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1. 发明申请

US20100196901A1 Method for Obtaining Information on Biological Rhythm by Using Hair 审中-公开
标题翻译：使用头发获取生物节律信息的方法
公开(公告)号：US20100196901A1
公开(公告)日：2010-08-05
申请号：US12669153
申请日：2008-07-16
申请人： Takuro Yamamoto , Makoto Akashi , Shiko Yamashita , Tomoteru Abe , Kazuhiro Nakagawa , Haruhiko Soma , Koichi Node , Noriyuki Kishii , Tomohiro Hayakawa
发明人： Takuro Yamamoto , Makoto Akashi , Shiko Yamashita , Tomoteru Abe , Kazuhiro Nakagawa , Haruhiko Soma , Koichi Node , Noriyuki Kishii , Tomohiro Hayakawa
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6876 , C12Q2600/158
摘要： To provide a simple and low-invasive method for obtaining information on a biorhythm of an individual organism. Provided is a method for obtaining information on a biorhythm of an individual organism based on variations over time in an expression level of a clock gene in a hair follicle cell of the individual organism. According to this method, a phase shift of the biorhythm of the individual organism can be detected by preparing a plurality of times about the individual organism and conducting a collation. Further, a phase shift of the biorhythm of the individual organism can also be detected by collating an expression level of the clock gene at a predetermined time with the molecular clock table.
摘要翻译：提供一种用于获取关于个体生物体的生物节律信息的简单且低侵入性的方法。本发明提供一种基于个体生物体的毛囊细胞中的时钟基因的表达水平随时间变化获得关于个体生物体的生物节律的信息的方法。根据该方法，可以通过多次制备关于个体生物体并进行核对来检测个体生物体的生物节律的相位偏移。此外，也可以通过将时钟基因在预定时间的表达水平与分子时钟表进行比较来检测个体生物体的生物节律的相移。

2. 发明申请

US20110196619A1 METHOD FOR PREDICTING BIOLOGICAL RHYTHM 审中-公开
标题翻译：预测生物RHYTHM的方法
公开(公告)号：US20110196619A1
公开(公告)日：2011-08-11
申请号：US13123847
申请日：2009-10-13
申请人： Haruhiko Soma , Takuro Yamamoto , Makoto Akashi , Koichi Node , Noriyuki Kishii , Kazuhiro Nakagawa , Shiko Yamashita , Tomohiro Hayakawa
发明人： Haruhiko Soma , Takuro Yamamoto , Makoto Akashi , Koichi Node , Noriyuki Kishii , Kazuhiro Nakagawa , Shiko Yamashita , Tomohiro Hayakawa
IPC分类号： G06F19/00
CPC分类号： C12Q1/6876 , A61B10/02 , C12Q1/6809 , C12Q2600/158 , G16B25/00 , G16B40/00 , C12Q2537/165
摘要： There is provided a method that achieves the prediction of a biological rhythm with high precision while minimizing the number of times a biological specimen is collected from a subject. There is also provided a method for predicting a biological rhythm of a subject on the basis of time series expression level data obtained by measuring expression levels of two clock genes in biological specimens collected from the subject three times within 24 hours, the clock genes having different phases of circadian cycles of a change in expression levels. In this method for predicting a biological rhythm, a biological rhythm can be predicted with particularly high precision by collecting a biological specimen from a subject three times within 24 hours at eight-hour intervals.
摘要翻译：提供了一种以最小化从受试者收集生物标本的次数来实现高精度的生物节律预测的方法。还提供了一种基于通过在24小时内测量从受试者收集的生物标本中的两个时钟基因的表达水平获得的时间序列表达水平数据，时钟基因具有不同的方式来预测受试者的生物节律的方法表达水平发生变化的昼夜循环阶段。在这种用于预测生物节律的方法中，通过以8小时的间隔在24小时内收集受试者三次生物样本，可以以特别高的精度预测生物节律。

3. 发明授权

US08900815B2 Platelet-derived microparticles as a novel diagnosis maker for a cardiovascular disease 有权
标题翻译：血小板衍生的微粒作为心血管疾病的新型诊断制剂
公开(公告)号：US08900815B2
公开(公告)日：2014-12-02
申请号：US11883447
申请日：2005-02-21
申请人： Koichi Node , Teruo Inoue
发明人： Koichi Node , Teruo Inoue
IPC分类号： G01N33/53 , C12Q1/00 , G01N33/86
CPC分类号： G01N33/86
摘要： The present invention is directed to a method for evaluating whether coronary artery disease has progressed in a patient previously diagnosed as having the disease, wherein the method includes: (a) obtaining a biological sample from the patient at a first time point and a second time point; (b) detecting the level of platelet-derived microparticles (PDMPs) or a fragment thereof, in the first time point sample and the second time point sample with an antibody to PDMPs or a fragment thereof; wherein an increase in a level of the PDMPs in the second time point sample in comparison to a level in the first time point sample is indicative of progression of coronary artery disease.
摘要翻译：本发明涉及一种用于评估先前诊断为患有该疾病的患者是否进行冠状动脉疾病的方法，其中所述方法包括：（a）在第一时间点和第二时间从患者获得生物样品点; （b）在第一时间点样品和第二时间点样品中用PDMP抗体或其片段检测血小板衍生的微粒（PDMP）或其片段的水平; 其中与第一时间点样品中的水平相比，第二时间点样品中的PDMP水平的增加指示冠状动脉疾病的进展。

