专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090041851A1 Composition for the delivery of live cells and methods of use thereof 审中-公开
标题翻译：用于递送活细胞的组合物及其使用方法
公开(公告)号：US20090041851A1
公开(公告)日：2009-02-12
申请号：US12070503
申请日：2008-02-19
申请人： Henry R. Costantino , Lawrence J. Bonassar , Mark A. Tracy
发明人： Henry R. Costantino , Lawrence J. Bonassar , Mark A. Tracy
IPC分类号： A61K35/12 , A61K9/14 , A61K35/32 , A61K35/39 , A61P3/10 , A61P19/04
CPC分类号： A61K35/32 , A61K35/30 , A61K35/39 , C12N5/0655 , C12N2531/00 , C12N2533/40
摘要： The invention relates to an improved method for administering live cells to a patient and compositions useful in the method. The composition comprises live cells and biocompatible, biodegradable polymer microparticles. The cells and microparticles of the cell/microparticle composition can be contacted immediately prior to administration, or can be contacted in culture for a specified period of time prior to administration. In the method of the invention, an effective amount of the cell/microparticle composition is administered to a patient in need thereof by injection to a treatment site of the patient to provide a therapeutic effect in the patient. The therapeutic effect can be, for example, the formation of new tissue at the treatment site, or the production and secretion of a biologically active secretory molecule at the treatment site. The therapeutic effect resulting from injection of the cell/microparticle composition into a treatment site, is determined by the type of cell present in the composition. The composition comprising lives cells and biocompatible, biodegradable polymer microparticles can further comprise a biologically active agent. In a preferred embodiment, the biologically active agent is incorporated into the microparticle. The biologically active agent can be, for example, factors which modulate cell growth.
摘要翻译：本发明涉及向患者施用活细胞的改进方法和用于该方法的组合物。该组合物包含活细胞和生物相容的可生物降解的聚合物微粒。细胞/微粒组合物的细胞和微粒可以在给药前立即接触，或者可以在施用之前在培养中接触指定的时间段。在本发明的方法中，将有效量的细胞/微粒组合物通过注射给患者的治疗部位给予有需要的患者，以在患者体内提供治疗效果。治疗效果可以是例如在治疗部位形成新组织，或者在治疗部位生产和分泌生物活性分泌分子。将细胞/微粒组合物注入治疗部位所产生的治疗效果由组合物中存在的细胞类型决定。包含生命细胞和生物相容的可生物降解的聚合物微粒的组合物可进一步包含生物活性剂。在优选的实施方案中，将生物活性剂掺入微粒中。生物活性剂可以是例如调节细胞生长的因子。

2. 发明授权

US06719970B1 Method of generating cartilage 失效
标题翻译：产生软骨的方法
公开(公告)号：US06719970B1
公开(公告)日：2004-04-13
申请号：US09612744
申请日：2000-07-10
申请人： Henry R. Costantino , Lawrence J. Bonassar , Mark A. Tracy
发明人： Henry R. Costantino , Lawrence J. Bonassar , Mark A. Tracy
IPC分类号： C12N506
CPC分类号： A61K35/32 , A61K35/30 , A61K35/39 , C12N5/0655 , C12N2531/00 , C12N2533/40
摘要： The invention relates to an improved method for administering live cells to a patient and compositions useful in the method. The composition comprises live cells and biocompatible, biodegradable polymer microparticles. The cells and microparticles of the cell/microparticle composition can be contacted immediately prior to administration, or can be contacted in culture for a specified period of time prior to administration. In the method of the invention, an effective amount of the cell/microparticle composition is administered to a patient in need thereof by injection to a treatment site of the patient to provide a therapeutic effect in the patient. The therapeutic effect can be, for example, the formation of new tissue at the treatment site, or the production and secretion of a biologically active secretory molecule at the treatment site. The composition comprising lives cells and biocompatible, biodegradable polymer microparticles can further comprise a biologically active agent. In a preferred embodiment, the biologically active agent is incorporated into the microparticle. The biologically active agent can be, for example, factors which modulate cell growth.
摘要翻译：本发明涉及向患者施用活细胞的改进方法和用于该方法的组合物。该组合物包含活细胞和生物相容的可生物降解的聚合物微粒。细胞/微粒组合物的细胞和微粒可以在给药前立即接触，或者可以在施用之前在培养中接触指定的时间段。在本发明的方法中，将有效量的细胞/微粒组合物通过注射给患者的治疗部位给予有需要的患者，以在患者体内提供治疗效果。治疗效果可以是例如在治疗部位形成新组织，或者在治疗部位生产和分泌生物活性分泌分子。包含生命细胞和生物相容的可生物降解的聚合物微粒的组合物可进一步包含生物活性剂。在优选的实施方案中，将生物活性剂掺入微粒中。生物活性剂可以是例如调节细胞生长的因子。

