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1. 发明授权

US4185629A Method and apparatus for processing blood 失效
标题翻译：血液处理方法及装置
公开(公告)号：US4185629A
公开(公告)日：1980-01-29
申请号：US843222
申请日：1977-10-18
申请人： Herbert M. Cullis , James H. DeVries , David A. Lohr , Rodolfo R. Rodriquez , Michael B. Uffer
发明人： Herbert M. Cullis , James H. DeVries , David A. Lohr , Rodolfo R. Rodriquez , Michael B. Uffer
IPC分类号： A61M1/02 , A61M1/36 , B04B5/04 , A61M5/00 , B04B11/00
CPC分类号： A61M1/3693 , A61M1/3646 , A61M1/3696 , B04B5/0442 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355
摘要： The blood processing method, and the apparatus for performing the steps of the method are utilized in separating whole blood into its components and include the steps of, or component parts of the apparatus for carrying out these steps of: pumping whole blood from a donor; passing the whole blood through a first chamber in a centrifuge device: centrifuging the whole blood in the centrifuge device to cause sedimentation of red blood cells from the whole blood in, and separation of platelet rich plasma from the whole blood in, the first chamber; pumping the separated platelet rich plasma from the first chamber and out of the centrifuge device where it is monitored and then back into the centrifuge device and through a second chamber in the centrifuge device where the platelet rich plasma is centrifuged to cause sedimentation of the platelets therein while passing the remaining blood fluid though the first chamber and back to the donor; recombining the plasma passed through the second chamber with the blood fluid passed through the first chamber for return to the donor; monitoring the platelet rich plasma outisde of the centrifuge device and sensing the presence of red blood cells in the platelet rich plasma; stopping and then reversing movement of the platelet rich plasma mixed with red blood cells when a mixture is sensed to return the mixture of platelet rich plasma mixed with red blood cells to the first chamber for separation of the blood components; adjusting the difference in volumetric flow rates of the pump for the whole blood pump and the pump for platelet rich plasma in response to the sensing of red blood cells; repeating the above steps until a desired volume of whole blood has been processed, and stopping operation of the centrifuge device and removing the second chamber with platelets therein from the apparatus.
摘要翻译：血液处理方法和用于执行该方法的步骤的装置用于将全血分离成其组分，并且包括用于执行以下步骤的装置的步骤或组成部分：从供体泵送全血; 将全血通过离心机装置中的第一腔室：离心机中的全血离心，使全血中的红细胞沉淀，并将富血小板血浆从全血中分离出来; 将分离的富含血小板的血浆从第一腔室抽出并离开被监测的离心机装置，然后回到离心机装置中并通过离心机装置中的第二腔室，其中富血小板血浆被离心以引起血小板的沉淀同时使剩余的血液通过第一腔室并返回到供体; 将通过第二腔室的血浆与通过第一腔室的血液流体重新组合以返回供体; 监测离心机装置中富含血小板的血浆异常，并感测富血小板血浆中红细胞的存在; 当感测到混合物以使与红血细胞混合的富含血小板的血浆的混合物返回到第一腔室以分离血液成分时，停止然后反转与红细胞混合的富含血小板的血浆的运动，响应于红细胞的感测，调整全血泵的泵的体积流量与富含血小板的血浆泵的差异; 重复上述步骤，直到已经处理了所需体积的全血，并且停止操作离心机装置并从该装置中除去具有血小板的第二腔室。

