专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5039696A Maleimide derivatives and fungicides for agriculture and horticulture containing the same 失效
标题翻译：用于农业和园艺的马来酰亚胺衍生物和杀真菌剂
公开(公告)号：US5039696A
公开(公告)日：1991-08-13
申请号：US473632
申请日：1990-02-01
申请人： Shinjiro Niwata , Harukazu Fukami , Masaki Hashimoto , Norio Ohtsuka , Fumio Fujita
发明人： Shinjiro Niwata , Harukazu Fukami , Masaki Hashimoto , Norio Ohtsuka , Fumio Fujita
IPC分类号： C07D207/452 , A01N37/46 , C07D207/44 , C07D207/456
CPC分类号： C07D207/456 , A01N37/46
摘要： A maleimide derivative useful as an active agent for a fungicide for agriculture and horticulture, having the formula (I): ##STR1## wherein X and Y each independently represent a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an aralkyloxy group or a trifluoromethyl group,Z represents a chlorine atom or bromine atom,and R represents a straight or branched alkyl group having 1 to 15 carbon atoms, an alkenyl group having 2 to 5 carbon atoms, an alkynyl group having 2 to 5 carbon atoms, an alkoxyalkyl group having 2 to 5 carbon atoms, an oxoalkyl group having 3 to 6 carbon atoms or a phenyl group or a phenyl alkyl group which may be substituted.

2. 发明授权

US4945104A Maleimide derivatives and use thereof in agricultural and horticultural fungicides 失效
标题翻译：马来酰亚胺衍生物及其在农业和园艺杀真菌剂中的应用
公开(公告)号：US4945104A
公开(公告)日：1990-07-31
申请号：US370800
申请日：1989-06-23
申请人： Harukazu Fukami , Masaki Hashimoto , Shinjiro Niwata , Norio Ohtsuka , Fumio Fujita
发明人： Harukazu Fukami , Masaki Hashimoto , Shinjiro Niwata , Norio Ohtsuka , Fumio Fujita
IPC分类号： C07D207/452 , A01N37/32 , A01N39/00 , A01N43/36 , C07D207/44 , C07D207/456
CPC分类号： C07D207/456 , A01N39/00
摘要： A maleimide derivative having the formula (I): ##STR1## wherein R.sub.1 represents a lower alkyl group having 1 to 4 carbon atoms, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 independently represent a hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms, a phenyl group which may be substituted, or an aralkyl group having 7 to 10 carbon atoms, and X.sub.1 and X.sub.2 independently represent a hydrogen atom or a halogen atom, and a production process thereof as well as a agricultural and horticultural fungicide containing, as an active ingredient, the maleimide derivative.

3. 发明授权

US5141551A Benzoxazine derivative and benzothiazine derivative and herbicide comprising the same as active ingredient 失效
标题翻译：苯并恶嗪衍生物和苯并噻嗪衍生物和除草剂包含其中的活性成分
公开(公告)号：US5141551A
公开(公告)日：1992-08-25
申请号：US631978
申请日：1990-12-21
申请人： Naoko Kawaguchi , Harukazu Fukami , Shinjiro Niwata , Ryuichi Sago , Fumio Fujita
发明人： Naoko Kawaguchi , Harukazu Fukami , Shinjiro Niwata , Ryuichi Sago , Fumio Fujita
IPC分类号： A01N43/84 , C07D265/36 , C07D279/16 , C07D413/12 , C07D417/12
CPC分类号： C07D413/10 , A01N43/84 , C07D265/36 , C07D279/16 , C07D417/12
摘要： A benzoxazine derivative and a benzothiazine derivative having the formula (I): ##STR1## wherein A is N or a CH group;B is O, S, and SO group or an SO.sub.2 group;W is O, S, a CR.sup.4 R.sup.5 group or an NR.sup.4 group wherein R.sup.4 and R.sup.5 are each independently a hydrogen atom, a CN group or an NO.sub.2 group;X, Y and Z are each independently a hydrogen atom, a halogen atom or a lower haloalkyl group having 1 to 3 carbon atoms;R.sup.1 is a hydrogen atom, a lower alkyl group having 1 to 5 carbon atoms, a lower alkenyl group having 2 to 5 carbon atoms, a lower alkynyl group having 2 to 5 carbon atoms, a lower hydroxyalkyl group having 1 to 5 carbon atoms or a lower haloalkyl group having 1 to 3 carbon atoms; andR.sup.2 and R.sup.3 are each independently a hydrogen atom, a lower alkyl group having 1 to 5 carbon atoms or an aryl group having 6 to 10 carbon atoms and a herbicidal composition containing the compound of the formula (I) as an active ingredient.

