专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

标题翻译：脂肪代谢相关生理学可能性的预测

公开(公告)号：WO2010060996A2

公开(公告)日：2010-06-03

申请号：PCT/EP2009/066003

申请日：2009-11-27

申请人： Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) , SUHRE, Karsten , GIEGER, Christian

发明人： SUHRE, Karsten , GIEGER, Christian

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172

摘要： The present invention relates to a method for determining a predisposition of a human subject for physiological susceptibilities that result from alterations in lipid metabolism, wherein the physiological susceptibilities are selected from sensitivity to functional food, physical health schemes, identification of non-responsiveness to treatment by diet or physical activity. The present invention further relates to a method for determining a predisposition of a human subject for physiological susceptibilities that result from alterations in lipid metabolism, wherein the physiological susceptibilities are selected from sensitivity to drug treatment or identification of non-responsiveness to treatment by medication. The methods of the present invention comprise determining, in a sample obtained from the human subject, the genotype of that person with respect to at least two genetic polymorphisms selected from the group consisting of a) rs2014355; wherein the minor allele is represented by a cytidine and the major allele is represented by a thymidine; b) rs11161510; wherein the minor allele is represented by a thymidine and the major allele is represented by a cytidine; c) rs2286963; wherein the minor allele is represented by a guanosine and the major allele is represented by a thymidine; d) rs174548; wherein the minor allele is represented by a guanosine and the major allele is represented by a cytidine; e) rs9393903; wherein the minor allele is represented by a adenosine and the major allele is represented by a guanosine; f) rs168622; wherein the minor allele is represented by a thymidine and the major allele is represented by a guanosine; g) rs541503; wherein the minor allele is represented by a cytidine and the major allele is represented by a thymidine; h) rs2046813; wherein the minor allele is represented by a cytidine and the major allele is represented by a thymidine; i) rs272889; wherein the minor allele is represented by a adenosine and the major allele is represented by a guanosine; j) rs2216405; wherein the minor allele is represented by a guanosine and the major allele is represented by a adenosine; k) rs7156144; wherein the minor allele is represented by a adenosine and the major allele is represented by a guanosine; I) rs8396; wherein the minor allele is represented by a cytidine and the major allele is represented by a thymidine; m) rs7094971; wherein the minor allele is represented by a guanosine and the major allele is represented by a adenosine; n) rs603424; wherein the minor allele is represented by a adenosine and the major allele is represented by a guanosine; and/or o) at least one genetic polymorphism that is in linkage disequilibrium with any of the genetic polymorphisms of (a) to (n), wherein the presence of one or two copies of the minor allele of at least two genetic polymorphisms is indicative of a predisposition for said physiological susceptibilities.

摘要翻译：本发明涉及一种用于确定由于脂质代谢改变而导致的生理敏感性的人类受试者易感性的方法，其中所述生理敏感性选自对功能性食物的敏感性，身体健康方案，对治疗无反应性的鉴定饮食或身体活动。本发明还涉及一种用于确定人类受试者对由脂质代谢改变引起的生理敏感性的易感性的方法，其中所述生理敏感性选自对药物治疗的敏感性或鉴定对药物治疗的不响应性。本发明的方法包括在从人受试者获得的样品中确定该人的基因型，其选自以下组中的至少两种遗传多态性：a）rs2014355; 其中次要等位基因由胞苷代表，主要等位基因由胸苷代表; b）rs11161510; 其中次要等位基因由胸苷代表，主要等位基因由胞苷代表; c）rs2286963; 其中次要等位基因由鸟苷代表，主等位基因由胸苷代表; d）rs174548; 其中次要等位基因由鸟苷代表，主要等位基因由胞苷代表; e）rs9393903; 其中次要等位基因由腺苷表示，主要等位基因由鸟苷代表; f）rs168622; 其中次要等位基因由胸苷代表，主要等位基因由鸟苷代表; g）rs541503; 其中次要等位基因由胞苷代表，主要等位基因由胸苷代表; h）rs2046813; 其中次要等位基因由胞苷代表，主要等位基因由胸苷代表; i）rs272889; 其中次要等位基因由腺苷表示，主要等位基因由鸟苷代表; j）rs2216405; 其中次要等位基因由鸟苷代表，主要等位基因由腺苷表示; k）rs7156144; 其中次要等位基因由腺苷表示，主要等位基因由鸟苷代表; I）rs8396; 其中次要等位基因由胞苷代表，主要等位基因由胸苷代表; m）rs7094971; 其中次要等位基因由鸟苷代表，主要等位基因由腺苷表示; n）rs603424; 其中次要等位基因由腺苷表示，主要等位基因由鸟苷代表; 和/或o）与（a）至（n）的任何遗传多态性处于连锁不平衡的至少一个遗传多态性，其中存在至少两个遗传多态性的次要等位基因的一个或两个拷贝是指示对于所述生理敏感性的倾向。

IPRDB

热门服务

关于我们

友情链接

联系方式