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1. 发明申请

US20080287428A1 Novel Heterocyclidene Acetamide Derivative 有权
标题翻译：新型杂环亚乙基乙酰胺衍生物
公开(公告)号：US20080287428A1
公开(公告)日：2008-11-20
申请号：US11988659
申请日：2006-07-24
申请人： Hideharu Uchida , Naoto Kosuga , Tsutomu Satoh , Daido Hotta , Tomoyuki Kamino , Yoshitaka Maeda , Ken-ichi Amano , Yasushige Akada
发明人： Hideharu Uchida , Naoto Kosuga , Tsutomu Satoh , Daido Hotta , Tomoyuki Kamino , Yoshitaka Maeda , Ken-ichi Amano , Yasushige Akada
IPC分类号： A61K31/5383 , C07D405/02 , A61K31/4709 , C07D313/08 , A61K31/335 , C07D498/04
CPC分类号： C07D405/12 , C07D215/14 , C07D215/38 , C07D313/08 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： A compound represented by formula (I′): (wherein m, n, and p each represent 0 to 2; q represents 0 or 1; R1 represents halogen, a hydrocarbon group, a heterocyclic group, an alkoxy group, an alkoxycarbonyl group, a sulfamoyl group, a CN group, an NO2 group, or the like; R2 represents halogen, amino, a hydrocarbon group, an aromatic heterocyclic group, or an oxo group; X1 represents O, —NR3—, or —S(O)r-; X2 represents a methylene group, O, —NR3—, or —S(O)r-; Q′ represents a heteroaryl group, a heteroarylalkyl group, a substituted aryl group, or an aralkyl group; Cycle moiety represents an aryl ring or a heteroaryl ring; and the wavy line represents an E-isomer or a Z-isomer), a salt of the compound, or a solvate of the compound or the salt. A pharmaceutical composition and a transient receptor potential type I (TRPV1) receptor antagonist each contain, as an active ingredient, at least one of the compound, a salt of the compound, and a solvate of the compound or the salt.
摘要翻译：由式（I'）表示的化合物：其中m，n和p各自表示0〜2; q表示0或1; R 1表示卤素，烃基，杂环基，烷氧基，烷氧基羰基，氨磺酰基，CN基，NO 2 2基等; R 2表示卤素，氨基，烃基，芳族杂环基或氧代基; X 1表示O，-NR 3 - 或-S（O）r - ; X 2， SUB>表示亚甲基，O，-NR 3 - 或-S（O）r - ; Q'表示杂芳基，杂芳基烷基，取代的芳基或芳烷基 ;环状部分表示芳基环或杂芳基环;波浪线表示E-异构体或Z-异构体），化合物的盐或化合物或其盐的溶剂合物。药物组合物和瞬时受体电位型I（TRPV1）受体拮抗剂各自含有化合物，化合物的盐和化合物或其盐的溶剂合物中的至少一种作为活性成分。

