专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100048536A1 Novel Substituted Diaryl Azepine Derivatives as Integrin Ligands 审中-公开
标题翻译：新型取代的二芳基Azepine衍生物作为整合素配体
公开(公告)号：US20100048536A1
公开(公告)日：2010-02-25
申请号：US12396698
申请日：2009-03-03
申请人： Herve Geneste , Andreas Kling , Arnulf Lauterbach , Claudia Isabella Graef , Thomas Subkoski , Wilfried Hornberger
发明人： Herve Geneste , Andreas Kling , Arnulf Lauterbach , Claudia Isabella Graef , Thomas Subkoski , Wilfried Hornberger
IPC分类号： A61K31/55 , C07D403/02
CPC分类号： A61K45/06
摘要： The invention relates to novel compounds which bind to integrin receptors, their use as ligands of integrin receptors, in particular as ligands of the αvβ3 integrin receptor, and pharmaceutical preparations comprising these compounds.
摘要翻译：本发明涉及结合整联蛋白受体的新化合物，它们作为整联蛋白受体的配体，特别是作为αv＆bgr 3整联蛋白受体的配体的用途，以及包含这些化合物的药物制剂。

2. 发明授权

US07279468B2 Integrin ligands 有权
标题翻译：整合素配体
公开(公告)号：US07279468B2
公开(公告)日：2007-10-09
申请号：US10311369
申请日：2001-06-15
申请人： Herve Geneste , Andreas Kling , Udo Lange , Werner Seitz , Claudia Isabella Graef , Thomas Subkoski , Wilfried Hornberger , Arnulf Lauterbach
发明人： Herve Geneste , Andreas Kling , Udo Lange , Werner Seitz , Claudia Isabella Graef , Thomas Subkoski , Wilfried Hornberger , Arnulf Lauterbach
IPC分类号： A01N43/00 , A61K31/55 , C07D513/00 , C07D487/00
CPC分类号： A61K45/06
摘要： The invention relates to novel compounds which bind to integrin receptors, their use as ligands of integrin receptors, in particular as ligands of the αvβ3 integrin receptor, their use, and pharmaceutical preparations comprising these compounds.
摘要翻译：本发明涉及结合整联蛋白受体的新型化合物，它们作为整联蛋白受体的配体，特别是作为α3β3整联蛋白受体的配体的用途，和包含这些化合物的药物制剂。

3. 发明申请

US20080221082A1 Ligands of Integrin Receptors 审中-公开
标题翻译：整合素受体配体
公开(公告)号：US20080221082A1
公开(公告)日：2008-09-11
申请号：US10297202
申请日：2001-06-06
申请人： Herve Geneste , Andreas Kling , Udo Lange , Werner Seitz , Claudia Isabella Graef , Thomas Subkowski , Wilfried Hornberger , Arnulf Lauterbach
发明人： Herve Geneste , Andreas Kling , Udo Lange , Werner Seitz , Claudia Isabella Graef , Thomas Subkowski , Wilfried Hornberger , Arnulf Lauterbach
IPC分类号： A61K31/55 , C07D487/14 , C07D235/30 , C07D277/02 , A61K31/426 , A61K31/4168
CPC分类号： A61K45/06
摘要： The invention relates to the use of cyclic compounds as ligands of integrin receptors, in particular as ligands of the αVβ3 integrin receptor, the novel compounds themselves, their use, and pharmaceutical preparations comprising these compounds.
摘要翻译：本发明涉及环状化合物作为整联蛋白受体的配体的用途，特别是作为α3β3整联蛋白受体的配体，新化合物本身，其用途，和包含这些化合物的药物制剂。

