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1. 发明授权

US08334308B2 Renin inhibitors 失效
标题翻译：肾素抑制剂
公开(公告)号：US08334308B2
公开(公告)日：2012-12-18
申请号：US12674040
申请日：2008-08-18
申请人： Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Rejean Fortin , Patrick Lacombe , Daniel McKay , Tom Yao-Hsiang Wu
发明人： Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Rejean Fortin , Patrick Lacombe , Daniel McKay , Tom Yao-Hsiang Wu
IPC分类号： A01N43/40 , A01N37/34 , A01N37/12 , A01N33/02 , A61K31/44 , A61K31/275 , C07D213/78 , C07D213/24 , C07C211/00
CPC分类号： C07C217/62 , C07C217/48 , C07C229/38 , C07C237/10 , C07C237/20 , C07C255/43 , C07C271/12 , C07C323/32 , C07D213/38 , C07D213/64 , C07D213/89 , C07D317/60
摘要： The present invention relates to biphenyl-based renin inhibitor compounds having amino-terminal groups, and their use in treating cardiovascular events and renal insufficiency.
摘要翻译：本发明涉及具有氨基末端基团的联苯基肾素抑制剂化合物及其在治疗心血管事件和肾功能不全中的用途。

2. 发明申请

US20110263658A1 RENIN INHIBITORS 失效
标题翻译：雷宁抑制剂
公开(公告)号：US20110263658A1
公开(公告)日：2011-10-27
申请号：US12674040
申请日：2008-08-18
申请人： Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Rejean Fortin , Patrick Lacombe , Daniel McKay , Tom Yao-Hsiang Wu
发明人： Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Rejean Fortin , Patrick Lacombe , Daniel McKay , Tom Yao-Hsiang Wu
IPC分类号： A61K31/4412 , A61K31/135 , C07C229/34 , A61K31/216 , C07D213/38 , A61K31/4418 , C07C255/43 , A61K31/277 , C07C271/12 , A61K31/27 , C07C237/20 , A61K31/165 , C07D211/76 , A61P9/12 , A61P13/12 , A61P9/00 , A61P3/10 , A61P27/06 , A61P15/10 , A61P25/22 , A61P25/28 , C07C211/01
CPC分类号： C07C217/62 , C07C217/48 , C07C229/38 , C07C237/10 , C07C237/20 , C07C255/43 , C07C271/12 , C07C323/32 , C07D213/38 , C07D213/64 , C07D213/89 , C07D317/60
摘要： The present invention relates to biphenyl-based renin inhibitor compounds having amino-terminal groups, and their use in treating cardiovascular events and renal insufficiency.
摘要翻译：本发明涉及具有氨基末端基团的联苯基肾素抑制剂化合物及其在治疗心血管事件和肾功能不全中的用途。

3. 发明授权

US08343968B2 Case of renin inhibitors 失效
标题翻译：肾素抑制剂病例
公开(公告)号：US08343968B2
公开(公告)日：2013-01-01
申请号：US12594905
申请日：2008-05-23
申请人： Tom Yao-Hsiang Wu , Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Erich I. Grimm , Sebastien Laliberte , Austin Chen
发明人： Tom Yao-Hsiang Wu , Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Erich I. Grimm , Sebastien Laliberte , Austin Chen
IPC分类号： A61K31/535 , A61K31/445 , C07D413/12 , C07D211/60
CPC分类号： C07D211/60 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/12
摘要： The present invention relates to piperidine-based renin inhibitor compounds having carboxylate or carboxylic acid terminal groups, and their use in treating cardiovascular events and renal insufficiency.
摘要翻译：本发明涉及具有羧酸酯或羧酸端基的哌啶基肾素抑制剂化合物及其在治疗心血管事件和肾功能不全中的用途。

4. 发明申请

US20100120859A1 NOVEL CASE OF RENIN INHIBITORS 失效
标题翻译：瑞恩抑制剂新案例
公开(公告)号：US20100120859A1
公开(公告)日：2010-05-13
申请号：US12594905
申请日：2008-05-23
申请人： Tom Yao-Hsiang Wu , Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Erich L. Grimm , Sebastien Laliberte , Austin Chen
发明人： Tom Yao-Hsiang Wu , Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Erich L. Grimm , Sebastien Laliberte , Austin Chen
IPC分类号： A61K31/451 , A61K31/4545 , A61K31/454 , C07D401/04 , C07D401/12 , C07D211/60 , A61P25/00 , A61P9/00
CPC分类号： C07D211/60 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/12
摘要： The present invention relates to piperidine-based renin inhibitor compounds having carboxylate or carboxylic acid terminal groups, and their use in treating cardiovascular events and renal insufficiency.
摘要翻译：本发明涉及具有羧酸酯或羧酸端基的哌啶基肾素抑制剂化合物及其在治疗心血管事件和肾功能不全中的用途。