4. 发明授权

US5424310A Substituted 1,2,4-triazine-3,5-dione derivative and anticoccidial drug composition containing the same as active component 失效
标题翻译：取代的1,2,4-三嗪-3,5-二酮衍生物和含有活性成分的抗球虫药物组合物
公开(公告)号：US5424310A
公开(公告)日：1995-06-13
申请号：US79925
申请日：1993-06-23
申请人： Harukazu Fukami , Masaki Hashimoto , Shinjiro Niwata , Jun Imose , Harumoto Kawaguchi , Toshio Takahashi
发明人： Harukazu Fukami , Masaki Hashimoto , Shinjiro Niwata , Jun Imose , Harumoto Kawaguchi , Toshio Takahashi
IPC分类号： A61K31/53 , A61P33/02 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D253/075
CPC分类号： C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： A substituted 1,2,4-triazine-3,5-dione derivative having the formula (I) or a salt thereof: ##STR1## wherein R represents a 5- or 6-membered heterocyclic group which may have at least one substituent selected from the group consisting of a halogen, a lower alkyl group and a halogenated lower alkyl group, and an anticoccidial drug composition containing the same as an active component.
摘要翻译：具有式（I）的取代的1,2,4-三嗪-3,5-二酮衍生物或其盐：其中R表示可以具有至少5或6元杂环基选自卤素，低级烷基和卤代低级烷基的一个取代基和含有它们作为活性组分的抗球虫药物组合物。

5. 发明授权

US5814631A Quinazoline derivatives and applications thereof 失效
标题翻译：喹唑啉衍生物及其应用
公开(公告)号：US5814631A
公开(公告)日：1998-09-29
申请号：US849114
申请日：1997-05-28
申请人： Harukazu Fukami , Akiko Ito , Shinjiro Niwata , Saki Kakutani , Motoo Sumida , Yoshinobu Kiso
发明人： Harukazu Fukami , Akiko Ito , Shinjiro Niwata , Saki Kakutani , Motoo Sumida , Yoshinobu Kiso
IPC分类号： C07D239/96 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07F9/6512 , A61K31/495 , A61K31/505 , C07D239/72 , C07D403/02
CPC分类号： C07D401/06 , C07D239/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07F9/65128
摘要： A chymase inhibitor containing as its effective ingredient a quinazoline derivative, or a pharmaceutically acceptable salt thereof, having the formula (1): ##STR1## and a pharmaceutical preparation for the prevention of cardiac and circulatory system diseases derived from abnormal exacerbation of Ang II production containing the same as its effective ingredient.
摘要翻译： PCT No.PCT / JP96 / 02830 Sec。 371日期：1997年5月8日 102（e）日期1997年5月8日PCT提交1996年9月27日PCT公布。公开号WO97 / 11941 日期1997年3月4日含有具有式（1）的喹唑啉衍生物或其药学上可接受的盐作为其有效成分的胃促胰酶抑制剂：（1）和用于预防心脏和循环系统疾病的药物制剂衍生自与其有效成分相同的Ang II产生异常恶化。