4. 发明授权

US07125883B1 Integrin receptor ligands 有权
标题翻译：整合素受体配体
公开(公告)号：US07125883B1
公开(公告)日：2006-10-24
申请号：US09958491
申请日：2000-03-29
申请人： Johann-Christian Zechel , Andreas Kling , Herve Geneste , Udo Lange , Arnulf Lauterbach , Claudia Isabella Graef , Thomas Subkowski , Jens Sadowski , Wilfried Hornberger
发明人： Johann-Christian Zechel , Andreas Kling , Herve Geneste , Udo Lange , Arnulf Lauterbach , Claudia Isabella Graef , Thomas Subkowski , Jens Sadowski , Wilfried Hornberger
IPC分类号： C07D401/14 , A61K31/505
CPC分类号： C07D405/14 , A61K45/06 , C07D239/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/14 , C07D417/12 , C07D417/14
摘要： The invention relates to novel compounds which bind to integrin receptors, to their preparation, to their use as integrin receptor ligands and for treating diseases, to pharmaceutical preparations comprising these compounds, and to pharmaceutical preparations comprising at least one other active compound.
摘要翻译：本发明涉及结合整联蛋白受体，其制备，其作为整联蛋白受体配体和用于治疗疾病的药物，包含这些化合物的药物制剂以及包含至少一种其它活性化合物的药物制剂的新型化合物。

5. 发明授权

US07105508B1 Integrin receptors antagonists 有权
标题翻译：整合素受体拮抗剂
公开(公告)号：US07105508B1
公开(公告)日：2006-09-12
申请号：US10049266
申请日：2000-08-01
申请人： Andreas Kling , Hervé Geneste , Udo Lange , Arnulf Lauterbach , Claudia Isabella Graef , Thomas Subkowski , Uta Holzenkamp , Helmut Mack , Jens Sadowski , Wilfried Hornberger , Volker Laux
发明人： Andreas Kling , Hervé Geneste , Udo Lange , Arnulf Lauterbach , Claudia Isabella Graef , Thomas Subkowski , Uta Holzenkamp , Helmut Mack , Jens Sadowski , Wilfried Hornberger , Volker Laux
IPC分类号： C07D401/12 , A61K31/55
CPC分类号： C07D401/06 , C07D223/20 , C07D243/38 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14
摘要： The invention relates to novel compounds which bind to integrin receptors, and to the preparation thereof and the use thereof as drugs.
摘要翻译：本发明涉及结合整联蛋白受体的新化合物及其制备及其作为药物的用途。

6. 发明申请

US20060235004A1 Pyrimidin-2-one compounds and their use as dopamine d3 receptor ligands 有权
标题翻译：嘧啶-2-酮化合物及其作为多巴胺d3受体配体的用途
公开(公告)号：US20060235004A1
公开(公告)日：2006-10-19
申请号：US10548931
申请日：2004-03-12
申请人： Herve Geneste , Andreas Kling , Wilfried Braje , Andreas Haupt , Lillian Unger
发明人： Herve Geneste , Andreas Kling , Wilfried Braje , Andreas Haupt , Lillian Unger
IPC分类号： A61K31/551 , A61K31/513 , C07D403/14 , C07D413/14 , C07D417/14
CPC分类号： C07D239/36 , C07D239/52 , C07D239/54 , C07D239/553 , C07D239/56 , C07D401/12 , C07D403/14 , C07D405/14 , C07D409/14
摘要： The invention relates to pyrimidin 2-one compounds of general formula (I), in addition to the derivatives and tautomers of (I) and the physiologically acceptable salts of said compounds. In said formula, A represents linear or branched C3-C6 alkene, which can have a double bond or triple bond and/or a group Z, which is not adjacent to the nitrogen atom of the pyrimidinone ring and is selected from O, S, C(O), NR3, C(O)NR3, NR3C(O), OC(O) and C(O)O; B represents a group of the formula (II), in which X stands for CH2 or N and Y stands for CH2 or CH2CH2, or X—Y can also jointly represent C═CH, C═CH—CH2 or CH—CH═CH; R1 and R2 are defined as cited in the description and the claims; and Ar represents an optionally substituted aromatic group. The invention also relates to a pharmaceutical agent, containing at least one compound (I) and the tautomers, derivatives and/or acid addition salts of said compound, optionally together with physiologically acceptable carriers and/or auxiliary agents. The invention also relates to the use of compounds of formula (I), and their tautomers, derivatives and pharmacologically acceptable acid addition salts for producing a phrmaceutical agent for treating diseases which respond to the influence of dopamine D3 receptor ligands.
摘要翻译：除了（I）的衍生物和互变异构体以及所述化合物的生理学上可接受的盐之外，本发明涉及通式（I）的嘧啶-2-酮化合物。在所述式中，A表示可以具有双键或三键和/或不相邻的基团Z的直链或支链C 3 -C 6亚烷基选自O，S，C（O），NR 3，C（O）NR 3，NR 3， C（O），OC（O）和C（O）O; B表示式（II）的基团，其中X代表CH 2或N，Y代表CH 2或CH 2， CH 2或XY也可以共同表示C-CH，C-CH-CH 2 CH或CH-CH-CH; R 1和R 2定义如说明书和权利要求书中所引用的; 并且Ar表示任选取代的芳族基团。本发明还涉及含有至少一种化合物（I）和所述化合物的互变异构体，衍生物和/或酸加成盐，任选地与生理上可接受的载体和/或辅助剂一起的药剂。本发明还涉及式（I）化合物及其互变异构体，衍生物和药理学上可接受的酸加成盐的用途，用于制备用于治疗对多巴胺D 3的影响作出反应的疾病的药物制剂受体配体。

