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1. 发明申请

US20110213143A1 COMPOUND HAVING TAFIA INHIBITORY ACTIVITY 审中-公开
标题翻译：具有TAFIA抑制活性的化合物
公开(公告)号：US20110213143A1
公开(公告)日：2011-09-01
申请号：US13126685
申请日：2009-10-28
申请人： Hideaki Amada , Daisuke Matsuda , Masahiro Bohno , Shiuji Saito , Ayako Bohno
发明人： Hideaki Amada , Daisuke Matsuda , Masahiro Bohno , Shiuji Saito , Ayako Bohno
IPC分类号： C07D487/04 , C07D471/04 , C07D498/04 , C07D471/14
CPC分类号： C07D471/04 , C07D487/04
摘要： Provided are compounds having superior TAFIa inhibitory activity. Specifically, there are provided compounds represented by the following formula (I) or pharmaceutically acceptable salts thereof: wherein A is a benzene ring or a pyridine ring; X is the formula —(CH2)—, the formula —(CH2)2—, an oxygen atom, a nitrogen atom or a single bond; Y is the formula —(CH2)3—NH—R3, the formula —(CH2)4—NH—R3 or a 2-aminopyridyl group; R3 is a hydrogen atom, a C1-6 alkyl group, or the formula —CO2R4; R4 is a C1-6 alkyl group, the formula —CHR5OC(O)R6, or a substituent having the structure represented by the following formula Ia; R5 is a C1-6 alkyl group; R6 is a C1-6 alkyl group, a C3-8 cycloalkyl group, or a phenyl group; R7 is a C1-6 alkyl group or a phenyl group; R1 is a hydrogen atom, a halogen atom, a C1-4 alkyl group substituted by 1-3 halogen atoms, a C1-10 alkyl group, a C1-8 alkoxy group, a C3-8 cycloalkyl group, a C3-8 cycloalkoxy group, a C4-14 cycloalkylalkyl group, or a phenyl group; R2 is CO2R8, or a tetrazolyl group; R8 is a hydrogen atom, a C1-10 alkyl group, or a substituent having the structure represented by the following formula Ib or Ic; m and n are each an integer of zero or one.
摘要翻译：提供具有优异TAFIa抑制活性的化合物。具体地，提供由下式（I）表示的化合物或其药学上可接受的盐：其中A是苯环或吡啶环; X是式 - （CH 2） - ，式 - （CH 2）2 - ，氧原子，氮原子或单键; Y是式 - （CH2）3-NH-R3，式 - （CH2）4-NH-R3或2-氨基吡啶基; R 3是氢原子，C 1-6烷基或式-CO 2 R 4; R4是C1-6烷基，式-CHR5OC（O）R6或具有由下式Ia表示的结构的取代基; R5是C1-6烷基; R6是C1-6烷基，C3-8环烷基或苯基; R7是C1-6烷基或苯基; R1是氢原子，卤素原子，被1-3个卤素原子取代的C1-4烷基，C1-10烷基，C1-8烷氧基，C3-8环烷基，C3-8环烷氧基基团，C4-14环烷基烷基或苯基; R2是CO2R8或四唑基; R8是氢原子，C1-10烷基或具有由下式Ib或Ic表示的结构的取代基; m和n分别为0或1的整数。

2. 发明申请

US20120172598A1 COMPOUNDS HAVING TAFIa INHIBITORY ACTIVITY 审中-公开
标题翻译：具有TAFIA抑制活性的化合物
公开(公告)号：US20120172598A1
公开(公告)日：2012-07-05
申请号：US13496625
申请日：2010-09-17
申请人： Hideaki Amada , Daisuke Matsuda , Ayako Bohno
发明人： Hideaki Amada , Daisuke Matsuda , Ayako Bohno
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/4745
摘要： The present invention provides compounds having superior TAFIa inhibitory activity. They are dihydroimidazoquinoline compounds represented by the following formula (I) or pharmaceutically acceptable salts thereof: wherein R is a hydrogen atom or a C1-10 alkyl group; R1 is a hydrogen atom, a C1-10 alkyl group, a C3-8 cycloalkyl group or a substituent having the structure represented by the following formula Ia or Ib: where R3 is a C1-6 alkyl group; R4 is a C1-6 alkyl group, a C3-8 cycloalkyl group, or a benzyl group; and R2 is a hydrogen atom or a substituent having the structure represented by the following formula Ic or Id:
摘要翻译：本发明提供具有优异TAFIa抑制活性的化合物。它们是由下式（I）表示的二氢咪唑并喹啉化合物或其药学上可接受的盐：其中R是氢原子或C1-10烷基; R1是氢原子，C1-10烷基，C3-8环烷基或具有由下式Ia或Ib表示的结构的取代基：其中R3是C1-6烷基; R4是C1-6烷基，C3-8环烷基或苄基; 并且R 2是氢原子或具有由下式Ic或Id表示的结构的取代基：

