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1. 发明授权

US09186410B2 Derivatized hyperbranched polyglycerols 有权
标题翻译：衍生的超支化聚甘油
公开(公告)号：US09186410B2
公开(公告)日：2015-11-17
申请号：US13581463
申请日：2011-03-01
申请人： Helen Burt , Donald Brooks , Jayachandran Kizhakkedathu , Richard Liggins , Dechi Guan , Lu Ye , Clement Mugabe , Alan So , Martin E. Gleave , John K. Jackson , Rajesh Kumar Kainthan
发明人： Helen Burt , Donald Brooks , Jayachandran Kizhakkedathu , Richard Liggins , Dechi Guan , Lu Ye , Clement Mugabe , Alan So , Martin E. Gleave , John K. Jackson , Rajesh Kumar Kainthan
IPC分类号： A61K33/24 , C07C217/00 , C07D207/46 , A61K47/10 , A61K9/51 , A61K47/34 , C08G65/34 , C08G65/48 , C08G83/00 , C08G65/333 , A61K9/00
CPC分类号： A61K47/10 , A61K9/0034 , A61K9/006 , A61K9/5146 , A61K31/337 , A61K31/407 , A61K33/24 , A61K47/34 , A61K47/60 , C08G65/33306 , C08G65/33337 , C08G65/34 , C08G65/48 , C08G83/005 , C08G83/006 , C08G2650/54
摘要： Herein are provided derivatized hyperbranched polyglycerols (“dHPGs”). The dHPG comprises a core comprising a hyperbranched polyglycerol derivatized with C1C20 alkyl chains and a shell comprising at least one hydrophilic substituent bound to hydroxyl groups of the core, wherein the hyperbranched polyglycerol comprises from about 1 to about 200 moles of the at least one hydrophilic substituent. The dHPGs are for use as agents for the delivery of a drug or other biologically active moiety to the urinary tract, the digestive tract, the airways, the vaginal cavity and cervix and the peritoneal cavity to treat indications such as cancer, which may be useful in the treatment of or the manufacture of a medicament, in the preparation, of a pharmaceutical composition for the treatment of cancer, as a pre-treatment or co-treatment to improve drug uptake in a tissue. Furthermore, there are provided methods of making dHPGs.
摘要翻译：本文提供衍生的超支化聚甘油（“dHPG”）。 dHPG包含核心，其包含用C1C20烷基链衍生的超支化聚甘油和包含至少一个与核心羟基结合的亲水取代基的壳，其中超支化聚甘油包含约1至约200摩尔的至少一个亲水取代基。 dHPG用作将药物或其他生物活性部分递送至尿路，消化道，气道，阴道腔和子宫颈以及腹膜腔以治疗诸如癌症的适应症的药剂，其可能是有用的在制备中用于治疗癌症的药物组合物的治疗或制造中，作为用于改善组织中药物摄取的预处理或共处理。此外，还提供了制造dHPG的方法。