4. 发明申请

US20080248488A1 Platelet-Derived Microparticles as a Novel Diagnosis Maker for a Cardiovascular Disease 有权
标题翻译：血小板衍生的微粒作为心血管疾病的新型诊断制剂
公开(公告)号：US20080248488A1
公开(公告)日：2008-10-09
申请号：US11883447
申请日：2005-02-21
申请人： Koichi Node , Teruo Inoue
发明人： Koichi Node , Teruo Inoue
IPC分类号： G01N33/53
CPC分类号： G01N33/86
摘要： The present invention relates to a diagnosis maker for a cardiovascular disease comprising platelet-derived microparticles. The present invention also relates to a method for diagnosing a cardiovascular disease in a subject with symptoms of cardiovascular disease or suspected of having cardiovascular disease, wherein said method comprises: (a) obtaining a sample from said subject; (b) reacting an antibody to platelet-derived microparticles or a fragment thereof with a biological sample; (c) detecting a presence or an absence of the platelet-derived microparticles or a fragment thereof in said sample; and (d) diagnosing cardiovascular disease in said subject having said symptoms when said platelet-derived microparticles or a fragment thereof are detected in said sample.
摘要翻译：本发明涉及包含血小板衍生的微粒的心血管疾病的诊断制造者。本发明还涉及用于诊断具有心血管疾病症状或疑似患有心血管疾病的受试者的心血管疾病的方法，其中所述方法包括：（a）从所述受试者获得样品; （b）将抗体与血小板衍生的微粒或其片段与生物样品反应; （c）检测所述样品中血小板衍生的微粒或其片段的存在或不存在; 和（d）在所述样品中检测到所述血小板衍生的微粒或其片段时，在所述具有所述症状的受试者中诊断心血管疾病。

5. 发明申请

US20060188504A1 Interleukin-13 as a cardiovascular disease marker 失效
标题翻译：白细胞介素-13作为心血管疾病的标志物
公开(公告)号：US20060188504A1
公开(公告)日：2006-08-24
申请号：US11355089
申请日：2006-02-16
申请人： Koichi Node , Kenji Izuhara , Tetsuaki Hirase , Yuki Nishimura
发明人： Koichi Node , Kenji Izuhara , Tetsuaki Hirase , Yuki Nishimura
IPC分类号： A61K39/395 , G01N33/567 , C07K14/54 , C07K16/24
CPC分类号： G01N33/6869 , G01N33/6893 , G01N2800/32 , G01N2800/324 , G01N2800/325
摘要： The present invention relates to use of interleukin-13 as a cardiovascular disease marker. The therapeutic composition and diagnostic composition of the invention for cardiovascular diseases are characterized by comprising an antibody to an interleukin-13 receptor and/or an antibody to interleukin-13.
摘要翻译：本发明涉及白细胞介素-13作为心血管疾病标记物的用途。本发明的用于心血管疾病的治疗组合物和诊断组合物的特征在于包含白介素-13受体的抗体和/或白细胞介素-13抗体。

6. 发明授权

US08105842B2 Interleukin-13 as a cardiovascular disease marker 失效
标题翻译：白细胞介素-13作为心血管疾病的标志物
公开(公告)号：US08105842B2
公开(公告)日：2012-01-31
申请号：US11355089
申请日：2006-02-16
申请人： Koichi Node , Kenji Izuhara , Tetsuaki Hirase , Yuki Nishimura
发明人： Koichi Node , Kenji Izuhara , Tetsuaki Hirase , Yuki Nishimura
IPC分类号： G01N33/577 , C07K16/24 , C07K14/54
CPC分类号： G01N33/6869 , G01N33/6893 , G01N2800/32 , G01N2800/324 , G01N2800/325
摘要： The present invention relates to use of interleukin-13 as a cardiovascular disease marker. The therapeutic composition and diagnostic composition of the invention for cardiovascular diseases are characterized by comprising an antibody to an interleukin-13 receptor and/or an antibody to interleukin-13.
摘要翻译：本发明涉及白细胞介素-13作为心血管疾病标记物的用途。本发明的用于心血管疾病的治疗组合物和诊断组合物的特征在于包含白介素-13受体的抗体和/或白细胞介素-13抗体。

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