6. 发明授权

US5691335A Imidazolidine derivative and use thereof 失效
标题翻译：咪唑烷衍生物及其用途
公开(公告)号：US5691335A
公开(公告)日：1997-11-25
申请号：US615277
申请日：1996-03-28
申请人： Harukazu Fukami , Motoo Sumida , Shinjiro Niwata , Saki Kakutani , Saitoh Masayuki , Shibata Hiroshi , Kiso Yoshinobu
发明人： Harukazu Fukami , Motoo Sumida , Shinjiro Niwata , Saki Kakutani , Saitoh Masayuki , Shibata Hiroshi , Kiso Yoshinobu
IPC分类号： C07D233/80 , C07D233/84 , C07D233/86 , C07D401/04 , C07D403/04 , C07D405/12 , A61K31/415 , A61K31/495
CPC分类号： C07D401/04 , C07D233/80 , C07D233/86 , C07D403/04 , C07D405/12
摘要： The invention relates to an imidazolidine derivative represented by the following general formula (1): ##STR1## wherein A and B mean individually an aromatic hydrocarbon group which may be substituted by 1-3 substituents selected from halogen atoms, C.sub.1-4 alkyl groups, C.sub.1-4 alkoxy groups, C.sub.1-4 alkylenedioxy groups, a phenoxy group, a nitro group, a cyano group, a phenyl group, C.sub.2-5 alkanoylamino groups, a carboxyl group which may be esterified with a C.sub.1-4 alkyl or alkenyl group, carboxyalkyl groups which may be esterified with a C.sub.1-4 alkyl or alkenyl group, carboxyalkyloxy groups which may be esterified with a C.sub.1-4 alkyl or alkenyl group, N-alkylpiperazinylcarbonyl groups, N-alkylpiperazinylcarbonylalkyl groups, N-alkylpiperazinylcarbonylalkyloxy groups, and a morpholinocarbonyl group; X denotes a sulfonyl or carbonyl group; and Y stands for an oxygen or sulfur atom, a chymase inhibitor comprising the same as an active ingredient, and a medicine comprising the same as an active ingredient, typified by a prophylactic and therapeutic agent for a disease of the heart or circulatory system, which is caused by the abnormal acceleration of production of angiotensin II.
摘要翻译： PCT No.PCT / JP95 / 01485第 371日期：1996年3月28日 102（e）1996年3月28日PCT PCT 1995年7月26日PCT公布。出版物WO96 / 04248 日期：1996年2月15日本发明涉及由以下通式（1）表示的咪唑烷衍生物：其中A和B分别表示可被1-3个选自以下的取代基取代的芳族烃基：卤素原子，C 1-4烷基，C 1-4烷氧基，C 1-4亚烷基二氧基，苯氧基，硝基，氰基，苯基，C 2-5烷酰基氨基，可被酯化的羧基可以被C 1-4烷基或链烯基酯化的羧基烷基，可被C 1-4烷基或链烯基酯化的羧基烷氧基，N-烷基哌嗪基羰基，N-烷基哌嗪基羰基烷基，，N-烷基哌嗪基羰基烷氧基和吗啉代羰基; X表示磺酰基或羰基; Y表示氧或硫原子，包含与活性成分相同的胃促胰酶抑制剂和包含其作为活性成分的药物，以心脏或循环系统疾病的预防和治疗剂为代表，其中是由血管紧张素II的异常加速引起的。