2. 发明申请

US20110112071A1 NOVEL HETEROCYCLIDENE ACETAMIDE DERIVATIVE 失效
标题翻译：新型异喹喔啉乙酰胺衍生物
公开(公告)号：US20110112071A1
公开(公告)日：2011-05-12
申请号：US13008456
申请日：2011-01-18
申请人： Hideharu UCHIDA , Naoto Kosuga , Tsutomu Satoh , Daido Hotta , Tomoyuki Kamino , Yoshitaka Maeda , Ken-ichi Amano , Yasushige Akada
发明人： Hideharu UCHIDA , Naoto Kosuga , Tsutomu Satoh , Daido Hotta , Tomoyuki Kamino , Yoshitaka Maeda , Ken-ichi Amano , Yasushige Akada
IPC分类号： A61K31/55 , C07D407/12 , A61K31/357 , A61P19/02 , A61P11/06 , A61P13/06 , A61P25/06 , A61P17/06 , A61P3/04 , C07D311/76 , C07D313/08 , C07D405/12 , A61K31/4725 , A61K31/4709 , C07D417/12 , A61K31/428 , C07D413/14 , A61K31/5377 , A61K31/44 , A61K31/335 , C07D401/12
CPC分类号： C07D405/12 , C07D215/14 , C07D215/38 , C07D313/08 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： A compound represented by formula (I′): (wherein m, n, and p each represent 0 to 2; q represents 0 or 1; R1 represents halogen, a hydrocarbon group, a heterocyclic group, an alkoxy group, an alkoxycarbonyl group, a sulfamoyl group, a CN group, an NO2 group, or the like; R2 represents halogen, amino, a hydrocarbon group, an aromatic heterocyclic group, or an oxo group; X1 represents O, —NR3—, or —S(O)r-; X2 represents a methylene group, O, —NR3—, or —S(O)r-; Q′ represents a heteroaryl group, a heteroarylalkyl group, a substituted aryl group, or an aralkyl group; Cycle moiety represents an aryl ring or a heteroaryl ring; and the wavy line represents an E-isomer or a Z-isomer), a salt of the compound, or a solvate of the compound or the salt. A pharmaceutical composition and a transient receptor potential type I (TRPV1) receptor antagonist each contain, as an active ingredient, at least one of the compound, a salt of the compound, and a solvate of the compound or the salt.
摘要翻译：由式（I'）表示的化合物：其中m，n和p各自表示0〜2; q表示0或1; R1表示卤素，烃基，杂环基，烷氧基，烷氧基羰基，氨磺酰基，CN基，NO 2基等; R 2表示卤素，氨基，烃基，芳香族杂环基或氧代基; X 1表示O，-NR 3 - 或-S（O） R 2; X 2表示亚甲基，O，-NR 3 - 或-S（O）r - ; Q'表示杂芳基，杂芳基烷基，取代的芳基或芳烷基; 环或杂芳环;波浪线表示E-异构体或Z-异构体），化合物的盐或化合物或其盐的溶剂合物。药物组合物和瞬时受体电位型I（TRPV1）受体拮抗剂各自含有化合物，化合物的盐和化合物或其盐的溶剂合物中的至少一种作为活性成分。

3. 发明授权

US07910751B2 Heterocyclidene acetamide derivative 有权
标题翻译：杂环亚乙酰胺衍生物
公开(公告)号：US07910751B2
公开(公告)日：2011-03-22
申请号：US11988659
申请日：2006-07-24
申请人： Hideharu Uchida , Naoto Kosuga , Tsutomu Satoh , Daido Hotta , Tomoyuki Kamino , Yoshitaka Maeda , Ken-ichi Amano , Yasushige Akada
发明人： Hideharu Uchida , Naoto Kosuga , Tsutomu Satoh , Daido Hotta , Tomoyuki Kamino , Yoshitaka Maeda , Ken-ichi Amano , Yasushige Akada
IPC分类号： C07D313/00 , C07D309/00
CPC分类号： C07D405/12 , C07D215/14 , C07D215/38 , C07D313/08 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： A compound represented by formula (I′): (wherein m, n, and p each represent 0 to 2; q represents 0 or 1; R1 represents halogen, a hydrocarbon group, a heterocyclic group, an alkoxy group, an alkoxycarbonyl group, a sulfamoyl group, a CN group, an NO2 group, or the like; R2 represents halogen, amino, a hydrocarbon group, an aromatic heterocyclic group, or an oxo group; X1 represents O, —NR3—, or —S(O)r-; X2 represents a methylene group, O, —NR3—, or —S(O)r-; Q′ represents a heteroaryl group, a heteroarylalkyl group, a substituted aryl group, or an aralkyl group; Cycle moiety represents an aryl ring or a heteroaryl ring; and the wavy line represents an E-isomer or a Z-isomer), a salt of the compound, or a solvate of the compound or the salt. A pharmaceutical composition and a transient receptor potential type I (TRPV1) receptor antagonist each contain, as an active ingredient, at least one of the compound, a salt of the compound, and a solvate of the compound or the salt.
摘要翻译：由式（I'）表示的化合物：其中m，n和p各自表示0〜2; q表示0或1; R1表示卤素，烃基，杂环基，烷氧基，烷氧基羰基，氨磺酰基，CN基，NO 2基等; R 2表示卤素，氨基，烃基，芳香族杂环基或氧代基; X 1表示O，-NR 3 - 或-S（O） R 2; X 2表示亚甲基，O，-NR 3 - 或-S（O）r - ; Q'表示杂芳基，杂芳基烷基，取代的芳基或芳烷基; 环或杂芳环;波浪线表示E-异构体或Z-异构体），化合物的盐或化合物或其盐的溶剂合物。药物组合物和瞬时受体电位型I（TRPV1）受体拮抗剂各自含有化合物，化合物的盐和化合物或其盐的溶剂合物中的至少一种作为活性成分。