2. 发明申请

US20130122112A1 Derivatized Hyperbranched Polyglycerols 有权
标题翻译：衍生的超支化聚甘油
公开(公告)号：US20130122112A1
公开(公告)日：2013-05-16
申请号：US13581463
申请日：2011-03-01
申请人： Helen M. Burt , Donald Brooks , Jayachandran Kizhakkedathu , Richard Liggins , Dechi Guan , Lu Ye , Clement Mugabe , Alan So , Martin E. Gleave , John K. Jackson , Rajesh Kumar Kainthan
发明人： Helen M. Burt , Donald Brooks , Jayachandran Kizhakkedathu , Richard Liggins , Dechi Guan , Lu Ye , Clement Mugabe , Alan So , Martin E. Gleave , John K. Jackson , Rajesh Kumar Kainthan
IPC分类号： A61K47/10 , C08G65/333
CPC分类号： A61K47/10 , A61K9/0034 , A61K9/006 , A61K9/5146 , A61K31/337 , A61K31/407 , A61K33/24 , A61K47/34 , A61K47/60 , C08G65/33306 , C08G65/33337 , C08G65/34 , C08G65/48 , C08G83/005 , C08G83/006 , C08G2650/54
摘要： Herein are provided derivatized hyperbranched polyglycerols (“dHPGs”). The dHPG comprises a core comprising a hyperbranched polyglycerol derivatized with C1C20 alkyl chains and a shell comprising at least one hydrophilic substituent bound to hydroxyl groups of the core, wherein the hyperbranched polyglycerol comprises from about 1 to about 200 moles of the at least one hydrophilic substituent. The dHPGs are for use as agents for the delivery of a drug or other biologically active moiety to the urinary tract, the digestive tract, the airways, the vaginal cavity and cervix and the peritoneal cavity to treat indications such as cancer, which may be useful in the treatment of or the manufacture of a medicament, in the preparation, of a pharmaceutical composition for the treatment of cancer, as a pre-treatment or co-treatment to improve drug uptake in a tissue. Furthermore, there are provided methods of making dHPGs.
摘要翻译：本文提供衍生的超支化聚甘油（“dHPG”）。 dHPG包含核心，其包含用C1C20烷基链衍生的超支化聚甘油和包含至少一个与核心羟基结合的亲水取代基的壳，其中超支化聚甘油包含约1至约200摩尔的至少一个亲水取代基。 dHPG用作将药物或其他生物活性部分递送至尿路，消化道，气道，阴道腔和子宫颈以及腹膜腔以治疗诸如癌症的适应症的药剂，其可能是有用的在制备中用于治疗癌症的药物组合物的治疗或制造中，作为用于改善组织中药物摄取的预处理或共处理。此外，还提供了制备dHPG的方法。

3. 发明授权

US11357226B2 Polymer based transplant preservation solution 有权
公开(公告)号：US11357226B2
公开(公告)日：2022-06-14
申请号：US16737371
申请日：2020-01-08
申请人： Jayachandran Kizhakkedathu , Caigan Du , Donald Brooks , Christopher Nguan
发明人： Jayachandran Kizhakkedathu , Caigan Du , Donald Brooks , Christopher Nguan
IPC分类号： A01N1/02 , A61K35/12
摘要： Provided are transplant preservation solutions comprising a polyglycerol wherein the polyglycerol is of a molecular weight between about 0.15 kDa and about 3.99 kDa, methods and uses thereof as well as kits providing said transplant preservation solutions.

4. 发明授权

US08953200B2 Casino print system and corresponding methods 有权
标题翻译：赌场打印系统和相应的方法
公开(公告)号：US08953200B2
公开(公告)日：2015-02-10
申请号：US13248184
申请日：2011-09-29
申请人： Bart Shuldman , Benjamin Wyatt , Shawn Kevin Clarke , Donald Brooks
发明人： Bart Shuldman , Benjamin Wyatt , Shawn Kevin Clarke , Donald Brooks
IPC分类号： G07F17/00 , G07F17/32 , G06F3/12
CPC分类号： G07F17/3251 , G06F3/1285 , G07F17/3223 , G07F17/3255
摘要： Systems and methods for providing customized coupons in a casino gaming environment are provided. A printer resident in a gaming machine is provided and has at least one communication port for communication external to the gaming machine. A coupon layout generator may also be provided for creating customized coupons. A server manager may be provided for distributing the customized coupons to one or more targeted recipients. A server port device may be provided for connecting the server manager to the communication port of the printer and for converting an Ethernet signal from the server manager to a serial signal recognizable by the printer. With such a system, an IP address may be assigned to the server port device. The IP address, together with player identification information, is used by the server manager to determine appropriate coupons for distribution to the gaming machine.
摘要翻译：提供了在赌场游戏环境中提供定制优惠券的系统和方法。提供驻留在游戏机中的打印机，并且具有用于在游戏机外部通信的至少一个通信端口。还可以提供优惠券布局发生器来创建定制的优惠券。可以提供服务器管理器用于将定制的优惠券分发给一个或多个目标接收者。可以提供服务器端口设备，用于将服务器管理器连接到打印机的通信端口，并用于将来自服务器管理器的以太网信号转换成可由打印机识别的串行信号。使用这样的系统，可以将IP地址分配给服务器端口设备。服务器管理员使用IP地址和播放器识别信息来确定适用于分发给游戏机的优惠券。

