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1. 发明授权

US07172609B2 Apparatus for supporting a segmented blade on a balloon catheter 有权
标题翻译：用于支撑气囊导管上的分段叶片的装置
公开(公告)号：US07172609B2
公开(公告)日：2007-02-06
申请号：US10683893
申请日：2003-10-10
申请人： Herbert R. Radisch, Jr.
发明人： Herbert R. Radisch, Jr.
IPC分类号： A61B17/22 , A61M29/00
CPC分类号： A61B17/320725 , A61B2017/22061 , A61M2025/1086
摘要： A device for incising a stenosis in the vasculature of a patient includes a plurality of blades mounted on a resilient base member. The blades are arranged in a pattern to allow for relative movement between adjacent blades. Specifically, at least one end portion of each blade is juxtaposed with an end portion of the next closest blade. The base member includes a first end affixed to a catheter at a location proximal to an inflatable balloon and a second end affixed to the catheter at a location distal to the inflatable balloon. When the balloon is inserted into the vasculature of a patient, positioned across a stenosis and subsequently inflated, the individually moveable blades form an effective cutting edge that conforms to the surface of the stenosis to effectively allow the stenosis to be incised to a substantially uniform depth.
摘要翻译：用于切除患者脉管系统中的狭窄的装置包括安装在弹性基体上的多个叶片。叶片以图案布置以允许相邻叶片之间的相对运动。具体地，每个叶片的至少一个端部与下一个最接近的叶片的端部并置。基部构件包括在靠近可膨胀气囊的位置处固定到导管的第一端和在可膨胀气囊远侧的位置处固定到导管的第二端。当气囊插入到患者的脉管系统中时，定位在狭窄处并随后膨胀，单独的可移动刀片形成符合狭窄表面的有效切割边缘，以有效地将狭窄切开至基本均匀的深度。

2. 发明授权

US06730107B2 Single lumen rapid-exchange catheter 失效
标题翻译：单腔快速换尿导管
公开(公告)号：US06730107B2
公开(公告)日：2004-05-04
申请号：US09938008
申请日：2001-08-23
申请人： Gregory S. Kelley , Herbert R. Radisch, Jr. , Show-Mean Wu
发明人： Gregory S. Kelley , Herbert R. Radisch, Jr. , Show-Mean Wu
IPC分类号： A61M2900
CPC分类号： A61M25/0075 , A61M25/104 , A61M2025/0046 , A61M2025/0183 , A61M2025/1063
摘要： A single lumen rapid-exchange catheter includes a distal sealing port and a proximal sealing port both dimensioned for receiving a guidewire to establish a fluid-tight seal therewith. Each tubular shaped sealing port has a length, and a diameter, and is made of a hydrophilic polymer. In operation, the guidewire is inserted through the distal sealing port and exits from the catheter tube at the shoulder of the catheter tube and through the proximal sealing port. When fluid is present, each sealing port will enlarge to establish a fluid-tight seal with the guidewire. A diverter can be disposed at the proximal sealing port to redirect the guidewire from the lumen and out of the catheter tube through the proximal sealing port.
摘要翻译：单腔快速交换导管包括远端密封端口和近端密封端口，其尺寸适于接收导丝以与其形成不透液密封。每个管状密封口具有长度和直径，并由亲水聚合物制成。在操作中，导丝插入穿过远端密封端口并且在导管管的肩部处并通过近端密封口从导管管出口。当存在流体时，每个密封口都将扩大，以与导丝形成流体密封。分流器可以设置在近端密封端口处，以将引导线从内腔重新导向，并通过近端密封端口离开导管管。

