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1. 发明申请

US20100160755A1 Polyelectrolytes as Sublayers on Electrochemical Sensors 审中-公开
标题翻译：聚电解质作为电化学传感器的子层
公开(公告)号：US20100160755A1
公开(公告)日：2010-06-24
申请号：US12632623
申请日：2009-12-07
申请人： Henry W. Oviatt , James R. Petisce
发明人： Henry W. Oviatt , James R. Petisce
IPC分类号： A61B5/1473 , G01N27/26 , C12Q1/26 , C12Q1/00 , C12Q1/54
CPC分类号： C12Q1/001 , A61B5/14532 , A61B5/14865 , A61B5/415 , C12Q1/26 , C12Q1/54
摘要： Disclosed herein is an electrochemical sensor for measuring an analyte in a subject. More particularly, sensors comprising a polyelectrolyte layer at least partially covering the electroactive surface of an electrode are disclosed.
摘要翻译：本文公开了一种用于测量受试者中的分析物的电化学传感器。更具体地，公开了包括至少部分地覆盖电极的电活性表面的聚电解质层的传感器。

2. 发明申请

US20120283537A1 ANALYTE SENSOR LAYERS AND METHODS RELATED THERETO 审中-公开
标题翻译：分析传感器层及其相关方法
公开(公告)号：US20120283537A1
公开(公告)日：2012-11-08
申请号：US13503745
申请日：2010-10-28
申请人： James R. Petisce , Henry W. Oviatt
发明人： James R. Petisce , Henry W. Oviatt
IPC分类号： A61B5/1473 , G01N27/28
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/415 , C12Q1/002
摘要： Sensors for measuring an analyte in a subject comprising at least one electrode having an electroactive surface, at least one interferent-reducing layer comprising vinyl ester monomeric units disposed distally from the electroactive surface, an enzyme layer disposed distally from the electroactive surface and a flux-limiting membrane disposed over the at least one interferent-reducing layer and the enzyme layer. Methods of measuring an analyte in a subject comprising providing the electrochemical analyte sensor, contacting a sample comprising an analyte and an interferent with the at least one interferent-reducing layer comprising vinyl ester monomeric units, and measuring the analyte, where the amount of interferent reaching the electroactive surface is reduced.
摘要翻译：用于测量受试者中的分析物的传感器，包括至少一个具有电活性表面的电极，至少一个包含从电活性表面向远侧设置的乙烯基酯单体单元的干扰物减少层，远离电活性表面设置的酶层，设置在至少一个干扰物还原层和酶层上的限制膜。测量受试者中的分析物的方法，包括提供电化学分析物传感器，使包含分析物的样品和与包含乙烯基酯单体单元的至少一个干扰物降低层的干扰物接触，并测量分析物，其中干扰物达到的量电活性表面减少。

3. 发明申请

US20100160756A1 Membrane Layer for Electrochemical Biosensor and Method of Accommodating Electromagnetic and Radiofrequency Fields 审中-公开
标题翻译：电化学生物传感器膜层和容纳电磁场和射频场的方法
公开(公告)号：US20100160756A1
公开(公告)日：2010-06-24
申请号：US12636117
申请日：2009-12-11
申请人： James R. Petisce , Henry W. Oviatt
发明人： James R. Petisce , Henry W. Oviatt
IPC分类号： A61B5/1468 , A61B18/18
CPC分类号： C12Q1/002 , A61B5/14532 , A61B5/14542 , A61B5/14865 , A61B5/415
摘要： A method comprising providing an in vivo electrochemical biosensor, the biosensor comprising an electrode surface, a flux-limiting layer covering at least a portion of the electrode surface, covering at least a portion of the flux-limiting layer with a hydrophilic polymer membrane, and preventing or eliminating disruption of the output signal of the electrochemical biosensor by an external EMF or external RF source during in vivo use of the biosensor in a subject.
摘要翻译：一种包括提供体内电化学生物传感器的方法，所述生物传感器包括电极表面，覆盖所述电极表面的至少一部分的磁通限制层，用亲水性聚合物膜覆盖所述限流层的至少一部分，以及在对象体内使用生物传感器时，防止或消除外部EMF或外部RF源对电化学生物传感器的输出信号的破坏。

