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1. 发明授权

US07000296B1 Method and auxiliary device for leasing threads into guide elements of a handling device for handling threads and a handling device of this type 失效
标题翻译：用于将螺纹引入用于处理螺纹的处理装置的引导元件和这种处理装置的方法和辅助装置
公开(公告)号：US07000296B1
公开(公告)日：2006-02-21
申请号：US09763635
申请日：2000-06-15
申请人： Hans Berg , Heinrich Johann Mensing , Wolfgang Lange
发明人： Hans Berg , Heinrich Johann Mensing , Wolfgang Lange
IPC分类号： D02H13/16 , B65H57/16
CPC分类号： D06B23/06 , D02H13/16 , D03J1/14 , D03J3/00
摘要： In order to lease threads (F), in particular warp threads into guide elements (2) of a handling device (1), such as combs or reeds, the threads (F) are first leased in sequence into a leasing comb (11) and are fixed thereto. The threads (F) are subsequently guided through the device (1) by means of the leasing comb (11). During this process, the threads (F) are taken up by the guide elements (2).
摘要翻译：为了将线（F），特别是经线租赁到诸如梳子或芦苇的处理装置（1）的引导元件（2）中，螺纹（F）首先按顺序租赁到租赁梳（11）中，并固定在其上。螺纹（F）随后通过租赁梳子（11）被引导穿过设备（1）。在该过程中，螺纹（F）被引导元件（2）吸收。

2. 发明授权

US06557268B1 Dryer and method for drying continuously conveyed products 失效
标题翻译：烘干机和连续输送产品的干燥方法
公开(公告)号：US06557268B1
公开(公告)日：2003-05-06
申请号：US09743793
申请日：2001-06-11
申请人： Hans Berg , Heinrich Johann Mensing , Wolfgang Lange
发明人： Hans Berg , Heinrich Johann Mensing , Wolfgang Lange
IPC分类号： F26B504
CPC分类号： F26B13/10 , F26B13/001
摘要： The invention relates to a dryer (1) for drying continuously conveyed products, e.g. a warp, comprising essentially a first dryer array (2) and a second dryer array (3). A passage (4) for passing through the product (W) is formed between the dryer arrays (2, 3). The second dryer array (3) is configured in such a way as to be able to move in relation to the first dryer array (2). When the dryer (1) is in stop position (S), the second dryer array (3) is disposed relative to the first dryer array (2) in such a way that the cross section of the passage (4) is bigger than in the operating position (B).
摘要翻译：本发明涉及一种干燥器（1），用于干燥连续输送的产品，例如，翘曲，基本上包括第一干燥器阵列（2）和第二干燥器阵列（3）。在干燥器阵列（2,3）之间形成有通过产品（W）的通道（4）。第二干燥器阵列（3）被构造成能够相对于第一干燥器阵列（2）移动。当干燥器（1）处于停止位置（S）时，第二干燥器阵列（3）相对于第一干燥器阵列（2）设置成使得通道（4）的横截面大于操作位置（B）。

3. 发明授权

US08309709B2 Method of preparing a separation matrix 有权
标题翻译：制备分离基质的方法
公开(公告)号：US08309709B2
公开(公告)日：2012-11-13
申请号：US11913236
申请日：2006-06-28
申请人： Hans Berg , Maria Brannholm , David Buckley , Philippe Busson , Anders Hagvall , Eva Holmgren , Henrik Ihre , Anders Larsson , Dag Lindstrom
发明人： Hans Berg , Maria Brannholm , David Buckley , Philippe Busson , Anders Hagvall , Eva Holmgren , Henrik Ihre , Anders Larsson , Dag Lindstrom
IPC分类号： C07H1/00 , A61K31/715 , A01N43/04
CPC分类号： B01J20/291 , B01J20/24 , B01J20/262 , B01J20/267 , B01J20/28033 , B01J20/28042 , B01J20/285 , B01J20/3206 , B01J20/3244 , B01J20/3274 , B01J20/3282 , B01J2220/54 , C08B37/0039 , C08J3/24 , C08J2301/00
摘要： The present invention relates to a method of preparing an insoluble separation matrix, which method comprises salt-treatment of a polysaccharide gel followed by cross-linking of the polysaccharide polymers. In one embodiment, the method comprises providing an aqueous solution of a gelatable native polysaccharide; lowering the temperature of the polysaccharide solution to a value below its gelling point; salt-treatment by adding at least one salt to the resulting polysaccharide; and cross-linking the salt-treated polysaccharide. The polysaccharide may be prepared e.g. into particles, membranes or monoliths.
摘要翻译：本发明涉及一种制备不溶性分离基质的方法，该方法包括多糖凝胶的盐处理，然后交联多糖聚合物。在一个实施方案中，该方法包括提供可胶凝天然多糖的水溶液; 将多糖溶液的温度降低到低于其凝胶点的值; 通过向所得多糖中加入至少一种盐进行盐处理; 并交联盐处理的多糖。多糖可以例如制备。成颗粒，膜或整料。

