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1. 发明授权

US5539129A Nonionic amphiphilic compounds derived from glycerol, a process for preparing them, and corresponding intermediate compounds 失效
标题翻译：衍生自甘油的非离子两亲化合物，其制备方法和相应的中间体化合物
公开(公告)号：US5539129A
公开(公告)日：1996-07-23
申请号：US278961
申请日：1994-07-22
申请人： Alexandre Zysman , Henri Sebag , Alain Ribier , Guy Vanlerberghe , Claude Mahieu , Claude Berthelot
发明人： Alexandre Zysman , Henri Sebag , Alain Ribier , Guy Vanlerberghe , Claude Mahieu , Claude Berthelot
IPC分类号： A61K8/30 , A61K8/00 , A61K8/04 , A61K8/11 , A61K8/14 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/41 , A61K8/46 , A61K8/49 , A61K8/64 , A61K8/72 , A61K8/86 , A61K8/89 , A61K8/891 , A61K8/97 , A61K8/98 , A61K9/10 , A61K9/107 , A61K9/127 , A61K47/10 , A61Q1/00 , A61Q1/04 , A61Q1/06 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C07C41/26 , C07C43/11 , C07C43/13 , C07C43/178 , C07C43/23 , C07C69/33 , C07C323/12 , C07D317/22 , C07C43/30 , C07D317/00
CPC分类号： C07D317/22 , A61K8/14 , A61K8/39 , A61Q19/00 , C07C323/12 , C07C43/11 , C07C43/135 , C07C43/178 , C07C43/23 , C07C69/33 , A61Q1/06 , A61Q17/04 , A61Q19/002 , A61Q19/04 , A61Q19/08 , Y10S514/846 , Y10S514/847 , Y10S514/941 , Y10S514/944 , Y10S516/01 , Y10T428/2984
摘要： ##STR1## Non-ionic amphiphilic, glycerol-derived compounds having formula (I), where R is a radical selected from the group consisting of C
4-28 branched or linear alkenyl or alkyl radicals or mixtures thereof, or is a --CH
2 A grouping in which A is --OR', --SR, (II) where R' is a saturated or unsaturated hydrocarbonated radical and n represents an average statistical value n greater than 1 and equal to or less than 6; and, when R' is a --CH
2 A radical, n is also 2. These compounds are surface-active agents and some may form vesicles.
摘要翻译：（I）（II）具有式（I）的非离子两亲性甘油衍生化合物，其中R是选自C4-28支链或直链烯基或烷基或基团的基团或者是其中A是-OR'，-SR，（II）的-CH 2 A基团，其中R'是饱和或不饱和的烃基，n表示大于1且等于或小于6的平均统计值n ; 当R'是-CH 2 A基团时，n也是2.这些化合物是表面活性剂，一些可以形成囊泡。

2. 发明授权

US5164488A New hemiacetal compounds and the applications thereof 失效
标题翻译：新型HEMIACETAL化合物及其应用
公开(公告)号：US5164488A
公开(公告)日：1992-11-17
申请号：US654517
申请日：1991-02-13
申请人： Guy Vanlerberghe , Alexandre Zysman , Henri Sebag
发明人： Guy Vanlerberghe , Alexandre Zysman , Henri Sebag
IPC分类号： A61K8/14 , A61K9/127 , A61K47/48 , A61Q19/00 , B01F17/32 , B01J13/02 , C07B41/00 , C07B43/00 , C07C43/04 , C07C43/11 , C07C43/13 , C07C43/178 , C07C43/305 , C07C217/08 , C07C323/12 , C07D319/06 , C07D319/12 , C07D321/08 , C07K16/00
CPC分类号： A61Q19/00 , A61K47/48238 , A61K47/48815 , A61K8/14 , A61K9/1272 , C07C217/08 , C07C323/00 , C07C323/12 , C07C43/11 , C07C43/135 , C07C43/178 , C07D319/12 , C07D321/08 , A61K2800/57 , Y10S424/812 , Y10S530/81 , Y10T428/2984
摘要： The invention relates to compounds of formula: ##STR1## in which m, n, p and q are equal to 0 or 1, p being different from q and the sum m+n+p+q being equal to 2, A denotes a nonionic chain arrangement chosen from the groups:C.sub.2 H.sub.4 O.sub.r and/orC.sub.3 H.sub.5 (OH)O.sub.s,in which r denotes a number which can assume all integral values between 0 and 5 or a statistical average value between 0 and 20,s denotes a number which can assume all integral values between 0 and 5 or a statistical average value between 0 and 10,u is equal to 0 or 1, with the restriction that when u=0, s and r are also zero,R denotes(i) a linear or branched hydrocarbon radical which has 1 to 32 carbon atoms and can contain one or more oxygen atoms in the chain or bear one or more OH groups or(ii) a (C.sub.8 -C.sub.18 alkyl)phenyl radical.These compounds can be used for preparing stable chemical compounds, for conveying active substances or for forming vesicles.

