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1. 发明授权

US06290957B1 Anti-IgE antibodies and method of improving polypeptides 有权
标题翻译：抗IgE抗体和改善多肽的方法
公开(公告)号：US06290957B1
公开(公告)日：2001-09-18
申请号：US09296005
申请日：1999-04-21
申请人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
发明人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
IPC分类号： A61K39395
CPC分类号： C07K16/00 , A61K38/00 , C07K16/4291 , C07K2317/24 , Y10S424/81 , Y10S530/868
摘要： The present invention relates to a method for adjusting the affuinity of a polypeptide to a target molecule by a combination of steps, including: (1) the identification of aspartyl residues which are prone to isomerization; (2) the substitution of alternative residues and screening the resulting mutants for affinity against the target molecule. In a preferred embodiment, the method of subtituting residues is affinity maturation with phage display (AMPD). In a further preferred embodiment the polypeptide is an antibody and the target molecule is an antigen. In a further preferred embodiment, the antibody is anti-IgE and the target molecule is IgE. In another embodiment, the invention relates to an anti-IgE antibody having improved affinity to IgE.
摘要翻译：本发明涉及通过步骤的组合来调节多肽与靶分子的亲和力的方法，包括：（1）鉴定易于异构化的天冬氨酰残基; （2）替代替代残基并筛选得到的突变体对靶分子的亲合力。在优选的实施方案中，残基残基的方法是用噬菌体展示（AMPD）进行亲和力成熟。在另一优选实施方案中，多肽是抗体，靶分子是抗原。在另一个优选的实施方案中，抗体是抗IgE，靶分子是IgE。在另一个实施方案中，本发明涉及对IgE具有改善的亲和力的抗IgE抗体。

2. 发明授权

US07157085B2 Method for treating IgE-mediated disorders 有权
标题翻译：治疗IgE介导的疾病的方法
公开(公告)号：US07157085B2
公开(公告)日：2007-01-02
申请号：US10791619
申请日：2004-03-02
申请人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
发明人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
IPC分类号： A61K39/395
CPC分类号： C07K16/4291 , A61K39/39566 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to a method for adjusting the affinity of a polypeptide to a target molecule by a combination of steps, including: (1) the identification of aspartyl residues which are prone to isomerization; (2) the substitution of alternative residues and screening the resulting mutants for affinity against the target molecule. In a preferred embodiment, the method of subtituting residues is affinity maturation with phage display (AMPD). In a further preferred embodiment the polypeptide is an antibody and the target molecule is an antigen. In a further preferred embodiment, the antibody is anti-IgE and the target molecule is IgE. In another embodiment, the invention relates to an anti-IgE antibody having improved affinity to IgE.
摘要翻译：本发明涉及通过以下步骤的组合来调节多肽与靶分子的亲和力的方法，包括：（1）鉴定易于异构化的天冬氨酰残基; （2）替代替代残基并筛选得到的突变体对靶分子的亲合力。在优选的实施方案中，残基残基的方法是用噬菌体展示（AMPD）进行亲和力成熟。在另一优选实施方案中，多肽是抗体，靶分子是抗原。在另一个优选的实施方案中，抗体是抗IgE，靶分子是IgE。在另一个实施方案中，本发明涉及对IgE具有改善的亲和力的抗IgE抗体。

