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1. 发明申请

US20060042361A1 Measuring instrument provided with solid composnent concentrating means 有权
标题翻译：测量仪器配有固体成分浓缩装置
公开(公告)号：US20060042361A1
公开(公告)日：2006-03-02
申请号：US10533602
申请日：2003-10-30
申请人： Hideaki Yamaoka , Koji Katsuki
发明人： Hideaki Yamaoka , Koji Katsuki
IPC分类号： G01N1/40
CPC分类号： C12Q1/006 , C12Q1/001 , C12Q1/005 , G01N27/3272
摘要： The present invention relates to a measuring instrument (1) comprising a channel (60) for moving a sample liquid (BL) containing a solid component (B1) and providing a liquid reaction field and first and second electrodes (31, 32) which are used to apply voltage to the liquid reaction field. The first electrode (31) has an electron transfer interface (31a) for transferring electrons between it and the liquid reaction field when voltage is applied to the liquid reaction field via the first and second electrodes (31, 32). The measuring instrument (1) comprises concentrating means (51) for increasing the concentration of solid components at portions thereof which contact the electron transfer interface (31a) in the liquid reaction field. The concentrating means (51) preferably comprises a water-absorbing layer containing an absorbent polymer material.
摘要翻译：本发明涉及一种测量仪器（1），其包括用于移动含有固体组分（B 1）并提供液体反应场的样品液体（BL）的通道（60）和第一和第二电极（31,32），所述第一和第二电极用于向液体反应场施加电压。当电压通过第一和第二电极（31,32）施加到液体反应场时，第一电极（31）具有用于在其与液体反应场之间转移电子的电子转移界面（31a）。测量仪器（1）包括浓缩装置（51），用于增加在液体反应场中接触电子传递界面（31a）的部分处的固体组分的浓度。浓缩装置（51）优选包括含有吸收性聚合物材料的吸水层。

2. 发明授权

US07201042B2 Measuring instrument provided with solid component concentrating means 有权
标题翻译：带有固体成分浓缩装置的测量仪器
公开(公告)号：US07201042B2
公开(公告)日：2007-04-10
申请号：US10533602
申请日：2003-10-30
申请人： Hideaki Yamaoka , Koji Katsuki
发明人： Hideaki Yamaoka , Koji Katsuki
IPC分类号： G01N15/06 , G01N1/00
CPC分类号： C12Q1/006 , C12Q1/001 , C12Q1/005 , G01N27/3272
摘要： The present invention relates to a measuring instrument (1) comprising a channel (60) for moving a sample liquid (BL) containing a solid component (B1) and providing a liquid reaction field and first and second electrodes (31, 32) which are used to apply voltage to the liquid reaction field. The first electrode (31) has an electron transfer interface (31a) for transferring electrons between it and the liquid reaction field when voltage is applied to the liquid reaction field via the first and second electrodes (31, 32). The measuring instrument (1) comprises concentrating means (51) for increasing the concentration of solid components at portions thereof which contact the electron transfer interface (31a) in the liquid reaction field. The concentrating means (51) preferably comprises a water-absorbing layer containing an absorbent polymer material.
摘要翻译：本发明涉及一种测量仪器（1），包括用于移动含有固体组分（B 1）并提供液体反应场的样品液体（BL）的通道（60）和第一和第二电极（31,32），所述第一和第二电极用于向液体反应场施加电压。当电压通过第一和第二电极（31,32）施加到液体反应场时，第一电极（31）具有用于在其和液体反应场之间转移电子的电子转移界面（31a）。测量仪器（1）包括浓缩装置（51），用于增加在液体反应场中接触电子传递界面（31a）的部分处的固体组分的浓度。浓缩装置（51）优选包括含有吸收性聚合物材料的吸水层。

3. 发明申请

US20090101499A1 Protein-Immobilized membrane, method for immobilization of protein, enzyme-immobilized electrode, and biosensor 审中-公开
标题翻译：蛋白质固定化膜，固定蛋白质的方法，固定酶的电极和生物传感器
公开(公告)号：US20090101499A1
公开(公告)日：2009-04-23
申请号：US11920782
申请日：2006-05-18
申请人： Koji Katsuki , Hideaki Yamaoka
发明人： Koji Katsuki , Hideaki Yamaoka
IPC分类号： G01N27/26 , C12N11/16
CPC分类号： G01N27/3272 , C07K14/705 , C07K14/80 , C12N9/0006 , C12N11/06 , C12N11/08 , C12Q1/006 , G01N2333/80
摘要： The present invention relates to a protein-immobilized membrane (14) including a cell membrane homologous layer (14A) and a protein (14B) immobilized to the cell membrane homologous layer (14A), where the protein contains cytochrome or a cytochrome complex. The present invention also relates to a method for forming a protein-immobilized membrane (14), and an enzyme-immobilized electrode and a biosensor (X1) provided with a protein-immobilized membrane (14). Preferably, the cell membrane homologous layer (14A) may contain a phospholipid polymer, and the protein (14B) may be CyGDH including an α subunit having a glucose dehydrogenase activity and cytochrome C having a function of electron transfer.
摘要翻译：本发明涉及固定在细胞膜同源层（14A）上的细胞膜同源层（14A）和蛋白质（14B）的蛋白质固定化膜（14），其中蛋白质含有细胞色素或细胞色素复合物。本发明还涉及一种形成固定蛋白质的膜（14）的方法，以及具有固定蛋白质的膜（14）的酶固定化电极和生物传感器（X1）。优选地，细胞膜同源层（14A）可以含有磷脂聚合物，并且蛋白质（14B）可以是包含具有葡萄糖脱氢酶活性的α亚基和具有电子转移功能的细胞色素C的CyGDH。