3. 发明授权

US09187492B2 Pyripyropene derivative having ACAT2 inhibiting activity and stable to metabolizing enzymes 有权
标题翻译：具有ACAT2抑制活性并且对代谢酶稳定的吡哆醛衍生物
公开(公告)号：US09187492B2
公开(公告)日：2015-11-17
申请号：US13638332
申请日：2011-03-25
申请人： Hiroshi Tomoda , Tohru Nagamitsu , Daisuke Matsuda , Taichi Ohshiro , Masaki Ohtawa , Satoshi Omura
发明人： Hiroshi Tomoda , Tohru Nagamitsu , Daisuke Matsuda , Taichi Ohshiro , Masaki Ohtawa , Satoshi Omura
IPC分类号： C07D493/14 , A61K31/453 , C07D493/04
CPC分类号： C07D493/14 , A61K31/453 , C07D493/04
摘要： A compound effective in prevention and treatment of arteriosclerosis with a mechanism different from that of statin drugs has the following formula or a pharmaceutically acceptable salt, solvate, or hydrate thereof: wherein R1 is an aliphatic, alicyclic, or aromatic acyloxy group, or a group of the formula —O—CH(R7)—R8 where R7 is a lower alkoxy group and R8 is an aryl group, and R2 is carboxyl, a lower alkoxycarbonyl group, or an arylmethylcarbamoyl group, or a —CH2-acyloxy group and R3 is an aliphatic, alicyclic or aromatic acyloxy group, provided that at least one of R4 and R3 is a group other than acetoxy, or R2 and R3 taken together form a group of the formula —O—CH(R5)—O— where R5 is an aryl group.
摘要翻译：具有与他汀类药物不同的机制预防和治疗动脉硬化的化合物具有下式或其药学上可接受的盐，溶剂合物或水合物：其中R1是脂族，脂环族或芳族酰氧基或基团的式-O-CH（R7）-R8，其中R7是低级烷氧基，R8是芳基，R2是羧基，低级烷氧基羰基或芳基甲基氨基甲酰基，或-CH2-酰氧基和R3 是脂族，脂环族或芳香族酰氧基，条件是R 4和R 3中的至少一个是除乙酰氧基以外的基团，或者R 2和R 3一起形成式-O-CH（R 5）-O-基团，其中R 5 是芳基。

4. 发明申请

US20130085163A1 Pyripyropene Derivative Having ACAT2 Inhibiting Activity and Stable to Metabolizing Enzymes 有权
标题翻译：具有ACAT2抑制活性和稳定代谢酶的吡哆醛衍生物
公开(公告)号：US20130085163A1
公开(公告)日：2013-04-04
申请号：US13638332
申请日：2011-03-25
申请人： Hiroshi Tomoda , Tohru Nagamitsu , Daisuke Matsuda , Taichi Ohshiro , Masaki Ohtawa , Satoshi Omura
发明人： Hiroshi Tomoda , Tohru Nagamitsu , Daisuke Matsuda , Taichi Ohshiro , Masaki Ohtawa , Satoshi Omura
IPC分类号： C07D493/14 , C07D493/04
CPC分类号： C07D493/14 , A61K31/453 , C07D493/04
摘要： A compound effective in prevention and treatment of arteriosclerosis with a mechanism different from that of statin drugs has the following formula or a pharmaceutically acceptable salt, solvate, or hydrate thereof: wherein R1 is an aliphatic, alicyclic, or aromatic acyloxy group, or a group of the formula —13—O—CH(R7)—R8 where R7 is a lower alkoxy group and R8 is an aryl group, and R2 is carboxyl, a lower alkoxycarbonyl group, or an arylmethylcarbamoyl group, or a —CH2-acyloxy group and R3 is an aliphatic, alicyclic or aromatic acyloxy group, provided that at least one of R4 and R3 is a group other than acetoxy, or R2 and R3 taken together form a group of the formula —O—CH(R5)—O— where R5 is an aryl group.
摘要翻译：具有与他汀类药物不同的机制预防和治疗动脉硬化的化合物具有下式或其药学上可接受的盐，溶剂化物或水合物：其中R1是脂族，脂环族或芳族酰氧基或基团的式-13-O-CH（R7）-R8，其中R7是低级烷氧基，R8是芳基，R2是羧基，低级烷氧基羰基或芳基甲基氨基甲酰基或-CH2-酰氧基并且R 3是脂族，脂环族或芳族酰氧基，条件是R 4和R 3中的至少一个是除乙酰氧基以外的基团，或者R 2和R 3一起形成式-O-CH（R 5）-O- 其中R5是芳基。