7. 发明授权

US5205855A Herbicidally active phenoxyalkanecarboxylic acid derivatives 失效
标题翻译：除草活性苯氧亚硬脂酸衍生物
公开(公告)号：US5205855A
公开(公告)日：1993-04-27
申请号：US578254
申请日：1990-09-06
申请人： Harukazu Fukami , Naoki Higuchi , Naoko Kawaguchi , Masaki Hashimoto , Kinya Ide , Toshio Takahashi
发明人： Harukazu Fukami , Naoki Higuchi , Naoko Kawaguchi , Masaki Hashimoto , Kinya Ide , Toshio Takahashi
IPC分类号： A01N39/02 , A01N39/04 , A01N41/06 , A01N43/40 , A01N47/12 , A01N47/24 , C07C69/712 , C07C205/38 , C07D213/64 , C07D213/643
CPC分类号： C07D213/643 , A01N39/02 , A01N39/04 , A01N41/06 , A01N43/40 , A01N47/12 , A01N47/24 , C07C205/38 , C07C69/712
摘要： A compound of the formula: ##STR1## wherein Q.sup.1 is CH or N; R is H or C.sub.1 -C.sub.5 alkyl; X is H, halogen, CF.sub.3, or NO.sub.2 ; Y is H or halogen; Z is --O-- or --NH--; A is ##STR2## wherein Q.sup.2, and Q.sup.3 are each CH or N; R.sup.1 and R.sup.2 are each H, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, or C.sub.2 -C.sub.6 alkoxycarbonyl; R.sup.3, R.sup.4, and R.sup.5 are each H or C.sub.1 -C.sub.5 alkyl; R.sup.6 is H, halogen, or C.sub.1 -C.sub.5 alkyl; R.sup.7, R.sup.8, R.sup.9, and R.sup.10 are each H or C.sub.1 -C.sub.5 alkyl; R.sup.11 is H, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, C.sub.2 -C.sub.6 alkenyl, C.sub.6 -C.sub.10 aryl, C.sub.7 -C.sub.15 aryloxyalkyl, or C.sub.7 -C.sub.15 aralkyl; R.sup.12 and R.sup.13 are each H or C.sub.1 -C.sub.5 alkyl; R.sup.14 is C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.5 -C.sub.10 aryl, or C.sub.7 -C.sub.15 aralkyl; or R.sup.13 and R.sup.14 taken together form C.sub.3 -C.sub.4 alkylene, V.sup.1 and V.sup.2 and are each H, halogen, NO.sub.2, CN, or CF.sub.3 ; V.sup.3 is halogen or CF.sub.3 ; W.sup.1 is --O-- or --NH--; W.sup.2 is --(CH.sub.2).sub.n -- wherein n is 0 or 1, or CO; X.sup.1 is halogen, or a salt thereof, which is effective as a herbicidal agent.
摘要翻译：下式的化合物：其中Q 1是CH或N; R是H或C 1 -C 5烷基; X是H，卤素，CF 3或NO 2; Y为H或卤素; Z是-O-或-NH-; A是其中Q2和Q3各自为CH或N; R 1和R 2各自为H，C 1 -C 5烷基，C 1 -C 5烷氧基或C 2 -C 6烷氧基羰基; R 3，R 4和R 5各自为H或C 1 -C 5烷基; R6是H，卤素或C1-C5烷基; R 7，R 8，R 9和R 10各自为H或C 1 -C 5烷基; R11是H，C1-C5烷基，C1-C5烷氧基，C2-C6烯基，C6-C10芳基，C7-C15芳氧基烷基或C7-C15芳烷基; R 12和R 13各自为H或C 1 -C 5烷基; R14是C1-C5烷基，C2-C6烯基，C5-C10芳基或C7-C15芳烷基; 或R 13和R 14一起形成C 3 -C 4亚烷基，V 1和V 2，各自为H，卤素，NO 2，CN或CF 3; V3是卤素或CF 3; W1是-O-或-NH-; W2是 - （CH2）n-，其中n是0或1，或CO; X1是作为除草剂有效的卤素或其盐。

