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1. 发明授权

US5187166A Azabicyclo derivatives and their use as antiemetics 失效
标题翻译：雅各布衍生物及其作为抗原的用途
公开(公告)号：US5187166A
公开(公告)日：1993-02-16
申请号：US730699
申请日：1991-07-16
申请人： Haruhiko Kikuchi , Hiroaki Satoh , Nobuhiro Yahata , Koichiro Hagihara , Toru Hayakawa , Setsuko Mino , Makoto Yanai
发明人： Haruhiko Kikuchi , Hiroaki Satoh , Nobuhiro Yahata , Koichiro Hagihara , Toru Hayakawa , Setsuko Mino , Makoto Yanai
IPC分类号： C07D471/08 , C07D498/08 , C07D513/08
CPC分类号： C07D471/08 , C07D513/08
摘要： Azabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein A is a group of formula (a), (b) or (c): ##STR2## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.10 alkyl, aralkyl or di(C.sub.1 -C.sub.4) alkylamino(C.sub.1 -C.sub.6)alkyl;R.sub.2, R.sub.3 and R.sub.4 may be the same or different and each is hydrogen, amino, halogen, C.sub.1 -C.sub.4 alkoxy or phthalimide; X is O or NH;R is C.sub.1 -C.sub.4 alkyl; andY is NR, O or S;having 5-HT.sub.3 receptor antagonist activity.

2. 发明授权

US5256656A Azabicyclo derivatives 失效
标题翻译：氮杂双环衍生物
公开(公告)号：US5256656A
公开(公告)日：1993-10-26
申请号：US853521
申请日：1992-05-12
申请人： Haruhiko Kikuchi , Hiroaki Satoh , Nobuhiro Yahata , Kiochiro Hagihara , Toru Hayakawa , Setsuko Mino , Makoto Yanai
发明人： Haruhiko Kikuchi , Hiroaki Satoh , Nobuhiro Yahata , Kiochiro Hagihara , Toru Hayakawa , Setsuko Mino , Makoto Yanai
IPC分类号： C07D471/08 , C07D498/08 , C07D513/08 , A61K31/54 , A61K31/535 , C07D265/36 , C07D498/02
CPC分类号： C07D471/08 , C07D513/08
摘要： Azabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein A is a group of formula (a), (b) or (c): ##STR2## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.10 alkyl, aralkyl or di(C.sub.1 -C.sub.4) alkylamino(C.sub.1 -C.sub.6)alkyl;R.sub.2, R.sub.3 and R.sub.4 may be the same or different and each is hydrogen, amino, halogen, C.sub.1 -C.sub.4 alkoxy or phthalimide;X is O or NH;R is C.sub.1 -C.sub.4 alkyl; andY is NR, O or S;having 5-HT.sub.3 receptor antagonist activity.
摘要翻译：（I）的叠氮杂双环衍生物及其药学上可接受的盐：其中A是式（a），（b）或（c）的基团：（a）（c）其中R1是氢，C1-C10烷基，芳烷基或二（C1-C4）烷基氨基（C1-C6）烷基; R2，R3和R4可以相同或不同，各自为氢，氨基，卤素，C1-C4烷氧基或邻苯二甲酰亚胺; X是O或NH; R是C 1 -C 4烷基; Y为NR，O或S; 具有5-HT 3受体拮抗剂活性。