3. 发明授权

US06428815B1 Method of producing sub-micron particles of biologically active agents and uses thereof 失效
标题翻译：生产生物活性剂亚微米颗粒的方法及其应用
公开(公告)号：US06428815B1
公开(公告)日：2002-08-06
申请号：US09898524
申请日：2001-07-03
申请人： Henry R. Costantino , Warren E. Jaworowicz , Mark A. Tracy , Christopher P. Beganski
发明人： Henry R. Costantino , Warren E. Jaworowicz , Mark A. Tracy , Christopher P. Beganski
IPC分类号： A61K950
CPC分类号： A61K9/1688 , A61K9/1694 , Y10S977/906 , Y10T428/2985
摘要： Submicron particles of a biologically active agent are prepared by atomizing using multifluid atomization a dispersed system comprising at least one biologically active agent and at least one solvent to produce droplets, freezing the droplets to produce frozen droplets, lyophilizing the frozen droplets to obtain microstructures capable of being further fragmented into submicron particles by techniques such as probe sonication. The submicron particles can be incorporated into sustained release compositions having a reduced initial release of biologically active agent. The sustained release compositions can be administered to a human or animal.
摘要翻译：通过使用多流体雾化将包含至少一种生物活性剂和至少一种溶剂的分散系统进行雾化来制备生物活性剂的亚微米颗粒，以产生液滴，冷冻液滴以产生冷冻液滴，冻干冷冻液滴以获得能够通过诸如探针超声处理的技术进一步碎裂成亚微米颗粒。亚微米颗粒可以并入具有降低的生物活性剂的初始释放的缓释组合物中。持续释放组合物可以施用于人或动物。

4. 发明授权

US06284283B1 Method of producing sub-micron particles of biologically active agents and uses thereof 有权
标题翻译：生产生物活性剂亚微米颗粒的方法及其应用
公开(公告)号：US06284283B1
公开(公告)日：2001-09-04
申请号：US09422751
申请日：1999-10-21
申请人： Henry R. Costantino , Warren E. Jaworowicz , Mark A. Tracy , Christopher P. Beganski
发明人： Henry R. Costantino , Warren E. Jaworowicz , Mark A. Tracy , Christopher P. Beganski
IPC分类号： A61K950
CPC分类号： A61K9/1688 , A61K9/1694 , Y10S977/906 , Y10T428/2985
摘要： Submicron particles of a biologically active agent are prepared by atomizing using multifluid atomization a dispersed system comprising at least one biologically active agent and at least one solvent to produce droplets, freezing the droplets to produce frozen droplets, lyophilizing the frozen droplets to obtain microstructures capable of being further fragmented into submicron particles by techniques such as probe sonication. The submicron particles can be incorporated into sustained release compositions having a reduced initial release of biologically active agent. The sustained release compositions can be administered to a human or animal.
摘要翻译：通过使用多流体雾化将包含至少一种生物活性剂和至少一种溶剂的分散系统进行雾化来制备生物活性剂的亚微米颗粒，以产生液滴，冷冻液滴以产生冷冻液滴，冻干冷冻液滴以获得能够通过诸如探针超声处理的技术进一步碎裂成亚微米颗粒。亚微米颗粒可以并入具有降低的生物活性剂的初始释放的缓释组合物中。持续释放组合物可以施用于人或动物。