5. 发明申请

US20110301143A1 HETEROCYCLIC DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE 审中-公开
标题翻译：作为硬脂酸苄酯A DELTA-9去饱和酶的抑制剂的杂环衍生物
公开(公告)号：US20110301143A1
公开(公告)日：2011-12-08
申请号：US13201720
申请日：2010-02-18
申请人： Elise Isabel , Nicolas Lachance , Jean-Philippe Leclerc , Serge Leger , Renata M. Oballa , David Powell , Yeeman K. Ramtohul , Patrick Roy , Geoffrey K. Tranmer , Renee Aspiotis , Lianhai Li , Evelyn Martins
发明人： Elise Isabel , Nicolas Lachance , Jean-Philippe Leclerc , Serge Leger , Renata M. Oballa , David Powell , Yeeman K. Ramtohul , Patrick Roy , Geoffrey K. Tranmer , Renee Aspiotis , Lianhai Li , Evelyn Martins
IPC分类号： A61K31/497 , C07D417/14 , C07D413/14 , C07D401/14 , A61K31/506 , A61K31/496 , A61K31/427 , A61K31/454 , A61K31/4439 , A61K31/4995 , A61K31/551 , A61P3/10 , A61P5/48 , A61P3/00 , A61P3/06 , A61P7/00 , C07D403/14
CPC分类号： C07D413/14 , A61K31/454 , A61K31/496 , A61K31/4995 , A61K31/551 , C07D403/04 , C07D403/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D487/08
摘要： Heterocyclic compounds of structural formula (I), or a pharmaceutically acceptable salt thereof, wherein W is a R1— substituted heteroaryl, R1 is an heteroaryl ring substituted with an ester or carboxylic acid containing radical, X-T is N—CR5R6, C═CR5 or CR13—CR5R6, Y is a bond or —C(O)—, a and b represent an integer selected from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The heterocyclic compounds are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis, obesity, diabetes, neurological disease, Metabolic Syndrome, insulin resistance, cancer, liver steatosis, and non-alcoholic steatohepatitis.
摘要翻译：结构式（I）的杂环化合物或其药学上可接受的盐，其中W是R1-取代的杂芳基，R1是被含有或含羧酸基团取代的杂芳基环，XT是N-CR5R6，C = CR5或 CR13-CR5R6，Y是键或-C（O） - ，a和b表示选自1至4的整数，Ar是任选取代的苯基或萘基，是硬脂酰辅酶A-9去饱和酶的抑制剂 SCD）杂环化合物可用于预防和治疗与脂质合成和代谢异常有关的病症，包括心血管疾病，动脉粥样硬化，肥胖，糖尿病，神经系统疾病，代谢综合征，胰岛素抵抗，癌症，肝脂肪变性和非酒精性脂肪性肝炎

6. 发明授权

US06498151B2 Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors 失效
标题翻译：具有含硫取代基的芳基二氟甲基膦酸作为PTP-1B抑制剂
公开(公告)号：US06498151B2
公开(公告)日：2002-12-24
申请号：US09813489
申请日：2001-03-21
申请人： Chun Sing Li , Christopher Bayly , Jacques Yves Gauthier , Yves Leblanc , Cheuk Kun Lau , Patrick Roy , Michel Therien , Zhaoyin Wang , Claude Dufresne , Rejean Fortin
发明人： Chun Sing Li , Christopher Bayly , Jacques Yves Gauthier , Yves Leblanc , Cheuk Kun Lau , Patrick Roy , Michel Therien , Zhaoyin Wang , Claude Dufresne , Rejean Fortin
IPC分类号： C07D23995
CPC分类号： C07F9/65583 , A61K31/66 , A61K45/06 , C07F9/3882 , C07F9/4056 , C07F9/5537 , C07F9/58 , C07F9/59 , C07F9/60 , C07F9/6506 , C07F9/65068 , C07F9/6512 , C07F9/65128 , C07F9/6518 , C07F9/6524 , C07F9/65312 , C07F9/65318 , C07F9/6539 , C07F9/65395 , C07F9/6552 , C07F9/65522 , A61K2300/00
摘要： The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes.
摘要翻译：本发明包括由下式表示的新型化合物，其是PTP-1B酶的抑制剂。本发明还包括治疗或预防PTP-1B介导的疾病包括糖尿病的药物组合物和方法。

7. 发明申请

US20100048551A1 Tricyclic Compounds Useful as Inhibitors of Kinases 有权
标题翻译：可用作激酶抑制剂的三环化合物
公开(公告)号：US20100048551A1
公开(公告)日：2010-02-25
申请号：US12085331
申请日：2006-11-17
申请人： Jean-Francois Truchon , Nicolas Lachance , Cheuk Lau , Yves Leblanc , Christophe Mellon , Patrick Roy , Elise Isabel , Ryan D. Otte , Jonathan R. Young
发明人： Jean-Francois Truchon , Nicolas Lachance , Cheuk Lau , Yves Leblanc , Christophe Mellon , Patrick Roy , Elise Isabel , Ryan D. Otte , Jonathan R. Young
IPC分类号： A61K31/437 , A61K31/5377 , A61K31/4365 , C07D491/107 , C07D495/04 , C07D471/04 , A61P17/00 , A61K31/444 , A61P35/00 , A61P11/00 , A61P11/06 , A61P29/00 , A61P27/02 , A61P9/12 , A61P9/10 , A61P25/00
CPC分类号： C07D491/10 , C07D471/04
摘要： The present invention provides inhibitors of kinases, specifically IκB kinases, JAK1, JAK2, JAK3 and TYK2. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting said kinase activity by administering the compound to a patient in need of treatment for myeloproliferative disorders, cancer or NF-κB-mediated diseases.
摘要翻译：本发明提供激酶抑制剂，特别是I＆Kgr B激酶，JAK1，JAK2，JAK3和TYK2。本发明还提供了包含这种抑制性化合物的组合物和通过将该化合物施用于需要治疗骨髓增生性疾病，癌症或NF-和κB介导的疾病的患者来抑制所述激酶活性的方法。