4. 发明授权

US08383839B2 Heterocyclidene acetamide derivative 失效
标题翻译：杂环亚乙酰胺衍生物
公开(公告)号：US08383839B2
公开(公告)日：2013-02-26
申请号：US13008456
申请日：2011-01-18
申请人： Hideharu Uchida , Naoto Kosuga , Tsutomu Satoh , Daido Hotta , Tomoyuki Kamino , Yoshitaka Maeda , Ken-ichi Amano , Yasushige Akada
发明人： Hideharu Uchida , Naoto Kosuga , Tsutomu Satoh , Daido Hotta , Tomoyuki Kamino , Yoshitaka Maeda , Ken-ichi Amano , Yasushige Akada
IPC分类号： C07D313/00 , C07D309/00
CPC分类号： C07D405/12 , C07D215/14 , C07D215/38 , C07D313/08 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： A compound represented by formula (I′): (wherein m, n, and p each represent 0 to 2; q represents 0 or 1; R1 represents halogen, a hydrocarbon group, a heterocyclic group, an alkoxy group, an alkoxycarbonyl group, a sulfamoyl group, a CN group, an NO2 group, or the like; R2 represents halogen, amino, a hydrocarbon group, an aromatic heterocyclic group, or an oxo group; X1 represents O, —NR3—, or —S(O)r-; X2 represents a methylene group, O, —NR3—, or —S(O)r-; Q′ represents a heteroaryl group, a heteroarylalkyl group, a substituted aryl group, or an aralkyl group; Cycle moiety represents an aryl ring or a heteroaryl ring; and the wavy line represents an E-isomer or a Z-isomer), a salt of the compound, or a solvate of the compound or the salt. A pharmaceutical composition and a transient receptor potential type I (TRPV1) receptor antagonist each contain, as an active ingredient, at least one of the compound, a salt of the compound, and a solvate of the compound or the salt.
摘要翻译：由式（I'）表示的化合物：其中m，n和p各自表示0〜2; q表示0或1; R1表示卤素，烃基，杂环基，烷氧基，烷氧基羰基，氨磺酰基，CN基，NO 2基等; R 2表示卤素，氨基，烃基，芳香族杂环基或氧代基; X 1表示O，-NR 3 - 或-S（O） R 2; X 2表示亚甲基，O，-NR 3 - 或-S（O）r - ; Q'表示杂芳基，杂芳基烷基，取代的芳基或芳烷基; 环或杂芳环;波浪线表示E-异构体或Z-异构体），化合物的盐或化合物或其盐的溶剂合物。药物组合物和瞬时受体电位型I（TRPV1）受体拮抗剂各自含有化合物，化合物的盐和化合物或其盐的溶剂合物中的至少一种作为活性成分。

5. 发明申请

US20130029978A1 NOVEL ARYL UREA DERIVATIVE 审中-公开
标题翻译：新ARYL UREA DERIVATIVE
公开(公告)号：US20130029978A1
公开(公告)日：2013-01-31
申请号：US13261340
申请日：2010-12-24
申请人： Tomoyuki Kamino , Yoshitaka Maeda
发明人： Tomoyuki Kamino , Yoshitaka Maeda
IPC分类号： C07D405/14 , C07D405/04 , C07D417/14 , C07D401/14 , C07D413/14 , A61P29/00 , A61K31/501 , A61K31/496 , A61K31/538 , A61K31/506 , A61K31/497 , C07D413/04 , A61K31/454
CPC分类号： C07D311/68 , C07D401/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D417/12
摘要： There is a need for FAAH inhibitors capable of oral administration and having excellent efficacy, particularly agents for the prevention and treatment of pain. Disclosed are novel arylurea compounds represented by formula (I), salts or solvates thereof, and pharmaceutical compositions comprising the same as an active ingredient. The pharmaceutical composition is used primarily for FAAH inhibitors, or agents for prevention and treatment of pain.
摘要翻译：需要能够口服给药并具有优异疗效的FAAH抑制剂，特别是用于预防和治疗疼痛的药剂。公开了由式（I）表示的新型芳基脲化合物，其盐或溶剂合物，以及包含其作为活性成分的药物组合物。该药物组合物主要用于FAAH抑制剂或用于预防和治疗疼痛的药剂。