3. 发明授权

US06761889B2 Anti-IgE antibodies 有权
标题翻译：抗IgE抗体
公开(公告)号：US06761889B2
公开(公告)日：2004-07-13
申请号：US10113996
申请日：2002-04-01
申请人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
发明人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
IPC分类号： A61K39395
CPC分类号： C07K16/00 , A61K38/00 , C07K16/4291 , C07K2317/24 , Y10S424/81 , Y10S530/868
摘要： The present invention relates to a method for adjusting the affinity of a polypeptide to a target molecule by a combination of steps, including: (1) the identification of aspartyl residues which are prone to isomerization; (2) the substitution of alternative residues and screening the resulting mutants for affinity against the target molecule. In a preferred embodiment, the method of subtituting residues is affinity maturation with phage display (AMPD). In a further preferred embodiment the polypeptide is an antibody and the target molecule is an antigen. In a further preferred embodiment, the antibody is anti-lgE and the target molecule is lgE. In another embodiment, the invention relates to an anti-IgE antibody having improved affinity to IgE.
摘要翻译：本发明涉及通过以下步骤的组合来调节多肽与靶分子的亲和力的方法，包括：（1）鉴定易于异构化的天冬氨酰残基; （2）替代替代残基并筛选得到的突变体对靶分子的亲合力。在优选的实施方案中，残基残基的方法是用噬菌体展示（AMPD）进行亲和力成熟。在另一优选实施方案中，多肽是抗体，靶分子是抗原。在另一个优选的实施方案中，抗体是抗-IgE，靶分子是IgG。在另一个实施方案中，本发明涉及对IgE具有改善的亲和力的抗IgE抗体。

4. 发明授权

US06682735B2 Anti-IgE antibodies 有权
标题翻译：抗IgE抗体
公开(公告)号：US06682735B2
公开(公告)日：2004-01-27
申请号：US09920171
申请日：2001-08-01
申请人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
发明人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
IPC分类号： A61K39395
CPC分类号： C07K16/00 , A61K38/00 , C07K16/4291 , C07K2317/24 , Y10S424/81 , Y10S530/868
摘要： The present invention relates to a method for adjusting the affinity of a polypeptide to a target molecule by a combination of steps, including: (1) the identification of aspartyl residues which are prone to isomerization; (2) the substitution of alternative residues and screening the resulting mutants for affinity against the target molecule. In a preferred embodiment, the method of subtituting residues is affinity maturation with phage display (AMPD). In a further preferred embodiment the polypeptide is an antibody and the target molecule is an antigen. In a further preferred embodiment, the antibody is anti-IgE and the target molecule is IgE. In another embodiment, the invention relates to an anti-IgE antibody having improved affinity to IgE.
摘要翻译：本发明涉及通过以下步骤的组合来调节多肽与靶分子的亲和力的方法，包括：（1）鉴定易于异构化的天冬氨酰残基; （2）替代替代残基并筛选得到的突变体对靶分子的亲合力。在优选的实施方案中，取代残基的方法是用噬菌体展示（AMPD）进行亲和力成熟。在另一优选实施方案中，多肽是抗体，靶分子是抗原。在另一个优选的实施方案中，抗体是抗IgE，靶分子是IgE。在另一个实施方案中，本发明涉及对IgE具有改善的亲和力的抗IgE抗体。

5. 发明授权

US06172213B2 Anti-IgE antibodies and method of improving polypeptides 失效
标题翻译：抗IgE抗体和改善多肽的方法
公开(公告)号：US06172213B2
公开(公告)日：2001-01-09
申请号：US09109207
申请日：1998-06-30
申请人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
发明人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
IPC分类号： C07H2104
CPC分类号： C07K16/4291 , A61K39/39566 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to a method for adjusting the affinity of a polypeptide to a target molecule by a combination of steps, including: (1) the identification of aspartyl residues which are prone to isomerization; (2) the substitution of alternative residues and screening the resulting mutants for affinity against the target molecule. In a preferred embodiment, the method of substituting residues is affinity maturation with phage display (AMPD). In a further preferred embodiment the polypeptide is an antibody and the target molecule is an antigen. In a further preferred embodiment, the antibody is anti-IgE and the target molecule is IgE. In another embodiment, the invention relates to an anti-IgE antibody having improved affinity to IgE.
摘要翻译：本发明涉及通过以下步骤的组合来调节多肽与靶分子的亲和力的方法，包括：（1）鉴定易于异构化的天冬氨酰残基; （2）替代替代残基并筛选得到的突变体对靶分子的亲合力。在优选的实施方案中，取代残基的方法是用噬菌体展示（AMPD）进行亲和力成熟。在另一优选实施方案中，多肽是抗体，靶分子是抗原。在另一个优选的实施方案中，抗体是抗IgE，靶分子是IgE。在另一个实施方案中，本发明涉及对IgE具有改善的亲和力的抗IgE抗体。