5. 发明申请

US20080038035A1 Interface for voucher and coupon printing 审中-公开
标题翻译：接收凭证和优惠券打印
公开(公告)号：US20080038035A1
公开(公告)日：2008-02-14
申请号：US11974460
申请日：2007-10-12
申请人： Bart Shuldman , Richard Quaif , Donald Brooks
发明人： Bart Shuldman , Richard Quaif , Donald Brooks
IPC分类号： B41J5/00
CPC分类号： G07F17/3202 , G06F3/1206 , G06F3/1209 , G06F3/1222 , G06F3/1236 , G06F3/1244 , G06F3/1284 , G06F3/1285 , G06Q20/387 , G07F17/32 , G07F17/323 , G07F17/42
摘要： An interface is disclosed for driving a printer to print highly secure vouchers and less secure coupons. The printer can reside, for example, in a wagering terminal (e.g., slot machine), ticket machine, point-of-sale terminal or the like. A first driver receives, e.g., from a local controller, data indicative of voucher information to be printed. A second driver receives, e.g., from a central system controller, data indicative of coupon information to be printed. A processor responsive to the first and second drivers generates printer commands in a standard printer format so that the same printer can be used to print vouchers and coupons. Coupons do not have to be processed by the secure (and usually proprietary) hardware and/or software provided by the terminal manufacturer for printing vouchers.
摘要翻译：公开了一种用于驱动打印机打印高度安全的凭证和较不安全的优惠券的界面。打印机可以驻留在例如投注终端（例如，老虎机），售票机，销售点终端等中。第一驾驶员例如从本地控制器接收指示要打印的凭证信息的数据。第二驱动器例如从中央系统控制器接收指示要打印的优惠券信息的数据。响应于第一和第二驱动器的处理器以标准打印机格式生成打印机命令，以便可以使用相同的打印机来打印凭单和优惠券。优惠券不必由终端制造商提供的用于打印凭证的安全（通常是专有的）硬件和/或软件来处理。

6. 发明申请

US20120081717A1 CASINO PRINT SYSTEM AND CORRESPONDING METHODS 有权
标题翻译： CASINO打印系统和相关方法
公开(公告)号：US20120081717A1
公开(公告)日：2012-04-05
申请号：US13248184
申请日：2011-09-29
申请人： Bart Shuldman , Benjamin Wyatt , Shawn Kevin Clarke , Donald Brooks
发明人： Bart Shuldman , Benjamin Wyatt , Shawn Kevin Clarke , Donald Brooks
IPC分类号： G06K15/02
CPC分类号： G07F17/3251 , G06F3/1285 , G07F17/3223 , G07F17/3255
摘要： Systems and methods for providing customized coupons in a casino gaming environment are provided. A printer resident in a gaming machine is provided and has at least one communication port for communication external to the gaming machine. A coupon layout generator may also be provided for creating customized coupons. A server manager may be provided for distributing the customized coupons to one or more targeted recipients. A server port device may be provided for connecting the server manager to the communication port of the printer and for converting an Ethernet signal from the server manager to a serial signal recognizable by the printer. With such a system, an IP address may be assigned to the server port device. The IP address, together with player identification information, is used by the server manager to determine appropriate coupons for distribution to the gaming machine.
摘要翻译：提供了在赌场游戏环境中提供定制优惠券的系统和方法。提供驻留在游戏机中的打印机，并且具有用于在游戏机外部通信的至少一个通信端口。还可以提供优惠券布局发生器来创建定制的优惠券。可以提供服务器管理器用于将定制的优惠券分发给一个或多个目标接收者。可以提供服务器端口设备，用于将服务器管理器连接到打印机的通信端口，并用于将来自服务器管理器的以太网信号转换成可由打印机识别的串行信号。使用这样的系统，可以将IP地址分配给服务器端口设备。服务器管理员使用IP地址和播放器识别信息来确定适用于分发给游戏机的优惠券。

