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    • 1. 发明申请
    • MULTI-LAYER MICRO/NANOFLUID DEVICES WITH BIO-NANOVALVES
    • 具有生物纳米值的多层微型/纳米级器件
    • US20130000764A1
    • 2013-01-03
    • US12391486
    • 2009-02-24
    • Hao LiLeonidas E. OcolaOrlando H. AucielloMillicent A. Firestone
    • Hao LiLeonidas E. OcolaOrlando H. AucielloMillicent A. Firestone
    • F15C1/00B05D3/06
    • B01F13/0061B01L3/50273B01L3/502738B01L2200/027B01L2300/0867B01L2300/0874B01L2300/0896B01L2400/0415B01L2400/0487B01L2400/0627B01L2400/0633F16K99/0003F16K99/0042F16K2099/0073Y10T137/206
    • A user-friendly multi-layer micro/nanofluidic flow device and micro/nano fabrication process are provided for numerous uses. The multi-layer micro/nanofluidic flow device can comprise: a substrate, such as indium tin oxide coated glass (ITO glass); a conductive layer of ferroelectric material, preferably comprising a PZT layer of lead zirconate titanate (PZT) positioned on the substrate; electrodes connected to the conductive layer; a nanofluidics layer positioned on the conductive layer and defining nanochannels; a microfluidics layer positioned upon the nanofluidics layer and defining microchannels; and biomolecular nanovalves providing bio-nanovalves which are moveable from a closed position to an open position to control fluid flow at a nanoscale. The micro/nano fabrication process for fabricating a multi-layer micro/nanofluidic flow device can comprise: forming a conductive layer on a substrate; forming an electrode pattern; forming a nanofluidics layer with a nanochannel pattern to define nanochannels; forming a microfluidics layer with a microchannel pattern to define microchannels; and assembling the microfluidics layer on the nanofluidics layer. The micro/nano fabrication process can include: synthesizing a thin film of PZT on ITO glass, electron beam lithography, sputtering, spin-coating, photolithography, and plasma treatment.
    • 提供用户友好的多层微/纳流体流动装置和微/纳米制造工艺用于许多用途。 多层微/纳流体流动装置可以包括:衬底,例如氧化铟锡涂层玻璃(ITO玻璃); 铁电材料的导电层,优选地包括位于基底上的锆钛酸铅(PZT)的PZT层; 连接到导电层的电极; 定位在导电层上并限定纳米通道的纳米流体层; 位于纳米流体层上并限定微通道的微流体层; 和生物分子纳米阀提供可从关闭位置移动到打开位置的生物纳米阀,以控制纳米尺度的流体流动。 用于制造多层微/纳流体流动装置的微/纳米制造工艺可以包括:在衬底上形成导电层; 形成电极图案; 形成具有纳米通道图案的纳米流体层以限定纳米通道; 形成具有微通道图案的微流体层以限定微通道; 并将微流体层组装在纳米流体层上。 微/纳米制造工艺可以包括:在ITO玻璃上合成PZT薄膜,电子束光刻,溅射,旋涂,光刻和等离子体处理。