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1. 发明专利

JP2015027455A マグネシウムおよびマグネシウム合金を含有する生体吸収性コンポジット材料ならびに前記コンポジットから作製されたインプラント有权
标题翻译：含有镁和镁合金的生物吸收性复合材料和从复合材料制成的植入物
公开(公告)号：JP2015027455A
公开(公告)日：2015-02-12
申请号：JP2014151852
申请日：2014-07-25
申请人：ヘレーウスメディカルゲゼルシャフトミットベシュレンクテルハフツングHeraeus Medical GmbH , Heraeus Medical Gmbh , ヘレーウスメディカルゲゼルシャフトミットベシュレンクテルハフツングHeraeus Medical GmbH , メディツィーニッシェウニヴェアズィテートグラーツMedizinische Universitaet Graz , Medizinische Universitaet Graz , メディツィーニッシェウニヴェアズィテートグラーツMedizinische Universitaet Graz
发明人： KUEHN KLAUS-DIETER , ANNELIE WEINBERG , PETER UGGOWITZER , VOGT SEBASTIAN , JOERG LOEFFLER
IPC分类号： A61L27/00 , C22C23/00
CPC分类号： A61L31/124 , A61F2/885 , A61F2220/005 , A61L27/047 , A61L27/54 , A61L27/58 , A61L31/028 , A61L31/148 , A61L31/16 , A61L2300/206 , A61L2300/23 , A61L2300/406 , A61L2300/414 , C22C21/06
摘要：【課題】マグネシウムおよびマグネシウム合金の好ましい特性を示すが、その欠点を補う材料を提供する。【解決手段】コンポジット材料を、純粋なマグネシウムもしくはマグネシウム合金から作製し、そこに10mg/L未満の室温(25℃)での水中の溶解度を有する1種以上の抗感染薬を含ませる。【選択図】なし
摘要翻译：要解决的问题：提供一种表现出镁镁合金优选特性的材料，并补救其缺陷。解决方案：复合材料由纯镁或镁合金制成，包括一种或多种抗感染药物，其具有在室温（25℃）下，在水中的溶解度小于10mg / L。