7. 发明申请

US20110152325A1 CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV 有权
标题翻译：羧酰胺化合物及其作为抑制剂的用途IV
公开(公告)号：US20110152325A1
公开(公告)日：2011-06-23
申请号：US12972679
申请日：2010-12-20
申请人： Andreas Kling , Katja Jantos , Helmut Mack , Achim Möller , Wilfried Hornberger , Gisela Backfisch , Yanbin Lao , Marjoleen Nijsen
发明人： Andreas Kling , Katja Jantos , Helmut Mack , Achim Möller , Wilfried Hornberger , Gisela Backfisch , Yanbin Lao , Marjoleen Nijsen
IPC分类号： A61K31/4439 , C07D401/04 , A61P25/28 , A61P25/00 , A61P25/08 , A61P25/04 , A61P13/12 , A61P35/00 , A61P31/18 , A61P37/02 , A61P33/06
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14
摘要： The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity.The carboxamide compounds are compounds of the general formula I in which R1, R2, R3 R4, R5, m and n have the meanings mentioned in the claims and the description, the tautomers thereof, the hydrates thereof and the pharmaceutically suitable salts thereof. Of these compounds those are preferred wherein R1 is optionally substituted phenyl-C1-C2-alkyl or hetaryl-C1-C2-alkyl, R2 is optionally substituted aryl, hetaryl, aryl-C1-C6-alkyl, aryl-C2-C6-alkenyl or hetaryl-C1-C4-alkyl, R3 is C3-C4-alkyl, C1-C4-haloalkyl, C2-C4-alkenyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C2-alkyl, C3-C6-heterocycloalkyl-C1-C2-alkyl, phenyl-C1-C3-alkyl, pyridin-2-yl-C1-C3-alkyl or 1,3-benzoxazol-2-yl-methyl, R4 and R5 independently of one another are halogen, CF3, CHF2, CH2F, C1-C2-alkyl or C1-C2-alkoxy, and m and n independently of one another are 0 or 1.
摘要翻译：本发明涉及新的羧酰胺化合物及其用于制备药物的用途。羧酰胺化合物是钙蛋白酶（钙依赖性半胱氨酸蛋白酶）的抑制剂。因此，本发明还涉及这些羧酰胺化合物用于治疗与升高的钙蛋白酶活性相关的病症的用途。羧酰胺化合物是通式I的化合物，其中R 1，R 2，R 3，R 4，R 5，m和n具有权利要求书和描述中所述的含义，其互变异构体，其水合物及其药学上合适的盐。在这些化合物中，优选其中R 1为任选取代的苯基-C 1 -C 2 - 烷基或杂芳基-C 1 -C 2烷基，R 2为任选取代的芳基，杂芳基，芳基-C 1 -C 6 - 烷基，芳基-C 2 -C 6 - 烯基或杂芳基-C 1 -C 4 - 烷基，R 3是C 3 -C 4 - 烷基，C 1 -C 4 - 卤代烷基，C 2 -C 4 - 烯基，C 3 -C 6 - 环烷基，C 3 -C 6 - 环烷基-C 1 -C 2烷基，C 3 -C 6 - 杂环烷基-C 1 -C 2 - 烷基，苯基-C 1 -C 3 - 烷基，吡啶-2-基-C 1 -C 3 - 烷基或1,3-苯并恶唑-2-基 - 甲基，R 4和R 5彼此独立地是卤素，CF 3，CHF 2，CH 2 F，C 1 -C 2 - 烷基或C 1 -C 2 - 烷氧基，m和n彼此独立地为0或1。

