhibiting substance according to the present invention is characterized in that the ice-crystal growth inhibiting substance is derived from a plant, and has a molecular weight of 400 kDa or more as measured by gel filtration chromatography.
摘要翻译：本发明要达到的目的是提供一种冰晶生长抑制物质，它具有优良的适用于实际应用的冰晶生长抑制活性，可以容易地，高效地和经济地制备用于食品生产的安全步骤。本发明的另一个目的是提供一种冰晶生长抑制物质的制造方法，作为冰晶生长抑制物质的活性成分的多肽，以及冰晶生长抑制物质组合物，食品，生物样品保护剂和含有冰晶生长抑制物质或多肽的化妆品。本发明的冰晶生长抑制物质的特征在于，冰晶生长抑制物质来自植物，通过凝胶过滤色谱法测定分子量为400kDa以上。

3. 发明申请

US20140213663A1 ICE CRYSTALLIZATION INHIBITOR DERIVED FROM PLANT SEED 审中-公开
标题翻译：来自植物种子的ICE结晶抑制剂
公开(公告)号：US20140213663A1
公开(公告)日：2014-07-31
申请号：US14002849
申请日：2012-03-02
申请人： Hidehisa Kawahara , Hideaki Kegasa , Naoki Arai
发明人： Hidehisa Kawahara , Hideaki Kegasa , Naoki Arai
IPC分类号： C09K5/20 , E01C21/00 , A23L3/37
CPC分类号： C09K5/20 , A23L3/37 , E01C21/00 , G02B3/0031 , G02B13/0095 , G02B13/14 , G02B26/0875 , H01L27/14621 , H01L27/14625 , H04N5/2254 , H04N5/349
摘要： The objective to be solved by the present invention is to provide a novel ice crystallization inhibitor which is industrially useful, which can be efficiently and stably produced in a safe process suitable for a food production without difficulty and which has excellent functions and properties. Also, the objective of the present invention is to provide an antibody which specifically reacts with the ice crystallization inhibitor, and a composition, a food, a biological sample protectant and a cosmetic which contain the ice crystallization inhibitor. Furthermore, the objective of the present invention is to provide a peptide which gives an indication of a protein having an ice crystallization inhibitory activity. The ice crystallization inhibitor according to the present invention is characterized in comprising a seed protein derived from a plant belonging to genus Vigna in Leguminosae, an allied species thereof or an improved species thereof. The ice crystallization inhibitor according to the present invention is characterized in comprising a seed protein derived from a plant belonging to genus Vigna in Leguminosae, an allied species thereof or an improved species thereof.
摘要翻译：本发明要解决的目的是提供一种工业上有用的新型冰结晶抑制剂，其可以在难以适应食品生产的安全工艺中有效且稳定地生产，并具有优异的功能和性能。此外，本发明的目的是提供与冰结晶抑制剂特异性反应的抗体，以及含有冰结晶抑制剂的组合物，食品，生物样品保护剂和化妆品。此外，本发明的目的是提供给出具有冰结晶抑制活性的蛋白质的指示的肽。根据本发明的冰结晶抑制剂的特征在于包含衍生自豆科中属于维根属的植物的种子蛋白，其联合物种或其改良物种。根据本发明的冰结晶抑制剂的特征在于包含衍生自豆科中属于维根属的植物的种子蛋白，其联合物种或其改良物种。