2. 发明专利

JP2012130707A Coating method and coating apparatus 有权
标题翻译：涂料方法和涂料装置
公开(公告)号：JP2012130707A
公开(公告)日：2012-07-12
申请号：JP2011281615
申请日：2011-12-22
申请人： Heraeus Medical Gmbh , ヘレーウスメディカルゲゼルシャフトミットベシュレンクテルハフツングHeraeus Medical GmbH
发明人： VOGT SEBASTIAN , KUEHN KLAUS-DIETER
IPC分类号： A61F2/28 , A61L27/00 , A61L31/00
CPC分类号： A61L31/16 , A61L27/306 , A61L27/32 , A61L27/54 , A61L31/086 , A61L31/088 , A61L2300/60 , A61L2430/24
摘要： PROBLEM TO BE SOLVED: To provide a simple and easily applied method and apparatus usable for coating a medical endoprosthesis without disturbing an ongoing operation (OR).SOLUTION: A medical implant having a surface to be coated is provided and brought into contact with an elastically deformable transfer means containing at least one liquid that contains at least one pharmaceutically active substance, and the liquid is transferred onto the medical implant from the transfer means by the contact with the transfer means. Particularly, immediately before the use, the liquid is led into the transfer means, preferably into a channel, at least one reservoir chamber, holes, fibers, and/or interposed spaces of the transfer means, or the transfer means is submerged in the liquid, and the liquid is transferred to the medical implant surface to be coated from the transfer means, preferably from the channel, at least one reservoir chamber, holes, fibers and/or interposed spaces of the transfer means.
摘要翻译：要解决的问题：提供一种简单且易于应用的方法和装置，其可用于涂覆医用内置假体，而不会干扰正在进行的操作（OR）。提供具有待涂覆表面的医用植入物，并与含有至少一种含有至少一种药物活性物质的液体的可弹性变形的转移装置接触，并将液体从医用植入物转移到医疗植入物上转印装置通过与转印装置的接触。特别地，在使用之前，将液体优选地引入传送装置，通道中，至少一个储存室，转印装置的孔，纤维和/或插入空间，或者转印装置浸没在液体中并且液体被转移到医疗植入物表面，以从转移装置，优选地从通道，至少一个储存室，孔，纤维和/或转移装置的插入空间中被涂覆。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2012130706A Coating method and coating apparatus 有权
标题翻译：涂料方法和涂料装置
公开(公告)号：JP2012130706A
公开(公告)日：2012-07-12
申请号：JP2011281607
申请日：2011-12-22
申请人： Heraeus Medical Gmbh , ヘレーウスメディカルゲゼルシャフトミットベシュレンクテルハフツングHeraeus Medical GmbH
发明人： VOGT SEBASTIAN , KUEHN KLAUS-DIETER
IPC分类号： A61L31/00 , A61F2/30 , A61K31/7036 , A61L27/00 , A61P31/04
CPC分类号： A61L27/54 , A61L2300/406 , A61L2420/02 , B05D1/18 , B05D2451/00 , B05D2401/40 , B05D2401/32
摘要： PROBLEM TO BE SOLVED: To provide a method and device which can be used to coat a medical implant simply and easily.SOLUTION: A surface to be coated is soaked in at least one liquid which contains at least one pharmaceutically active substance, the liquid is made to be transferred to the surface of the medical implant by the soaking, and the surface is drawn out from the liquid, a portion of the liquid remains adhering to the surface, the liquid is provided to a container which has an opening, and to coat the surface, the medical implant is introduced through the opening. The medical implant is introduced into the container where the liquid is arranged before soaked in the liquid, is drawn out from the container after the transition of the liquid to the medical implant, a portion of the transferred liquid is suitably wiped to be dropped by the wiper especially when drawing out the medical implant from the container, and the wiper is designed for this purpose.
摘要翻译：要解决的问题：提供可以简单且容易地用于涂覆医疗植入物的方法和装置。解决方案：待涂覆的表面浸泡在至少一种含有至少一种药物活性物质的液体中，通过浸泡将液体转移到医用植入物的表面，并将表面拉出从液体中，一部分液体保持粘附到表面，液体被提供到具有开口的容器，并且为了涂覆表面，医疗植入物通过开口引入。将医用植入物引入容器中，其中在液体中浸泡之前将液体排列在容器中，在将液体转移到医用植入物之后，将其从容器中抽出，一部分被转移的液体被适当地擦拭掉擦拭器特别是从容器中拔出医用植入物时，擦拭器是为此设计的。版权所有（C）2012，JPO＆INPIT

4. 发明专利

JP2013223721A Anti-infective spacer for osteosynthesis plate 有权
标题翻译：用于骨质疏松板的抗感染间隔物
公开(公告)号：JP2013223721A
公开(公告)日：2013-10-31
申请号：JP2013059179
申请日：2013-03-21
申请人： Heraeus Medical Gmbh , ヘレウスメディカルゲーエムベーハー
发明人： VOGT SEBASTIAN , KUEHN KLAUS-DIETER
IPC分类号： A61B17/68 , A61L31/00
CPC分类号： A61B17/8028 , A61B2017/00889 , A61B2017/00893 , A61F2250/0067
摘要： PROBLEM TO BE SOLVED: To provide an anti-infective spacer for osteosynthesis plates that ensures a safe distance between the osteosynthesis plates and a bone.SOLUTION: An anti-infective spacer 1 for osteosynthesis plates comprises a plate 1 having at least one opening 2 for accommodating a screw, wherein the plate is made up of at least one biocompatible material, and in the spacer, at least one antimicrobial substance is distributed, dispersed or dissolved. Also, a set is disclosed which comprises at least one osteosynthesis plate and at least one spacer 1, and preferably comprises at least one screw for each recess 2 of each spacer.
摘要翻译：要解决的问题：提供用于骨接合板的抗感染间隔物，其确保骨接合板和骨之间的安全距离。解剖：用于骨接合板的抗感染性间隔物1包括板1，板1具有至少一个开口2，用于容纳螺钉，其中所述板由至少一种生物相容性材料制成，并且在所述间隔物中，至少一种抗微生物物质被分散，分散或溶解。此外，公开了一种包括至少一个骨接合板和至少一个间隔物1的组，并且优选地包括用于每个间隔物的每个凹部2的至少一个螺钉。