8. 发明申请

US20100298326A1 Carboxamide compounds and their use as calpain inhibitors 有权
公开(公告)号：US20100298326A1
公开(公告)日：2010-11-25
申请号：US11990652
申请日：2007-12-28
申请人： Andreas Kling , Wilfried Hornberger , Helmut Mack , Achim Moeller , Volker Nimmrich , Dietmar Seemann , Wilfried Lubisch
发明人： Andreas Kling , Wilfried Hornberger , Helmut Mack , Achim Moeller , Volker Nimmrich , Dietmar Seemann , Wilfried Lubisch
IPC分类号： A61K31/5377 , C07D401/02 , A61K31/455 , C07D413/14 , C07D401/14 , A61K31/465 , A61P25/16 , A61P13/12 , A61P27/12 , A61P35/00 , A61P31/18
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D491/048 , C07D493/04 , C07D513/04
摘要： The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity.The carboxamide compounds are compounds of the general formula I in which R1, R2, R3a, R3b, W, Y and X have the meanings mentioned in the claims and the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula I-A.a′ and I-A.a″ in which m, E, R1, R3a, R3b, R2, Ry, Rw and Rw6* have the meanings mentioned in the claims, n is 0, 1 or 2, the tautomers thereof and the pharmaceutically suitable salts thereof.

9. 发明授权

US09018206B2 Carboxamide compounds and their use as calpain inhibitors 有权
标题翻译：羧酰胺化合物及其作为钙蛋白酶抑制剂的用途
公开(公告)号：US09018206B2
公开(公告)日：2015-04-28
申请号：US13610975
申请日：2012-09-12
申请人： Helmut Mack , Andreas Kling , Katja Jantos , Achim Moeller , Wilfried Hornberger , Charles W. Hutchins
发明人： Helmut Mack , Andreas Kling , Katja Jantos , Achim Moeller , Wilfried Hornberger , Charles W. Hutchins
IPC分类号： C07D211/76 , C07D233/34 , C07D239/10 , C07D207/22 , C07D211/78 , C07D233/32 , C07D275/03 , C07D401/06 , C07D405/12 , C07D409/12 , C07D417/12 , C07D207/26
CPC分类号： C07D207/22 , C07D207/26 , C07D207/28 , C07D211/76 , C07D211/78 , C07D213/81 , C07D233/32 , C07D233/34 , C07D239/10 , C07D275/03 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity.The carboxamide compounds are compounds of the general formula I in which R1, R2, R3a, R3b, R4, Q, Y, A and X have the meanings mentioned in the claims and the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula Ia and Ib in which R1, r, R2b, R3a, R3b, R4, Y and X have the meanings mentioned in the claims, including the tautomers thereof and the pharmaceutically suitable salts thereof. Of these compounds those are preferred wherein Y is a moiety CH2—CH2, CH2—CH2—CH2, N(Ry#)—CH2, N(Ry#)—CH2—CH2 or CH═CH—CH═, each optionally having 1 or 2 H-atoms replaced with identical or different radicals Ry, wherein Ry and Ry# have the meanings mentioned in the claims.
摘要翻译：本发明涉及新的羧酰胺化合物及其用于制备药物的用途。羧酰胺化合物是钙蛋白酶（钙依赖性半胱氨酸蛋白酶）的抑制剂。因此，本发明还涉及这些羧酰胺化合物用于治疗与升高的钙蛋白酶活性相关的病症的用途。羧酰胺化合物是通式I的化合物，其中R 1，R 2，R 3a，R 3b，R 4，Q，Y，A和X具有权利要求和说明书中所述的含义及其互变异构体及其药学上合适的盐。特别地，化合物具有通式Ia和Ib，其中R1，r，R2b，R3a，R3b，R4，Y和X具有权利要求中提及的含义，包括其互变异构体及其药学上合适的盐。在这些化合物中，优选其中Y为CH2-CH2，CH2-CH2-CH2，N（Ry＃）-CH2，N（Ry＃）-CH2-CH2或CH = CH-CH≡，各自任选具有1 或2个H原子被相同或不同的基团Ry取代，其中Ry和Ry＃具有权利要求中提及的含义。