4. 发明授权

US08734672B2 Ice crystallization inhibitor derived from basidiomycete 有权
标题翻译：来自担子菌的冰结晶抑制剂
公开(公告)号：US08734672B2
公开(公告)日：2014-05-27
申请号：US13818637
申请日：2011-08-11
申请人： Hidehisa Kawahara , Yoshihide Koide , Naoki Arai , Jun Tomono
发明人： Hidehisa Kawahara , Yoshihide Koide , Naoki Arai , Jun Tomono
IPC分类号： C09K3/18 , C08K3/00 , A23L1/03 , A23L1/30 , A01N1/02 , A61K8/73 , A61K8/99
CPC分类号： C09K5/20 , A01N1/0221 , A23L3/3463 , A23L3/3472 , A23L5/00 , A23L15/20 , A23L15/30 , A23L17/00 , A23L31/00 , A61K8/73 , A61Q19/00 , C07K14/415 , C07K16/44
摘要： The objective to be solved by the present invention is to provide an ice-crystallization inhibitor which has a practicable and excellent ice-crystallization inhibiting property and which can be efficiently and stably produced in a safe process suitable for food production. Also, the objective of the present invention is to provide an antibody which specifically reacts with the ice-crystallization inhibitor, and a composition, a food, a biological sample protectant and a cosmetic which contain the ice-crystallization inhibitor. Furthermore, the objective of the present invention is to provide a polysaccharide which is derived from a basidiomycete and which is used for inhibiting ice-crystallization of a liquid containing water, and a method for inhibiting ice-crystallization of a liquid containing water. The ice-crystallization inhibitor according to the present invention is characterized in being a polysaccharide derived from a basidiomycete.
摘要翻译：本发明要解决的目的是提供一种冰结晶抑制剂，其具有可行且优异的结晶结晶抑制性能，并且可以在适于食品生产的安全工艺中有效且稳定地生产。此外，本发明的目的是提供与冰结晶抑制剂特异性反应的抗体，以及含有冰结晶抑制剂的组合物，食品，生物样品保护剂和化妆品。此外，本发明的目的是提供一种源自担子菌的多糖，其用于抑制含水液体的冰结晶，以及抑制含有水的液体的冰结晶的方法。根据本发明的结冰抑制剂的特征在于来自担子菌的多糖。

5. 发明申请

US20130146803A1 ICE CRYSTALLIZATION INHIBITOR DERIVED FROM BASIDIOMYCETE 有权
标题翻译： ICE结晶抑制剂衍生自BASIDIOMYCETE
公开(公告)号：US20130146803A1
公开(公告)日：2013-06-13
申请号：US13818637
申请日：2011-08-11
申请人： Hidehisa Kawahara , Yoshihide Koide , Naoki Arai , Jun Tomono
发明人： Hidehisa Kawahara , Yoshihide Koide , Naoki Arai , Jun Tomono
IPC分类号： C09K5/20
CPC分类号： C09K5/20 , A01N1/0221 , A23L3/3463 , A23L3/3472 , A23L5/00 , A23L15/20 , A23L15/30 , A23L17/00 , A23L31/00 , A61K8/73 , A61Q19/00 , C07K14/415 , C07K16/44
摘要： The objective to be solved by the present invention is to provide an ice-crystallization inhibitor which has a practicable and excellent ice-crystallization inhibiting property and which can be efficiently and stably produced in a safe process suitable for food production. Also, the objective of the present invention is to provide an antibody which specifically reacts with the ice-crystallization inhibitor, and a composition, a food, a biological sample protectant and a cosmetic which contain the ice-crystallization inhibitor. Furthermore, the objective of the present invention is to provide a polysaccharide which is derived from a basidiomycete and which is used for inhibiting ice-crystallization of a liquid containing water, and a method for inhibiting ice-crystallization of a liquid containing water. The ice-crystallization inhibitor according to the present invention is characterized in being a polysaccharide derived from a basidiomycete.
摘要翻译：本发明要解决的目的是提供一种冰结晶抑制剂，其具有可行且优异的结晶结晶抑制性能，并且可以在适于食品生产的安全工艺中有效且稳定地生产。此外，本发明的目的是提供与冰结晶抑制剂特异性反应的抗体，以及含有冰结晶抑制剂的组合物，食品，生物样品保护剂和化妆品。此外，本发明的目的是提供一种源自担子菌的多糖，其用于抑制含水液体的冰结晶，以及抑制含有水的液体的冰结晶的方法。根据本发明的结冰抑制剂的特征在于来自担子菌的多糖。