3. 发明授权

US4277581A Polyamino-polyamide crosslinked with crosslinking agent 失效
公开(公告)号：US4277581A
公开(公告)日：1981-07-07
申请号：US57684
申请日：1979-07-16
申请人： Guy Vanlerberghe , Henri Sebag , Jean-Francois Grollier , Alexandre Zysman
发明人： Guy Vanlerberghe , Henri Sebag , Jean-Francois Grollier , Alexandre Zysman
IPC分类号： A61K8/88 , A61Q5/00 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/12 , C08G69/48
CPC分类号： A61Q5/12 , A61K8/88 , A61Q5/00 , A61Q5/02 , A61Q5/04 , A61Q5/06 , C08G69/48
摘要： A cosmetic composition for the hair comprises at least one water-soluble crosslinked polymer obtained by crosslinking a polyamino-polyamide with a crosslinking agent, said polyamino-polyamide being prepared by the polycondensation of (a) an acidic compound selected from the group consisting of (i) organic dicarboxylic acid, (ii) ethylenically unsaturated aliphatic mono- or di-carboxylic acid, (iii) ester of said acids of (i) and (ii), and (iv) mixtures of (i), (ii) and (iii) on (b) a polyamine selected from the group consisting of bis-primary and mono- and bis-secondary polyalkylene polyamines, said polyamine (b) being replaceable by a member selected from the group consisting of (1) 0-20 mole percent hexamethylene diamine, (2) 0-40 mole percent bis-primary amine and (3) 0-40 mole percent bis-secondary amine, said crosslinking agent being selected from the group consisting of (a') simple bi-functional compounds selected from bis-halohydrins, bis-azetidinium, bis-haloacyl diamine and alkyl bis-halides, (b') oligomers obtained by the reaction of (1') a compound selected from the group consisting of the compounds in (a') above or an epihalohydrin,a bis-epoxide, or a bis-unsaturated derivative with (2') a compound reactive with the compound in (1'), and (c') the quaternized compounds comprising said crosslinked polymer alkylated with an alkylating agent selected from the group consisting of (a) epoxides, (b) ethylenically unsaturated compounds, (c) chloroacetic acid, and (d) alkane sultone selected from the group consisting of propane sultone and butane sultone. The crosslinking agent is employed in amounts of 0.025-0.35 mole per amine group in said polyamino-polyamide. The said crosslinked polymer is soluble in water in amounts of 10 weight percent thereof without essentially any gel formation and a 10 weight percent aqueous solution of the said crosslinked polymer has a viscosity greater than 3 centipoises at 25.degree. C.

