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1. 发明申请

US20070037802A1 Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands 有权
标题翻译：取代的3-磺基吲唑衍生物作为5-羟色胺-6配体
公开(公告)号：US20070037802A1
公开(公告)日：2007-02-15
申请号：US11504350
申请日：2006-08-14
申请人： Hassan Elokdah , Alexander Greenfield , Kevin Liu , Robert McDevitt , Geraldine McFarlane , Cristina Grosanu , Jennifer Lo , Yanfang Li , Albert Robichaud , Ronald Bernotas
发明人： Hassan Elokdah , Alexander Greenfield , Kevin Liu , Robert McDevitt , Geraldine McFarlane , Cristina Grosanu , Jennifer Lo , Yanfang Li , Albert Robichaud , Ronald Bernotas
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/416 , C07D413/02 , C07D403/02 , C07D231/56
CPC分类号： C07D231/56 , C07D401/12 , C07D403/06 , C07D403/12 , C07D413/12
摘要： The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供式I化合物及其用于治疗与5-HT 6受体相关或受其影响的中枢神经系统疾病的用途。

2. 发明授权

US07723329B2 Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands 有权
标题翻译：取代的3-磺基吲唑衍生物作为5-羟色胺-6配体
公开(公告)号：US07723329B2
公开(公告)日：2010-05-25
申请号：US11504350
申请日：2006-08-14
申请人： Hassan Mahmoud Elokdah , Alexander Alexei Greenfield , Kevin Liu , Robert Emmett McDevitt , Geraldine Ruth McFarlane , Cristina Grosanu , Jennifer Rebecca Lo , Yanfang Li , Albert Jean Robichaud , Ronald Charles Bernotas
发明人： Hassan Mahmoud Elokdah , Alexander Alexei Greenfield , Kevin Liu , Robert Emmett McDevitt , Geraldine Ruth McFarlane , Cristina Grosanu , Jennifer Rebecca Lo , Yanfang Li , Albert Jean Robichaud , Ronald Charles Bernotas
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/416 , C07D413/02 , C07D231/56
CPC分类号： C07D231/56 , C07D401/12 , C07D403/06 , C07D403/12 , C07D413/12
摘要： The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供式I化合物及其用于治疗与5-HT 6受体相关或受其影响的中枢神经系统疾病的用途。

3. 发明申请

US20070191431A1 2-Amino-5-piperidinylimidazolone compounds and use thereof for beta-secretase modulation 审中-公开
标题翻译： 2-氨基-5-哌啶基咪唑酮化合物及其用于β-分泌酶调节的用途
公开(公告)号：US20070191431A1
公开(公告)日：2007-08-16
申请号：US11640751
申请日：2006-12-18
申请人： Ping Zhou , Ronald Bernotas , Yanfang Li , Pawel Nowak , Derek Cole , Eric Manas , Yi Fan , Yinfa Yan
发明人： Ping Zhou , Ronald Bernotas , Yanfang Li , Pawel Nowak , Derek Cole , Eric Manas , Yi Fan , Yinfa Yan
IPC分类号： A61K31/454 , C07D403/02 , C07D405/14
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D405/14
摘要： The present invention provides a 2-amino-5-piperidinylimidazolone compound of formula I The present invention also provides methods and compositions for the inhibition of β-secretase (BACE) and the treatment of β-amyloid deposits and neurofibrillary tangles.
摘要翻译：本发明提供式I的2-氨基-5-哌啶基咪唑酮化合物本发明还提供了抑制β-分泌酶（BACE）和β-淀粉样蛋白沉积物和神经原纤维缠结的治疗的方法和组合物。

4. 发明申请

US20070004730A1 Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation 失效
标题翻译：氨基-5-（6元）杂芳基咪唑酮化合物及其用于β-分泌酶调节的用途
公开(公告)号：US20070004730A1
公开(公告)日：2007-01-04
申请号：US11478098
申请日：2006-06-29
申请人： Ping Zhou , Michael Malamas , Yanfang Li , Albert Robichaud , Dominick Quagliato
发明人： Ping Zhou , Michael Malamas , Yanfang Li , Albert Robichaud , Dominick Quagliato
IPC分类号： A61K31/53 , A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4439 , C07D403/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14
摘要： The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles
摘要翻译：本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样蛋白沉积物和神经原纤维缠结的方法

