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1. 发明申请

US20050060112A1 Method of resonance spectroscopy for the analysis of statistical properties of samples 失效
标题翻译：共振光谱法分析样品的统计性质
公开(公告)号：US20050060112A1
公开(公告)日：2005-03-17
申请号：US10921108
申请日：2004-08-19
申请人： Hartmut Schafer , Peter Neidig , Christian Fischer , Manfred Spraul
发明人： Hartmut Schafer , Peter Neidig , Christian Fischer , Manfred Spraul
IPC分类号： G01R33/46 , G01R23/16
CPC分类号： G01R33/4625 , Y10T436/24
摘要： The invention refers to a method of resonance spectroscopy for the analysis of statistical properties of samples, comprising the following steps: a) recording of a complex resonance frequency spectrum of each sample by means of phase sensitive quadrature detection; b) numerical differentiation of the recorded complex resonance frequency spectra versus frequency; c) determination of the absolute value of each differentiated complex resonance frequency spectrum (=fingerprint); d) allocation of each fingerprint to a point of a multidimensional point set; and e) performing a pattern analysis of the generated points for characterizing the statistical properties of the samples. The inventive method tolerates unintended variances of measurement in the recorded resonance. frequency spectra, in particular caused by phase errors, and allows reliable automated spectral analysis.
摘要翻译：本发明涉及一种用于分析样品的统计性质的共振光谱法，包括以下步骤：a）通过相敏检测记录每个样品的复共振频谱; b）记录的复共振频谱与频率的数值分化; c）确定每个微分复合共振频谱（=指纹）的绝对值; d）将每个指纹分配到多维点集的点; 以及e）对生成的点进行模式分析，以表征样本的统计特性。本发明的方法允许在记录的共振中的非预期的测量方差。频谱，特别是由相位误差引起，并允许可靠的自动光谱分析。

2. 发明授权

US07076383B2 Method of resonance spectroscopy for the analysis of statistical properties of samples 失效
标题翻译：共振光谱法分析样品的统计性质
公开(公告)号：US07076383B2
公开(公告)日：2006-07-11
申请号：US10921108
申请日：2004-08-19
申请人： Hartmut Schäfer , Peter Neidig , Christian Fischer , Manfred Spraul
发明人： Hartmut Schäfer , Peter Neidig , Christian Fischer , Manfred Spraul
IPC分类号： G01R23/16
CPC分类号： G01R33/4625 , Y10T436/24
摘要： The invention refers to a method of resonance spectroscopy for the analysis of statistical properties of samples, comprising the following steps: a) recording of a complex resonance frequency spectrum of each sample by means of phase sensitive quadrature detection; b) numerical differentiation of the recorded complex resonance frequency spectra versus frequency; c) determination of the absolute value of each differentiated complex resonance frequency spectrum (=fingerprint); d) allocation of each fingerprint to a point of a multidimensional point set; and e) performing a pattern analysis of the generated points for characterizing the statistical properties of the samples. The inventive method tolerates unintended variances of measurement in the recorded resonance frequency spectra, in particular caused by phase errors, and allows reliable automated spectral analysis.
摘要翻译：本发明涉及一种用于分析样品的统计性质的共振光谱法，包括以下步骤：a）通过相敏检测记录每个样品的复共振频谱; b）记录的复共振频谱与频率的数值分化; c）确定每个微分复合共振频谱（=指纹）的绝对值; d）将每个指纹分配到多维点集的点; 以及e）对生成的点执行模式分析，以表征样本的统计特性。本发明的方法容忍记录的共振频谱中的非预期的测量方差，特别是由相位误差引起的，并且允许可靠的自动光谱分析。

