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1. 发明申请

US20110098445A1 COVALENT ATTACHMENT OF PEPTIDES AND BIOLOGICAL MOLECULES TO LUMINESCENT SEMICONDUCTOR NANOCRYSTALS 有权
标题翻译：肽和生物分子共价连接到发光半导体纳米晶体
公开(公告)号：US20110098445A1
公开(公告)日：2011-04-28
申请号：US12606766
申请日：2009-10-27
申请人： Hedi M. Mattoussi , Philip E. Dawson , Harry Tetsuo Uyeda , Igor L. Medintz , Johanna C. Scheinost
发明人： Hedi M. Mattoussi , Philip E. Dawson , Harry Tetsuo Uyeda , Igor L. Medintz , Johanna C. Scheinost
IPC分类号： C07K1/06 , C07K1/04
CPC分类号： C07K1/13 , B82Y15/00 , C07K1/042 , G01N33/587 , G01N33/588
摘要： A method for covalent attachment of peptides to luminescent quantum dots or other inorganic nanoparticles. The first step in the method involves functionalizing at least a portion of a surface of the quantum dot or nanoparticle with one or more materials having at least one reactive functional group therein. Subsequently, a peptide having a reactive functional group is reacted with at least some of the quantum dot or nanoparticle reactive functional groups to covalently bond at least some of the peptide to the quantum dots or nanoparticles. Modifications of the basic method are disclosed which provide methods allowing customized fabrication of quantum dots having a variety of different functional properties and combinations of functional properties. Also disclosed are quantum dots and nanoparticles made by the methods of the present invention.
摘要翻译：将肽共价连接到发光量子点或其它无机纳米粒子的方法。该方法的第一步包括用其中具有至少一个反应性官能团的一种或多种材料官能化量子点或纳米颗粒的表面的至少一部分。随后，具有反应性官能团的肽与至少一些量子点或纳米颗粒反应性官能团反应，以将至少一些肽共价结合到量子点或纳米颗粒上。公开了基本方法的修改，其提供允许定制制造具有各种不同功能特性和功能特性组合的量子点的方法。还公开了通过本发明的方法制备的量子点和纳米颗粒。

2. 发明授权

US08378075B2 Covalent attachment of peptides and biological molecules to luminescent semiconductor nanocrystals 有权
标题翻译：肽和生物分子共价连接到发光半导体纳米晶体上
公开(公告)号：US08378075B2
公开(公告)日：2013-02-19
申请号：US12606766
申请日：2009-10-27
申请人： Hedi M Mattoussi , Philip E Dawson , Harry Tetsuo Uyeda , Igor L Medintz , Johanna Scheinost
发明人： Hedi M Mattoussi , Philip E Dawson , Harry Tetsuo Uyeda , Igor L Medintz , Johanna Scheinost
IPC分类号： C07K14/00
CPC分类号： C07K1/13 , B82Y15/00 , C07K1/042 , G01N33/587 , G01N33/588
摘要： A method for covalent attachment of peptides to luminescent quantum dots or other inorganic nanoparticles. The first step in the method involves functionalizing at least a portion of a surface of the quantum dot or nanoparticle with one or more materials having at least one reactive functional group therein. Subsequently, a peptide having a reactive functional group is reacted with at least some of the quantum dot or nanoparticle reactive functional groups to covalently bond at least some of the peptide to the quantum dots or nanoparticles. Modifications of the basic method are disclosed which provide methods allowing customized fabrication of quantum dots having a variety of different functional properties and combinations of functional properties. Also disclosed are quantum dots and nanoparticles made by the methods of the present invention.
摘要翻译：将肽共价连接到发光量子点或其它无机纳米粒子的方法。该方法的第一步包括用其中具有至少一个反应性官能团的一种或多种材料官能化量子点或纳米颗粒的表面的至少一部分。随后，具有反应性官能团的肽与至少一些量子点或纳米颗粒反应性官能团反应，以将至少一些肽共价结合到量子点或纳米颗粒上。公开了基本方法的修改，其提供允许定制制造具有各种不同功能特性和功能特性组合的量子点的方法。还公开了通过本发明的方法制备的量子点和纳米颗粒。