3. 发明授权

US5344831A Diazabicyclo derivatives 失效
标题翻译：二氮杂双环衍生物
公开(公告)号：US5344831A
公开(公告)日：1994-09-06
申请号：US10145
申请日：1993-01-28
申请人： Hiroaki Satoh , Haruhiko Kikuchi , Kazuhiko Yamada , Ruta Fukutomi , Masashi Suzuki , Koichiro Hagihara , Toru Hayakawa , Takeo Arai , Setsuko Mino
发明人： Hiroaki Satoh , Haruhiko Kikuchi , Kazuhiko Yamada , Ruta Fukutomi , Masashi Suzuki , Koichiro Hagihara , Toru Hayakawa , Takeo Arai , Setsuko Mino
IPC分类号： C07D471/08 , C07D247/02 , A61K31/495 , C07D487/08
CPC分类号： C07D471/08
摘要： Diazabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, oxoalkyl, alkoxycarbonylalkyl, alkoxycarbonyl, acyl, dialkylaminoalkyl, hydroxyalkyl, haloalkyl, cyanoalkyl, heterocycloalkyl, aryl, heteroarylalkyl or arylalkyl, the aryl group and the aryl moiety being optionally substituted by alkoxy, nitro, alkyl, amino or halo;R.sup.2 is hydrogen or alkyl;R.sup.3 and R.sup.4 may be the same or different and each is hydrogen, alkyl, alkenyl, acyl, alkoxyalkyl or arylalkyl wherein the aryl moiety is optionally substituted by alkoxy, nitro, alkyl, amino or halo;with the proviso that when R.sup.2 is hydrogen and both R.sup.3 and R.sup.4 are methyl, R.sup.1 does not represent hydrogen, alkyl, unsubstituted benzyl or dimethylaminoethyl; having 5-HT.sub.3 receptor antagonist activity.
摘要翻译：式（I）的二氮杂双环衍生物及其药学上可接受的盐：其中R是氢，烷基，烯基，炔基，环烷基，环烷基烷基，烷氧基烷基，氧代烷基，烷氧基羰基烷基，烷氧基羰基，酰基，二烷基氨基烷基，羟基烷基，卤代烷基，氰基烷基，杂环烷基，芳基，杂芳基烷基或芳烷基，芳基和芳基部分任选被烷氧基，硝基，烷基，氨基或卤素取代; R2是氢或烷基; R 3和R 4可以相同或不同，各自为氢，烷基，烯基，酰基，烷氧基烷基或芳烷基，其中芳基部分任选被烷氧基，硝基，烷基，氨基或卤素取代; 条件是当R 2是氢并且R 3和R 4都是甲基时，R 1不代表氢，烷基，未取代的苄基或二甲基氨基乙基; 具有5-HT 3受体拮抗剂活性。

4. 发明授权

US5246945A Piperidine derivatives 失效
标题翻译：哌啶衍生物
公开(公告)号：US5246945A
公开(公告)日：1993-09-21
申请号：US830853
申请日：1992-02-04
申请人： Haruhiko Kikuchi , Hiroaki Satoh , Toshio Suguro , Koichiro Hagihara , Toru Hayakawa , Setsuko Mino
发明人： Haruhiko Kikuchi , Hiroaki Satoh , Toshio Suguro , Koichiro Hagihara , Toru Hayakawa , Setsuko Mino
IPC分类号： A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/451 , A61K31/47 , A61P1/00 , A61P1/04 , A61P1/08 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/18 , A61P25/20 , A61P43/00 , C07D211/18 , C07D211/22 , C07D211/26 , C07D401/12 , C07D417/12 , C07D471/04
CPC分类号： C07D401/12 , C07D211/18 , C07D211/22 , C07D417/12 , C07D471/04
摘要： Disclosed are compounds of formula (I) ##STR1## in which A is ##STR2## The compounds are selective antagonists of 5HT at 5-HT.sub.3 receptors and useful in the treatment of psychotic disorders, neurotic diseases, gastric stasis symptoms, gastrointestinal disorders, nausea and vomiting.

5. 发明申请

US20110223686A1 PROTEIN PRODUCTION METHOD, FUSION PROTEIN, AND ANTISERUM 有权
标题翻译：蛋白质生产方法，融合蛋白和抗原
公开(公告)号：US20110223686A1
公开(公告)日：2011-09-15
申请号：US13056944
申请日：2009-07-30
申请人： Hiroshi Sakai , Toru Hayakawa
发明人： Hiroshi Sakai , Toru Hayakawa
IPC分类号： G01N33/566 , C12P21/02 , C07K19/00 , C07K16/12
CPC分类号： C12N15/62 , C07K14/4737 , C07K2319/35 , C12P21/02
摘要： Disclosed are a highly efficient method for production of heterologous proteins performed by utilizing microorganisms, as well as fusion proteins, and an antiserum. The method includes a method for production of a protein (A) in the form of a fusion protein, comprising the steps of (a) preparing a DNA which codes for a fusion protein comprising the peptide chain forming the protein (A) and the C-terminal peptide or its fragment (B) of the Cry proteins produced by Bacillus thuringiensis, and (b) introducing the DNA into a host bacterium to transform the same, and (c) allowing the fusion protein to be expressed in the transformed host bacterium, as well as a method for production of the protein (A) itself comprising a further step of removing the peptide chain (B) from the fusion protein obtained.
摘要翻译：公开了通过利用微生物以及融合蛋白和抗血清来生产异源蛋白质的高效方法。该方法包括生产融合蛋白形式的蛋白质（A）的方法，包括以下步骤：（a）制备编码包含形成蛋白质（A）的肽链和C蛋白的融合蛋白的DNA - 末端肽或其片段（B），和（b）将DNA引入宿主细菌以转化其，和（c）使融合蛋白在转化的宿主细菌中表达以及生产蛋白质（A）本身的方法，其还包括从获得的融合蛋白中除去肽链（B）的步骤。