5. 发明专利

JP2011240135A Antibiotic coating 有权
标题翻译：抗生素涂料
公开(公告)号：JP2011240135A
公开(公告)日：2011-12-01
申请号：JP2011104891
申请日：2011-05-10
申请人： Heraeus Medical Gmbh , ヘレウスメディカルゲーエムベーハー
发明人： VOGT SEBASTIAN , BUECHNER HUBERT , KUEHN KLAUS-DIETER
IPC分类号： A61L27/00
CPC分类号： A61L27/54 , A61L27/28 , A61L2300/406
摘要： PROBLEM TO BE SOLVED: To provide an implant having an antibiotic coating that is easily and relatively inexpensively produced, that sufficiently and stably sticks on a surface of the implant, that does not generate poisonous products, that can be dissolved in a body, that prevents crystallization of antibiotics existing in the coating, that ensures an antibiotic concentration that is high, and instantly and locally effective in parts of the implant.SOLUTION: The coating of the implant includes at least one antibiotic and at least one wetting agent selected from a group composed of water, a water-soluble polyol, an oligo-alkylene glycol, and amino acid.
摘要翻译：要解决的问题：为了提供具有容易且相对便宜地生产的抗生素涂层的植入物，其能够充分且稳定地粘附在植入物的表面上，其不会产生有毒物质，其可以溶解在体内，其防止存在于涂层中的抗生素的结晶，其确保抗生素浓度高，并且在植入物的部分中立即和局部有效。解决方案：植入物的包衣包括至少一种抗生素和至少一种选自水，水溶性多元醇，低聚亚烷基二醇和氨基酸的润湿剂。版权所有（C）2012，JPO＆INPIT

6. 发明专利

JP2014100559A Antiseptic polymethylmethacrylate bone cement 审中-公开
标题翻译：抗粘蛋白聚甲基丙烯酸酯骨水泥
公开(公告)号：JP2014100559A
公开(公告)日：2014-06-05
申请号：JP2013227629
申请日：2013-10-31
申请人： Heraeus Medical Gmbh , ヘレウスメディカルゲーエムベーハー
发明人： VOGT SEBASTIAN , KUEHN KLAUS-DIETER
IPC分类号： A61L24/00 , A61L27/00 , C08K5/101 , C08L33/06
CPC分类号： A61K33/40 , A61L24/0015 , A61L2300/11 , A61L2430/02 , C08L33/12 , C08L2312/00
摘要： PROBLEM TO BE SOLVED: To provide an antiseptic polymethyl methacrylate bone cement that can be used for mechanical fixation of primary total articular endoprostheses, for mechanical fixation of revision total articular endoprostheses, and for producing spacers.SOLUTION: The invention proposes an antiseptic composition for use as bone cement, in particular an antiseptic polymethylmethacrylate bone cement, that can be cured and comprises a content of at least one component that is a compound with an oxidizing effect or from which a compound with an oxidizing effect can be released. Preferably, hydrogen peroxide is an antiseptic agent having a strong bactericidal effect due to the oxidizing effect. In this context, it is particularly preferred to use an adduct, a salt, a chelate or a cocrystal of a hydrogen peroxide compound that releases hydrogen peroxide in the presence of water or aqueous conditions.
摘要翻译：要解决的问题：提供可用于初级全关节内假体的机械固定的抗菌性聚甲基丙烯酸甲酯骨粘固剂，用于修复全关节内假体的机械固定和用于制备间隔物。解决方案：本发明提出了一种使用的防腐组合物作为骨水泥，特别是防腐聚甲基丙烯酸甲酯骨粘固剂，其可以固化，并且包含作为具有氧化作用的化合物的至少一种成分的含量，或者可以从其中释放具有氧化作用的化合物。优选地，过氧化氢是由于氧化效果而具有强杀菌作用的防腐剂。在本文中，特别优选使用在水或水溶液条件下释放过氧化氢的过氧化氢化合物的加合物，盐，螯合物或共结晶。