4. 发明授权

US4172887A Hair conditioning compositions containing crosslinked polyaminopolyamides 失效
标题翻译：含有交联聚氨基多酰胺的调理组合物
公开(公告)号：US4172887A
公开(公告)日：1979-10-30
申请号：US762804
申请日：1977-01-26
申请人： Guy Vanlerberghe , Henri Sebag , Jean-Francois Grollier , Alexandre Zysman
发明人： Guy Vanlerberghe , Henri Sebag , Jean-Francois Grollier , Alexandre Zysman
IPC分类号： A61K8/88 , A61Q5/00 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/12 , A61K7/06 , A61K7/08 , A61K7/09 , A61K7/11
CPC分类号： A61Q5/12 , A61K8/88 , A61Q5/06 , A61Q5/02 , A61Q5/04 , Y10S424/02
摘要： A cosmetic composition for the hair comprises at least one water-soluble crosslinked polymer selected from the group consisting of (1) crosslinked polymer obtained by crosslinking a polyamino-polyamide with a crosslinking agent, said polyamino-polyamide being prepared by the polycondensation of (a) an acidic compound selected from the group consisting of (i) organic dicarboxylic acid, (ii) ethylenically unsaturated aliphatic mono- or di- carboxylic acid, (iii) ester of said acids of (i) and (ii), and (iv) mixtures of (i), (ii) and (iii) on (b) a polyamine selected from the group consisting of bis primary and mono- or bis-secondary polyalkylene polyamines, said polyamine (b) being replaceable by a member selected from the group consisting of (1) 0-20 mole percent hexamethylene diamine, (2) 0-40 mole percent bis-primary amine and (3) 0-40 mole percent bis-secondary amine, said crosslinking agent being selected from the group consisting of epihalohydrins, diepoxides, dianhydrides and bis unsaturated derivatives, and being employed in amounts of 0.025-0.35 mole per amine group in said polyamino-polyamide and (2) the crosslinked polymer of (1) alkylated with an alkylating agent selected from the group consisting of (a) epoxides, (b) ethylenically unsaturated compounds, (c) chloroacetic acid, and (d) alkane sultone selected from the group consisting of propane sultone and butane sultone. The said crosslinked polymer is soluble in water in amounts of 10 weight percent thereof without essentially any gel formation and a 10 weight percent aqueous solution of the said crosslinked polymer has a viscosity greater than 3 centipoises at 25.degree. C.
摘要翻译：用于毛发的化妆品组合物包含至少一种水溶性交联聚合物，其选自（1）通过交联聚氨基 - 聚酰胺与交联剂交联而获得的交联聚合物，所述聚氨基聚酰胺是通过（a ）选自（i）有机二羧酸，（ii）烯键式不饱和脂族单或二羧酸的酸性化合物，（iii）所述酸（i）和（ii）的酯和（iv （i），（ii）和（iii）的混合物在（b）选自双原料和单 - 或二 - 仲聚亚烷基多胺的多胺中，所述多胺（b）可以由选自由（1）0-20摩尔％六亚甲基二胺，（2）0-40摩尔％双 - 伯胺和（3）0-40摩尔％双仲胺组成的组，所述交联剂选自的表卤代醇，二环氧化物，二酐和双不饱和衍生物，并且在所述聚氨基聚酰胺中以每个胺基计0.025-0.35摩尔的量使用（2）（1）烷基化剂与（a）环氧化物，（b）的烷基化剂烷基化的交联聚合物）烯键式不饱和化合物，（c）氯乙酸和（d）选自丙烷磺内酯和丁烷磺内酯的烷基磺内酯。所述交联聚合物以10重量％的量溶解在水中而基本上没有任何凝胶形成，并且所述交联聚合物的10重量％水溶液的粘度在25℃下具有大于3厘泊的粘度。

5. 发明授权

US5149860A Lipid compounds derived from sphingosines, process for preparing these and their applications, in particular in cosmetics and in the pharmacy of skin conditions 失效
标题翻译：衍生自丝胶蛋白的脂质化合物，制备这些及其应用的方法，特别是化妆品和皮肤条件的药物
公开(公告)号：US5149860A
公开(公告)日：1992-09-22
申请号：US585653
申请日：1990-09-20
申请人： Alexandre Zysman , Guy Vanlerberghe , Henri Sebag
发明人： Alexandre Zysman , Guy Vanlerberghe , Henri Sebag
IPC分类号： A61K31/23 , A61K8/00 , A61K8/04 , A61K8/14 , A61K8/66 , A61K8/68 , A61K8/92 , A61K8/97 , A61K8/98 , A61K8/99 , A61K9/127 , A61K47/18 , A61P17/00 , A61Q19/00 , C07C269/04 , C07C271/16
CPC分类号： A61Q5/00 , A61K47/18 , A61K8/06 , A61K8/062 , A61K8/14 , A61K8/68 , A61K9/0014 , A61K9/1272 , A61Q19/00 , C07C271/16
摘要： The invention relates to a lipid compound of formula (I): ##STR1## where R.sub.1 denotes a C.sub.11 to C.sub.21 alkyl or alkenyl radical and R.sub.2 denotes a linear or branched C.sub.8 to C.sub.30 hydrocarbon radical, saturated or bearing one or more ethylenically unsaturated bonds, and also to a process for preparing it and to compositions for cosmetic use of pharmaceutical use for skin conditions containing this compound.
摘要翻译：本发明涉及式（I）的脂质化合物：其中R 1表示C 11至C 21烷基或烯基，R 2表示直链或支链C 8至C 30烃基，饱和或带有一个或多个烯属不饱和键，以及其制备方法和用于化妆品用于含有该化合物的皮肤病症的药物用组合物。