6. 发明授权

US07715549B2 Communication terminal device, hold melody sending method, incoming melody playing method and information storing medium 有权
标题翻译：通信终端设备，保持旋律发送方式，传入旋律播放方式和信息存储介质
公开(公告)号：US07715549B2
公开(公告)日：2010-05-11
申请号：US11206785
申请日：2005-08-19
申请人： Toru Hayakawa , Shungo Kiyota
发明人： Toru Hayakawa , Shungo Kiyota
IPC分类号： H04M1/00 , H04M3/00
CPC分类号： H04M19/041 , H04M1/274508 , H04M1/578 , H04M1/72513
摘要： A control block recognizes the other party of the telephone call when both calling and called case. When the user operates the reservation melody key of the key input block while talking over the telephone and the telephone call reservation is directed, the control block retrieves telephone/E-mail memory and judges for the calling melody number whether to be registered. Because calling melody number 1 is registered, music data 1 is read, and the mute is placed “on” so that the voice from mike is not transmitted. When the control block outputs music data 1 to melody generation block, the melody generation block generates the calling melody signal based on music data 1, and transmits it to the other party of the telephone call via modem, sending and receiving block and antenna. Moreover, the control block always observes the control channel specified by the base station while waiting. When detecting the arrival of a call and “4” of the calling melody specification data, the control block judges for caller information transmitted at the same time whether to be registered in telephone/E-mail memory. In this case, the control block displays the caller number and Hanako Yamada of the name because it is registered in memory number 1. In addition, because the calling melody specification data is “4”, “Good news” of the character data corresponding to it is displayed, and “Beautiful Sunday” of music data 4 registered in memory number 4 is performed as a calling melody.
摘要翻译：控制块在通话和被呼叫的情况下都识别电话的另一方。当用户在通过电话通话时操作键输入块的预约旋律键并且指示电话呼叫预约时，控制块检索电话/电子邮件存储器并判断呼叫音调号码是否被注册。由于注册了1号呼叫旋律，所以读取音乐数据1，并且静音被置于“开启”，从而不发送来自麦克风的声音。当控制块将音乐数据1输出到旋律产生块时，旋律产生块基于音乐数据1产生呼叫旋律信号，并通过调制解调器，发送和接收块和天线将其发送到电话呼叫的另一方。此外，控制块始终观察基站在等待时指定的控制信道。当检测到呼叫的到来和呼叫旋律指定数据的“4”时，控制块判断同时发送的呼叫者信息是否被登记在电话/电子邮件存储器中。在这种情况下，控制块显示名称的呼叫者号码和花田花子，因为它被登记在存储器号码1中。此外，由于呼叫旋律规格数据为“4”，所以对应于字符数据的“好消息” 显示，并且在存储器编号4中登记的音乐数据4的“美丽星期日”作为呼叫旋律被执行。