4. 发明授权

US09795327B2 Measuring apparatus and measurement method 有权
公开(公告)号：US09795327B2
公开(公告)日：2017-10-24
申请号：US13377994
申请日：2010-09-13
申请人： Tomohiro Shoshihara , Yasunori Shiraki , Koji Katsuki
发明人： Tomohiro Shoshihara , Yasunori Shiraki , Koji Katsuki
IPC分类号： A61B5/05 , A61B5/145 , A61B5/1486 , A61B5/00
CPC分类号： A61B5/14532 , A61B5/0015 , A61B5/14865 , A61B5/6805
摘要： Disclosed is a measuring device for obtaining numerical information concerning a substance present in the interstitial subcutaneous fluid, the device being equipped with a sensor unit that outputs signals in accordance with the numerical information concerning the substance and an arithmetic unit (control unit) that receives the signals outputted from the sensor unit and arithmetically processes the signals. The sensor unit is equipped with a sensor, some of which is punctured into the skin. The arithmetic unit (control unit) has been disposed so as to be separate from the sensor unit.

5. 发明授权

US08679310B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US08679310B2
公开(公告)日：2014-03-25
申请号：US13091325
申请日：2011-04-21
申请人： Yosuke Murase , Koji Katsuki
发明人： Yosuke Murase , Koji Katsuki
IPC分类号： G01N27/327
CPC分类号： C12Q1/001 , A61B5/14532 , A61B5/14865 , A61B5/7203 , G01N27/3274
摘要： A biosensor includes a first working electrode that a biocatalyst, which has a property that reacts on a specified ground substance, is disposed, a second working electrode that the biocatalyst, which the property is lost, is disposed, and at least one counter electrode for respectively applying a voltage to the first working electrode and the second working electrode.
摘要翻译：一种生物传感器包括具有对规定的研磨物质进行反应的特性的生物催化剂的第一工作电极，配置有该特性丧失的生物催化剂的第二工作电极，以及至少一个对置电极分别向第一工作电极和第二工作电极施加电压。

6. 发明授权

US08647488B2 Biosensor 有权
公开(公告)号：US08647488B2
公开(公告)日：2014-02-11
申请号：US13091325
申请日：2011-04-21
申请人： Yosuke Murase , Koji Katsuki
发明人： Yosuke Murase , Koji Katsuki
IPC分类号： G01N27/327
摘要： A biosensor includes a first working electrode that a biocatalyst, which has a property that reacts on a specified ground substance, is disposed, a second working electrode that the biocatalyst, which the property is lost, is disposed, and at least one counter electrode for respectively applying a voltage to the first working electrode and the second working electrode.

7. 发明申请

US20110174638A1 MONITORING DEVICE AND MONITORING METHOD 有权
标题翻译：监控设备和监控方法
公开(公告)号：US20110174638A1
公开(公告)日：2011-07-21
申请号：US13009295
申请日：2011-01-19
申请人： Koji Katsuki
发明人： Koji Katsuki
IPC分类号： G01N27/28 , G01N33/48
CPC分类号： A61B5/1495 , A61B5/14503 , A61B5/14532 , A61B5/1473 , A61B5/14865 , A61B5/1491 , A61B5/6849 , A61B2560/0252 , A61B2562/0271
摘要： A monitoring device which measures numerical value information on a subject substance in a body fluid has an electrochemical sensor including a sensor unit for detecting the subject substance which is used in the way of being embedded subcutaneously and generating an electric signal correlating to the numerical value information on the subject substance, and a temperature control unit which adjusts the detected ambient temperature as a temperature ambient to a sensor unit when detecting the subject substance so as to reach a target setting temperature when measuring the subject substance.
摘要翻译：测量体液中的被检物质的数值信息的监视装置具有电化学传感器，其包括用于检测以皮下埋入的方式使用的被检物体的传感器单元，并产生与数值信息相关的电信号以及温度控制单元，其在检测被检物体时将检测到的环境温度调节为传感器单元的温度环境，以便在测量被检物体时达到目标设定温度。