3. 发明授权

US07648843B2 Field of modular multifunctional ligands 有权
标题翻译：模块化多功能配体领域
公开(公告)号：US07648843B2
公开(公告)日：2010-01-19
申请号：US11775255
申请日：2007-07-10
申请人： Harry Tetsuo Uyeda , Hedi M Mattoussi , Igor L Medintz
发明人： Harry Tetsuo Uyeda , Hedi M Mattoussi , Igor L Medintz
IPC分类号： G01N33/543 , G01N33/551 , G01N33/544 , C07C321/12 , C07C321/16
CPC分类号： B82Y15/00 , B82Y5/00 , B82Y10/00 , G01N33/532 , G01N33/588 , Y10T436/182
摘要： This invention pertains to a surface ligand; preparation of the ligand; colloidal nanoparticle, such as quantum dot bearing one or more of the ligand; and a bioconjugate characterized by a nanoparticle bearing one or more of the ligand conjugated to a biomolecule. The ligand is characterized by the presence of a first module containing atoms that can attach to an inorganic surface; a second module that imparts water-solubility to the ligand and to the inorganic surface that may be attached to the ligand; and a third module that contains a functional group that can, directly or indirectly, conjugate to a biomolecule. Order of the modules can be different and other modules and groups can be on the ligand. Preparation of the ligand includes the steps of reacting a compound having atoms that can attach to an inorganic surface with a water-solubilizing compound that imparts the property of water-solubility to the ligand and the inorganic surface to which it may be attached and purification thereof. Colloidal nanoparticle is characterized by an inorganic surface having attached to it one or more of the ligands. The colloidal bioconjugate is characterized by an inorganic surface having attached thereto one or more of the ligand wherein at least some of the ligand have a biomolecule conjugated thereto.
摘要翻译：本发明涉及表面配体; 配体的制备; 胶体纳米颗粒，例如带有一个或多个配体的量子点; 其特征在于具有一个或多个与生物分子缀合的配体的纳米颗粒。该配体的特征在于存在可以附着到无机表面上的原子的第一模块; 赋予配体和附着于配体的无机表面的水溶性的第二模块; 以及包含可以直接或间接缀合到生物分子的官能团的第三模块。模块的顺序可以不同，其他模块和组可以在配体上。配体的制备包括以下步骤：将具有可附着于无机表面的原子的化合物与赋予其可配位的无机表面和赋予其水溶性的水溶性化合物反应。胶体纳米颗粒的特征在于其上连接有一个或多个配体的无机表面。胶体生物缀合物的特征在于其上附着有一种或多种配体的无机表面，其中至少一些配体具有与其缀合的生物分子。

4. 发明授权

US09816054B2 Cleavable surfactants 有权
公开(公告)号：US09816054B2
公开(公告)日：2017-11-14
申请号：US12249584
申请日：2008-10-10
申请人： Sergei Saveliev , Daniel Simpson , Keith V. Wood , Harry Tetsuo Uyeda , Carolyn Woodroofe Hitko , Dieter Klaubert
发明人： Sergei Saveliev , Daniel Simpson , Keith V. Wood , Harry Tetsuo Uyeda , Carolyn Woodroofe Hitko , Dieter Klaubert
IPC分类号： C07C309/64 , C11D1/20 , C07C309/10 , C07C309/14 , C07C309/15 , C07C309/16 , C07C323/12 , C07C329/06 , C07D307/40 , C07D307/56 , C07D317/22 , C07D333/16 , C11D1/14
CPC分类号： C11D1/20 , C07C309/10 , C07C309/14 , C07C309/15 , C07C309/16 , C07C323/12 , C07C329/06 , C07D307/40 , C07D307/56 , C07D317/22 , C07D333/16 , C11D1/143
摘要： The invention provides surfactant compounds of formulas I-IX, which can be used in methods for aiding the solubilization, digestion, preparation, analysis, and/or characterization of biological material, for example, proteins or cell membranes. The compounds can also aid in the recovery of peptides generated during protein digestion, particularly for in-gel digestion protocol. Additionally, the compounds can improve enzymatic protein deglycosylation without interfering with downstream sample preparation steps and mass spectrometric analysis. The compounds can be specifically useful as digestion aids that can be decomposed by an acid, by heat, or a combination thereof. Decomposition of the surfactants allows for facile separation from isolated samples, and/or allows for analysis of the sample without interfering with the sensitivity of various analytical techniques.