7. 发明授权

US4324784A Process for preventing growth of marine organisms on a substance using hydrogen peroxide 失效
标题翻译：使用过氧化氢防止海洋生物对物质生长的过程
公开(公告)号：US4324784A
公开(公告)日：1982-04-13
申请号：US131631
申请日：1980-03-19
申请人： Akira Naito , Toru Hayakawa , Masakatsu Nakanishi , Sunao Ikuta , Shoichiro Kajiwara , Hitoshi Yamaguchi
发明人： Akira Naito , Toru Hayakawa , Masakatsu Nakanishi , Sunao Ikuta , Shoichiro Kajiwara , Hitoshi Yamaguchi
IPC分类号： A01N59/00 , A01N43/40 , A01N43/48 , A01N43/84
CPC分类号： A01N59/00
摘要： A process for preventing growth of marine animals, i.e. shellfish, Polyzoa, and Hydrozoa on a surface, characterized by supplying hydrogen peroxide and/or a hydrogen peroxide-generating agent into sea water in contact with the surface is disclosed. Surfaces of apparatus and/or pipe constituting flow paths for sea water and plant utilizing sea water are kept clean by the process.
摘要翻译：公开了一种防止海洋动物，即表面上的贝类，Polyzoa和Hydrozoa生长的方法，其特征在于向与表面接触的海水中提供过氧化氢和/或过氧化氢生成剂。用海水和植物利用海水构成流路的装置和/或管道的表面通过该过程保持清洁。

8. 发明申请

US20050276410A1 Communication terminal equipment, reservation melody sending method, calling melody performing method and information storage medium 有权
标题翻译：通信终端设备，预约旋律发送方式，呼叫音乐演奏方法和信息存储介质
公开(公告)号：US20050276410A1
公开(公告)日：2005-12-15
申请号：US11206785
申请日：2005-08-19
申请人： Toru Hayakawa , Shungo Kiyota
发明人： Toru Hayakawa , Shungo Kiyota
IPC分类号： H04M1/57 , H04M1/725 , H04M19/04 , H04M11/00
CPC分类号： H04M19/041 , H04M1/274508 , H04M1/578 , H04M1/72513
摘要： A control block recognizes the other party of the telephone call when both calling and called case. When the user operates the reservation melody key of the key input block while talking over the telephone and the telephone call reservation is directed, the control block retrieves telephone/E-mail memory and judges for the calling melody number whether to be registered. Because calling melody number 1 is registered, music data 1 is read, and the mute is put so that the voice from mike is not transmitted. When the control block outputs music data 1 to melody generation block, the melody generation block generates the calling melody signal based on music data 1, and transmits it to the other party of the telephone call via modem, sending and receiving block and antenna. Moreover, the control block always observes the control channel specified by the base station while waiting. When detecting the arrival of a call and “4” of the calling melody specification data, the control block judges for caller information transmitted at the same time whether to be registered in telephone/E-mail memory. In this case, the control block displays the caller number and Hanako Yamada of the name because it is registered in memory number 1. In addition, because the calling melody specification data is “4”, “Good news” of the character data corresponding to it is displayed, and “Beautiful Sunday” of music data 4 registered in memory number 4 is performed as a calling melody.
摘要翻译：控制块在通话和被呼叫的情况下都识别电话的另一方。当用户在通过电话通话时操作键输入块的预约旋律键并且指示电话呼叫预约时，控制块检索电话/电子邮件存储器并判断呼叫音调号码是否被注册。由于登录了呼号1，所以读取音乐数据1，静音被放置，从而不发送来自麦克风的声音。当控制块将音乐数据1输出到旋律产生块时，旋律产生块基于音乐数据1产生呼叫旋律信号，并通过调制解调器，发送和接收块和天线将其发送到电话呼叫的另一方。此外，控制块始终观察基站在等待时指定的控制信道。当检测到呼叫的到来和呼叫旋律指定数据的“4”时，控制块判断同时发送的呼叫者信息是否被登记在电话/电子邮件存储器中。在这种情况下，控制块显示名称的呼叫者号码和花子花子，因为它在内存编号1中注册。此外，由于呼叫旋律规格数据为“4”，所以显示与其相对应的字符数据的“好消息”，并且将登记在存储器编号4中的音乐数据4的“美丽星期日”作为呼叫旋律进行。