8. 发明授权

US08784624B2 Enzyme electrode 有权
标题翻译：酶电极
公开(公告)号：US08784624B2
公开(公告)日：2014-07-22
申请号：US12309222
申请日：2007-07-11
申请人： Koji Katsuki , Konomu Hirao , Kenji Nagakawa , Masashi Okamoto , Yoshiaki Fujinawa
发明人： Koji Katsuki , Konomu Hirao , Kenji Nagakawa , Masashi Okamoto , Yoshiaki Fujinawa
IPC分类号： G01N27/327
CPC分类号： C12Q1/001
摘要： The present invention relates to an enzyme electrode including: a carbon particle; a metal particle held on the carbon particle, the metal particle having a catalytic activity against a redox reaction; a redox enzyme. The enzyme electrode of the present invention further includes a high-resistance particle enhancing an electrical resistance, the high-resistance particle being chemically stable. The high-resistance particle contains an inorganic substance, for example. The inorganic substance is aluminum oxide or smectite, for example.
摘要翻译：本发明涉及一种酶电极，包括：碳粒子; 保持在碳粒子上的金属粒子，具有对氧化还原反应的催化活性的金属粒子; 一种氧化还原酶。本发明的酶电极还包括提高电阻的高电阻粒子，高电阻粒子化学稳定。高电阻粒子例如含有无机物质。无机物质例如是氧化铝或绿土。

9. 发明授权

US07879211B2 Analyzing instrument, lancet-integrated attachment for concentration measuring device provided with analyzing instrument, and body fluid sampling tool 失效
标题翻译：分析仪器，配有分析仪器的浓度测量装置的刺血针一体式附件，以及体液取样工具
公开(公告)号：US07879211B2
公开(公告)日：2011-02-01
申请号：US10483443
申请日：2002-07-11
申请人： Koji Katsuki , Tetsuya Sakata , Yasuhide Kusaka
发明人： Koji Katsuki , Tetsuya Sakata , Yasuhide Kusaka
IPC分类号： B01J19/12 , C25D17/00 , C12M1/00 , C12N9/00 , C12N11/00 , C25B9/00 , C25B11/00 , C25B13/00 , A61B5/00 , A61B17/14 , A61B17/32 , B65D81/00 , G01N1/00 , G01N27/26 , G01N31/00 , G01N33/487
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/150022 , A61B5/150213 , A61B5/150412 , A61B5/150503 , A61B5/15117 , A61B5/15123 , A61B5/1519 , A61B5/15194 , A61B5/157 , A61B2562/0295 , G01N27/3271
摘要： The present invention relates to an analyzing instrument (1A) which includes a capillary (31), a fluid feed port (20) for introducing a sample liquid to the capillary (31), and a fluid feed promoter (6) for promoting the introduction of the sample liquid into the feed port (20). The capillary (31) of the analyzer (1A) may be formed on a substrate (2) for example. The fluid feed promoter (6) may include at lease one of a water-absorbing layer having a higher water-absorbing capacity than the substrate (2) and an adhesive layer having a greater adhesion to the skin than the substrate (2).
摘要翻译：本发明涉及一种分析仪器（1A），其包括毛细管（31），用于将样品液体引入毛细管（31）的流体供给口（20）和用于促进引入的流体促进剂（6）的样品液体进入进料口（20）。分析器（1A）的毛细管（31）例如可以形成在基板（2）上。流体进料促进剂（6）可以包括至少一个具有比基材（2）更高的吸水能力的吸水层和与基材（2）相比具有更大粘合力的粘合剂层。

10. 发明申请

US20100187107A1 Enzyme electrode 有权
标题翻译：酶电极
公开(公告)号：US20100187107A1
公开(公告)日：2010-07-29
申请号：US12309222
申请日：2007-07-11
申请人： Koji Katsuki , Konomu Hirao , Kenji Nagakawa , Masashi Okamoto , Yoshiaki Fujinawa
发明人： Koji Katsuki , Konomu Hirao , Kenji Nagakawa , Masashi Okamoto , Yoshiaki Fujinawa
IPC分类号： G01N27/26
CPC分类号： C12Q1/001
摘要： The present invention relates to an enzyme electrode including: a carbon particle; a metal particle held on the carbon particle, the metal particle having a catalytic activity against a redox reaction; a redox enzyme. The enzyme electrode of the present invention further includes a high-resistance particle enhancing an electrical resistance, the high-resistance particle being chemically stable. The high-resistance particle contains an inorganic substance, for example. The inorganic substance is aluminum oxide or smectite, for example.
摘要翻译：本发明涉及一种酶电极，包括：碳粒子; 保持在碳粒子上的金属粒子，具有对氧化还原反应的催化活性的金属粒子; 一种氧化还原酶。本发明的酶电极还包括提高电阻的高电阻粒子，高电阻粒子化学稳定。高电阻粒子例如含有无机物质。无机物质例如是氧化铝或绿土。

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