6. 发明授权

US4371517A Composition for treating fibrous materials, based on cationic and anionic polymers 失效
标题翻译：用于处理基于阳离子和阴离子聚合物的纤维材料的组合物
公开(公告)号：US4371517A
公开(公告)日：1983-02-01
申请号：US75197
申请日：1979-09-12
申请人： Guy Vanlerberghe , Henri Sebag , Alexandre Zysman , Claude Dubief
发明人： Guy Vanlerberghe , Henri Sebag , Alexandre Zysman , Claude Dubief
IPC分类号： D06M15/00 , A61K8/00 , A61K8/20 , A61K8/23 , A61K8/36 , A61K8/365 , A61K8/81 , A61K8/84 , A61K8/88 , A61K8/91 , A61Q5/00 , A61Q5/02 , A61Q5/10 , C11D3/02 , C11D3/37 , D06L1/12 , D06M15/19 , D06M15/263 , D06M15/61 , D06M101/12 , A61K7/06 , D06M9/00
CPC分类号： C11D3/046 , A61K8/8147 , A61K8/8164 , A61K8/817 , A61K8/8182 , A61K8/84 , A61K8/88 , A61K8/91 , A61Q5/02 , C11D3/3703 , C11D3/3719 , C11D3/3723 , C11D3/3773 , D06M15/263 , D06M15/61 , A61K2800/5424 , A61K2800/5426 , A61K2800/594
摘要： The invention provides compositions intended for the treatment of fibrous materials. These compositions contain at least one cationic polymer, at least one anionic polymer, at least one alkali metal salt and at least one non-ionic surface-active agent or surface-active agent which contains one or more carboxyl or carboxylate groups in addition to non-ionic groups.
摘要翻译：本发明提供了用于处理纤维材料的组合物。这些组合物包含至少一种阳离子聚合物，至少一种阴离子聚合物，至少一种碱金属盐和至少一种非离子表面活性剂或表面活性剂，其除了非离子表面活性剂或非表面活性剂之外还含有一个或多个羧基或羧酸酯基团非离子基团。