9. 发明授权

US08865428B2 Protein production method, fusion protein, and antiserum 有权
标题翻译：蛋白质生产方法，融合蛋白和抗血清
公开(公告)号：US08865428B2
公开(公告)日：2014-10-21
申请号：US13056944
申请日：2009-07-30
申请人： Hiroshi Sakai , Toru Hayakawa
发明人： Hiroshi Sakai , Toru Hayakawa
IPC分类号： C12P21/06 , C12P21/02 , C07K14/47 , C12N15/62
CPC分类号： C12N15/62 , C07K14/4737 , C07K2319/35 , C12P21/02
摘要： Disclosed are a highly efficient method for production of heterologous proteins performed by utilizing microorganisms, as well as fusion proteins, and an antiserum. The method includes a method for production of a protein (A) in the form of a fusion protein, comprising the steps of (a) preparing a DNA which codes for a fusion protein comprising the peptide chain forming the protein (A) and the C-terminal peptide or its fragment (B) of the Cry proteins produced by Bacillus thuringiensis, and (b) introducing the DNA into a host bacterium to transform the same, and (c) allowing the fusion protein to be expressed in the transformed host bacterium, as well as a method for production of the protein (A) itself comprising a further step of removing the peptide chain (B) from the fusion protein obtained.
摘要翻译：公开了通过利用微生物以及融合蛋白和抗血清来生产异源蛋白质的高效方法。该方法包括生产融合蛋白形式的蛋白质（A）的方法，包括以下步骤：（a）制备编码包含形成蛋白质（A）的肽链和C蛋白的融合蛋白的DNA - 末端肽或其片段（B），和（b）将DNA引入宿主细菌以转化其，和（c）使融合蛋白在转化的宿主细菌中表达以及生产蛋白质（A）本身的方法，其还包括从获得的融合蛋白中除去肽链（B）的步骤。

10. 发明授权

US06944285B2 Communication terminal device, holds melody sensing method, incoming melody playing and information storing medium 失效
标题翻译：通信终端设备，保持旋律感应方式，传入旋律播放和信息存储介质
公开(公告)号：US06944285B2
公开(公告)日：2005-09-13
申请号：US10297918
申请日：2001-06-19
申请人： Toru Hayakawa , Shungo Kiyota
发明人： Toru Hayakawa , Shungo Kiyota
IPC分类号： H04M1/57 , H04M1/725 , H04M19/04 , H04M1/00
CPC分类号： H04M19/041 , H04M1/274508 , H04M1/578 , H04M1/72513
摘要： A control block recognizes the other party of the telephone call when both calling and called case. When the user operates the reservation melody key of the key input block while talking over the telephone and the telephone call reservation is directed, the control block retrieves telephone/E-mail memory and judges for the calling melody number whether to be registered. Because calling melody number 1 is registered, music data 1 is read, and the mute is put so that the voice from mike is not transmitted. When the control block outputs music data 1 to melody generation block, the melody generation block generates the calling melody signal based on music data 1, and transmits it to the other party of the telephone call via modem, sending and receiving block and antenna. Moreover, the control block always observes the control channel specified by the base station while waiting. When detecting the arrival of a call and “4” of the calling melody specification data, the control block judges for caller information transmitted at the same time whether to be registered in telephone/E-mail memory. In this case, the control block displays the caller number and Hanako Yamada of the name because it is registered in memory number 1. In addition, because the calling melody specification data is “4”, “Good news” of the character data corresponding to it is displayed, and “Beautiful Sunday” of music data 4 registered in memory number 4 is performed as a calling melody.
摘要翻译：控制块在通话和被呼叫的情况下都识别电话的另一方。当用户在通过电话通话时操作键输入块的预约旋律键并且指示电话呼叫预约时，控制块检索电话/电子邮件存储器并判断呼叫音调号码是否被注册。由于登录了呼号1，所以读取音乐数据1，静音被放置，从而不发送来自麦克风的声音。当控制块将音乐数据1输出到旋律产生块时，旋律产生块基于音乐数据1产生呼叫旋律信号，并通过调制解调器，发送和接收块和天线将其发送到电话呼叫的另一方。此外，控制块始终观察基站在等待时指定的控制信道。当检测到呼叫的到来和呼叫旋律指定数据的“4”时，控制块判断同时发送的呼叫者信息是否被登记在电话/电子邮件存储器中。在这种情况下，控制块显示名称的呼叫者号码和花田花子，因为它被登记在存储器号码1中。此外，由于呼叫旋律规格数据为“4”，所以对应于字符数据的“好消息” 显示，并且在存储器编号4中登记的音乐数据4的“美丽星期日”作为呼叫旋律被执行。

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