5. 发明申请

US20100124663A1 RESIN COMPOSITION AND SHEET USING RESIN COMPOSITION 审中-公开
标题翻译：树脂组合物和树脂组合物
公开(公告)号：US20100124663A1
公开(公告)日：2010-05-20
申请号：US12275135
申请日：2008-11-20
申请人： Tatsuo Furusawa , Koichi Furusawa , Noriyuki Ishihara , Yoshihiro Hirano , Tsuneyasu Ariyoshi , Teruhisa Kanadani , Daisuke Matsuda
发明人： Tatsuo Furusawa , Koichi Furusawa , Noriyuki Ishihara , Yoshihiro Hirano , Tsuneyasu Ariyoshi , Teruhisa Kanadani , Daisuke Matsuda
IPC分类号： G21F1/10 , B32B27/06 , G21F1/12
CPC分类号： G21F1/106 , B32B7/12 , B32B27/08 , B32B27/18 , B32B27/22 , B32B27/283 , B32B27/36 , B32B2250/02 , B32B2264/102 , B32B2264/105 , B32B2307/3065 , B32B2571/00 , C08J5/18 , C08J2367/02 , C08K3/08 , C08K3/36 , C08K5/34924 , C08L67/025 , C08L83/04 , Y10T428/31663 , C08L83/00
摘要： A resin composition with no substantial halogen element content contains a tungsten powder, a polyester elastomer, silica, a polysiloxane compound, and melamine cyanurate. Relative to 100% in weight of the polyester elastomer, the total content of silica and the polysiloxane compound is 22% or more in weight, the content of melamine cyanurate is 17% or more in weight, and the total content of silica, the polysiloxane compound, and melamine cyanurate is 45% to 53% in weight. The oxygen index of the resin composition is 26 or more. The number of times of circumferentially bending a test piece at 90 degrees around a 10 mm-diameter column in a repetitive bending test using the test piece made of the resin composition having a length of 50 mm, a width of 100 mm, and a thickness of 2.25 mm is 1000 or more.
摘要翻译：没有实质的卤素元素含量的树脂组合物含有钨粉，聚酯弹性体，二氧化硅，聚硅氧烷化合物和氰尿酸三聚氰胺。相对于聚酯弹性体的100重量％，二氧化硅和聚硅氧烷化合物的总含量为22重量％以上，三聚氰胺氰脲酸酯的含量为17重量％以上，二氧化硅，聚硅氧烷化合物和三聚氰胺氰脲酸酯的重量比为45％至53％。树脂组合物的氧指数为26以上。在使用由长度为50mm，宽度为100mm的树脂组合物制成的试件和厚度为100mm的试验片的重复弯曲试验中，在10mm直径的柱上周向弯曲试验片的周期的次数 2.25毫米是1000或更多。

6. 发明授权

US5759367A Gas sensor 失效
标题翻译：气体传感器
公开(公告)号：US5759367A
公开(公告)日：1998-06-02
申请号：US747287
申请日：1996-11-12
申请人： Yoshinobu Matsuura , Toru Nomura , Daisuke Matsuda , Yuki Fujimori , Maki Kitora
发明人： Yoshinobu Matsuura , Toru Nomura , Daisuke Matsuda , Yuki Fujimori , Maki Kitora
IPC分类号： G01N27/409 , G01N27/04 , G01N27/12 , G01N27/407 , G01N27/26
CPC分类号： G01N27/4074 , G01N27/12
摘要： An insulating glass film is formed on a heater film, and a gas sensitive film is formed on the glass film. The MgO content in the glass is kept at 0.1 wt % or under to prevent Mg from eluting into absorbed water at low temperatures and segregating on the cathode by the detection voltage.
摘要翻译：在加热膜上形成绝缘玻璃膜，在玻璃膜上形成气敏膜。玻璃中的MgO含量保持在0.1重量％以下，以防止Mg在低温下被洗脱到吸收的水中，并通过检测电压在阴极上分离。

