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1. 发明授权

US08273325B2 Contrast agents 失效
标题翻译：对比剂
公开(公告)号：US08273325B2
公开(公告)日：2012-09-25
申请号：US12519183
申请日：2007-12-19
申请人： Helge Tolleshaug , Alan Cuthbertson , Hege Karlsen
发明人： Helge Tolleshaug , Alan Cuthbertson , Hege Karlsen
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K49/0054 , A61K49/0032 , A61K49/0056
摘要： The present invention provides novel compounds and pharmaceutical compositions containing such compounds, wherein the compounds have affinity for proteoglycans. The compounds comprise an amino acid based core unit linked to positively charged moieties. The compounds further comprise at least one imaging moiety detectable in in vivo imaging making the compounds useful as diagnostic contrast agents for imaging of proteoglycans, such as heparan sulphate proteoglycans.
摘要翻译：本发明提供含有这些化合物的新化合物和药物组合物，其中化合物对蛋白聚糖具有亲和力。所述化合物包含与带正电荷部分连接的基于氨基酸的核心单元。所述化合物还包含在体内成像中可检测的至少一个成像部分，使得该化合物可用作蛋白聚糖成像的诊断造影剂，例如硫酸乙酰肝素蛋白聚糖。

2. 发明申请

US20100111865A1 CONTRAST AGENTS 失效
标题翻译：对比剂
公开(公告)号：US20100111865A1
公开(公告)日：2010-05-06
申请号：US12519183
申请日：2007-12-19
申请人： Helge Tolleshaug , Alan Cuthbertson , Hege Karlsen
发明人： Helge Tolleshaug , Alan Cuthbertson , Hege Karlsen
IPC分类号： A61K49/00 , C07K4/00 , A61K38/00
CPC分类号： A61K49/0054 , A61K49/0032 , A61K49/0056
摘要： The present invention provides novel compounds and pharmaceutical compositions containing such compounds, wherein the compounds have affinity for proteoglycans. The compounds comprise an amino acid based core unit linked to positively charged moieties. The compounds further comprise at least one imaging moiety detectable in in vivo imaging making the compounds useful as diagnostic contrast agents for imaging of proteoglycans, such as heparan sulphate proteoglycans.
摘要翻译：本发明提供含有这些化合物的新化合物和药物组合物，其中化合物对蛋白聚糖具有亲和力。所述化合物包含与带正电荷部分连接的基于氨基酸的核心单元。所述化合物还包含在体内成像中可检测的至少一个成像部分，使得该化合物可用作蛋白聚糖成像的诊断造影剂，例如硫酸乙酰肝素蛋白聚糖。

3. 发明授权

US06680047B2 Diagnostic/therapeutic agents 失效
标题翻译：诊断/治疗剂
公开(公告)号：US06680047B2
公开(公告)日：2004-01-20
申请号：US09925715
申请日：2001-08-10
申请人： Jo Klaveness , Pål Rongved , Anders Høgset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Nævestad , Dagfinn Løvhaug , Halldis Hellebust , Magne Solbakken
发明人： Jo Klaveness , Pål Rongved , Anders Høgset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Nævestad , Dagfinn Løvhaug , Halldis Hellebust , Magne Solbakken
IPC分类号： A61B800
CPC分类号： A61K51/1255 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0002 , A61K49/0043 , A61K49/0047 , A61K49/0054 , A61K49/0056 , A61K49/0058 , A61K49/0091 , A61K49/223 , A61K51/065 , A61K51/1227 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
摘要翻译：靶向诊断和/或治疗活性剂，例如超声造影剂，其包含在包含含气体或气体产生材料的报道分子的含水载体液体中的悬浮液，所述试剂能够与靶形成至少两种结合对。

4. 发明申请

US20050002865A1 Diagnostic/therapeutic agents 审中-公开
标题翻译：诊断/治疗剂
公开(公告)号：US20050002865A1
公开(公告)日：2005-01-06
申请号：US10734730
申请日：2003-12-15
申请人： Jo Klaveness , Pal Rongved , Anders Hogset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Naevestad , Dagfinn Lovhaug , Halldis Hellebust , Magne Solbakken
发明人： Jo Klaveness , Pal Rongved , Anders Hogset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Naevestad , Dagfinn Lovhaug , Halldis Hellebust , Magne Solbakken
IPC分类号： A61K47/48 , A61K49/00 , A61K49/08 , A61K49/18 , A61K49/22 , A61K51/04 , A61K51/08 , A61K51/12
CPC分类号： A61K51/1255 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0002 , A61K49/0043 , A61K49/0047 , A61K49/0054 , A61K49/0056 , A61K49/0058 , A61K49/0091 , A61K49/223 , A61K51/065 , A61K51/1227 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
摘要翻译：靶向诊断和/或治疗活性剂，例如超声造影剂，其包含在包含含气体或气体产生材料的报道分子的含水载体液体中的悬浮液，所述试剂能够与靶形成至少两种结合对。