5. 发明授权

US07282216B2 Biocompatible polymer blends and uses thereof 失效
标题翻译：生物相容性聚合物共混物及其用途
公开(公告)号：US07282216B2
公开(公告)日：2007-10-16
申请号：US10293974
申请日：2002-11-12
申请人： Henry R. Costantino , Mark A. Tracy , Kevin L. Ward , Wendy W. Nelson
发明人： Henry R. Costantino , Mark A. Tracy , Kevin L. Ward , Wendy W. Nelson
IPC分类号： A61K9/22
CPC分类号： A61K9/1647
摘要： The present invention relates to a novel series of polymers which have been prepared by blending hydrophobic biocompatible, biodegradable polymers or copolymers, such as poly(lactide-co-glycolide), and a biocompatible, amphipathic copolymer having a water absorption ratio of about 2 or less. A process for the preparation of the novel polymer blends and sustained release compositions comprising the novel polymer blends are also part of the invention described herein. Further the sustained release compositions can be used to deliver a biologically active with a desirable release profile and in a sustained fashion to a patient in need thereof.
摘要翻译：本发明涉及一种新型的聚合物系列，其通过将疏水性生物相容的可生物降解的聚合物或共聚物如聚（丙交酯 - 共 - 乙交酯）和生物相容性两亲性共聚物与吸水比为约2或减。包含新型聚合物共混物的新型聚合物共混物和持续释放组合物的制备方法也是本文所述的本发明的一部分。此外，持续释放组合物可以用于以期望的释放曲线递送具有生物学活性并且以持续的方式递送给有需要的患者。

6. 发明申请

US20180331356A1 NANO-FEATURED POROUS SILICON MATERIALS 审中-公开
公开(公告)号：US20180331356A1
公开(公告)日：2018-11-15
申请号：US15752566
申请日：2016-08-12
申请人： Christopher Timmons , Chad Goodwin , Henry R. Costantino , Sarah Fredrick , Sakshaug J. Avery , Benjamin E. Kron , Katharine Geramita , Leah A. Thompkins , Aaron M. Feaver , EnerG2 Technologies, Inc.
发明人： Aaron M. Feaver , Leah A. Thompkins , Katharine Geramita , Benjamin E. Kron , Avery J. Sakshaug , Sarah Fredrick , Henry R. Costantino , Chad Goodwin , Christopher Timmons
IPC分类号： H01M4/38 , C01B33/021 , H01M10/0525
CPC分类号： H01M4/386 , C01B33/021 , C01P2002/72 , C01P2002/85 , C01P2004/03 , C01P2006/10 , C01P2006/11 , C01P2006/12 , C01P2006/14 , C01P2006/16 , C01P2006/17 , C01P2006/21 , C01P2006/40 , C01P2006/80 , C23F1/00 , H01M4/366 , H01M4/587 , H01M10/0525 , H01M2004/021 , H01M2004/027
摘要： Porous silicon and methods for preparation and use of the same are disclosed. The porous silicon materials have utility either alone or in combination with other materials, for example, combined with carbon particles for energy storage applications.

7. 发明申请

US20180294484A1 LOW-GASSING CARBON MATERIALS FOR IMPROVING PERFORMANCE OF LEAD ACID BATTERIES 审中-公开
公开(公告)号：US20180294484A1
公开(公告)日：2018-10-11
申请号：US15766321
申请日：2016-10-14
申请人： Sarah FREDRICK , Avery SAKSHAUG , Benjamin E. KRON , Dion HUBBLE , Henry R. COSTANTINO , Aaron M. FEAVER , Leah A. THOMPKINS , Virginia Katherine ALSPAUGH , Phil HAMILTON , Katharine GERAMITA , Corey MEKELBURG , Frank REUTER , Jacob Ebenstein GROSE , Rebekka VON BENTEN , EnerG2 Technologies, Inc.
发明人： Sarah Fredrick , Avery J. Sakshaug , Benjamin E. Kron , Dion Hubble , Henry R. Costantino , Aaron M. Feaver , Leah A. Thompkins , Virginia Katherine Alspaugh , Phil Hamilton , Katharine Geramita , Cory Mekelburg , Frank Reuter , Jacob Ebenstein Grose , Rebekka Von Benten
IPC分类号： H01M4/66 , H01M4/14 , C01B32/05 , G01N27/30 , H01M4/62
摘要： Carbon materials having low gassing properties and electrodes and electrical energy storage devices, especially lead-acid batteries, comprising the same are provided.