7. 发明申请

US20070195365A1 Method and apparatus for converting a printer firmware download port to a communicatons port 有权
标题翻译：将打印机固件下载端口转换为通信端口的方法和装置
公开(公告)号：US20070195365A1
公开(公告)日：2007-08-23
申请号：US11787490
申请日：2007-04-16
申请人： Donald Brooks
发明人： Donald Brooks
IPC分类号： G06F3/12
CPC分类号： G06F3/1284 , G06F3/1209 , G06F3/123 , G07F17/32 , G07F17/323 , G07F17/42
摘要： Methods and apparatus for converting a firmware download port on a printer to a communications port are provided. The apparatus includes a printed circuit board arrangement connected to the firmware download port of the printer. A secondary communications port is provided on the printed circuit board arrangement for enabling communications between the printer and a central system controller. The printer may include one or more primary communications ports. Each of the one or more primary communications ports may be selectable for enabling communications between the printer and a local controller. The local controller may provide data to the printer via a selected one of the primary communications ports indicative of cash information to be printed on a voucher. The central system controller may provide data to the printer via the secondary communications port indicative of non-cash data to be printed on a coupon.
摘要翻译：提供了将打印机上的固件下载端口转换为通信端口的方法和装置。该装置包括连接到打印机的固件下载端口的印刷电路板装置。在印刷电路板装置上提供二次通信端口，以实现打印机和中央系统控制器之间的通信。打印机可以包括一个或多个主要通信端口。一个或多个主要通信端口中的每一个可以是可选择的，以实现打印机和本地控制器之间的通信。本地控制器可以通过选择的一个主要通信端口向打印机提供指示将要打印在凭单上的现金信息的数据。中央系统控制器可以经由次要通信端口向打印机提供指示将要打印在优惠券上的非现金数据的数据。

8. 发明申请

US20060058709A1 Ultrasound systems and methods for treating ischemic limbs or tissue affected by peripheral arterial disease 有权
标题翻译：用于治疗由外周动脉疾病影响的缺血性肢体或组织的超声系统和方法
公开(公告)号：US20060058709A1
公开(公告)日：2006-03-16
申请号：US11178244
申请日：2005-07-08
申请人： Martin Mason , Donald Brooks
发明人： Martin Mason , Donald Brooks
IPC分类号： A61H1/00
CPC分类号： A61N7/00 , A61H23/0245
摘要： A method of treating tissue within a body includes aiming an ultrasound transducer towards target tissue, and delivering ultrasound energy towards the target tissue to thereby reduce pain at the target tissue. A method of treating tissue within a body includes aiming an ultrasound transducer towards target tissue, and delivering ultrasound energy towards the target tissue to increase nitric oxide at the target tissue. An ultrasound system includes a first ultrasound transducer for emitting ultrasound energy from outside a patient, and drive circuitry coupled to the first ultrasound transducer, wherein the drive circuitry is configured to generate a drive signal at a frequency that is between 20 kHz and 100 kHz for the first ultrasound transducer.
摘要翻译：治疗身体内的组织的方法包括将超声换能器瞄准目标组织，并将超声能量朝向目标组织递送，从而减少目标组织的疼痛。治疗身体内的组织的方法包括将超声换能器瞄准目标组织，并向目标组织输送超声能量以增加靶组织上的一氧化氮。超声系统包括用于从患者外部发射超声波能量的第一超声波换能器以及耦合到第一超声换能器的驱动电路，其中驱动电路被配置为产生频率在20kHz与100kHz之间的驱动信号，以便第一超声换能器。