4. 发明授权

US07396467B2 Method of preparing a chromatography matrix 有权
标题翻译：制备色谱基质的方法
公开(公告)号：US07396467B2
公开(公告)日：2008-07-08
申请号：US10964269
申请日：2004-10-13
申请人： Hans Berg , David Buckley , Maria Brännholm , Anders Hagvall , Henrik Ihre , Eva Holmgren , Anders Larsson , Dag Lindstrom
发明人： Hans Berg , David Buckley , Maria Brännholm , Anders Hagvall , Henrik Ihre , Eva Holmgren , Anders Larsson , Dag Lindstrom
IPC分类号： B01D15/08
CPC分类号： B01J20/262 , B01J20/24 , B01J20/26 , B01J20/267 , B01J20/285 , B01J2220/4825
摘要： The present invention relates to a method of preparing a porous cross-linked polysaccharide chromatography matrix, which comprises to provide an aqueous solution of a gellable polysaccharide, wherein part of the hydroxyl groups are substituted with groups which are not susceptible to nucleophilic attack; to provide essentially spherical droplets of the substituted polysaccharide solution; to form a gel of the substituted polysaccharide solution; and to cross-link the gel by adding a cross-linking agent. The invention also encompasses a chromatography column packed with a matrix so produced as well as use thereof in e.g. protein purification.
摘要翻译：本发明涉及一种制备多孔交联多糖色谱基质的方法，其包括提供可凝胶多糖的水溶液，其中部分羟基被不易受亲核攻击的基团取代; 以提供取代的多糖溶液的基本上球形的液滴; 以形成取代的多糖溶液的凝胶; 并通过加入交联剂来交联凝胶。本发明还包括填充有如此制备的基质的色谱柱，以及其在例如，蛋白质纯化。

5. 发明申请

US20060252152A1 Attachment of cells to surfaces 审中-公开
标题翻译：细胞附着在表面
公开(公告)号：US20060252152A1
公开(公告)日：2006-11-09
申请号：US10571193
申请日：2004-10-05
申请人： James Alstine , Hans Berg , Asa Bjurling
发明人： James Alstine , Hans Berg , Asa Bjurling
IPC分类号： C12N1/20 , C12N5/02 , C12N5/00 , C12M3/00
CPC分类号： C07K17/02 , C12N5/0075 , C12N2533/30 , C12N2533/70
摘要： The present invention relates to a microcarrier onto the surface of which a cationic compound has been immobilised via a guanidine group. The microcarrier is capable of attachment of cells, e.g. via charge-based interaction, and is advantageously used as a support in the culture of cells. Said compound may comprise one or two amino acids, such as arginine (Arg) or a dipeptide. The invention also relates to a method of preparing a polycationic microcarrier, which method comprises to immobilise a compound that comprises at least one guanidine group to an epoxide-activated substrate.
摘要翻译：本发明涉及通过胍基固定有阳离子化合物的表面上的微载体。微载体能够附着细胞，例如细胞。通过基于电荷的相互作用，并且有利地用作细胞培养物中的载体。所述化合物可以包含一个或两个氨基酸，例如精氨酸（Arg）或二肽。本发明还涉及一种制备聚阳离子微载体的方法，该方法包括将包含至少一个胍基的化合物固定在环氧化物活化的底物上。