6. 发明申请

US20090035417A1 Emulsifying Agent 有权
标题翻译：乳化剂
公开(公告)号：US20090035417A1
公开(公告)日：2009-02-05
申请号：US12087586
申请日：2007-01-18
申请人： Hidehisa Kawahara , Jun Tomono , Hiroaki Inoue , Hitoshi Obata
发明人： Hidehisa Kawahara , Jun Tomono , Hiroaki Inoue , Hitoshi Obata
IPC分类号： A23L1/035 , A23L1/28
CPC分类号： B01F17/005 , A23L29/10 , A61K8/06 , A61K8/99 , A61Q19/00 , B01F17/0021
摘要： The present invention has its object to provide a novel emulsifier which is obtainable from an edible yeast and is highly safe and shows by itself a high level of emulsifying property and high emulsion stability; a water-soluble composition containing a liposoluble substance, together with the emulsifier; and methods of producing these. The present invention includes: an emulsifier which comprises, as an active ingredient, a carbohydrate- and protein-based complex derived from a culture fluid obtained by cultivating an edible yeast; a water-soluble composition which comprises an emulsifier and a liposoluble substance; and a method of producing the emulsifier and the water-soluble composition.
摘要翻译：本发明的目的是提供一种可食用酵母获得的新型乳化剂，其安全性高，本身具有高水平的乳化性和高乳化稳定性; 与乳化剂一起含有脂溶性物质的水溶性组合物; 以及生产这些的方法。本发明包括：乳化剂，其包含作为活性成分的来自通过培养可食用酵母获得的培养液的碳水化合物和蛋白质的复合物; 包含乳化剂和脂溶性物质的水溶性组合物; 以及乳化剂和水溶性组合物的制造方法。

7. 发明申请

US20080317704A1 Control of ice-crystal growth by non-proteinaceous substance 审中-公开
标题翻译：通过非蛋白质物质控制冰晶生长
公开(公告)号：US20080317704A1
公开(公告)日：2008-12-25
申请号：US12222863
申请日：2008-08-18
申请人： Hitoshi Obata , Hidehisa Kawahara , Takashi Tomita
发明人： Hitoshi Obata , Hidehisa Kawahara , Takashi Tomita
IPC分类号： C08G73/10 , C12H1/00 , A01N1/02 , A61K31/785 , A01N1/00
CPC分类号： C09K3/18 , C09K5/20
摘要： The present invention makes it possible to attain various applications using antifreeze activity without an antifreeze protein. The agent for the inhibition of ice-crystal growth includes a non-proteinaceous substance, wherein an aqueous solution of the non-proteinaceous substance in a concentration of 10 mg/ml causes the deposition of non-flat disk-shaped ice crystals. The agent for the lowering of an ice-crystal growth initiation temperature includes a non-proteinaceous substance, wherein an aqueous solution of the non-proteinaceous substance in a concentration of 10 mg/ml shows thermal hysteresis by a temperature of 0.020° C. or higher. The agent for the control of water freezing includes a non-proteinaceous substance, wherein an aqueous solution of the non-proteinaceous substance in a concentration of 10 mg/ml shows thermal hysteresis by a temperature of 0.020° C. or higher and causes the deposition of non-flat disk-shaped ice crystals. The above non-proteinaceous substances are usually polymers each having a carbon chain as the main chain.
摘要翻译：本发明可以在没有防冻蛋白的情况下获得使用防冻活性的各种应用。用于抑制冰晶生长的试剂包括非蛋白质物质，其中浓度为10mg / ml的非蛋白质物质的水溶液导致非平坦盘状冰晶的沉积。用于降低冰晶生长开始温度的试剂包括非蛋白质物质，其中浓度为10mg / ml的非蛋白质物质的水溶液显示温度为0.020℃的热滞后，或更高。用于控制水冷冻的试剂包括非蛋白质物质，其中浓度为10mg / ml的非蛋白质物质的水溶液在0.020℃或更高的温度下显示出热滞后，并导致沉积的非平板状冰晶体。上述非蛋白质物质通常是以碳链为主链的聚合物。