9. 发明申请

US20070248393A1 Method and apparatus for driving a printer 审中-公开
标题翻译：用于驱动打印机的方法和装置
公开(公告)号：US20070248393A1
公开(公告)日：2007-10-25
申请号：US11821066
申请日：2007-06-20
申请人： Bart Shuldman , Donald Brooks
发明人： Bart Shuldman , Donald Brooks
IPC分类号： G06K3/00
CPC分类号： G07F17/3202 , G06F3/1206 , G06F3/1209 , G06F3/1222 , G06F3/1236 , G06F3/1244 , G06F3/1284 , G06F3/1285 , G06Q20/387 , G07F17/32 , G07F17/323 , G07F17/42
摘要： Methods and apparatus for driving a printer are provided. Data indicative of cash information to be printed on a cash voucher is received at a first driver from a local controller. Data indicative of non-cash information to be printed on a coupon is received at a second driver from a media controller. Printer commands are then generated by a processor in a standard format for the printer in response to data received from the first and second drivers. The data indicative of non-cash information may be stored in and obtained from media storage associated with the media controller. The media controller may forward the data indicative of non-cash information to the second driver in response to a signal received from the local controller. Alternatively, the media controller may forward the data indicative of non-cash information to the second driver in response to a signal received from a central system controller.
摘要翻译：提供了用于驱动打印机的方法和装置。在本地控制器的第一个驾驶员处接收指示要在现金凭证上打印的现金信息的数据。在媒体控制器的第二驱动器处接收表示要在打折券上的非现金信息的数据。打印机命令然后由打印机的标准格式的处理器响应于从第一和第二驱动器接收到的数据而生成。指示非现金信息的数据可以存储在与媒体控制器相关联的媒体存储器中并从其获得。媒体控制器可以响应于从本地控制器接收的信号将指示非现金信息的数据转发给第二驱动程序。或者，媒体控制器可以响应于从中央系统控制器接收到的信号将指示非现金信息的数据转发给第二驱动程序。

10. 发明申请

US20060003605A1 Method and apparatus for maintaining an electrical connection to a withdrawn electrical device 有权
标题翻译：用于维持与撤回的电气装置的电连接的方法和装置
公开(公告)号：US20060003605A1
公开(公告)日：2006-01-05
申请号：US10884449
申请日：2004-07-02
申请人： Donald Brooks , Robert Bullivant
发明人： Donald Brooks , Robert Bullivant
IPC分类号： H01R11/30
CPC分类号： G07F9/00 , G06Q20/387 , G07F17/3202 , G07F17/42 , G07G1/0018 , H01R35/02
摘要： An electrical device is disposed on a base for sliding movement between first and second ends of the base. The electrical device includes a first electrical connector configured to connect to a connector board disposed on the base. The connector board includes a second electrical connector configured to mate with the first electrical connector. The connector board can move between the first and second ends. A cable electrically couples the second connector to a signal. The cable is configured to maintain electrical connectivity between the signal and the second connector as the connector board slides between the first and second ends. The electrical device can removably connect to the connector board via the first and second connectors. The connector board can slide along with the electrical device to provide electrical connectivity of the signal to the electrical device as the electrical device slides between the first and second ends.
摘要翻译：电气设备设置在基座上，用于在基座的第一和第二端之间滑动。电气设备包括被配置为连接到设置在基座上的连接器板的第一电连接器。连接器板包括配置成与第一电连接器配合的第二电连接器。连接器板可以在第一和第二端之间移动。电缆将第二连接器电耦合到信号。电缆被配置为当连接器板在第一和第二端之间滑动时，保持信号和第二连接器之间的电连接。电气设备可以通过第一和第二连接器可拆卸地连接到连接器板。连接器板可以与电气设备一起滑动，以在电气设备在第一和第二端之间滑动时提供信号到电气设备的电连接。

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