7. 发明授权

US4349532A Cosmetic compositions based on poly-(quaternary ammonium) polymers 失效
标题翻译：基于聚（季铵）聚合物的化妆品组合物
公开(公告)号：US4349532A
公开(公告)日：1982-09-14
申请号：US942319
申请日：1978-09-14
申请人： Guy Vanlerberghe , Henri Sebag , Alexandre Zysman
发明人： Guy Vanlerberghe , Henri Sebag , Alexandre Zysman
IPC分类号： C08L79/00 , A61K20060101 , A61K8/00 , A61K8/72 , A61K8/84 , A61Q5/00 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/10 , A61Q5/12 , B01F17/18 , C07D295/16 , C08G20060101 , C08G73/00 , C08G73/02 , C08G73/06 , C08L20060101 , C08L67/00 , C08L77/00 , C11D3/37 , A61K7/06 , A61K7/09 , A61K7/11 , A61K7/13
CPC分类号： A61K8/84 , A61Q5/06 , A61Q5/12 , Y10S424/04
摘要： Composition suitable for treating the hair or skin, which conains at least one poly-(quaternary ammonium) polymer having units of the formula: ##STR1## in which A denotes an alkylene, hydroxyalkylene, alkenylene or alkynylene radical;B denotes:(a) --O--Z--O-- in which Z denotes a hydrocarbon radical or a group ##STR2## in which x and 4 denote a number from 1 to 4; (b) a bis-secondary diamine radical;(c) a radical --NH--Y--NH-- in which Y denotes a hydrocarbon radical or the radical --CH.sub.2 --CH.sub.2 --S--S--CH.sub.2 --CH.sub.2 --; or(d) a group --NH--CO--NH--;R.sub.1 denotes C.sub.1 -C.sub.4 alkyl; R.sub.2 denotes a hydrocarbon radical or two R.sub.2 radicals can complete a radical ##STR3## X denotes a halide; and n is 1 or an integer from 3 to 10. The polymers used in the composition of the invention have a good compatibility with anionic surface-active agents, are degradable and do not accumulate on the hair.
摘要翻译：组合物，其适用于处理头发或皮肤，其含有至少一种具有下式的单元的聚（季铵）聚合物：其中A表示亚烷基，羟基亚烷基，亚烯基或亚炔基; B表示：（a）-O-Z-O-，其中Z表示烃基或基团，其中x和4表示1至4的数; （b）二仲二胺基团; （c）基团-NH-Y-NH-，其中Y表示烃基或基团-CH2-CH2-S-S-CH2-CH2-; 或（d）基团-NH-CO-NH-; R1表示C1-C4烷基; R2表示烃基或两个R2基团可以完成基团X表示卤化物; 并且n为1或3至10的整数。本发明组合物中使用的聚合物与阴离子表面活性剂具有良好的相容性，是可降解的并且不会积聚在头发上。

8. 发明授权

US4275054A Deodorants or deodorisers and compositions containing them 失效
标题翻译：除臭剂或除臭剂及含有它们的组合物
公开(公告)号：US4275054A
公开(公告)日：1981-06-23
申请号：US69859
申请日：1979-08-27
申请人： Henri Sebag , Alexandre Zysman , Guy Vanlerberghe
发明人： Henri Sebag , Alexandre Zysman , Guy Vanlerberghe
IPC分类号： C08F8/00 , A61K8/00 , A61L9/01 , A61Q15/00 , C08F8/14 , C08G69/48 , C08G73/02 , C08G85/00 , C08L77/00 , C08F8/44 , A61K7/32 , A61K9/14 , C08F8/46
CPC分类号： A61K8/88 , A61Q15/00 , C08G73/0233 , Y10S424/05
摘要： A polyanionic polyamide salt which comprises chain units of the formula: ##STR1## in which X denotes ##STR2## R being an aliphatic radical containing 1 to 4 carbon atoms, each Y independently denotes a divalent aliphatic or cycloaliphatic radical, Z denotes a divalent radical of the formula: ##STR3## and M.sup.+ denotes a sodium or potassium ion or a quaternary ammonium ion of the formula: ##STR4## in which each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently denotes a hydrogen atom or a methyl, ethyl, hydroxymethyl, hydroxyethyl, hydroxypropyl, methylhydroxypropyl or methyl-dihydroxypropyl radical, the viscosity of a 5% by weight aqueous solution of the salt being from 1 to 500 centipoises at a temperature of 25.degree. C., are provided which act as deodorants and deodorisers.
摘要翻译：一种聚阴离子聚酰胺盐，其包含下式的链单元：其中X表示R 1为含有1至4个碳原子的脂族基团，每个Y独立地表示二价脂族或脂环族基团，Z表示二价基团其中，R 1，R 2，R 3和R 4各自独立地表示氢原子或甲基，乙基，羟甲基羟乙基，羟丙基，甲基羟丙基或甲基 - 二羟丙基，在25℃的温度下，5重量％盐的水溶液的粘度为1至500厘泊，其用作除臭剂和除臭剂。