5. 发明申请

US20050065186A1 Heterocyclyloxy-, -thioxy-and-aminobenzazole derivatives as 5-hydroxytryptamine-6 ligands 审中-公开
标题翻译：作为5-羟基色胺-6配体的杂环氧基 - ， - 羟基 - 和 - 氨基苯甲唑衍生物
公开(公告)号：US20050065186A1
公开(公告)日：2005-03-24
申请号：US10949062
申请日：2004-09-24
申请人： Ping Zhou , Boyd Harrison , Yanfang Li
发明人： Ping Zhou , Boyd Harrison , Yanfang Li
IPC分类号： A61K31/404 , A61K31/416 , A61K31/454 , A61K31/4709 , A61P1/04 , A61P1/14 , A61P3/04 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/36 , A61P43/00 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D403/02 , A61K31/4184
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14
摘要： The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供式I化合物及其用于治疗与5-HT 6受体有关或受其影响的病症的用途。

6. 发明申请

US20090042908A1 AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR BETA-SECRETASE MODULATION 审中-公开
标题翻译： AMINO-5-（6-MEMBERED）异环糊精化合物及其用于BETA-分泌酶调节的用途
公开(公告)号：US20090042908A1
公开(公告)日：2009-02-12
申请号：US12248996
申请日：2008-10-10
申请人： Ping Zhou , Michael Sotirios Malamas , Yanfang Li , Albert Jean Robichaud , Dominick Anthony Quagliato
发明人： Ping Zhou , Michael Sotirios Malamas , Yanfang Li , Albert Jean Robichaud , Dominick Anthony Quagliato
IPC分类号： A61K31/497 , A61K31/4439 , A61K31/444 , A61P25/28 , A61P25/00 , A61K31/506
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14
摘要： The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles
摘要翻译：本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样蛋白沉积物和神经原纤维缠结的方法

7. 发明授权

US07297704B2 Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives 失效
标题翻译：环烷基稠合吲哚，苯并噻吩，苯并呋喃和异烯衍生物
公开(公告)号：US07297704B2
公开(公告)日：2007-11-20
申请号：US11355452
申请日：2006-02-16
申请人： Annmarie Louise Sabb , Robert Lewis Vogel , Gary Paul Stack , Deborah Ann Evrard , Amedeo Arturo Failli , Lalitha Krishnan , Anita Wai-Yin Chan , Jianxin Ren , Charles J. Guinosso , Reinhardt Bernhard Baudy , Jean Yi-ching Sze , Yanfang Li , Charles John Stanton, III , Antonia Nikitenko
发明人： Annmarie Louise Sabb , Robert Lewis Vogel , Gary Paul Stack , Deborah Ann Evrard , Amedeo Arturo Failli , Lalitha Krishnan , Anita Wai-Yin Chan , Jianxin Ren , Charles J. Guinosso , Reinhardt Bernhard Baudy , Jean Yi-ching Sze , Yanfang Li , Charles John Stanton, III , Antonia Nikitenko
IPC分类号： C07D209/48 , C07D207/40 , C07D207/444
CPC分类号： C07D209/88 , C07D233/76 , C07D491/04 , C07D493/04
摘要： The present invention provides cycloalkylfused indole, benzothiophene, benzofuran, and indene derivatives, and methods for using them to, for example, treat, prevent and/or ameliorate central nervous system diseases by antagonizing 5-HT1A receptors and modulating serotonin levels.
摘要翻译：本发明提供环烷基稠合的吲哚，苯并噻吩，苯并呋喃和茚衍生物，以及使用它们例如通过拮抗5-HT 1A受体来治疗，预防和/或改善中枢神经系统疾病的方法。并调节5-羟色胺水平。

8. 发明申请

US20070073251A1 Easily retrieved biological specimen pouch 审中-公开
标题翻译：容易回收的生物样本袋
公开(公告)号：US20070073251A1
公开(公告)日：2007-03-29
申请号：US10575500
申请日：2004-10-15
申请人： Xing Zhou , Yanfang Li , Aijun Guo
发明人： Xing Zhou , Yanfang Li , Aijun Guo
IPC分类号： A61M1/00
CPC分类号： A61B10/00 , A61B17/221 , A61B2017/00287 , A61B2017/00867
摘要： The invention relates to an easily retrieved biological specimen pouch. The said easily retrieved biological specimen pouch of the invention comprises a flexible wall, an open end and a closed end, and the specimen pouch can receive a biological specimen; A) The flexible wall of the open end of the specimen pouch has discontinuous serration; B) On the said serration, there are slots through which an open and retrieval string or an open spring or a retrieval noose can pass. As the open end of the specimen pouch is provided with a flexible wall of discontinuous serration, and the open and retrieval string or the retrieval noose passes through the slots on the discontinuous serration of the flexible wall of the open end of the specimen pouch, when the open and retrieval string is pulled towards an outer sheath to retrieve the specimen pouch of the invention, the bulk of contracted open end is reduced due to the discontinuous serration of the flexible wall of the open end. It is easy to close the open end of the specimen pouch, and convenient to retrieve the specimen pouch into the outer sheath or extract it through a small incision. The specimen pouch of the invention is simple, convenient, safe and efficient.
摘要翻译：本发明涉及容易回收的生物样本袋。本发明的所述容易回收的生物样本袋包括柔性壁，开口端和封闭端，并且样本袋可以容纳生物样本; A）试样袋开口端的柔性壁具有不连续的锯齿状; B）在上述锯齿处，有一个槽，一个开放的和取出的绳子或一个开放的弹簧或一个取出的套索可以通过。由于试样袋的开放端设置有不连续锯齿的柔性壁，开放和取出的绳索或取回的索糖通过样品袋开放端的柔性壁的不连续锯齿上的槽，当打开和取出的绳子被拉向外护套以取回本发明的试样袋，由于开口端的柔性壁的不连续的锯齿，收缩的开口端的大部分被减小。容易关闭样品袋的开口端，方便将样本袋取回到外护套中或通过小切口提取。本发明的样品袋简单，方便，安全，高效。