6. 发明申请

US20060060534A1 Method of preparing a chromatography matrix 有权
标题翻译：制备色谱基质的方法
公开(公告)号：US20060060534A1
公开(公告)日：2006-03-23
申请号：US10964269
申请日：2004-10-13
申请人： Hans Berg , David Buckley , Maria Brannholm , Anders Hagvall , Henrik Ihre , Eva Holmgren , Anders Larsson , Dag Lindstrom
发明人： Hans Berg , David Buckley , Maria Brannholm , Anders Hagvall , Henrik Ihre , Eva Holmgren , Anders Larsson , Dag Lindstrom
IPC分类号： C12P19/04 , B01J20/22 , C08B37/00
CPC分类号： B01J20/262 , B01J20/24 , B01J20/26 , B01J20/267 , B01J20/285 , B01J2220/4825
摘要： The present invention relates to a method of preparing a porous cross-linked polysaccharide chromatography matrix, which comprises to provide an aqueous solution of a gellable polysaccharide, wherein part of the hydroxyl groups are substituted with groups which are not susceptible to nucleophilic attack; to provide essentially spherical droplets of the substituted polysaccharide solution; to form a gel of the substituted polysaccharide solution; and to cross-link the gel by adding a cross-linking agent. The invention also encompasses a chromatography column packed with a matrix so produced as well as use thereof in e.g. protein purification.
摘要翻译：本发明涉及一种制备多孔交联多糖色谱基质的方法，其包括提供可凝胶多糖的水溶液，其中部分羟基被不易受亲核攻击的基团取代; 以提供取代的多糖溶液的基本上球形的液滴; 以形成取代的多糖溶液的凝胶; 并通过加入交联剂来交联凝胶。本发明还包括填充有如此制备的基质的色谱柱，以及其在例如，蛋白质纯化。

7. 发明申请

US20060025585A1 Manufacturing process for porous material 审中-公开
标题翻译：多孔材料的制造工艺
公开(公告)号：US20060025585A1
公开(公告)日：2006-02-02
申请号：US11224574
申请日：2005-09-12
申请人： Hans Berg , Mats Carlsson
发明人： Hans Berg , Mats Carlsson
IPC分类号： C08B37/00
CPC分类号： C08J9/28 , C08B37/0039 , C08J3/075 , C08J2201/0544 , C08J2305/12
摘要： A method for the manufacture of a solid porous separation material based on a polysaccharide, said method comprising the steps of: (a) providing an aqueous solution (I) of a polysaccharide, (b) solidifying the solution, preferably by transforming the solution to a gel, and (c) optionally cross-linking the polysaccharide, with the proviso that, if step (c) is present, steps (b) and (c) may be carried out simultaneously. The method is characterised in that the polysaccharide provided in step (a) is modified by being inter-molecularly cross-linked to an extent such that the viscosity of solution (I) is at least 110%, preferably at least 200%, of the viscosity of an aqueous solution (II) of the corresponding polysaccharide which has not been inter-molecularly cross-linked and which is present in the same concentration as the inter-molecularly cross-linked polysaccharide is in solution (I).
摘要翻译：一种制备基于多糖的固体多孔分离材料的方法，所述方法包括以下步骤：（a）提供多糖的水溶液（I），（b）固化溶液，优选通过将溶液转化为凝胶，和（c）任选地交联多糖，条件是如果存在步骤（c），则可以同时进行步骤（b）和（c）。该方法的特征在于，步骤（a）中提供的多糖通过分子内交联以使溶液（I）的粘度为至少110％，优选至少200％在溶液（I）中，未分子间交联并且与分子内交联的多糖以相同浓度存在的相应多糖的水溶液（II）的粘度是。