8. 发明授权

US09993425B2 Compositions for intranasal delivery of human insulin and uses thereof 有权
公开(公告)号：US09993425B2
公开(公告)日：2018-06-12
申请号：US13314080
申请日：2011-12-07
申请人： Henry R. Costantino , Annemarie Stoudt Cohen , Anthony P. Sileno
发明人： Henry R. Costantino , Annemarie Stoudt Cohen , Anthony P. Sileno
IPC分类号： A61K38/28 , A61K9/00 , A61K47/40
CPC分类号： A61K9/0043 , A61K38/28 , A61K47/40
摘要： What is described is a pharmaceutical formulation for intranasal delivery of insulin to a patient, comprising an aqueous mixture of human insulin, a solubilizing agent, a surface active agent, and a thickening agent, wherein said formulation provides a ultra-rapid acting profile to regular human insulin.

9. 发明申请

US20130004841A1 CARBON - LEAD BLENDS FOR USE IN HYBRID ENERGY STORAGE DEVICES 审中-公开
标题翻译：碳 - 用于混合能源储存装置的铅混合物
公开(公告)号：US20130004841A1
公开(公告)日：2013-01-03
申请号：US13486731
申请日：2012-06-01
申请人： Leah A. Thompkins , Aaron M. Feaver , Henry R. Costantino , Alan Tzu-Yang Chang , Katharine Geramita , Avery Sakshaug
发明人： Leah A. Thompkins , Aaron M. Feaver , Henry R. Costantino , Alan Tzu-Yang Chang , Katharine Geramita , Avery Sakshaug
IPC分类号： H01M4/36 , H01M10/08 , H01M4/58 , H01M4/56 , H01M4/60
CPC分类号： H01M4/625 , C08K3/04 , C08K3/08 , C08K7/22 , H01B1/02 , H01B1/04 , H01B1/18 , H01G11/50 , H01M4/14 , H01M4/56 , H01M4/583 , H01M10/06 , H01M2004/021 , Y02E60/126 , Y02E60/13 , Y02T10/7016 , Y02T10/7022
摘要： The present application is directed to blends comprising a plurality of carbon particles and a plurality of lead particles. The blends find utility in any number of electrical devices, for example, in lead acid batteries. Methods for making and using the blends are also disclosed.
摘要翻译：本申请涉及包含多个碳颗粒和多个铅颗粒的共混物。混合物可用于任何数量的电气设备，例如铅酸电池。还公开了制备和使用共混物的方法。

10. 发明授权

US08129339B2 Microencapsulation and sustained release of biologically active polypeptides 有权
标题翻译：生物活性多肽的微囊化和持续释放
公开(公告)号：US08129339B2
公开(公告)日：2012-03-06
申请号：US12289857
申请日：2008-11-06
申请人： Henry R. Costantino , Joyce M. Hotz , James R. Dasch , M. Gary I. Riley , Paul A. Burke , Susan A. Steitz-Abadi , Stephen E. Zale
发明人： Henry R. Costantino , Joyce M. Hotz , James R. Dasch , M. Gary I. Riley , Paul A. Burke , Susan A. Steitz-Abadi , Stephen E. Zale
IPC分类号： A61K38/00 , A61K38/28 , A61P5/50 , A61P3/08 , A61P3/10 , A61P7/12
CPC分类号： A61K9/5031 , A61K9/1611 , A61K9/1623 , A61K9/1647 , A61K38/2278
摘要： The invention relates to compositions and methods for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein a biologically active polypeptide, and a corticosteroid to modify the release profile and provide increased bioavailability.
摘要翻译：本发明涉及用于持续释放生物活性多肽的组合物和方法。本发明的持续释放组合物包含其中分散有生物活性多肽的生物相容性聚合物和用于改变释放曲线并提供增加的生物利用度的皮质类固醇。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式