9. 发明申请

US20050065185A1 Heterocyclylalkoxy-, -alkylthio- and -alkylaminobenzazole derivatives as 5-hydroxytryptamine-6 ligands 审中-公开
标题翻译：杂环基烷氧基 - ， - 烷硫基 - 和 - 烷基氨基苯唑衍生物作为5-羟色胺-6配体
公开(公告)号：US20050065185A1
公开(公告)日：2005-03-24
申请号：US10949061
申请日：2004-09-24
申请人： Yanfang Li , Ping Zhou
发明人： Yanfang Li , Ping Zhou
IPC分类号： A61K31/404 , A61K31/416 , A61K31/4709 , A61P25/00 , A61P25/16 , A61P25/22 , A61P25/28 , A61P43/00 , C07D207/06 , C07D401/14 , C07D403/12 , C07D409/14 , C07D403/02 , A61K31/4184 , A61K31/454
CPC分类号： C07D401/14 , C07D207/06 , C07D403/12 , C07D409/14
摘要： The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供式I化合物及其用于治疗与5-HT 6受体有关或受其影响的病症的用途。

10. 发明申请

US20110288483A1 Groove Universal Radial Seal Ring Used in a Trocar and Trocar 审中-公开
标题翻译：沟槽通用径向密封环用于套管针和套管针
公开(公告)号：US20110288483A1
公开(公告)日：2011-11-24
申请号：US13146185
申请日：2009-07-02
申请人： Xing Zhou , Yanfang Li
发明人： Xing Zhou , Yanfang Li
IPC分类号： A61B17/34
CPC分类号： A61B17/3462 , A61B2017/3464
摘要： A grooved universal radial seal ring used in a trocar and a trocar are provided. The radial seal ring includes one or more easily-deformable grooves, one or more supporting areas capable of guiding surgical device movement, and a through hole, the supporting areas of the seal ring are connected by the easily-deformable grooves, a thickness of the easily-deformable grooves is much smaller than an average thickness of the supporting areas, so that when a surgical device is inserted along a cone-shaped guiding groove of the supporting areas, the easily-deformable grooves deform first and surround the surgical device because a wall thickness of the easily-deformable grooves is very small, thereby achieving a sealing effect. When the surgical device shakes, the supporting areas separated by the easily-deformable grooves also shake together, but the seal ring formed by the easily-deformable grooves still surrounds the surgical device, thereby always keeping a sealed state and achieving an excellent dynamic sealing effect. Particularly, the thickness of the easily-deformable grooves is small, not only a dynamic sealing effect is excellent, but also surgical device moving resistance is small. The trocar realizes any replacement among surgical devices with diameters being 12 millimeters (mm), 10 mm, and 5 mm, thereby bringing convenience to surgical operation.
摘要翻译：提供了一种用于套管针和套针针的开槽通用径向密封环。径向密封环包括一个或多个容易变形的凹槽，一个或多个能够引导手术装置运动的支撑区域，以及通孔，密封环的支撑区域由容易变形的凹槽连接，厚度为容易变形的凹槽远小于支撑区域的平均厚度，使得当手术装置沿着支撑区域的锥形引导槽插入时，容易变形的凹槽首先变形并围绕外科手术装置，因为易变形槽的壁厚非常小，从而实现密封效果。当手术装置摇动时，由容易变形的凹槽分开的支撑区域也摇动在一起，但由容易变形的凹槽形成的密封环仍然包围手术装置，从而始终保持密封状态并实现优异的动态密封效果。特别地，易变形槽的厚度小，不仅动态密封效果优异，而且手术装置的移动阻力小。套管针实现直径为12毫米（10mm），10mm和5mm的手术装置之间的任何替换，从而为外科手术带来便利。

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