2. 发明授权

US4151844A Method and apparatus for separating whole blood into its components and for automatically collecting one component 失效
标题翻译：用于将全血分离成其组分并自动收集一种组分的方法和装置
公开(公告)号：US4151844A
公开(公告)日：1979-05-01
申请号：US850624
申请日：1977-11-11
申请人： Herbert M. Cullis , Almond, Anthony L. , Michael B. Uffer , Mirza A. Kohja , Rodolfo R. Rodgriguez
发明人： Herbert M. Cullis , Almond, Anthony L. , Michael B. Uffer , Mirza A. Kohja , Rodolfo R. Rodgriguez
IPC分类号： G01N33/48 , A61K35/14 , A61M1/02 , A61M1/36 , B04B5/04 , A61M5/00
CPC分类号： B04B5/0442 , A61M1/3693 , A61M1/3696
摘要： The method, and the apparatus for carrying out the steps of the method, are utilized in the centrifugal liquid processing of whole blood wherein whole blood is withdrawn from a donor, passed through a fluid system and the blood is centrifuged to separate the same into at least three components. One component which is to be collected is withdrawn at a fixed rate of volumetric displacement while the other two components are withdrawn at variable rates of volumetric displacement. The other two components are recombined and returned to the donor. The withdrawal of the one component is optically monitored to determine whether or not either one of the other components is being mixed with the one component. When such a mixing is sensed, the rate of withdrawal of one of the other two components is increased while the rate of withdrawal of the other components is decreased thereby to ensure withdrawal of the desired one component, e.g., white blood cells with minimal contamination thereof with the other two components, e.g., red blood cells and plasma containing platelets. A given amount of the one component withdrawn is collected in a receptacle.
摘要翻译：该方法和用于实施该方法的装置用于全血的离心液体处理，其中全血从供体排出，通过流体系统，并将血液离心以将其分离成至少三个组成部分。要收集的一个组分以固定的体积位移速率取出，而另外两个组分以可变的体积位移速率取出。另外两个组分被重组并返回给供体。光学地监测一个组分的抽出，以确定其它组分中的任一个是否与一个组分混合。当感测到这种混合时，其他两种组分之一的提取速率增加，而其它组分的抽出速率降低，从而确保所需的一种组分例如白细胞的最小污染与其他两个组分，例如红细胞和血浆含血小板。将给定量的一个组分撤回收集在容器中。

3. 发明授权

US4146172A Centrifugal liquid processing system 失效
标题翻译：离心液体处理系统
公开(公告)号：US4146172A
公开(公告)日：1979-03-27
申请号：US843296
申请日：1977-10-18
申请人： Herbert M. Cullis , James H. DeVries
发明人： Herbert M. Cullis , James H. DeVries
IPC分类号： B04B5/00 , A61M1/02 , A61M1/36 , B04B5/04 , B04B5/02
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696
摘要： An intervivos blood processing system for centrifugally separating red blood cell and platelet components from whole blood includes a separation chamber for separating red blood cell and white blood cell components, and a collection chamber for collecting platelet components. Each chamber is formed with closely-spaced sidewalls defining respective generally flat interior chambers therebetween and is mounted on a rotatably driven carriage substantially tilted from a parallel arrangement with respect to the carriage axis of rotation at a slight angle whereby the red blood cell component is caused to collect in shoulder regions of the separation chamber and the platelet component is caused to collect on the sidewalls of the collection chamber. The processing chambers are preferably each formed from sheets of flexible hemo-compatible plastic sealed about their periphery to define the chambers therebetween, and are received on the carriage between removable carrier plates having recesses which define the shape of the chambers under fluid pressure.
摘要翻译：用于从全血中离心分离红细胞和血小板成分的相互作用血液处理系统包括用于分离红细胞和白细胞成分的分离室和用于收集血小板成分的收集室。每个室形成有紧密间隔的侧壁，其间限定相应的大致平坦的内部室，并且安装在可旋转地驱动的滑架上，该滑动架以相对于滑架的旋转轴线的平行布置基本上从稍微的角度倾斜，由此引起红细胞部件收集在分离室的肩部区域，并且使血小板成分收集在收集室的侧壁上。处理室优选地各自由柔性的可变血液相容的塑料片形成，围绕它们的周边密封以限定它们之间的腔室，并且被容纳在具有在流体压力下限定腔室的形状的凹部的可移除的载体板之间的滑架上。