3. 发明授权

US4895166A Rotatable cutter for the lumen of a blood vesel 失效
标题翻译：用于血液囊腔的可旋转切割器
公开(公告)号：US4895166A
公开(公告)日：1990-01-23
申请号：US123713
申请日：1987-11-23
申请人： Andrew F. Farr , Herbert R. Radisch, Jr.
发明人： Andrew F. Farr , Herbert R. Radisch, Jr.
IPC分类号： A61B17/22 , A61B10/00
CPC分类号： A61B17/320758
摘要： A cutter penetrates at its forward end into, and excises, obstructive tissue in a lumen in a living being by providing two spaced external segments of a conical generally hollow portion with cutting surfaces at their edges. The cutter may have a forward portion of restricted dimensions to facilitate the penetration of the cutter into the obstructive tissue. A progressively expanding portion such as a truncated cone extends rearwardly from the portion of restricted dimensions. In this way, the cutter expands the area of excision of the obstructive tissue from the lumen wall at progressive positions rearwardly from the forward end. The obstructive tissue in the lumen at the progressively expanding positions may be excised at the positions of penetration of the obstructive tissue by rotating the cutter manually or by a motor. The cutter may then be moved forwardly to penetrate the obstructive tissue through an additional distance in the lumen. The cutter may also have a hollow portion of substantially constant dimensions, such as a hollow cylinder, at the laterally expanded end. This hollow cylinder is coupled to a torque tube which has strong and resilient properties to follow the contour of the lumen and to communicate a penetrating force to the forward end of the cutter and a torque to the cutter to rotate the cutter. A vacuum may be applied to the cutter through the torque tube to remove fragments of obstructive tissue excised from the lumen.
摘要翻译：切割器通过在其边缘处设置切割表面的两个具有锥形的中空部分的间隔开的外部部分，在其前端穿过其中并阻塞生物体腔内的阻塞性组织。切割器可以具有限制尺寸的前部，以便于切割器穿入阻塞性组织。逐渐扩大的部分，例如截头圆锥体从受限尺寸的部分向后延伸。以这种方式，切割器从前端向后扩展从阻塞性组织切除的区域。在逐渐扩大的位置处的内腔中的阻塞性组织可以通过手动或电动机旋转切割器在阻塞性组织的穿透位置处被切除。然后可以向前移动切割器以在管腔中通过另外的距离穿透阻塞性组织。切割器还可以在横向扩展的端部处具有基本恒定尺寸的中空部分，例如中空圆柱体。该中空圆柱体连接到扭矩管，该扭矩管具有强烈和弹性的特性，以跟随管腔的轮廓并且将穿透力传递到切割器的前端，并且向切割器传递扭矩以使切割器旋转。可以通过扭矩管向切割器施加真空以去除从内腔切除的阻塞性组织的碎片。

4. 发明授权

US08043311B2 Medical device systems 有权
标题翻译：医疗器械系统
公开(公告)号：US08043311B2
公开(公告)日：2011-10-25
申请号：US10744507
申请日：2003-12-22
申请人： Herbert R. Radisch, Jr. , Fuh-Sheng Chen , Show-Mean Wu
发明人： Herbert R. Radisch, Jr. , Fuh-Sheng Chen , Show-Mean Wu
IPC分类号： A61M29/00 , A61F2/06
CPC分类号： A61L29/126
摘要： Medical device systems and related methods are disclosed.
摘要翻译：公开了医疗装置系统及相关方法。

5. 发明授权

US5746968A Method for manufacturing a high strength angioplasty balloon 失效
标题翻译：制造高强度血管成形术球囊的方法
公开(公告)号：US5746968A
公开(公告)日：1998-05-05
申请号：US631525
申请日：1996-04-12
申请人： Herbert R. Radisch, Jr.
发明人： Herbert R. Radisch, Jr.
IPC分类号： A61M25/00 , B29C55/00 , B29C55/22 , B29C55/26 , B29C61/08 , B29C69/00 , B29D22/00 , B29D23/00 , B29C49/18
CPC分类号： B29C55/26 , B29C55/005 , B29K2105/24
摘要： A method of manufacturing polymeric material having enhanced structural integrity includes heating the material to a temperature between the material's glass transition temperature and the material's melt temperature. Once heated, the material is highly overstretched in a first direction and moderately overstretched in a second direction. The material is then held in the overstretched condition while it is allowed to cool to room temperature. Cooling is followed by reheating to a curing temperature. After curing for a predetermined period, the material is again allowed to cool. The completed material has high polymeric orientation in the first direction and moderate polymeric orientation in the second direction. Therefore, the material is characterized by enhanced structural integrity and absence of pinhole defects common to highly oriented polymeric materials.
摘要翻译：制造具有增强的结构完整性的聚合物材料的方法包括将材料加热到材料的玻璃化转变温度和材料的熔融温度之间的温度。一旦被加热，材料在第一方向上被高度过度地拉伸并且在第二方向上适度地过度拉伸。然后将材料保持在过度拉伸状态，同时使其冷却至室温。冷却后再加热至固化温度。固化预定时间后，再次使材料冷却。完成的材料在第一方向上具有高聚合物取向，在第二方向上具有适度的聚合物取向。因此，该材料的特征在于增强的结构完整性和高度取向的聚合物材料常见的针孔缺陷。