8. 发明授权

US5198458A Pyrrolidineamide derivatives of acylamino acid and pharmaceutical composition containing the same 失效
标题翻译：酰氨基酸的吡咯烷酰胺衍生物和含有它们的药物组合物
公开(公告)号：US5198458A
公开(公告)日：1993-03-30
申请号：US638148
申请日：1991-01-09
申请人： Naoki Higuchi , Masayuki Saitoh , Masaki Hashimoto , Harukazu Fukami , Takaharu Tanaka
发明人： Naoki Higuchi , Masayuki Saitoh , Masaki Hashimoto , Harukazu Fukami , Takaharu Tanaka
IPC分类号： C07D207/16 , C07D295/185
CPC分类号： C07D295/185 , C07D207/16
摘要： A compound of the general formula: ##STR1## wherein m is an integer of 1 to 7,n is 0 or an integer of 1 to 5,R.sup.1 is the phenyl, a substituted phenyl, the phenoxy, a substituted phenoxy or a saturated or unsaturated straight alkyl having 5 to 18 carbon atoms,R.sup.2 is hydrogen atom,R.sup.3 is hydrogen atom, a branched or unbranched alkyl having 3 to 5 carbon atoms, the phenyl, hydroxyphenyl, benzyloxyphenyl, an alkylthio having 1 to 3 carbon atoms in its alkyl moiety, amino, carboxyl, hydroxy, benzyloxy, indolyl or imidazolyl, or R.sup.2 and R.sup.3 together form a single bond between the carbon atom and the nitrogen atom, and a pharmaceutical composition containing said compound are provided. The compound is effective in curing amnesia because of its anti-prolyl endopeptidase activity.
摘要翻译：一种通式如下的化合物：其中m为1〜7的整数，n为0或1〜5的整数，R 1为苯基，取代苯基，苯氧基，取代的苯氧基或具有5至18个碳原子的饱和或不饱和直链烷基，R 2是氢原子，R 3是氢原子，具有3至5个碳原子的支链或非支链烷基，苯基，羟基苯基，苄氧基苯基，具有1至3个碳原子的烷硫基在其烷基部分中，氨基，羧基，羟基，苄氧基，吲哚基或咪唑基，或R2和R3一起形成碳原子和氮原子之间的单键，并提供含有所述化合物的药物组合物。该化合物由于其抗脯氨酰内肽酶活性而有效地治愈健忘症。

9. 发明授权

US4757083A Novel pyrrolidinylamide ester derivatives having anti-prolyl endopeptidase activity and synthesis and use thereof 失效
标题翻译：具有抗脯氨酰内肽酶活性的新型吡咯烷酰胺酯衍生物及其合成和用途
公开(公告)号：US4757083A
公开(公告)日：1988-07-12
申请号：US936445
申请日：1986-12-01
申请人： Naoki Higuchi , Masayuki Saitoh , Masaki Hashimoto , Harukazu Fukami , Takaharu Tanaka
发明人： Naoki Higuchi , Masayuki Saitoh , Masaki Hashimoto , Harukazu Fukami , Takaharu Tanaka
IPC分类号： A61K31/445 , A61K31/40 , A61K31/401 , A61P25/00 , A61P43/00 , C07D295/10 , C07D295/185 , C12N9/99 , C07D295/18
CPC分类号： C07D295/185
摘要： A novel pyrrolidinylamide ester derivative that exhibits inhibitory activity against prolyl endopeptidase, methods for synthesis thereof and its use as an inhibitor against said enzyme are disclosed. The pyrrolidinylamide ester of the invention has the following general formula: ##STR1## wherein n is 0 or an integer of 1 to 7 and R is hydrogen atom or a straight or branched alkyl having 1 to 8 carbon atoms.
摘要翻译：公开了一种对脯氨酰内肽酶具有抑制活性的新型吡咯烷酰胺酯衍生物，其合成方法及其作为对所述酶的抑制剂的用途。本发明的吡咯烷酰胺酯具有以下通式：其中n为0或1〜7的整数，R为氢原子或碳原子数为1〜8的直链或支链烷基。