3. 发明授权

US08883671B2 Monolithic catalyst system for the photolysis of water 有权
标题翻译：用于光解水的单片催化剂体系
公开(公告)号：US08883671B2
公开(公告)日：2014-11-11
申请号：US12734330
申请日：2008-10-31
申请人： Sigrid Obenland , Christian Fischer
发明人： Sigrid Obenland , Christian Fischer
IPC分类号： B01J31/00 , B01J23/00 , B01J35/00 , B01J23/26 , C25B1/00 , C01B3/04 , B01J31/18 , B01J23/652 , B01J27/045 , B01J31/22 , B01J21/06 , B01J23/52 , B01J23/42
CPC分类号： B01J35/0033 , B01J21/063 , B01J23/26 , B01J23/42 , B01J23/52 , B01J23/6527 , B01J27/045 , B01J31/1815 , B01J31/1865 , B01J31/2226 , B01J35/0006 , B01J35/0013 , B01J35/004 , B01J2231/62 , B01J2231/70 , B01J2531/0216 , B01J2531/72 , B01J2531/821 , B01J2531/824 , C01B3/042 , C25B1/003 , Y02E60/364 , Y02E60/368
摘要： A monolithic catalyst system for the cleavage of water into hydrogen and oxygen comprises a first photoactive material capable by itself or together with an auxiliary material and/or an auxiliary catalyst when irradiated with light having a wavelength≧420 nm of generating oxygen and protons from water, and a second photoactive material capable by itself or together with an auxiliary material and/or an auxiliary catalyst when irradiated with light having a wavelength≧420 nm of reducing protons in water to hydrogen. The first and second photoactive materials are in electrical contact via an electron-conducting material.
摘要翻译：用于将水切割成氢气和氧气的整体式催化剂体系包括当用波长≥420nm的光照射时自身或与辅助材料和/或辅助催化剂一起工作的第一光活性材料，以产生氧和质子的光以及第二光活性材料，当用波长≥420nm的光将水中的还原质子照射到氢时，能够自身或与辅助材料和/或辅助催化剂一起使用。第一和第二光敏材料通过电子传导材料电接触。

4. 发明授权

US08684413B2 Pretensioning device for a safety belt 有权
标题翻译：安全带预张紧装置
公开(公告)号：US08684413B2
公开(公告)日：2014-04-01
申请号：US13643125
申请日：2011-03-03
申请人： Thomas Schmidt , Martin Schmidt , Christian Fischer , Michael Pech , Matthias Steinberg , Tobias Voss
发明人： Thomas Schmidt , Martin Schmidt , Christian Fischer , Michael Pech , Matthias Steinberg , Tobias Voss
IPC分类号： B60R22/405
CPC分类号： B60R22/4628 , B60R2022/4642 , B60R2022/4661
摘要： A pretensioning device (10) for a safety belt, of a motor vehicle, having a gas generator (17), a piston (21) guided in a tube (16), which closes a pressure area (20) in the tube (16) that is pressurized by the gas generator (17) whereupon the piston (21) is able to move in a pretensioning movement which is able to be conveyed to the safety belt by means of an inertia body (19a) resting on a front face (9) of the piston (21). The piston (21) forms a pass-through opening (1) releasable upon exceeding of a predetermined pressure and a recess (26) is provided in the front face (9) with an inertia body (19a) resting thereon, so that a flow connection is created from the pass-through opening (1) to the area (25) located behind the piston (21) in the direction of the pretensioning movement (S).
摘要翻译：一种用于机动车辆的安全带的预张紧装置（10），具有气体发生器（17），在管（16）中引导的活塞（21），其封闭管（16）中的压力区域（20）），由气体发生器（17）加压，于是活塞（21）能够通过借助于静止在正面上的惯性体（19a）被传送到安全带的预张紧运动中移动 9）。活塞（21）形成可以超过预定压力而可释放的通过开口（1），并且在前表面（9）上设置有一个在其上放置有惯性体（19a）的凹部（26）在预张紧运动（S）的方向上从穿通开口（1）到位于活塞（21）后面的区域（25）形成连接。

5. 发明授权

US08575150B2 Triazole derivatives for treatment of Alzheimer's disease 有权
标题翻译：用于治疗阿尔茨海默病的三唑衍生物
公开(公告)号：US08575150B2
公开(公告)日：2013-11-05
申请号：US13139830
申请日：2009-12-07
申请人： Christian Fischer , Joey Methot , Hua Zhou , Adam J. Schell , Benito Munoz , Alexey A. Rivkin , Sean P. Ahearn , Stephanie Chichetti , Rachel N. MacCoss , Sam Kattar , Matthew Christopher , Chaomin Li , Andrew Rosenau , William Colby Brown
发明人： Christian Fischer , Joey Methot , Hua Zhou , Adam J. Schell , Benito Munoz , Alexey A. Rivkin , Sean P. Ahearn , Stephanie Chichetti , Rachel N. MacCoss , Sam Kattar , Matthew Christopher , Chaomin Li , Andrew Rosenau , William Colby Brown
IPC分类号： C07D249/14 , A61K31/4196
CPC分类号： A61K31/41 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： According to the invention there is provided a compound of formula I or a pharmaceutically acceptable salt or hydrate thereof; wherein the variables are as defined herein. The compounds selectively attenuate the production of Aβ42 and hence are useful in treatment of Alzheimer's disease and related conditions.
摘要翻译：根据本发明，提供式I化合物或其药学上可接受的盐或水合物; 其中变量如本文所定义。这些化合物选择性地减弱Abeta42的产生，因此可用于治疗阿尔茨海默病和相关病症。