6. 发明授权

US5209727A Guide wire with integral angioplasty balloon 失效
标题翻译：导丝与整体血管成形术球囊
公开(公告)号：US5209727A
公开(公告)日：1993-05-11
申请号：US827330
申请日：1992-01-29
申请人： Herbert R. Radisch, Jr. , Andrew F. Farr
发明人： Herbert R. Radisch, Jr. , Andrew F. Farr
IPC分类号： A61M29/02
CPC分类号： A61M25/09 , A61M2025/09008 , A61M2025/09066
摘要： An angioplasty device for dilating the lumen of a human blood vessel has a balloon and a tubular guide wire bonded to one end of the balloon. The guide wire is in fluid communication with the balloon. A guide extension is bonded to the opposite end of the balloon from the guide wire. An elongated spring member is positioned within the balloon, and is bonded at one end of the spring to the guide wire and at the opposite end of the spring to the guide extension to interconnect the wire and the extension. The spring member is attached between the wire and the extension in compression to urge the balloon into a collapsed configuration when the balloon is not inflated with fluid. The guide wire is strengthened by bonding a helical structural member to the outer wall of the guide wire.
摘要翻译：用于扩张人血管腔的血管成形术装置具有气球和连接到气囊的一端的管状引导线。导丝与球囊流体连通。引导延伸部从引导线结合到球囊的相对端。细长的弹簧构件定位在球囊内，并且在弹簧的一端处连接到导丝线并且在弹簧的相对端处连接到引导件延伸部以使线材和延伸部互连。当气囊未被流体充气时，弹簧构件被连接在电线和延伸部之间以压缩，以将气囊推入塌缩构型。通过将螺旋结构构件接合到导丝的外壁来加强导丝。

7. 发明授权

US08246762B2 Implantable medical devices comprising bio-degradable alloys 有权
标题翻译：包括生物可降解合金的植入式医疗装置
公开(公告)号：US08246762B2
公开(公告)日：2012-08-21
申请号：US12684081
申请日：2010-01-07
申请人： Gordon F. Janko , Herbert R. Radisch, Jr. , Thomas A. Trozera
发明人： Gordon F. Janko , Herbert R. Radisch, Jr. , Thomas A. Trozera
IPC分类号： C22C38/04 , C22C38/10 , C22C38/18 , C22C38/40 , C22C38/12 , C22C38/14
CPC分类号： A61L31/022 , A61B17/064 , A61B17/8085 , A61B17/84 , A61B17/866 , A61B2017/00004 , A61C8/0012 , A61F2/82 , A61F2210/0004 , A61L31/148 , C22C38/04 , C22C38/44 , C22C38/48 , C22C38/50 , C22C38/52 , C22C38/58
摘要： The invention provides medical devices comprising high-strength alloys which degrade over time in the body of a human or animal, at controlled degradation rates, without generating emboli. In one embodiment the alloy is formed into a bone fixation device such as an anchor, screw, plate, support or rod. In another embodiment the alloy is formed into a tissue fastening device such as staple. In yet another embodiment, the alloy is formed into a dental implant or a stent.
摘要翻译：本发明提供包含高强度合金的医疗装置，其以受控的降解速率在人体或动物体内随时间推移而不产生栓塞。在一个实施例中，合金形成骨固定装置，例如锚固件，螺钉，板，支撑件或杆。在另一个实施方案中，合金被形成组织紧固装置如钉。在又一实施例中，合金被形成为牙科植入物或支架。