10. 发明申请

US20130150367A1 CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS 审中-公开
标题翻译：羧酰胺化合物及其作为钙蛋白酶抑制剂的用途
公开(公告)号：US20130150367A1
公开(公告)日：2013-06-13
申请号：US13610975
申请日：2012-09-12
申请人： Helmut Mack , Andreas Kling , Katja Jantos , Achim Moeller , Wilfried Hornberger , Charles W. Hutchins
发明人： Helmut Mack , Andreas Kling , Katja Jantos , Achim Moeller , Wilfried Hornberger , Charles W. Hutchins
IPC分类号： C07D207/22 , C07D275/03 , C07D409/12 , C07D401/06 , C07D417/12 , C07D405/12 , C07D211/78 , C07D233/32
CPC分类号： C07D207/22 , C07D207/26 , C07D207/28 , C07D211/76 , C07D211/78 , C07D213/81 , C07D233/32 , C07D233/34 , C07D239/10 , C07D275/03 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity.The carboxamide compounds are compounds of the general formula I in which R1, R2, R3a, R3b, R4, Q, Y, A and X have the meanings mentioned in the claims and the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula Ia and Ib in which R1, r, R2b, R3a, R3b, R4, Y and X have the meanings mentioned in the claims, including the tautomers thereof and the pharmaceutically suitable salts thereof. Of these compounds those are preferred wherein Y is a moiety CH2—CH2, CH2—CH2—CH2, N(Ry#)—CH2, N(Ry#)—CH2—CH2 or CH═CH—CH═, each optionally having 1 or 2 H-atoms replaced with identical or different radicals Ry, wherein Ry and Ry# have the meanings mentioned in the claims.
摘要翻译：本发明涉及新的羧酰胺化合物及其用于制备药物的用途。羧酰胺化合物是钙蛋白酶（钙依赖性半胱氨酸蛋白酶）的抑制剂。因此，本发明还涉及这些羧酰胺化合物用于治疗与升高的钙蛋白酶活性相关的病症的用途。羧酰胺化合物是通式I的化合物，其中R 1，R 2，R 3a，R 3b，R 4，Q，Y，A和X具有权利要求和说明书中所述的含义及其互变异构体及其药学上合适的盐。特别地，化合物具有通式Ia和Ib，其中R1，r，R2b，R3a，R3b，R4，Y和X具有权利要求中提及的含义，包括其互变异构体及其药学上合适的盐。在这些化合物中，优选其中Y为CH2-CH2，CH2-CH2-CH2，N（Ry＃）-CH2，N（Ry＃）-CH2-CH2或CH = CH-CH =，各自任选具有1 或2个H原子被相同或不同的基团Ry取代，其中Ry和Ry＃具有权利要求中提及的含义。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式