6. 发明申请

US20130037414A1 CATALYST SYSTEM AND METHOD FOR THE PHOTOLYSIS OF WATER 审中-公开
标题翻译：催化剂体系和水分光化学方法
公开(公告)号：US20130037414A1
公开(公告)日：2013-02-14
申请号：US13318525
申请日：2010-05-03
申请人： Sigrid Obenland , Christian Fischer
发明人： Sigrid Obenland , Christian Fischer
IPC分类号： C25B1/04 , C25B1/06 , C25B9/00
CPC分类号： C01B3/042 , B01J21/063 , B01J23/462 , B01J23/6527 , B01J27/04 , B01J27/045 , B01J31/223 , B01J33/00 , B01J35/004 , B01J35/04 , B01J37/0215 , B01J37/0219 , B01J37/0244 , B01J37/0248 , B01J37/20 , B01J2531/72 , C01B13/0207 , C01B2203/1023 , Y02E60/364 , Y02E60/366
摘要： A monolithic catalyst system for the cleavage of water into hydrogen and oxygen with the aid of light comprises a first photoactive material capable by itself or together with one or more of an auxiliary material and an auxiliary catalyst of generating oxygen and protons from water, when irradiated with light having a wavelength ≧420 nm of generating oxygen and protons from water, and a second photoactive material selected from gallium arsenide, copper indium disulphide/selenide, copper indium gallium disulphide/selenide and cadmium sulphide/selenide/telluride and having a water resistant coating transparent to visible light capable of the reducing protons in water to hydrogen, when irradiated with visible light. The first photoactive material and the second photoactive material are supported on at least one substrate and are in electrical contact, particularly in direct electrical contact, exclusively via one or more electron-conducting materials. The first photoactive material is not silicon, a III-V semiconductor or II-VI semiconductor or II-VI semiconductor or similar semiconductor having divalent or trivalent cations and anions of the groups Va and VIa of the periodic table of elements or semiconductor which is comprised of elements of the groups Ib (copper group), IIa, and VI or another inorganic photoconductor which is used in photovoltaic. Also disclosed is a process for cleaving water into hydrogen and oxygen with the aid of light using the catalyst system.
摘要翻译：用于借助于光将水切割成氢和氧的整体式催化剂体系包括第一光活性材料，其本身或与辅助材料和辅助催化剂一起产生氧和质子的辅助催化剂，当照射时具有波长≥420nm的来自水的光和质子的光，以及选自砷化镓，二硫化铟/硒化物，铜铟镓二硒化物/硒化物和硫化镉/硒化物/碲化物的第二光活性材料，并具有防水性当用可见光照射时，对能够将水中的还原质子的可见光透明化为氢。第一光活性材料和第二光活性材料被支撑在至少一个基底上，并且特别是通过一种或多种导电材料电接触，特别是直接电接触。第一光活性材料不是硅，具有二价或三价阳离子的III-V半导体或II-VI半导体或II-VI半导体或类似的半导体或元素或半导体的元素周期表的基团Va和VIa的阴离子的Ib族（铜基），IIa和VI族的元素或用于光伏的其它无机光电导体。还公开了使用催化剂体系借助于光将水分解成氢和氧的方法。

7. 发明授权

US08242150B2 Triazole derivatives for treating alzheimer'S disease and related conditions 失效
标题翻译：用于治疗阿尔茨海默氏病和相关病症的三唑衍生物
公开(公告)号：US08242150B2
公开(公告)日：2012-08-14
申请号：US12663432
申请日：2008-06-09
申请人： Christian Fischer , Ben Munoz , Susan Zultanski , Joey Methot , Hua Zhou , W. Colby Brown
发明人： Christian Fischer , Ben Munoz , Susan Zultanski , Joey Methot , Hua Zhou , W. Colby Brown
IPC分类号： A61K31/41 , C07D249/00 , C07D249/08
CPC分类号： C07D403/10 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D455/04 , C07D471/04 , C07D487/04 , C07D487/06 , C07D491/048 , C07D495/04 , C07D513/04
摘要： Compounds of formula I: Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain, in particular Alzheimer's disease.
摘要翻译：式I化合物：选择性减弱A＆Bgr的产生（1-42），因此可用于治疗或预防与A＆Bgr沉积相关的疾病; 在大脑中，特别是阿尔茨海默病。