5. 发明授权

US06331289B1 Targeted diagnostic/therapeutic agents having more than one different vectors 失效
标题翻译：具有多于一种不同载体的靶向诊断/治疗剂
公开(公告)号：US06331289B1
公开(公告)日：2001-12-18
申请号：US08959206
申请日：1997-10-28
申请人： Jo Klaveness , Pål Rongved , Anders Høgset , Helge Tolleshaug , Alan Cuthbertson , Lars Hoff , Klaus Bryn , Halldis Hellebust , Magne Solbakken
发明人： Jo Klaveness , Pål Rongved , Anders Høgset , Helge Tolleshaug , Alan Cuthbertson , Lars Hoff , Klaus Bryn , Halldis Hellebust , Magne Solbakken
IPC分类号： A61B800
CPC分类号： A61K51/1255 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0002 , A61K49/0043 , A61K49/0047 , A61K49/0054 , A61K49/0056 , A61K49/0058 , A61K49/0091 , A61K49/223 , A61K51/065 , A61K51/1227 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
摘要翻译：靶向诊断和/或治疗活性剂，例如超声造影剂，其包含在包含含气体或气体产生材料的报道分子的含水载体液体中的悬浮液，所述试剂能够与靶形成至少两种结合对。

6. 发明授权

US06261537B1 Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors 失效
标题翻译：具有偶联至一种或多种载体的微泡的诊断/治疗剂
公开(公告)号：US06261537B1
公开(公告)日：2001-07-17
申请号：US08960054
申请日：1997-10-29
申请人： Jo Klaveness , Pål Rongved , Anders Høgset , Helge Tolleshaug , Anne Nævestad , Halldis Hellebust , Lars Hoff , Alan Cuthbertson , Dagfinn Løvhaug , Magne Solbakken
发明人： Jo Klaveness , Pål Rongved , Anders Høgset , Helge Tolleshaug , Anne Nævestad , Halldis Hellebust , Lars Hoff , Alan Cuthbertson , Dagfinn Løvhaug , Magne Solbakken
IPC分类号： A61B800
CPC分类号： A61K51/1255 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0002 , A61K49/0043 , A61K49/0047 , A61K49/0054 , A61K49/0056 , A61K49/0058 , A61K49/0091 , A61K49/223 , A61K51/088 , A61K51/1227 , Y10S977/928
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilised by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.
摘要翻译：靶向诊断和/或治疗活性剂，例如超声造影剂，具有包含通过成膜表面活性剂的单层稳定的充气微泡的记者，所述报告基团与至少一个载体偶联或连接。

7. 发明申请

US20070258904A1 Optical Imaging Contrast Agents 审中-公开
标题翻译：光学成像对比剂
公开(公告)号：US20070258904A1
公开(公告)日：2007-11-08
申请号：US10582679
申请日：2004-12-17
申请人： Jo Klaveness , Edvin Johannesen , Helge Tolleshaug
发明人： Jo Klaveness , Edvin Johannesen , Helge Tolleshaug
IPC分类号： A61K49/00 , C12N15/00
CPC分类号： A61K49/0032 , A61K49/0043 , A61K49/0052 , A61K49/0056
摘要： The invention provides contrast agents for optical imaging of oesophageal cancer and Barrett's oesophagus in patients. The contrast agents may be used in diagnosis of oesophageal cancer and Barrett's oesophagus, for follow up of progress in disease development, for follow up of treatment of oesophageal cancer and Barrett's oesophagus and for surgical guidance. Further, the invention provides methods for optical imaging of oesophageal cancer and Barrett's oesophagus in patients.
摘要翻译：本发明提供了用于患者食管癌和Barrett食管的光学成像的造影剂。造影剂可用于食管癌和巴雷特食管的诊断，用于跟踪疾病发展进展，跟进食管癌和巴雷特食管的治疗以及手术指导。此外，本发明提供了食管癌和Barrett食管的光学成像方法。