9. 发明授权

US5362494A Cosmetic, dermo-pharmaceutical or vesicle-containing composition including clycerol-derived compounds 失效
标题翻译：含有甘油衍生化合物的化妆品，皮肤药物或含囊泡的组合物
公开(公告)号：US5362494A
公开(公告)日：1994-11-08
申请号：US910174
申请日：1992-07-14
申请人： Alexandre Zysman , Henri Sebag , Alain Ribier , Guy Vanlerberghe , Claude Mahieu , Claude Berthelot
发明人： Alexandre Zysman , Henri Sebag , Alain Ribier , Guy Vanlerberghe , Claude Mahieu , Claude Berthelot
IPC分类号： A61K8/30 , A61K8/00 , A61K8/04 , A61K8/11 , A61K8/14 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/41 , A61K8/46 , A61K8/49 , A61K8/64 , A61K8/72 , A61K8/86 , A61K8/89 , A61K8/891 , A61K8/97 , A61K8/98 , A61K9/10 , A61K9/107 , A61K9/127 , A61K47/10 , A61Q1/00 , A61Q1/04 , A61Q1/06 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , C07C41/26 , C07C43/11 , C07C43/13 , C07C43/178 , C07C43/23 , C07C69/33 , C07C323/12 , C07D317/22 , A61K7/40
CPC分类号： C07D317/22 , A61K8/14 , A61K8/39 , A61Q19/00 , C07C323/12 , C07C43/11 , C07C43/135 , C07C43/178 , C07C43/23 , C07C69/33 , A61Q1/06 , A61Q17/04 , A61Q19/002 , A61Q19/04 , A61Q19/08 , Y10S514/846 , Y10S514/847 , Y10S514/941 , Y10S514/944 , Y10S516/01 , Y10T428/2984
摘要： ##STR1## Non-ionic amphiphilic, glycerol-derived compounds having formula (I), where R is a radical selected from the group consisting of C
4-28 branched or linear alkenyl or alkyl radicals or mixtures thereof, or is a --CH
2 A grouping in which A is --OR', --SR, (II) where R' is a saturated or unsaturated hydrocarbonated radical and n represents an average statistical value n greater than 1 and equal to or less than 6; and, when R' is a --CH
2 A radical, n is also 2. These compounds are surface-active agents and some may form vesicles.
摘要翻译：（I）（II）具有式（I）的非离子两亲性甘油衍生化合物，其中R是选自C4-28支链或直链烯基或烷基或基团的基团或者是其中A是-OR'，-SR，（II）的-CH 2 A基团，其中R'是饱和或不饱和的烃基，n表示大于1且等于或小于6的平均统计值n ; 当R'是-CH 2 A基团时，n也是2.这些化合物是表面活性剂，一些可以形成囊泡。

10. 发明授权

US5198470A Lipid compounds derived from sphingosines, process for preparing these and their applications, in particular in cosmetics and in the pharmacy of skin conditions 失效
标题翻译：衍生自鞘氨醇的脂质化合物，其制备方法及其应用，特别是在化妆品和皮肤病症药物中
公开(公告)号：US5198470A
公开(公告)日：1993-03-30
申请号：US904503
申请日：1992-06-25
申请人： Alexandre Zysman , Guy Vanlerberghe , Henri Sebag
发明人： Alexandre Zysman , Guy Vanlerberghe , Henri Sebag
IPC分类号： A61K8/14 , A61K8/68 , A61K9/127 , A61K47/18 , A61Q19/00 , C07C271/16
CPC分类号： A61Q5/00 , A61K47/18 , A61K8/14 , A61K8/68 , A61K9/0014 , A61K9/1272 , A61Q19/00 , C07C271/16 , Y10S514/844 , Y10S514/852 , Y10S514/88
摘要： The invention relates to a lipid compound of formula (I): ##STR1## where R.sub.1 denotes a C.sub.11 to C.sub.21 alkyl or alkenyl radical and R.sub.2 denotes a linear or branched C.sub.8 to C.sub.30 hydrocarbon radical, saturated or bearing one or more ethylenically unsaturated bonds, and also to a process for preparing it and to compositions for cosmetic use or pharmaceutical use for skin conditions containing this compound.
摘要翻译：本发明涉及式（I）的脂质化合物：其中R 1表示C 11至C 21烷基或烯基，R 2表示直链或支链C 8至C 30烃基，饱和或带有一个或多个烯属不饱和键，以及其制备方法和用于化妆品用途的组合物或含有该化合物的皮肤病症的药物用途。

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