4. 发明授权

US4934995A Blood component centrifuge having collapsible inner liner 失效
标题翻译：具有可折叠内衬的血液成分离心机
公开(公告)号：US4934995A
公开(公告)日：1990-06-19
申请号：US824182
申请日：1977-08-12
申请人： Herbert M. Cullis
发明人： Herbert M. Cullis
IPC分类号： B04B1/00 , B04B5/04 , C07K16/06 , C07K16/30 , F04B9/02 , F04B43/10
CPC分类号： C07K16/06 , B04B1/00 , B04B5/0428 , B04B5/0442 , C07K16/30 , F04B43/10 , F04B9/02 , B04B2005/045 , B04B2005/0464
摘要： A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer arcuate wall plus an inner circumferential wall, spaced from the outer wall, to define a arcuate slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.
摘要翻译：血液成分分离装置包括适于在离心机中围绕其轴旋转的离心机碗。碗定义了外弧形壁加上与外壁间隔开的内周壁，以限定适于接收血液成分的弧形槽。接入管适用于与槽连通。优选地，在狭槽中设置细长的，柔性的可折叠内衬。单独的进入管也可以与细长的可收缩容器的端部之间的细长的容器内部连通。此外，槽的一部分可以限定向外延伸的螺旋的形状，以在流体沿着狭槽移动时为其中的流体提供增加的重力场。

5. 发明授权

US4187979A Method and system for fractionating a quantity of blood into the components thereof 失效
$Method and system for fractionating a quantity of blood into the components thereof$
公开(公告)号：US4187979A
公开(公告)日：1980-02-12
申请号：US944640
申请日：1978-09-21
申请人： Herbert M. Cullis , Evelyn E. Dorsey , James H. De Vries
发明人： Herbert M. Cullis , Evelyn E. Dorsey , James H. De Vries
IPC分类号： A61M1/36 , B04B5/04 , B04B15/12
CPC分类号： B04B5/0442 , A61M1/3603 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2205/3306
摘要： The method, and system for carrying out the steps of the method, are utilized in taking whole blood from a supply of blood withdrawn from a donor or from a previously banked supply of whole blood in a container, centrifuging the blood in a centrifuge device to separate the whole blood into its components, and then collecting the components, namely red blood cells, white blood cells, platelets and plasma. The fractionation of the whole blood in the centrifuge device takes place in first, second and third separation chambers. The first chamber has a square shape and is positioned in the centrifuge device in a diamond position. Each corner of the first separation chamber has an opening. Whole blood is pumped into one side corner opening and red blood cells are withdrawn from the other side corner opening and returned to the container for recirculation through the first chamber. White blood cells, platelets and plasma are withdrawn from the upper corner opening and passed through the second chamber wherein white blood cells are separated by centrifugal force. The plasma and platelets are then withdrawn from the second chamber and passed through the third chamber wherein the platelets are separated from the plasma by centrifugal force. The plasma exiting from the third separation chamber is passed back into the bottom corner of the first chamber to cause a flow of plasma across the flow of whole blood and red blood cells to elute white blood cells and plateletstherefrom and to wash the red blood cells. By appropriate operation of electromechanically controlled clamps associated with tubing carrying the various blood components, plasma can be siphoned off into a plasma collection receptacle located outside the centrifuge device. After the red blood cells have been recirculated several times through the first separation chamber, the red blood cells then can be directed to a red blood cell collection receptacle by operation of other electromechanically controlled clamps.

6. 发明授权

US4120448A Centrifugal liquid processing apparatus with automatically positioned collection port 失效
标题翻译：离心液体处理设备具有自动定位的收集口
公开(公告)号：US4120448A
公开(公告)日：1978-10-17
申请号：US804697
申请日：1977-06-08
申请人： Herbert M. Cullis
发明人： Herbert M. Cullis
IPC分类号： B04B5/04 , B04B11/06
CPC分类号： B04B5/0442 , B04B2005/045
摘要： An intervivos blood processor includes a processing chamber wherein whole blood is separated into its red blood cell, white blood cell and plasma components in the presence of a centrifugal force field. The white blood cell component is removed from the chamber by means of a tubing segment having a free floating end within the chamber and a density corresponding to the density of the white blood cell component. Since the free end of the tubing assumes the same position in the chamber as the white blood cell component the tubing collects only this component notwithstanding variations in the flow rate of the blood through the chamber and the centifugal force field applied to the chamber.
摘要翻译：间歇血液处理器包括处理室，其中在存在离心力场的情况下，全血分离成其红细胞，白细胞和血浆成分。通过在腔室内具有自由浮动端的管段和与白细胞组分的密度相对应的密度将白细胞成分从腔室中除去。由于管道的自由端与白细胞组件在腔室中呈现相同的位置，所以管道仅收集该部件，尽管血液通过腔室的流速和施加到腔室的离心力场的变化。