8. 发明授权

US06610269B1 Contrast agents 失效
标题翻译：对比剂
公开(公告)号：US06610269B1
公开(公告)日：2003-08-26
申请号：US09422977
申请日：1999-10-22
申请人： Jo Klaveness , Anne Naevestad , Helge Tolleshaug
发明人： Jo Klaveness , Anne Naevestad , Helge Tolleshaug
IPC分类号： A61K4900
CPC分类号： A61K51/1255 , A61K49/0002 , A61K49/0017 , A61K49/0089 , A61K49/085 , A61K49/10 , A61K51/0459 , A61K51/0497 , A61K51/088 , A61K51/1241
摘要： The invention provides a composition of matter of the formula (I): V—L—R, where V is a vector moiety having affinity for an angiogenesis-related endothelias cell receptor, L is a linker moiety or a bond and R is a detectable moiety, characterized in that V is a non-peptidic organic group, or V is peptidic and R is a macromolecular or particulate species providing a multiplicity of labels detectable in in vivo imaging.
摘要翻译：本发明提供式（I）的物质组合物：VLR，其中V是对血管生成相关内皮细胞受体具有亲和性的载体部分，L是连接体部分或键，R是可检测部分，其特征在于 V是非肽类有机基团，或V是肽类，R是提供在体内成像中可检测到的多种标记物的大分子或微粒物质。

9. 发明申请

US20080279771A1 Novel Imaging Agents for Cancer 审中-公开
标题翻译：癌症新型成像剂
公开(公告)号：US20080279771A1
公开(公告)日：2008-11-13
申请号：US12091804
申请日：2006-10-30
申请人： Grete Mork Kindberg , Helge Tolleshaug
发明人： Grete Mork Kindberg , Helge Tolleshaug
IPC分类号： A61K51/08 , C07K7/06 , C07K7/08 , A61K49/14 , C07K7/50
CPC分类号： A61K51/088 , A61K49/0002 , A61K51/08
摘要： A novel imaging agent is described which comprises a semaphorin moiety and an imaging moiety. The novel imaging agent of the invention may be used in the diagnostic imaging of cancer and in particular, for targeting angiogenesis or metaplasia. Further aspects of the present invention presented herein include a method for the preparation of the imaging agent, a pharmaceutical composition comprising the imaging agent of the invention and a kit for the preparation of said pharmaceutical.
摘要翻译：描述了一种包含信号素部分和成像部分的新型成像剂。本发明的新型成像剂可用于癌症的诊断成像，特别是用于靶向血管生成或化生。本文提供的本发明的其它方面包括制备显像剂的方法，包含本发明的成像剂的药物组合物和用于制备所述药物的试剂盒。

10. 发明申请

US20070116646A1 Optical imaging of endometriosis 审中-公开
标题翻译：子宫内膜异位症的光学成像
公开(公告)号：US20070116646A1
公开(公告)日：2007-05-24
申请号：US10573604
申请日：2004-09-28
申请人： Jo Klaveness , Edvin Johannesen , Helge Tolleshaug
发明人： Jo Klaveness , Edvin Johannesen , Helge Tolleshaug
IPC分类号： A61K49/00 , C07K16/46
CPC分类号： A61K49/0056 , A61K49/0032 , A61K49/0043 , A61K49/0052
摘要： The invention provides contrast agents for optical imaging of endometriosis in patients. The contrast agent may be used in diagnosis of endometriosis, for follow-up of progress in disease development, and for follow-up of treatment of endometriosis. Further, the invention provides methods for optical imaging of endometriosis. The contrast agent has affinity for an abnormally expressed target associated with endometriosis. By abnormally expressed, is meant that the target is either overexpressed or downregulated. Endometriotic tissue containing a downregulated target may be identified by a low amount of bound contrast agent compared to normal tissue. In this situation, the amount of contrast agent should be less than 50% of that in normal tissue, preferably less than 10%.
摘要翻译：本发明提供了用于患者子宫内膜异位症的光学成像的造影剂。造影剂可用于诊断子宫内膜异位症，用于随访疾病发展进展，以及随访子宫内膜异位症的治疗。此外，本发明提供了用于子宫内膜异位症的光学成像的方法。造影剂对与子宫内膜异位症相关的异常表达的靶标具有亲和力。通过异常表达意味着靶标过表达或下调。与正常组织相比，含有下调靶的子宫内膜异位组织可以通过少量结合的造影剂来鉴定。在这种情况下，造影剂的量应小于正常组织的50％，优选小于10％。

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