8. 发明授权

US06174874B1 Phosphonic acids derivatives as inhibitors of protein tyrosine phosphate 1B (PTP-1B) 失效
标题翻译：磷酸衍生物作为蛋白质酪氨酸磷酸1B（PTP-1B）的抑制剂
公开(公告)号：US06174874B1
公开(公告)日：2001-01-16
申请号：US09398356
申请日：1999-09-17
申请人： Zhaoyin Wang , Claude Dufresne , Yves Leblanc , Chun Sing Li , Jacques Y. Gauthier , Cheuk K. Lau , Michel Therien , Patrick Roy
发明人： Zhaoyin Wang , Claude Dufresne , Yves Leblanc , Chun Sing Li , Jacques Y. Gauthier , Cheuk K. Lau , Michel Therien , Patrick Roy
IPC分类号： A61K31663
CPC分类号： H04M3/42314 , C07F9/3856 , C07F9/386 , C07F9/3865 , C07F9/3869 , C07F9/3882 , C07F9/5537 , C07F9/65068 , C07F9/65188 , C07F9/6524 , C07F9/65318 , C07F9/65324 , C07F9/6539 , C07F9/65395 , C07F9/6541 , H04Q3/625 , H04Q2213/13104 , H04Q2213/13107 , H04Q2213/1322 , H04Q2213/1329 , H04Q2213/13389
摘要： The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases.
摘要翻译：本发明包括作为PTP-1B酶抑制剂的由式I表示的新一类化合物。本发明还包括治疗或预防PTP-1B介导的疾病的药物组合物和方法。

9. 发明授权

US06169188A (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors 失效
标题翻译：（甲基磺酰基）苯基-2-（5H） - 呋喃酮作为COX-2抑制剂
公开(公告)号：US06169188A
公开(公告)日：2001-01-02
申请号：US09422151
申请日：1999-10-21
申请人： Michel Belley , Jacques Yves Gauthier , Erich Grimm , Yves LeBlanc , Chun-Sing Li , Michel Therien , Cameron Black , Petpiboon Prasit , Cheuk-Kun Lau , Patrick Roy
发明人： Michel Belley , Jacques Yves Gauthier , Erich Grimm , Yves LeBlanc , Chun-Sing Li , Michel Therien , Cameron Black , Petpiboon Prasit , Cheuk-Kun Lau , Patrick Roy
IPC分类号： C07D31744
CPC分类号： C07D405/12 , C07C317/24 , C07C2601/08 , C07D307/58 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/83 , C07D307/94 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
摘要翻译：本发明包括可用于治疗环加氧酶-2介导的疾病的新颖的式I化合物。本发明还包括用于治疗包含式I化合物的环氧合酶-2介导的疾病的某些药物组合物。

10. 发明授权

US08640202B2 Synchronizing user sessions in a session environment having multiple web services 失效
标题翻译：在具有多个Web服务的会话环境中同步用户会话
公开(公告)号：US08640202B2
公开(公告)日：2014-01-28
申请号：US11867348
申请日：2007-10-04
申请人： Patrick Roy
发明人： Patrick Roy
IPC分类号： H04L29/06
CPC分类号： H04L63/0807 , G06F21/335 , H04L67/02 , H04L67/14
摘要： A mechanism is provided for synchronizing a first user session and a second user session in a client-server system. The first user session is between a first Web service and a client and the second user session is between a second Web service and the same client. A request is received with a first session value by the second Web service. An indicator of the first session value is assigned to a shadow, and the shadow is sent in a response to the client. A subsequent request with the shadow and a subsequent session value is received from the client. The indicator is used to verify the subsequent session value at the second Web service. The second user session is terminated if the indicator in the shadow does not correspond to the subsequent session value.
摘要翻译：提供了一种用于在客户机 - 服务器系统中同步第一用户会话和第二用户会话的机制。第一个用户会话在第一个Web服务和一个客户端之间，第二个用户会话在第二个Web服务和同一个客户端之间。第二个Web服务接收到具有第一个会话值的请求。第一个会话值的指示符被分配给阴影，并且阴影是在响应中发送给客户端的。从客户端接收到带有影子和后续会话值的后续请求。该指示器用于验证第二个Web服务的后续会话值。如果阴影中的指示符不对应于后续会话值，则第二个用户会话将终止。

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