7. 发明授权

US5217426A Combination disposable plastic blood receiving container and blood component centrifuge 失效
标题翻译：组合一次性塑料血液接收容器和血液成分离心机
公开(公告)号：US5217426A
公开(公告)日：1993-06-08
申请号：US744947
申请日：1991-08-14
申请人： David V. Bacehowski , Herbert M. Cullis , Armand R. VanBaelen
发明人： David V. Bacehowski , Herbert M. Cullis , Armand R. VanBaelen
IPC分类号： B04B1/00 , B04B5/04 , C07K16/06 , C07K16/30 , F04B9/02 , F04B43/10
CPC分类号： C07K16/06 , B04B1/00 , B04B5/0428 , B04B5/0442 , C07K16/30 , F04B43/10 , F04B9/02 , B04B2005/045 , B04B2005/0464
摘要： A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer arcuate wall plus an inner circumferential wall, spaced from the outer wall, to define a arcuate slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.
摘要翻译：血液成分分离装置包括适于在离心机中围绕其轴旋转的离心机碗。碗定义了外弧形壁加上与外壁间隔开的内周壁，以限定适于接收血液成分的弧形槽。接入管适用于与槽连通。优选地，在狭槽中设置细长的，柔性的可折叠内衬。单独的进入管也可以与细长的可收缩容器的端部之间的细长的容器内部连通。此外，槽的一部分可以限定向外延伸的螺旋的形状，以在流体沿着狭槽移动时为其中的流体提供增加的重力场。

8. 发明授权

US4829002A System for metering nutrient media to cell culture containers and method 失效
标题翻译：用于计量营养培养基至细胞培养容器和方法的系统
公开(公告)号：US4829002A
公开(公告)日：1989-05-09
申请号：US862344
申请日：1986-05-12
申请人： Martha C. Pattillo , David V. Bacehowski , Arnold C. Bilstad , Herbert M. Cullis , T. Michael Dennehey , James W. Yang , William C. Brown
发明人： Martha C. Pattillo , David V. Bacehowski , Arnold C. Bilstad , Herbert M. Cullis , T. Michael Dennehey , James W. Yang , William C. Brown
IPC分类号： C12M3/00 , C12M1/00 , C12M1/26 , C12N5/00 , C12N5/10
CPC分类号： C12M23/14 , C12M33/07
摘要： A system for metering nutrient media to cell culture containers includes a media flow conduit which defines at one end means for substantially aseptic communication with the source of the media. In a preferred embodiment, sterile connectors may be used for essentially sterile conditions. A branch conduit extends from the flow conduit at a location spaced from the ends. The branch conduit communicates with means for receiving a predetermined-volume aliquot of media through the media flow conduit from said one end. The flow conduit also defines a portion downstream from the branch conduit, which communicates with at least one cell culture container, each container being a flexible bag. At least part of the flexible bag is made of a material capable of providing at least 2 times the oxygen diffusion and at least 2 times the carbon dioxide diffusion between the bag interior and exterior, compared with an identically-sized, sealed bag having polyethylene walls 0.013 inch thick.
摘要翻译：用于向细胞培养容器计量营养培养基的系统包括介质流动管道，其在一端限定用于与介质源实质上无菌的通信。在优选的实施方案中，无菌连接器可用于基本上无菌的条件。分支导管在与端部间隔开的位置处从流动管道延伸。分支管道与用于从所述一端通过介质流动管道接收预定体积等分的介质的装置连通。流动导管还限定了与至少一个细胞培养容器连通的分支导管下游的部分，每个容器是柔性袋。与具有聚乙烯壁的相同尺寸的密封袋相比，柔性袋的至少一部分由能够提供至少2倍的氧扩散和袋内部和外部之间的二氧化碳扩散的材料制成。 0.013英寸厚