10. 发明授权

US4976773A Herbicidally active phenoxyalkanecarboxylic acid derivatives 失效
标题翻译：除草活性苯氧亚硬脂酸衍生物
公开(公告)号：US4976773A
公开(公告)日：1990-12-11
申请号：US230481
申请日：1988-08-10
申请人： Harukazu Fukami , Naoki Higuchi , Naoko Kawaguchi , Masaki Hashimoto , Kinya Ide , Toshio Takahashi
发明人： Harukazu Fukami , Naoki Higuchi , Naoko Kawaguchi , Masaki Hashimoto , Kinya Ide , Toshio Takahashi
IPC分类号： A01N37/02 , A01N37/18 , A01N37/24 , A01N39/02 , A01N39/04 , A01N41/06 , A01N43/40 , A01N47/12 , A01N47/24 , C07C69/712 , C07C205/38 , C07C255/54 , C07C311/39 , C07D213/64 , C07D213/643 , C07D213/84 , C07D213/85
CPC分类号： C07D213/643 , A01N39/02 , A01N39/04 , A01N41/06 , A01N43/40 , A01N47/12 , A01N47/24 , C07C205/38 , C07C255/54 , C07C311/39
摘要： A compound of the formula: ##STR1## wherein Q.sup.1 is CH or N; R is H or C.sub.1 -C.sub.5 alkyl; X is H, halogen, CF.sub.3, or NO.sub.2 ; Y is H or halogen; Z is --O-- or --NH--; A is ##STR2## wherein Q.sup.2, and Q.sup.3 are each CH or N; R.sup.1 and R.sup.2 are each H, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, or C.sub.2 -C.sub.6 alkxoycarobnyl; R.sup.3, R.sup.4, and R.sup.5 are each H or C.sub.1 -C.sub.5 alkyl; R.sup.6 is H, halogen, or C.sub.1 -C.sub.5 alkyl; R.sup.7, R.sup.8, R.sup.9, and R.sup.10 are each H or C.sub.1 -C.sub.5 alkyl; R.sup.11 is H, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, C.sub.2 -C.sub.6 alkenyl, C.sub.6 -C.sub.10 aryl, C.sub.7 -C.sub.15 aryloxyalkyl, or C.sub.7 -C.sub.15 aralkyl; R.sup.12 and R.sup.13 are each H or C.sub.1 -C.sub.5 alkyl; R.sup.14 is C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.5 -C.sub.10 aryl, or C.sub.7 -C.sub.15 aralkyl; or R.sup.13 and R.sup.14 taken together form C.sub.3 -C.sub.4 alkylene, V.sup.1 and V.sup.2 are each H, halogen, NO.sub.2, CN, or CF.sub.3 ; V.sup.3 is halogen or CF.sub.3 ; W.sup.1 is --O-- or --NH--; W.sup.2 is --(CH.sub.2).sub.n -- wherein n is 0 or 1, or CO; X.sup.1 is halogen, or a salt thereof, which is effective as a herbicidal agent.
摘要翻译：下式的化合物：其中Q 1是CH或N; R是H或C 1 -C 5烷基; X是H，卤素，CF 3或NO 2; Y为H或卤素; Z是-O-或-NH-; A是，其中Q 2和Q 3各自为CH或N; R 1和R 2各自为H，C 1 -C 5烷基，C 1 -C 5烷氧基或C 1 -C 5烷氧基羰基; R 3，R 4和R 5各自为H或C 1 -C 5烷基; R 6是H，卤素或C 1 -C 5烷基; R 7，R 8，R 9和R 1各自为H或C 1 -C 5烷基; R 1是H，C 1 -C 5烷基，C 1 -C 5烷氧基，C 2 -C 6烯基，C 6 -C 10芳基，C 7 -C 15芳氧基烷基或C 7 -C 15芳烷基; R 1，R 2和R 3各自为H或C 1 -C 5烷基; R 1为C 1 -C 5烷基，C 2 -C 6烯基，C 5 -C 10芳基或C 7 -C 15芳烷基; 或R 1 3和R 1 4。一起形成C 3 -C 4亚烷基，V 1和V 2各自为H，卤素，NO 2，CN或CF 3; V 3是卤素或CF 3; W 1是-O-或-NH-; W 2为 - （CH 2）n - ，其中n为0或1，或CO; X 1是作为除草剂有效的卤素或其盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式