5. 发明授权

US08288559B2 Luminogenic compounds and methods to detect cytochrome P450 3A enzymes 有权
标题翻译：发光化合物和检测细胞色素P450 3A酶的方法
公开(公告)号：US08288559B2
公开(公告)日：2012-10-16
申请号：US12543376
申请日：2009-08-18
申请人： Cesear Corona , Poncho Meisenheimer , Harry Tetsuo Uyeda
发明人： Cesear Corona , Poncho Meisenheimer , Harry Tetsuo Uyeda
IPC分类号： C07D417/04
CPC分类号： C07D277/68 , C07D417/04 , C07D417/14 , C12Q1/26 , C12Q1/66 , G01N33/531
摘要： Described herein are antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical compositions.
摘要翻译：本文描述的是抗菌化合物，制备化合物的方法，含有该化合物的药物组合物和利用该化合物和药物组合物治疗细菌感染的方法。

6. 发明申请

US20100062470A1 LUMINOGENIC COMPOUNDS AND METHODS TO DETECT CYTOCHROME P450 3A ENZYMES 有权
标题翻译：荧光化合物和检测细胞色素P450 3A酶的方法
公开(公告)号：US20100062470A1
公开(公告)日：2010-03-11
申请号：US12543376
申请日：2009-08-18
申请人： Cesear Corona , Poncho Meisenheimer , Harry Tetsuo Uyeda
发明人： Cesear Corona , Poncho Meisenheimer , Harry Tetsuo Uyeda
IPC分类号： C12Q1/26 , C07D417/04
CPC分类号： C07D277/68 , C07D417/04 , C07D417/14 , C12Q1/26 , C12Q1/66 , G01N33/531
摘要： Described herein are antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical compositions.
摘要翻译：本文描述的是抗菌化合物，制备化合物的方法，含有该化合物的药物组合物和利用该化合物和药物组合物治疗细菌感染的方法。

7. 发明授权

US07445845B2 Synthesis, spectroscopy, photophysics of multi-chromophoric ZN(II) group 8 metal complexes 有权
标题翻译：多发色ZN（II）8族金属配合物的合成，光谱，光物理
公开(公告)号：US07445845B2
公开(公告)日：2008-11-04
申请号：US10403387
申请日：2003-03-28
申请人： Michael J. Therien , Harry Tetsuo Uyeda
发明人： Michael J. Therien , Harry Tetsuo Uyeda
IPC分类号： C07B47/00 , C07D487/22
CPC分类号： C07D487/22 , Y10T428/31504
摘要： Novel multichromophoric complexes comprising the formula R1—RA-[MC]-([RM]z-[MC])m-RA—R2 are provided. Polymeric compositions and devices comprising the same are also discussed. The complexes are characterized by a central bridging moiety comprising one or a plurality of linked conjugated macrocyclic molecules [MC] coupled to at least one inorganic moiety (R1 and/or R2) through organic linker RA. Preparation methods include metal-mediated cross-coupling techniques. The complexes can be useful in nonlinear optical devices and other optoelectronic applications.
摘要翻译：包含式<？in-line-formula description =“In-line Formulas”end =“lead”的新型多重离子配合物复合物R 1 R 1 -R A - [MC ] - （[R M] Z - ] - [MC]） - -line-formula description =“内联公式”end =“tail”？>。还讨论了聚合物组合物和包含它们的装置。络合物的特征在于包含一个或多个与至少一个无机部分（R 1'和/或R 2'）偶联的连接的共轭大环分子[MC]的中心桥连部分 >）通过有机接头R A A。制备方法包括金属介导的交叉偶联技术。该复合物可用于非线性光学器件和其他光电子应用。

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