8. 发明授权

US08168618B2 Emulsifying agent 有权
标题翻译：乳化剂
公开(公告)号：US08168618B2
公开(公告)日：2012-05-01
申请号：US12087586
申请日：2007-01-18
申请人： Hidehisa Kawahara , Jun Tomono , Hiroaki Inoue , Hitoshi Obata
发明人： Hidehisa Kawahara , Jun Tomono , Hiroaki Inoue , Hitoshi Obata
IPC分类号： A01N45/00 , A61K31/59
CPC分类号： B01F17/005 , A23L29/10 , A61K8/06 , A61K8/99 , A61Q19/00 , B01F17/0021
摘要： The present invention has its object to provide a novel emulsifier which is obtainable from an edible yeast and is highly safe and shows by itself a high level of emulsifying property and high emulsion stability; a water-soluble composition containing a liposoluble substance, together with the emulsifier; and methods of producing these. The present invention includes: an emulsifier which comprises, as an active ingredient, a carbohydrate- and protein-based complex derived from a culture fluid obtained by cultivating an edible yeast; a water-soluble composition which comprises an emulsifier and a liposoluble substance; and a method of producing the emulsifier and the water-soluble composition.
摘要翻译：本发明的目的是提供一种可食用酵母获得的新型乳化剂，其安全性高，本身具有高水平的乳化性和高乳化稳定性; 与乳化剂一起含有脂溶性物质的水溶性组合物; 以及生产这些的方法。本发明包括：乳化剂，其包含作为活性成分的来自通过培养可食用酵母获得的培养液的碳水化合物和蛋白质的复合物; 包含乳化剂和脂溶性物质的水溶性组合物; 以及乳化剂和水溶性组合物的制造方法。

9. 发明申请

US20070062437A1 Control of ice-crystal growth by non-proteinaceous substance 审中-公开
标题翻译：通过非蛋白质物质控制冰晶生长
公开(公告)号：US20070062437A1
公开(公告)日：2007-03-22
申请号：US10576293
申请日：2004-10-21
申请人： Hitoshi Obata , Hidehisa Kawahara , Takashi Tomita
发明人： Hitoshi Obata , Hidehisa Kawahara , Takashi Tomita
IPC分类号： H01L21/322
CPC分类号： C09K3/18 , C09K5/20
摘要： The present invention makes it possible to attain various applications using antifreeze activity without an antifreeze protein. The agent for the inhibition of ice-crystal growth includes a non-proteinaceous substance, wherein an aqueous solution of the non-proteinaceous substance in a concentration of 10 mg/ml causes the deposition of non-flat disk-shaped ice crystals. The agent for the lowering of an ice-crystal growth initiation temperature includes a non-proteinaceous substance, wherein an aqueous solution of the non-proteinaceous substance in a concentration of 10 mg/ml shows thermal hysteresis by a temperature of 0.020° C. or higher. The agent for the control of water freezing includes a non-proteinaceous substance, wherein an aqueous solution of the non-proteinaceous substance in a concentration of 10 mg/ml shows thermal hysteresis by a temperature of 0.020° C. or higher and causes the deposition of non-flat disk-shaped ice crystals. The above non-proteinaceous substances are usually polymers each having a carbon chain as the main chain.
摘要翻译：本发明可以在没有防冻蛋白的情况下获得使用防冻活性的各种应用。用于抑制冰晶生长的试剂包括非蛋白质物质，其中浓度为10mg / ml的非蛋白质物质的水溶液导致非平坦盘状冰晶的沉积。用于降低冰晶生长开始温度的试剂包括非蛋白质物质，其中浓度为10mg / ml的非蛋白质物质的水溶液显示温度为0.020℃的热滞后，或更高。用于控制水冷冻的试剂包括非蛋白质物质，其中浓度为10mg / ml的非蛋白质物质的水溶液在0.020℃或更高的温度下显示出热滞后，并导致沉积的非平板状冰晶体。上述非蛋白质物质通常是以碳链为主链的聚合物。

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