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1. 发明授权

US5607457A Pacemaker with evoked response detection by using differential sensing between two unipolar electrodes 失效
标题翻译：起搏器通过使用两个单极电极之间的差分感应进行诱发反应检测
公开(公告)号：US5607457A
公开(公告)日：1997-03-04
申请号：US536453
申请日：1995-09-29
申请人： Hans Schuller
发明人： Hans Schuller
IPC分类号： A61N1/368 , A61N1/37
CPC分类号： A61N1/371 , A61N1/368
摘要： A heart stimulator, operable for single-chamber and/or dual-chamber pacing, includes first and second electrical leads connected to a pulse generator and each terminating in an electrode, the electrodes being disposed respectively in the atrium and the ventricle. A differential detector is connected to the first and second leads and detects cardiac activity between the atrial electrode and the ventricular electrode. A correlation detector is connected between the pacemaker housing and one of the atrial or ventricular electrodes, and generates a correlation signal identifying whether the cardiac activity detected by the cardiac activity detector arose in the atrium or in the ventricle. The outputs of the differential detector and the correlation detector are supplied to a logic circuit which determines therefrom whether a stimulation pulse emitted by the pulse generator resulted in an evoked response in the heart.
摘要翻译：可用于单室和/或双室起搏的心脏刺激器包括连接到脉冲发生器并且各自终止于电极的第一和第二电引线，电极分别设置在心房和心室中。差分检测器连接到第一和第二引线并检测心房电极和心室电极之间的心脏活动。相关检测器连接在起搏器外壳和其中一个心房或心室电极之间，并产生一个相关信号，以确定心脏活动检测器检测到的心脏活动是在心房还是在心室中出现。差分检测器和相关检测器的输出被提供给逻辑电路，逻辑电路确定由脉冲发生器发出的刺激脉冲是否导致心脏中的诱发反应。

2. 发明申请

US20080234775A1 Implantable Heart Stimulator for Enabling Normal Atrio-Ventricular Stimulation Sequence in the Presence of Av-Nodal Interference 审中-公开
标题翻译：植入式心脏刺激器，用于在Av-Nodal干扰的存在下实现正常心室刺激序列
公开(公告)号：US20080234775A1
公开(公告)日：2008-09-25
申请号：US11885903
申请日：2005-03-10
申请人： Hans Schuller , Anders Lindgren
发明人： Hans Schuller , Anders Lindgren
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/368 , A61N1/3682
摘要： A heart stimulator for enhancing cardiac performance of a patient suffering from ventricular rhythms that tend to overdrive the patient's atrial rhythm, has sensing circuitry that detects atrial events and ventricular events, and an atrial stimulator that generates and supplies stimulation pulses to the atrium. A timer generates a detection window having a predetermined duration for the ventricular sensing, the detection window starting upon detection of an intrinsic or stimulated atrial event. If an R-wave is sensed from the ventricle during the detection window, a control unit determines that a focus, that pre-depolarizes the ventricles, exists, and the control unit operates the atrial stimulator to increase the atrial stimulation rate for a predetermined number of consecutive heart cycles.
摘要翻译：用于增强患有心室节律的患者的心脏刺激器，其倾向于过度驱动患者的心房节律，具有检测心房事件和心室事件的感测电路，以及产生并向心房提供刺激脉冲的心房刺激器。定时器产生具有用于心室感测的预定持续时间的检测窗口，该检测窗口在检测到内在或刺激的心房事件时开始。如果在检测窗口期间从心室感测到R波，则控制单元确定存在使脑室预去极化的焦点，并且控制单元操作心房刺激器以增加预定数量的心房刺激速率的连续心脏循环。

