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    • 4. 发明授权
    • Compositions for coloring the skin based on indole derivatives
    • 基于吲哚衍生物着色皮肤的组合物
    • US4956174A
    • 1990-09-11
    • US21931
    • 1987-03-05
    • Gerard LangHerve RichardMadeleine LeducAlex Junino
    • Gerard LangHerve RichardMadeleine LeducAlex Junino
    • A61K8/00A61K8/34A61K8/46A61K8/49A61K8/58A61K8/86A61K8/92A61Q1/02A61Q19/04
    • A61Q19/04A61K8/492
    • Cosmetic composition designed to impart to the skin a coloring which is substantially similar to the pigmentation resulting from natural tanning, characterized in that it contains, in a cosmetically acceptable medium suitable for topical application, at least one compound of the formula: ##STR1## in which R.sub.1 denotes a hydrogen atom, a lower alkyl group or a residue --SiR.sub.9 R.sub.10 R.sub.11, R.sub.2 and R.sub.3, which may be identical or different, denote a hydrogen atom, a lower alkyl group, a carboxyl group, a lower alkoxycarbonyl group or a group --COOSiR.sub.9 R.sub.10 R.sub.11 ; R.sub.4 and R.sub.5 which may be identical or different, denote a hydrogen atom, a linear or branched C.sub.1 -C.sub.20 alkyl group, a formyl group, a linear or branched C.sub.2 -C.sub.20 acyl group, a linear or branched C.sub.3 -C.sub.20 alkenoyl group, a group R.sub.6 OSO.sub.2 --, a group --SiR.sub.9 R.sub.10 R.sub.11, a group --P(O)(OR.sub.6).sub.2 or an aralkyl group, or alternatively R.sub.4 and R.sub.5, with the oxygen atoms to which they are attached, form a ring optionally containing a carbonyl group when at least one of the groups, R.sub.1, R.sub.2 or R.sub.3 is other than hydrogen or alternatively a thiocarbonyl group, a residue >P(O)OR.sub.6, a group >CR.sub.7 R.sub.8 or a methylene group, R.sub.6 denoting a hydrogen atom or a lower alkyl group, R.sub.7 denoting a hydrogen atom or a lower alkyl group, R.sub.8 denoting a lower alkoxy group or a mono- or dialkylamino group and R.sub.9, R.sub.10 or R.sub.11, which may be identical or different, denoting linear or branched lower alkyl groups, at least one of the substituents R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 being other than hydrogen; and the corresponding salts with alkali metals, alkaline earth metals, ammonium or amines.
    • 化妆品组合物被设计成赋予皮肤一种基本上类似于由天然鞣制引起的色素沉着的着色,其特征在于其在适合局部应用的化妆品可接受的介质中包含至少一种下式的化合物: I),其中R 1表示氢原子,低级烷基或残基-SiR 9 R 10 R 11,R 2和R 3可以相同或不同,表示氢原子,低级烷基,羧基,低级烷氧基羰基或 一组-COOSiR9R10R11; 可以相同或不同的R 4和R 5表示氢原子,直链或支链C 1 -C 20烷基,甲酰基,直链或支链C 2 -C 20酰基,直链或支链C 3 -C 20链烯酰基, 基团R6OSO2-,基团-SiR9R10R11,基团-P(O)(OR6)2或芳烷基,或者R4和R5与它们所连接的氧原子形成任选含有羰基的环, R 1,R 2或R 3中的至少一个不是氢或硫代羰基,残基> P(O)OR 6,基团> CR 7 R 8或亚甲基,R 6表示氢原子或低级烷基 ,R7表示氢原子或低级烷基,R8表示低级烷氧基或单或二烷基氨基,R9,R10或R11可以相同或不同,表示直链或支链的低级烷基,至少一个 的取代基R 1,R 2,R 3,R 4和R 5不是氢; 和与碱金属,碱土金属,铵或胺的相应的盐。