8. 发明授权

US06312488B1 Two-piece water separating apparatus and method of making same 失效
标题翻译：两件式水分离装置及其制作方法
公开(公告)号：US06312488B1
公开(公告)日：2001-11-06
申请号：US09335876
申请日：1999-06-18
申请人： Christian Fischer
发明人： Christian Fischer
IPC分类号： B01D5000
CPC分类号： F02M35/161 , B01D45/08 , B01D45/12 , F02M35/022 , F02M35/088
摘要： An apparatus for separating liquids, in particular water, from gasses, in particular for separating entrained water from the intake air of an internal combustion engine. This is achieved by appropriately configuring a selected connection site in the intake section which precedes the air filter of the internal combustion engine. This has the advantage of requiring no parts in addition to the air conduit pieces already present. Separated water may be discharged, for example, through an outlet valve or small opening.
摘要翻译：用于将液体特别是水从气体中分离的装置，特别是用于从内燃机的进气分离夹带的水。这通过适当地配置在内燃机的空气过滤器之前的进气段中的选定的连接部位来实现。这具有除了已经存在的空气管道件之外不需要零件的优点。分离的水可以例如通过出口阀或小开口排出。

9. 发明授权

US5861459A Aqueous silicone dispersion capable of being cross-linked into an adhesive elastomer using a condensation reaction mechanism 失效
标题翻译：能够使用缩合反应机理交联成粘合性弹性体的水性硅氧烷分散体
公开(公告)号：US5861459A
公开(公告)日：1999-01-19
申请号：US809077
申请日：1997-05-02
申请人： Denis Cardinaud , Michel Feder , Christian Fischer
发明人： Denis Cardinaud , Michel Feder , Christian Fischer
IPC分类号： C08J3/03 , C08K3/36 , C08K5/544 , C08L83/04 , C08L83/06 , C08L83/08
CPC分类号： C08J3/03 , C08L83/04 , C08G77/12 , C08G77/16 , C08G77/18 , C08G77/20 , C08G77/70 , C08J2383/04
摘要： The present invention relates to an aqueous silicone dispersion, capable of being cross-linked into an elastomer by removing water and optionally alcohol and/or carboxylic acid, said dispersion being based on at least one polyorganosiloxane (A) having at least two condensable or hydrolysable OR.sup.a groups per molecule wherein R.sup.a =H or alkyl, as well as at least one surficant (B). The technical problem consisting of perfecting a stable dispersion capable of being cross-linked into an elastomer that is highly adhesive on any support and that has suitable and economic mechanical properties is solved since this dispersion includes an amino-functionalised polyorganosiloxane (C) of the DTT(N)(OMe) resin type redistributed with aminoethylaminopropyltrimethoxysilane, optionally at least one hydroxylated and/or alkoxylated silicone resin (D), optionally at least on alkoxysilane (E) donating the -OR.sup.a terminals of the polydiorganosiloxane (A), optionally at least on condensation catalyst (F) and optionally at least one optionally siliceous filler (G).
摘要翻译： PCT No.PCT / FR95 / 01182 Sec。 371日期：1997年5月2日 102（e）日期1997年5月2日PCT提交1995年9月14日PCT公布。公开号WO96 / 08529 日期：1996年3月21日本发明涉及一种水分硅氧烷分散体，其能够通过除去水和任选的醇和/或羧酸而交联成弹性体，所述分散体基于至少一种聚有机硅氧烷（A），其具有每分子至少两个可缩合或可水解的OR a基团，其中R a = H或烷基，以及至少一个表面活性剂（B）。由于这种分散体包括DTT的氨基官能化的聚有机硅氧烷（C），因此解决了由完善能够交联成任何载体上高度粘合并且具有合适和经济的机械性能的弹性体的稳定分散体的技术问题（N）（OMe）树脂类型，任选地至少一个羟基化和/或烷氧基化硅氧烷树脂（D），任选至少在提供聚二有机硅氧烷（A）的-OR a端基的烷氧基硅烷（E）上，至少在缩合催化剂（F）和任选的至少一种任选的硅质填料（G）上。

10. 发明申请

US20200048259A1 KDM5 INHIBITORS 审中-公开
公开(公告)号：US20200048259A1
公开(公告)日：2020-02-13
申请号：US16341323
申请日：2017-10-06
申请人： Umar Faruk MANSOOR , Christian FISCHER , Phieng SILIPHAIVANH , Hakan GUNAYDIN , Merck Sharp & Dohme Corp.
发明人： UMAR FARUK MANSOOR , Christian Fischer , Phieng Siliphaivanh , Hakan Gunaydin
IPC分类号： C07D487/04
摘要： The present invention provides a compound of Formula (I) (represented as tautomers Ia and Ib): (I) or the pharmaceutically acceptable salts thereof, which are KDM5 inhibitors.

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