9. 发明授权

US4636193A Disposable centrifugal blood processing system 失效
标题翻译：一次性离心血液处理系统
公开(公告)号：US4636193A
公开(公告)日：1987-01-13
申请号：US872822
申请日：1986-06-11
申请人： Herbert M. Cullis
发明人： Herbert M. Cullis
IPC分类号： A61M1/36 , B04B5/04 , B04B7/08
CPC分类号： B04B5/0442 , A61M1/3693 , A61M1/3696 , B04B5/0428 , B04B2005/045 , B04B2005/0464
摘要： A continuous flow centrifugal processing system for separating whole blood into fractional components includes a centrifugal separator unit having a molded bowl-shaped outer shell dimensioned to fit within a rotatably-driven casing on an associated centrifuge apparatus. A bowl-shaped inner shell disposed within the outer shell forms therewith a thin separation channel radially spaced from the axis of rotation wherein fractions are separated from the whole blood under the influence of centrifugal force. A rotating seal carried on the processing chamber between ports in the chamber and the non-rotating portions of the system. The outer shell includes a relatively thin side wall portion which is inwardly biased toward a side wall portion on the inner shell when seated in the casing. A plurality of projections on the side walls limit inward deformation of the outer shell to maintain a very close concentric spacing between the shell members to facilitate rapid separation of blood flowing through the chamber. By reason of the shell members being molded, the processing chamber can be economically produced in large quantities for disposable one-time use.
摘要翻译：用于将全血分离成分数组分的连续流离心处理系统包括离心分离器单元，其具有模制的碗状外壳，其尺寸适于装配在相关联的离心机设备上的可旋转驱动的壳体内。设置在外壳内的碗形内壳形成与旋转轴线径向间隔开的薄的分离通道，其中部分在离心力的作用下与全血分离。旋转密封件承载在腔室中的端口与系统的非旋转部分之间的处理室中。外壳包括相当薄的侧壁部，当坐在壳体中时，该侧壁部向内偏压到内壳上的侧壁部分。侧壁上的多个突起限制外壳的向内变形，以保持壳体之间非常接近的同心间隔，以便于快速分离流过腔室的血液。由于外壳构件被模制，处理室可以经济地大量生产用于一次性一次使用。

10. 发明授权

US5759147A Blood separation chamber 失效
标题翻译：血液分离室
公开(公告)号：US5759147A
公开(公告)日：1998-06-02
申请号：US472671
申请日：1995-06-07
申请人： David V. Bacehowski , Herbert M. Cullis , Armand R. VanBaelen
发明人： David V. Bacehowski , Herbert M. Cullis , Armand R. VanBaelen
IPC分类号： B04B1/00 , B04B5/04 , C07K16/30 , F04B9/02 , F04B43/10 , B04B7/08
CPC分类号： F04B43/10 , B04B1/00 , B04B5/0428 , B04B5/0442 , C07K16/30 , F04B9/02 , B04B2005/045 , B04B2005/0464
摘要： A blood component separating device comprises a centrifuge bowl adapted for rotation about its axis in a centrifuge. The bowl defines an outer circumferential wall plus an inner circumferential wall, spaced from the outer wall, to define a circumferential slot adapted for receiving blood components. Access tubing is adapted for communication with the slot. Preferably, an elongated, flexible, collapsible inner liner is provided in the slot. Individual access tubing also may communicate with an elongated container interior between the ends of the elongated, collapsible container. Furthermore, a portion of the slot may define the shape of an outwardly extending spiral, to provide an increasing gravitational field upon fluids therein as the fluid moves along the slot.
摘要翻译：血液成分分离装置包括适于在离心机中围绕其轴旋转的离心机碗。碗限定外周壁加上与外壁间隔开的内周壁，以限定适于接收血液成分的圆周槽。接入管适用于与槽连通。优选地，在狭槽中设置细长的，柔性的可折叠内衬。单独的进入管也可以与细长的可收缩容器的端部之间的细长的容器内部连通。此外，槽的一部分可以限定向外延伸的螺旋的形状，以在流体沿着狭槽移动时为其中的流体提供增加的重力场。

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