6. 发明授权

US06723833B1 Therapeutic compositions comprising anti-IGE antibodies and immunosuppressive agent 有权
标题翻译：包含抗IGE抗体和免疫抑制剂的治疗组合物
公开(公告)号：US06723833B1
公开(公告)日：2004-04-20
申请号：US09716028
申请日：2000-11-17
申请人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
发明人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
IPC分类号： C07K1600
CPC分类号： C07K16/4291 , A61K39/39566 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to a method for adjusting the affinity of a polypeptide to a target molecule by a combination of steps, including: (1) the identification of aspartyl residues which are prone to isomerization; (2) the substitution of alternative residues and screening the resulting mutants for affinity against the target molecule. In a preferred embodiment, the method of substituting residues is affinity maturation with phage display (AMPD). In a further preferred embodiment the polypeptide is an antibody and the target molecule is an antigen. In a further preferred embodiment, the antibody is anti-IgE and the target molecule is IgE. In another embodiment, the invention relates to an anti-IgE antibody having improved affinity to IgE.
摘要翻译：本发明涉及通过以下步骤的组合来调节多肽与靶分子的亲和力的方法，包括：（1）鉴定易于异构化的天冬氨酰残基; （2）替代替代残基并筛选得到的突变体对靶分子的亲合力。在优选的实施方案中，取代残基的方法是用噬菌体展示（AMPD）进行亲和力成熟。在另一优选实施方案中，多肽是抗体，靶分子是抗原。在另一个优选的实施方案中，抗体是抗IgE，靶分子是IgE。在另一个实施方案中，本发明涉及对IgE具有改善的亲和力的抗IgE抗体。

7. 发明授权

US5994511A Anti-IgE antibodies and methods of improving polypeptides 失效
标题翻译：抗IgE抗体和改善多肽的方法
公开(公告)号：US5994511A
公开(公告)日：1999-11-30
申请号：US887352
申请日：1997-07-02
申请人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
发明人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
IPC分类号： C12N15/02 , A61K38/00 , A61K39/395 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07K16/00 , C07K16/42 , C12N15/13 , C12P21/08
CPC分类号： C07K16/00 , C07K16/4291 , A61K38/00 , C07K2317/24 , Y10S424/81 , Y10S530/868
摘要： The present invention relates to a method for adjusting the affinity of a polypeptide to a target molecule by a combination of steps, including: (1) the identification of aspartyl residues which are prone to isomerization; (2) the substitution of alternative residues and screening the resulting mutants for affinity against the target molecule. In a preferred embodiment, the method of subtituting residues is affinity maturation with phage display (AMPD). In a further preferred embodiment the polypeptide is an antibody and the target molecule is an antigen. In a further preferred embodiment, the antibody is anti-IgE and the target molecule is IgE. In another embodiment, the invention relates to an anti-IgE antibody having improved affinity to IgE.
摘要翻译：本发明涉及通过以下步骤的组合来调节多肽与靶分子的亲和力的方法，包括：（1）鉴定易于异构化的天冬氨酰残基; （2）替代替代残基并筛选得到的突变体对靶分子的亲合力。在优选的实施方案中，残基残基的方法是用噬菌体展示（AMPD）进行亲和力成熟。在另一优选实施方案中，多肽是抗体，靶分子是抗原。在另一个优选的实施方案中，抗体是抗IgE，靶分子是IgE。在另一个实施方案中，本发明涉及对IgE具有改善的亲和力的抗IgE抗体。