7. 发明授权

US07007745B2 Core structure of heat exchanger 失效
标题翻译：热交换器的核心结构
公开(公告)号：US07007745B2
公开(公告)日：2006-03-07
申请号：US10809484
申请日：2004-03-26
申请人： Mitsuru Iwasaki , Shinobu Asakawa , Daisuke Matsuda , Shouji Tasaka , Toshinobu Imamura
发明人： Mitsuru Iwasaki , Shinobu Asakawa , Daisuke Matsuda , Shouji Tasaka , Toshinobu Imamura
IPC分类号： F28F9/04
CPC分类号： F28F9/0226 , F28D2021/0084 , F28D2021/0094 , F28F9/182 , F28F2225/08 , F28F2265/26
摘要： In a core structure of a heat exchanger, tubes and corrugated fins are alternately arranged between seat plates arranged opposite to each other with a predetermined space interposed therebetween. End portions of the tubes are inserted into tube holes formed respectively in each of the top and bottom seat plates to be fixed. On the seat plates, there are provided connection portions having wall portions slanting from main body portions thereof toward the tube holes. When a thickness of the tubes is 0.13 mm to 0.23 mm, a slant angle θ of the wall portions of the connection portions is set to satisfy: slant angle θ (°)≧25χ(thickness (mm) of sheet plate)+(−125χ(thickness (mm) of tube)+25).
摘要翻译：在热交换器的芯结构中，管和波纹翅片交替地布置在彼此相对布置的间隔开的预定间隔的座板之间。管的端部插入分别形成在每个顶板和底座板中的管孔中，以固定。在座板上设有连接部分，其连接部分具有从其主体部分向管孔倾斜的壁部分。当管的厚度为0.13mm至0.23mm时，连接部的壁部的倾斜角θ设定为：倾斜角θ（°）> = 25chi（板的厚度（mm））+（ -125chi（管的厚度（mm））+25）。

8. 发明授权

US06932152B2 Core structure of heat exchanger 有权
标题翻译：热交换器的核心结构
公开(公告)号：US06932152B2
公开(公告)日：2005-08-23
申请号：US10806321
申请日：2004-03-23
申请人： Mitsuru Iwasaki , Shinobu Asakawa , Daisuke Matsuda , Shouji Tasaka , Toshinobu Imamura
发明人： Mitsuru Iwasaki , Shinobu Asakawa , Daisuke Matsuda , Shouji Tasaka , Toshinobu Imamura
IPC分类号： B21D28/24 , F28F9/02 , F28F9/18
CPC分类号： F28F9/0226 , F28D2021/0084 , F28D2021/0094 , F28F9/182 , F28F2225/08 , F28F2265/26
摘要： In a core structure of a heat exchanger, tubes and corrugated fins are alternately arranged between seat plates arranged opposite to each other with a predetermined space interposed therebetween. Both end portions of the tubes are inserted into tube holes of connection portions formed respectively in each of the top and bottom seat plates to be fixed. On the seat plates, there are provided connection portions on which are formed wall portions slanting from main body portions thereof toward the tubes and vulnerable portions formed thinner than the seat plates and in series on the wall portions and absorb thermal stress of the seat plates against the tubes by bending.
摘要翻译：在热交换器的芯结构中，管和波纹翅片交替地布置在彼此相对布置的间隔开的预定间隔的座板之间。管的两端部插入分别形成在每个顶板和底座板中的连接部分的管孔中，以固定。在座板上设有连接部分，其上形成有从其主体部分朝向管子倾斜的壁部分，并且脆弱部分形成为比座板更薄并且串联在壁部上并且吸收座板的热应力抵抗管弯曲。

9. 发明授权

US06779015B1 Method for implementation of power calculation on a fixed-point processor using table lookup and linear approximation 失效
标题翻译：使用表查找和线性近似在定点处理器上实现功率计算的方法
公开(公告)号：US06779015B1
公开(公告)日：2004-08-17
申请号：US09722086
申请日：2000-11-24
申请人： Da-Ming Chiang , Daisuke Matsuda
发明人： Da-Ming Chiang , Daisuke Matsuda
IPC分类号： G06F738
CPC分类号： G06F7/556
摘要： A method for calculating the power of an integer raised to a constant real number. The method may be used to process digital signals, which are encoded in such a fashion as to require such processing. An embodiment of the present invention first receives a segment of a bitstream. Next, the process determines whether an integer value of the segment is within a look-up table. The look-up table contains a list of integers and a corresponding list of the integers raised to the power of a real number. If the integer value is within the look-up table, the process indexes the look-up table with the integer value to determine substantially the value of the integer raised to the real power. If, however, the integer value is not within the look-up table, the process indexes the table with a plurality of integers which are within the table to approximate the value of the segment from the bitstream raised to the real power. The process repeats these steps for each segment in the signal bitstream.
摘要翻译：一种用于计算整数增加到恒定实数的幂的方法。该方法可以用于处理数字信号，这些信号以需要这种处理的方式进行编码。本发明的实施例首先接收比特流的片段。接下来，该处理确定片段的整数值是否在查找表内。查找表包含整数列表和相应的整数列表，提供给实数的幂。如果整数值在查找表中，则该进程将使用整数值对查找表进行索引，以确定实际提供给实际功率的整数的值。然而，如果整数值不在查找表内，则该过程用表内的多个整数对该表进行索引，以将该段的值从比特流提升到实际功率。该过程对信号比特流中的每个段重复这些步骤。

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