4. 发明申请

US20100243477A1 Analyte Sensor 审中-公开
标题翻译：分析物传感器
公开(公告)号：US20100243477A1
公开(公告)日：2010-09-30
申请号：US12547653
申请日：2009-08-26
申请人： Mena Valiket , James R. Petisce , Henry W. Oviatt
发明人： Mena Valiket , James R. Petisce , Henry W. Oviatt
IPC分类号： G01N27/26
CPC分类号： C12Q1/26 , A61B5/14532 , A61B5/14865 , A61B5/1495 , A61B5/6853 , C12Q1/54
摘要： Electrochemical sensors for measuring an analyte in a subject are described. More particularly, devices for measurement of an analyte incorporating a sensor comprising a hydrophilic polymer-enzyme composition covering an electroactive surface providing rapid and accurate analyte levels upon deployment are disclosed.
摘要翻译：描述了用于测量受试者中分析物的电化学传感器。更具体地，公开了用于测量包含传感器的分析物的装置，所述传感器包括覆盖电活性表面的亲水聚合物 - 酶组合物，其在部署时提供快速和准确的分析物水平。

5. 发明申请

US20110054284A1 Anti-Coagulant Calibrant Infusion Fluid Source 审中-公开
标题翻译：抗凝血剂校准液输液
公开(公告)号：US20110054284A1
公开(公告)日：2011-03-03
申请号：US12550151
申请日：2009-08-28
申请人： Henry W. Oviatt
发明人： Henry W. Oviatt
IPC分类号： A61B5/1473 , G01N33/487 , G01N27/26
CPC分类号： A61B5/14532 , A61B5/1473 , A61B5/1495 , A61B5/6852
摘要： Methods and systems for preventing or eliminating thrombus during use of a sensor are disclosed. The method comprises providing a calibrant infusion fluid source comprising a predetermined amount of a calibrant and adding a predetermined amount of a non-heparin anti-thrombotic agent into the calibrant infusion fluid source. A system and method is disclosed that includes an infusion calibrant source comprising a predetermined amount of a calibrant and a predetermined amount of a non-heparin anti-thrombotic agent with a glucose sensor.
摘要翻译：公开了在使用传感器期间预防或消除血栓的方法和系统。该方法包括提供包含预定量的校准物的校准液输注液源，并将预定量的非肝素抗血栓形成剂加入到校准液输注液源中。公开了一种系统和方法，其包括含有预定量的校准物和预定量的具有葡萄糖传感器的非肝素抗血栓形成剂的输注校正物源。

6. 发明授权

US07422607B2 Anti-calcification treatments for heart valves and vascular grafts 失效
标题翻译：心脏瓣膜和血管移植物的抗钙化治疗
公开(公告)号：US07422607B2
公开(公告)日：2008-09-09
申请号：US11209550
申请日：2005-08-23
申请人： Henry W. Oviatt , Neal K. Vail
发明人： Henry W. Oviatt , Neal K. Vail
IPC分类号： A61F2/02 , A61F2/76
CPC分类号： A61F2/2415 , A01N1/00 , A61L27/3683 , A61L27/50 , A61L2400/02 , A61L2430/40 , Y10S623/901 , Y10S623/915 , Y10S623/92
摘要： The present invention provides processes for fixation of biological tissue and/or post-fixation treatment of such tissue that result in modified tissues with reduced susceptibility to in vitro calcification when used in prosthetic devices. The invention also relates to calcification resistant biological tissue and to methods of using such tissue.
摘要翻译：本发明提供了用于固定生物组织的方法和/或这种组织的固定后处理，当用于假体装置时，其导致修饰的组织具有降低的体外钙化易感性。本发明还涉及抗钙化生物组织和使用这种组织的方法。

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