8. 发明授权

US07566319B2 Traction balloon 有权
标题翻译：牵引气球
公开(公告)号：US07566319B2
公开(公告)日：2009-07-28
申请号：US10828572
申请日：2004-04-21
申请人： Steven A. McAuley , Karen M. Cheves , Loren M. Crow , Gregory S. Kelley , Herbert R. Radisch, Jr. , Ricardo David Roman , Show-Mean Wu
发明人： Steven A. McAuley , Karen M. Cheves , Loren M. Crow , Gregory S. Kelley , Herbert R. Radisch, Jr. , Ricardo David Roman , Show-Mean Wu
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61M2025/1086
摘要： Balloon catheters and methods of making and using the same. A balloon catheter may include a catheter shaft and a balloon coupled thereto. A traction member may be coupled to the balloon catheter adjacent the balloon and may extend along a portion or all of the length of the balloon. The traction member can improve traction between the balloon and a target site.
摘要翻译：气球导管及其使用方法。气囊导管可以包括导管轴和与其联接的气囊。牵引构件可以与球囊邻近的球囊导管联接，并且可以沿气囊的一部分或全部长度延伸。牵引构件可以改善气球和目标位置之间的牵引力。

9. 发明授权

US06632231B2 Segmented balloon catheter blade 有权
标题翻译：分段球囊导管刀片
公开(公告)号：US06632231B2
公开(公告)日：2003-10-14
申请号：US09938010
申请日：2001-08-23
申请人： Herbert R. Radisch, Jr.
发明人： Herbert R. Radisch, Jr.
IPC分类号： A61B1708
CPC分类号： A61B17/320725 , A61B2017/22061 , A61M2025/1086
摘要： A device for incising a stenosis in the vasculature of a patient includes a plurality of blades mounted on a resilient base member. The blades are arranged in a pattern to allow for relative movement between adjacent blades. Specifically, at least one end portion of each blade is juxtaposed with an end portion of the next closest blade. The base member, in turn, is mounted on the external surface of an inflatable angioplasty balloon. When the balloon is inserted into the vasculature of a patient, positioned across a stenosis and subsequently inflated, the individually moveable blades form an effective cutting edge that conforms to the surface of the stenosis to effectively allow the stenosis to be incised to a substantially uniform depth.
摘要翻译：用于切除患者脉管系统中的狭窄的装置包括安装在弹性基体上的多个叶片。叶片以图案布置以允许相邻叶片之间的相对运动。具体地，每个叶片的至少一个端部与下一个最接近的叶片的端部并置。基部构件又安装在可膨胀的血管成形术气囊的外表面上。当气囊插入到患者的脉管系统中时，定位在狭窄处并随后膨胀，单独的可移动刀片形成符合狭窄表面的有效切割边缘，以有效地将狭窄切开至基本均匀的深度。

10. 发明授权

US06296651B1 Method of using neovascularization catheter 有权
标题翻译：使用新血管形成导管的方法
公开(公告)号：US06296651B1
公开(公告)日：2001-10-02
申请号：US09520070
申请日：2000-03-07
申请人： Banning Gray Lary , Herbert R. Radisch, Jr.
发明人： Banning Gray Lary , Herbert R. Radisch, Jr.
IPC分类号： A61B1732
CPC分类号： A61B17/3207 , A61B17/32002 , A61B17/320725 , A61B17/320783 , A61B2017/00247 , A61B2017/00252 , A61B2017/22044 , A61B2017/22069 , A61B2017/22072 , A61B2018/00392
摘要： The present invention is a device and a method for boring a perfusion channel from a coronary artery into a cardiac muscle of a patient. Structurally, the present invention includes a positioning catheter, anchor means and a cutting catheter. The cutting catheter includes a plurality of blades and is advanceable through a deployment lumen of the positioning catheter. Advancement of the cutting catheter through the deployment lumen causes a distal end of the cutting catheter to project laterally from the positioning catheter. In use, the positioning catheter is positioned within the coronary artery. The anchor means is then expanded to anchor the positioning catheter within the artery. The cutting catheter is then advanced through the deployment lumen to bore one or more perfusion channels in the myocardial tissue.
摘要翻译：本发明是一种用于将灌注通道从冠状动脉穿入患者的心肌的装置和方法。在结构上，本发明包括定位导管，锚定装置和切割导管。切割导管包括多个叶片，并且可以通过定位导管的展开内腔前进。通过展开腔导入切割导管导致切割导管的远端从定位导管横向突出。在使用中，定位导管位于冠状动脉内。然后将锚固装置膨胀以将定位导管锚定在动脉内。切割导管然后前进穿过展开腔以在心肌组织中穿过一个或多个灌注通道。

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