8. 发明授权

US06602990B1 Process for the production of a porous cross-linked polysaccharide gel and its use as a gel filtration media and in chromatography 有权
标题翻译：生产多孔交联多糖凝胶的方法及其作为凝胶过滤介质和色谱法的用途
公开(公告)号：US06602990B1
公开(公告)日：2003-08-05
申请号：US09155995
申请日：1999-05-11
申请人： Hans Berg
发明人： Hans Berg
IPC分类号： C08B3704
CPC分类号： B01J20/291 , B01D15/325 , B01D15/327 , B01D15/34 , B01D15/3804 , B01D15/3828 , B01J20/262 , B01J20/267 , B01J20/285 , B01J2220/54 , C08B37/0039
摘要： A process for the production of a porous cross-linked polysaccharide gel and a gel obtainable by the following steps: a) preparing a solution or dispersion of the polysaccharide; b) adding a bifunctional cross-linking agent having one active site and one inactive site to the solution or dispersion from step a); c) reacting hydroxylgroups of the polysaccharide with the active site of the cross-linking agent; d) forming a polysaccharide gel; e) activating the inactive site of the cross-linking agent; f) reacting the activated site from step e) with hydroxylgroups of the polysaccharide gel, whereby cross-linking of the gel takes place. The cross-linked polysaccharide gel obtained can further be cross-linked by conventional methods, one or several times.
摘要翻译：一种生产多孔交联多糖凝胶和凝胶的方法，可通过以下步骤获得：a）制备多糖的溶液或分散体; b）向来自步骤a）的溶液或分散体中加入具有一个活性位点和一个无活性位点的双功能交联剂; c）使多糖的羟基与交联剂的活性位点反应; d）形成多糖凝胶; e）活化交联剂的非活性位点; f）使来自步骤e）的活化部位与多糖凝胶的羟基反应，从而发生凝胶的交联。获得的交联多糖凝胶可以通过常规方法进一步交联一次或数次。

9. 发明授权

US08728828B2 Purification of immunoglobulins 有权
标题翻译：免疫球蛋白的纯化
公开(公告)号：US08728828B2
公开(公告)日：2014-05-20
申请号：US11315402
申请日：2005-12-22
申请人： Hans Berg , Hans Johansson , Gunnar Malmquist , Per-Mikael Aberg
发明人： Hans Berg , Hans Johansson , Gunnar Malmquist , Per-Mikael Aberg
IPC分类号： G01N33/543
CPC分类号： G01N33/543 , B01D15/3809 , B01J20/286 , B01J20/3212 , B01J20/3274 , G01N33/558 , Y10S436/824
摘要： The present invention relates to a separation matrix comprised of porous particles to which antibody-binding protein ligands have been immobilized, wherein the ligand density is in the range of 5.0-10 mg/ml; the gel phase distribution coefficient of the particles expressed as Kav for a dextran of size 110 kDa is above 0.65 and the median particle diameter is between 65-84 μm. The carbohydrate material is preferably highly cross-linked agarose.
摘要翻译：本发明涉及由多孔颗粒组成的分离基质，抗体结合蛋白质配体已经固定在其上，其中配体密度在5.0-10mg / ml的范围内; 表示为大小为110kDa的葡聚糖的Kav的颗粒的凝胶相分布系数大于0.65，中值粒径在65-84μm之间。碳水化合物材料优选是高度交联的琼脂糖。

10. 发明授权

US07341682B2 Manufacture of polysaccharide beads 有权
标题翻译：多糖珠的制造
公开(公告)号：US07341682B2
公开(公告)日：2008-03-11
申请号：US10512301
申请日：2003-04-17
申请人： Ralf Göran Andersson , Hans Berg , Ingemar Jonsson , Anders Larsson
发明人： Ralf Göran Andersson , Hans Berg , Ingemar Jonsson , Anders Larsson
IPC分类号： B29B9/00
CPC分类号： B01J20/291 , B01D15/325 , B01D15/327 , B01D15/34 , B01D15/361 , B01D15/3804 , B01J20/26 , B01J20/262 , B01J20/265 , B01J20/285 , B01J39/19 , B01J2220/54 , C08J3/14 , C08J2305/12 , C08L5/00 , G01N30/482
摘要： The present invention is a process of manufacture of one or more polysaccharide beads, comprising generating an aerosol of an aqueous polysaccharide solution, cooling the droplets of said aerosol in air to initiate gelling thereof and collecting droplets as gelled beads in a liquid or on a surface, characterised by adding a hydrophilic vapour pressure-lowering agent to said polysaccharide solution.
摘要翻译：本发明是一种制造一种或多种多糖珠粒的方法，其包括产生多糖水溶液的气雾剂，在空气中冷却所述气雾剂的液滴以引发其凝胶化，并以液体或表面上的胶凝珠收集液滴其特征在于向所述多糖溶液中加入亲水性蒸汽降压剂。

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