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    • 1. 发明授权
    • Substituted oxindole compounds
    • 取代的羟吲哚化合物
    • US08486931B2
    • 2013-07-16
    • US12529542
    • 2008-02-29
    • Herve GenesleThorsten OostCharles W. HutchinsLiliane UngerWilfried HornbergerWilfried LubischAstrid NetzAlfred Hahn
    • Herve GenesleThorsten OostCharles W. HutchinsLiliane UngerWilfried HornbergerWilfried LubischAstrid NetzWolfgang Wernet
    • A61K31/4439A61K31/454A61K31/4709A61K31/496A61K31/551
    • C07D401/14C07D401/04C07D401/12C07D471/08
    • The present invention relates to compounds of the general formula (I) in which A, B, R1, R2 and Het have the meaning given in claim 1; Y is a bivalent group of the formula in which D is C1-C3-alkylene, where D may have a substituent R5; R3 is hydrogen, C1-C8-alkyl or together with R4 is C1-C3-alkylene which may have a radical R5a, or together with R5 is C1-C3-alkylene, and R4 is hydrogen, C1-C8-alkyl or together with R3 is C1-C3-alkylene which may have a radical R5a, or together with R5 is C1-C3-alkylene, where R5 together with R5a, where present, are a bond or C1-C3-alkylene; and where one of the following conditions is satisfied: R3 together with R4 is C1-C3-alkylene which may have a radical R5a; or R3 together with R5 is C1-C3-alkylene; or R4 together with R5 is C1-C3-alkylene where the radical A is different from phenyl when the radical B is phenyl or naphthyl; and medicaments which comprise such compounds and the use thereof for the prophylaxis and/or treatment of vasopressin-dependent and/or oxytocin-dependent diseases.
    • 本发明涉及通式(I)的化合物,其中A,B,R1,R2和Het具有权利要求1中给出的含义; Y是下式的二价基团,其中D是C 1 -C 3 - 亚烷基,其中D可以具有取代基R 5; R 3是氢,C 1 -C 8烷基或与R 4一起是可以具有基团R 5a的C 1 -C 3亚烷基,或与R 5一起为C 1 -C 3 - 亚烷基,并且R 4是氢,C 1 -C 8 - 烷基或与 R 3是可以具有基团R 5a的C 1 -C 3亚烷基,或与R 5一起为C 1 -C 3 - 亚烷基,其中R 5与存在的R a a为键或C 1 -C 3 - 亚烷基; 并且其中满足以下条件之一:R 3与R 4一起可以具有基团R 5a的C 1 -C 3 - 亚烷基; 或R 3与R 5一起为C 1 -C 3 - 亚烷基; 或R 4与R 5一起为C 1 -C 3 - 亚烷基,其中基团B为苯基或萘基时,基团A不同于苯基; 以及包含这些化合物的药物及其用于预防和/或治疗加压素依赖性和/或催产素依赖性疾病的用途。