6. 发明授权

US07843717B2 Semiconductor storage device 有权
标题翻译：半导体存储设备
公开(公告)号：US07843717B2
公开(公告)日：2010-11-30
申请号：US12292380
申请日：2008-11-18
申请人： Tomoyuki Kamino , Toru Ishikawa , Hiroshi Ichikawa
发明人： Tomoyuki Kamino , Toru Ishikawa , Hiroshi Ichikawa
IPC分类号： G11C5/06
CPC分类号： G11C11/4097 , G11C5/063 , G11C11/4076 , G11C11/4096
摘要： A semiconductor storage device includes a memory array compartmentalized into first and second regions alternately arranged. The second regions are formed by odd and even columns alternately arranged. The semiconductor storage device includes: a memory mat array arranged in each first region; a sense amp array arranged in each second region; local IO lines arranged in each second region and connected to the sense amp array; main IO lines crossing the first and second regions; and a read/write amplifier arranged in each second region and at an intersection region where the local IO lines cross the main IO lines. The read/write amplifier in an odd column is connected to a local IO line therein and to a local IO line in the next odd column. The read/write amplifier in an even column is connected to a local IO line therein and to a local IO line in the next even column.
摘要翻译：半导体存储装置包括分隔成交替布置的第一和第二区域的存储器阵列。第二区域由奇数和偶数列交替布置形成。半导体存储装置包括：布置在每个第一区域中的存储器阵列阵列; 布置在每个第二区域中的感测放大器阵列; 局部IO线布置在每个第二区域中并连接到感测放大器阵列; 跨越第一和第二区域的主IO线; 以及布置在每个第二区域和本地IO线与主IO线交叉的交叉区域的读/写放大器。奇数列中的读/写放大器连接到其中的本地IO线，并连接到下一个奇数列中的本地IO线。偶数列中的读/写放大器连接到其中的本地IO线，并连接到下一偶数列中的本地IO线。

7. 发明申请

US20090129137A1 Semiconductor storage device 有权
标题翻译：半导体存储设备
公开(公告)号：US20090129137A1
公开(公告)日：2009-05-21
申请号：US12292380
申请日：2008-11-18
申请人： Tomoyuki Kamino , Toru Ishikawa , Hiroshi Ichikawa
发明人： Tomoyuki Kamino , Toru Ishikawa , Hiroshi Ichikawa
IPC分类号： G11C5/06 , G11C7/06
CPC分类号： G11C11/4097 , G11C5/063 , G11C11/4076 , G11C11/4096
摘要： A semiconductor storage device includes a memory array compartmentalized into first and second regions alternately arranged. The second regions are formed by odd and even columns alternately arranged. The semiconductor storage device includes: a memory mat array arranged in each first region; a sense amp array arranged in each second region; local IO lines arranged in each second region and connected to the sense amp array; main IO lines crossing the first and second regions; and a read/write amplifier arranged in each second region and at an intersection region where the local IO lines cross the main IO lines. The read/write amplifier in an odd column is connected to a local IO line therein and to a local IO line in the next odd column. The read/write amplifier in an even column is connected to a local 10 line therein and to a local IO line in the next even column.
摘要翻译：半导体存储装置包括分隔成交替布置的第一和第二区域的存储器阵列。第二区域由奇数和偶数列交替布置形成。半导体存储装置包括：布置在每个第一区域中的存储器阵列阵列; 布置在每个第二区域中的感测放大器阵列; 局部IO线布置在每个第二区域中并连接到感测放大器阵列; 跨越第一和第二区域的主IO线; 以及布置在每个第二区域和本地IO线与主IO线交叉的交叉区域的读/写放大器。奇数列中的读/写放大器连接到其中的本地IO线，并连接到下一个奇数列中的本地IO线。偶数列中的读/写放大器连接到其中的本地10线，并连接到下一偶数列中的本地IO线。

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