3. 发明授权

US4107409A Method of producing polymers of high molecular weight by the two-phase interfacial method 失效
标题翻译：通过两相界面法制备高分子量聚合物的方法
公开(公告)号：US4107409A
公开(公告)日：1978-08-15
申请号：US810083
申请日：1977-06-27
申请人： Otto Szabolcs , Hans Schuller
发明人： Otto Szabolcs , Hans Schuller
IPC分类号： B01F5/00 , B01J19/18 , C08F2/00 , C08G63/78 , C08G63/82 , C08G85/00 , C09D5/44
CPC分类号： B01F7/00758 , B01J19/1806 , C08G63/785 , C08G63/82 , C08G85/00 , C09D5/44 , B01F2005/0008 , B01J2219/00094 , B01J2219/00168
摘要： A process for producing high molecular weight polymers by the two-phase interfacial method comprising bringing two liquid phases containing polymerizable reactants continuously into contact with one another in a predetermined quantitative ratio to one another and passing the resulting mixture through one mixing stage or a plurality of serially connected mixing stages, the mixture being divided into a plurality of partial streams in each mixing stage, and causing the partial streams together with their flow boundaries to move transversely to their main directions of flow at mean speeds higher than 5 meters per second and to pass into a mixing chamber which has at least one outlet duct and in which the kinetic energy of the mixture is reduced from the highest value attained in the mixing to a value which is low in relation to said highest value, the portions of the mixture flowing in the mixing chamber being subjected to flow conditions which substantially vary at least periodically.
摘要翻译：通过两相界面方法制备高分子量聚合物的方法包括使含有可聚合反应物的两个液相以预定的数量比彼此连续接触，并将所得混合物通过一个混合阶段或多个串联连接的混合阶段，混合物在每个混合阶段被分成多个部分流，并使部分流与它们的流动边界一起以平均速度高于5米/秒横向移动至其主要流动方向，并且进入具有至少一个出口管道的混合室，其中混合物的动能从混合中获得的最高值降低到相对于所述最高值低的值，混合物的部分流动在混合室中经受至少周期性地变化的流动条件。

4. 发明授权

US5441522A Pacemaker 失效
标题翻译：起搏器
公开(公告)号：US5441522A
公开(公告)日：1995-08-15
申请号：US120561
申请日：1993-09-13
申请人： Hans Schuller
发明人： Hans Schuller
IPC分类号： A61N1/368 , A61N1/36
CPC分类号： A61N1/368
摘要： A pacemaker for stimulating both the atrium and the chamber of a heart is able to inhibit the emission of chamber stimulating pulses if a spontaneous chamber reaction is sensed before the expiry of an AV interval, counting from the emission of an atrial stimulating pulse. To prevent the pacemaker from being locked in a position where consecutive chamber stimulating pulses are emitted because of retrograde atrial reactions making the atrium insensitive to atrial stimulating pulses, the AV interval is shortened after the emission of a chamber stimulating pulse. After a predetermined time, a predetermined number of pulses, or when a spontaneous chamber reaction is sensed within the shortened AV interval, the longer AV interval is restored.
摘要翻译：如果在从间隔激发脉冲的发射计数的AV间隔期满之前检测到自发室反应，则能够抑制心脏的心房和腔室的起搏器。为了防止起搏器被锁定在连续腔室刺激脉冲发射的位置，因为使心房对心房刺激脉冲不敏感的逆行心房反应，在腔室刺激脉冲的发射之后，AV间隔被缩短。在预定时间之后，预定数量的脉冲，或者当在缩短的AV间隔内感测到自发室反应时，恢复较长的AV间隔。

5. 发明授权

US4141957A Apparatus for producing polymers of high molecular weight by the two-phase interfacial method 失效
标题翻译：用于通过两相界面方法制备高分子量聚合物的装置
公开(公告)号：US4141957A
公开(公告)日：1979-02-27
申请号：US899108
申请日：1978-04-24
申请人： Otto Szabolcs , Hans Schuller
发明人： Otto Szabolcs , Hans Schuller
IPC分类号： B01F5/00 , B01F7/00 , B01J19/18 , C08F2/00 , C08G63/78 , C08G63/82 , C08G85/00 , B01J1/00
CPC分类号： B01F7/00758 , B01J19/1806 , C08G63/785 , C08G63/82 , C08G85/00 , B01F2005/0008 , B01J2219/00094 , B01J2219/00168
摘要： Process and apparatus for producing high molecular weight polymers by the two-phase interfacial method comprising bringing two liquid phases containing polymerizable reactants continuously into contact with one another in a predetermined quantitative ratio to one another and passing the resulting mixture through one mixing stage or a plurality of serially connected mixing stages, the mixture being divided into a plurality of partial streams in each mixing stage, and causing the partial streams together with their flow boundaries to move transversely to their main directions of flow at mean speeds higher than 5 meters per second and to pass into a mixing chamber which has at least one outlet duct and in which the kinetic energy of the mixture is reduced from the highest value attained in the mixing to a value which is low in relation to said highest value, the portions of the mixture flowing in the mixing chamber being subjected to flow conditions which substantially vary at least periodically.
摘要翻译：通过两相界面方法制备高分子量聚合物的方法和装置，包括使包含可聚合反应物的两个液相以预定的数量比彼此连续接触，并将所得混合物通过一个混合阶段或多个串联连接的混合阶段，混合物在每个混合阶段被分成多个部分流，并使部分流与它们的流动边界一起以高于每秒5米的平均速度横向于其主要流动方向移动，进入具有至少一个出口管道的混合室，其中混合物的动能从混合中获得的最高值降低到相对于所述最高值低的值，混合物的部分在混合室中流动的流动条件至少基本上变化二，

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