7. 发明专利

CA2809115C ANTI-INFECTIVE SPACER FOR OSTEOSYNTHESIS PLATES 未知
公开(公告)号：CA2809115C
公开(公告)日：2016-05-03
申请号：CA2809115
申请日：2013-03-12
申请人： HERAEUS MEDICAL GMBH
发明人： VOGT SEBASTIAN , KUEHN KLAUS-DIETER
IPC分类号： A61L31/16 , A61B17/80 , A61L31/02 , A61L31/04
摘要： The invention relates to an anti-infective spacer for osteosynthesis plates comprising a plate having at least one opening for accommodating a screw, whereby the plate is made up of at least one biocompatible material, in which at least one antimicrobial substance is distributed, dispersed or dissolved. The invention also relates to a set comprising at least one osteosynthesis plate and at least one said spacer, preferably comprising at least one screw for each recess of each spacer.

8. 发明专利

CA2760893C METHOD FOR COATING A MEDICAL IMPLANT AND DEVICE THEREFOR 未知
公开(公告)号：CA2760893C
公开(公告)日：2015-01-27
申请号：CA2760893
申请日：2011-12-05
申请人： HERAEUS MEDICAL GMBH
发明人： VOGT SEBASTIAN , KUEHN KLAUS-DIETER
IPC分类号： B05D1/28 , A61L27/28 , A61L27/54
摘要： The invention relates to a method for coating, at least regions of, a medical implant, preferably of an artificial joint or a fixation for a joint, whereby a medical implant having a surface to be coated is provided and the medical implant surface to be coated is contacted with an elastically deformable transfer means that comprises at least one liquid that contains at least one pharmaceutically active substance, whereby the liquid is transferred from the transfer means to the medical implant surface through the contacting with the transfer means. The invention also relates to a device coating, at least regions of, a medical implant using a method of said type, whereby the device comprises an elastically deformable transfer means that comprises a liquid that contains at least one pharmaceutically active substance such that the liquid can be transferred to the medical implant when the transfer means is contacted with the medical implant surface to be coated.

9. 发明专利

DE102012006454A1 Antiinfektiver Abstandshalter für Osteosyntheseplatten 未知
公开(公告)号：DE102012006454A1
公开(公告)日：2013-10-02
申请号：DE102012006454
申请日：2012-03-30
申请人： HERAEUS MEDICAL GMBH
发明人： VOGT SEBASTIAN , KUEHN KLAUS-DIETER
IPC分类号： A61L27/54 , A61L27/04 , A61L27/10 , A61L27/16
摘要： Die Erfindung betrifft einen antiinfektiven Abstandhalter für Osteosyntheseplatten umfassend eine Platte mit mindestens einer Ausnehmung zur Aufnahme einer Schraube, wobei die Platte aus mindestens einem biokompatiblen Material aufgebaut ist, in dem mindestens eine antimikrobielle Substanz verteilt, dispergiert oder gelöst ist. Die Erfindung betrifft auch ein Set umfassend zumindest eine Ostheosyntheseplatte und zumindest einen solchen Abstandhalter, vorzugsweise umfassend wenigstens eine Schraube für jede Ausnehmung jedes Abstandhalters.

10. 发明专利

CA2760908A1 COATING METHOD AND COATING DEVICE 未知
公开(公告)号：CA2760908A1
公开(公告)日：2012-06-23
申请号：CA2760908
申请日：2011-12-05
申请人： HERAEUS MEDICAL GMBH
发明人： VOGT SEBASTIAN , KUEHN KLAUS-DIETER
IPC分类号： B05D1/28 , A61L27/28 , A61L27/54
摘要： The invention relates to a method for coating, at least regions of, a medical implant, preferably of an artificial joint or a fixation for a joint, whereby a medical implant having a surface to be coated is provided, the medical implant surface to be coated is immersed into a liquid comprising at least one pharmaceutically active substance, whereby liquid is transferred to the surface of the medical implant owing to the immersing, and the medical implant surface to be coated is pulled out of the liquid, whereby part of the liquid remains adhering to the medical implant surface to be coated. The invention also relates to a device for coating, at least regions of, a medical implant using said method, whereby the device comprises a container that has a liquid that contains at least one pharmaceutically active substance, and the container comprises an opening for introducing and pulling out the medical implant.

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