8. 发明申请

US20100136005A1 Method of Treatment Using Humanized Anti-CD11a Antibodies 审中-公开
标题翻译：人源化抗CD11a抗体治疗方法
公开(公告)号：US20100136005A1
公开(公告)日：2010-06-03
申请号：US12624379
申请日：2009-11-23
申请人： Paula M. Jardieu , Leonard G. Presta
发明人： Paula M. Jardieu , Leonard G. Presta
IPC分类号： A61K39/395 , A61P37/06 , A61P1/06
CPC分类号： C07K16/2845 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2319/00
摘要： Humanized anti-CD11a antibodies and various uses therefor are disclosed. The humanized anti-CD11a antibody may bind specifically to human CD11a I-domain, have an IC50(nM) value of no more than about 1 nM for preventing adhesion of Jurkat cells to normal human epidermal keratinocytes expressing ICAM-1, and/or an IC50 (nM) value of no more than about 1 nM in the mixed lymphocyte response assay.
摘要翻译：公开了人源化抗CD11a抗体及其各种用途。和/或表达ICA-1的人类抗CD11a抗体可以特异性结合人CD11a I-结构域，具有不大于约1nM的IC 50（nM）值以防止Jurkat细胞粘附到正常的人表皮角化细胞上，和/或在混合淋巴细胞反应测定中IC50（nM）值不超过约1nM。

9. 发明授权

US06914129B2 Anti-IgE antibodies 失效
标题翻译：抗IgE抗体
公开(公告)号：US06914129B2
公开(公告)日：2005-07-05
申请号：US09925179
申请日：2001-08-08
申请人： Paula M. Jardieu , Leonard G. Presta
发明人： Paula M. Jardieu , Leonard G. Presta
IPC分类号： A61K38/00 , C07K16/00 , C07K16/18 , C07K16/32 , C07K16/42 , C07K16/46 , C12P21/08 , A61K39/395
CPC分类号： C07K16/00 , A61K38/00 , C07K16/18 , C07K16/32 , C07K16/4291 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/565 , C07K2319/00
摘要： The present invention describes IgE antagonists (including variant anti-IgE antibodies) and their use in diagnosis, therapy or prophylaxis of allergic and other IgE-mediated disorders, including asthma, food allergies, hypersensitivity and anaphylactic reactions.
摘要翻译：本发明描述了IgE拮抗剂（包括变体抗IgE抗体）及其在诊断，治疗或预防过敏性和其它IgE介导的障碍（包括哮喘，食物过敏，超敏反应和过敏反应）中的用途。

10. 发明授权

US6037453A Immunoglobulin variants 失效
标题翻译：免疫球蛋白变体
公开(公告)号：US6037453A
公开(公告)日：2000-03-14
申请号：US466151
申请日：1995-06-06
申请人： Paula M. Jardieu , Leonard G. Presta
发明人： Paula M. Jardieu , Leonard G. Presta
IPC分类号： C07K16/42 , C07K16/18 , C07K16/28 , C07K16/44
CPC分类号： C07K16/4291 , C07K2317/24 , C07K2317/31
摘要： Two classes of polypeptides derived from human IgE are described. One class binds selectively to the high affinity IgE receptor on mast cells and basophils, but not to the low affinity IgE receptor on B-cells, monocytes, eosinophils and platelets. The other class binds to the low affinity receptor, but not the high affinity receptor. The differential binding polypeptides of this invention are useful in diagnostic procedures for IgE receptors or in the therapy of IgE-mediated disorders such as allergies. They also are useful in preparing antibodies capable of binding regions of IgE that participate in receptor binding.
摘要翻译：描述了衍生自人IgE的两类多肽。一类与肥大细胞和嗜碱性粒细胞上的高亲和力IgE受体有选择性结合，但不结合B细胞，单核细胞，嗜酸性粒细胞和血小板上的低亲和力IgE受体。另一类与低亲和力受体结合，但不结合高亲和力受体。本发明的差异结合多肽可用于IgE受体的诊断程序或IgE介导的疾病如过敏的治疗。它们也可用于制备能够结合参与受体结合的IgE区域的抗体。

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