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1. 发明申请

US20100303830A1 PREVENTION AND TREATMENT OF OTITIS MEDIA USING IgA ENRICHED MILK 审中-公开
标题翻译：使用IgA加强乳的预防和治疗OTITIS媒体
公开(公告)号：US20100303830A1
公开(公告)日：2010-12-02
申请号：US12747444
申请日：2008-12-08
申请人： Harald Bruessow , Nanda De Groot , Marie-Claire Fichot
发明人： Harald Bruessow , Nanda De Groot , Marie-Claire Fichot
IPC分类号： A61K39/40 , A61P27/16
CPC分类号： C07K16/1214 , A23L33/135 , A23L33/40 , A23V2002/00 , C07K16/1242 , C07K16/1275 , C07K2317/12 , A23V2200/314
摘要： This invention relates to a composition suitable for use in the prevention or treatment of otitis media comprising IgA derived from mature bovine milk and having specificity for at least one of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. The invention further extends to the use of such a composition in the prevention or treatment of otitis media.
摘要翻译：本发明涉及适用于预防或治疗包含来自成熟牛奶的IgA的中耳炎的组合物，并且对肺炎链球菌，流感嗜血杆菌和卡他莫拉菌中的至少一种具有特异性。本发明还涉及这种组合物在预防或治疗中耳炎中的用途。

2. 发明申请

US20110130545A1 PROCESS FOR PRODUCING MILK FRACTIONS RICH IN SECRETORY IMMUNOGLOBULINS 有权
标题翻译：用于生产秘密免疫球蛋白中的乳汁分泌物的方法
公开(公告)号：US20110130545A1
公开(公告)日：2011-06-02
申请号：US12992701
申请日：2009-05-11
申请人： Charles Maria Hubert Hensgens , Nanda De Groot
发明人： Charles Maria Hubert Hensgens , Nanda De Groot
IPC分类号： C07K16/04
CPC分类号： C07K16/04
摘要： The present invention concerns a process for producing compositions that are rich in secretory IgA (S-IgA) by fractionating milk containing S-IgA. Such compositions may be used in particular for treating and/or preventing infections and/or inflammation of the mucosal surfaces, e.g. the gastro-intestinal tract, urogenital tract, respiratory tract, nasal cavity or oral cavity, treating and/or preventing obesity and related diseases, or treating and/or preventing food allergies in subjects in need of such treatment. Briefly stated, the current invention provides a process for producing milk fractions rich in secretory Immunoglobulin A, using one or more microporous membrane filtration steps. A preferred protocol of the present process involves de-fatting, micro-filtration and ultrafiltration-concentration through a number of diafiltration cycles. The process of the invention, apart from the unexpectedly high yields achievable, offers advantages which are of particular interest in view of the scalability, application in existing diary factories and controllability of process parameters influencing the S-IgA quality and stability.
摘要翻译：本发明涉及通过分馏含有S-IgA的乳制备富含分泌型IgA（S-IgA）的组合物的方法。这些组合物可特别用于治疗和/或预防粘膜表面的感染和/或炎症，例如，胃肠道，泌尿生殖道，呼吸道，鼻腔或口腔，治疗和/或预防肥胖症和相关疾病，或治疗和/或预防需要这种治疗的受试者的食物过敏。简而言之，本发明提供了使用一个或多个微孔膜过滤步骤生产富含分泌型免疫球蛋白A的乳成分的方法。本方法的优选方案包括通过多个渗滤循环进行脱脂，微过滤和超滤浓缩。本发明的方法除了意想不到的高产率之外，还提供了在可扩展性，现有日记工厂中的应用以及影响S-IgA质量和稳定性的工艺参数的可控性方面特别有利的优点。

3. 发明授权

US08669353B2 Process for producing milk fractions rich in secretory immunoglobulins 有权
$Process for producing milk fractions rich in secretory immunoglobulins$
标题翻译：生产富含分泌型免疫球蛋白的乳成分的方法
公开(公告)号：US08669353B2
公开(公告)日：2014-03-11
申请号：US12992701
申请日：2009-05-11
申请人： Charles Maria Hubert Hensgens , Nanda De Groot
发明人： Charles Maria Hubert Hensgens , Nanda De Groot
IPC分类号： A23J1/00 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： C07K16/04
摘要： The present invention concerns a process for producing compositions that are rich in secretory IgA (S-IgA) by fractionating milk containing S-IgA. Such compositions may be used in particular for treating and/or preventing infections and/or inflammation of the mucosal surfaces, e.g. the gastro-intestinal tract, urogenital tract, respiratory tract, nasal cavity or oral cavity, treating and/or preventing obesity and related diseases, or treating and/or preventing food allergies in subjects in need of such treatment. Briefly stated, the current invention provides a process for producing milk fractions rich in secretory Immunoglobulin A, using one or more microporous membrane filtration steps. A preferred protocol of the present process involves de-fatting, micro-filtration and ultrafiltration-concentration through a number of diafiltration cycles. The process of the invention, apart from the unexpectedly high yields achievable, offers advantages which are of particular interest in view of the scalability, application in existing diary factories and controllability of process parameters influencing the S-IgA quality and stability.
摘要翻译：本发明涉及通过分馏含有S-IgA的乳制备富含分泌型IgA（S-IgA）的组合物的方法。这些组合物可特别用于治疗和/或预防粘膜表面的感染和/或炎症，例如，胃肠道，泌尿生殖道，呼吸道，鼻腔或口腔，治疗和/或预防肥胖症和相关疾病，或治疗和/或预防需要这种治疗的受试者的食物过敏。简而言之，本发明提供了使用一个或多个微孔膜过滤步骤生产富含分泌型免疫球蛋白A的乳成分的方法。本方法的优选方案包括通过多个渗滤循环进行脱脂，微过滤和超滤浓缩。本发明的方法除了意想不到的高产率之外，还提供了在可扩展性，现有日记工厂中的应用以及影响S-IgA质量和稳定性的工艺参数的可控性方面特别有利的优点。

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