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1. 发明授权

US07943353B2 Multi-layer cell encapsulation for tissue engineering 失效
标题翻译：用于组织工程的多层细胞包封
公开(公告)号：US07943353B2
公开(公告)日：2011-05-17
申请号：US12507900
申请日：2009-07-23
申请人： Hanry Yu , Kam W Leong , Ser-Mien Chia , Andrew C. A. Wan
发明人： Hanry Yu , Kam W Leong , Ser-Mien Chia , Andrew C. A. Wan
IPC分类号： C12N11/04
CPC分类号： C12N5/0062 , A61K2035/128 , C12N5/0012 , C12N5/0671 , C12N2533/30 , C12N2533/54 , C12N2533/72 , Y10S514/963 , Y10S514/97
摘要： A multi-layered microcapsule has an inner extracellular matrix and an outer shell. The inner extracellular matrix includes a first inner layer of biopolymer and a second intermediate layer of polymer that provides partial immune-protection and holds the first layer in place. The outer shell can form an exoskeleton to provide mechanical stability. Each of the individual layers can be varied to optimize mechanical stability, cell function, and immuno-protection.
摘要翻译：多层微胶囊具有内细胞外基质和外壳。内部细胞外基质包括生物聚合物的第一内层和聚合物的第二中间层，其提供部分免疫保护并将第一层保持在适当位置。外壳可以形成外骨骼以提供机械稳定性。每个单独的层可以变化以优化机械稳定性，细胞功能和免疫保护。

2. 发明授权

US06916640B2 Multi-layer cell encapsulation for tissue engineering 失效
标题翻译：用于组织工程的多层细胞包封
公开(公告)号：US06916640B2
公开(公告)日：2005-07-12
申请号：US09975273
申请日：2001-10-12
申请人： Hanry Yu , Kam W. Leong , Ser-Mien Chia , Andrew C. A. Wan
发明人： Hanry Yu , Kam W. Leong , Ser-Mien Chia , Andrew C. A. Wan
IPC分类号： A61K35/12 , C12N5/00 , C12N5/071 , C12N11/04 , C12N11/08
CPC分类号： C12N5/0062 , A61K2035/128 , C12N5/0012 , C12N5/0671 , C12N2533/30 , C12N2533/54 , C12N2533/72 , Y10S514/963 , Y10S514/97
摘要： A multi-layered microcapsule has an inner extracellular matrix and an outer shell. The inner extracellular matrix includes a first inner layer of biopolymer and a second intermediate layer of polymer that provides partial immune-protection and holds the first layer in place. The outer shell can form an exoskeleton to provide mechanical stability. Each of the individual layers can be varied to optimize mechanical stability, cell function, and immuno-protection.
摘要翻译：多层微胶囊具有内细胞外基质和外壳。内部细胞外基质包括生物聚合物的第一内层和聚合物的第二中间层，其提供部分免疫保护并将第一层保持在适当位置。外壳可以形成外骨骼以提供机械稳定性。每个单独的层可以变化以优化机械稳定性，细胞功能和免疫保护。

3. 发明授权

US06905875B2 Non-disruptive three-dimensional culture and harvest system for anchorage-dependent cells 失效
标题翻译：用于锚定依赖细胞的非破坏性三维文化和收获系统
公开(公告)号：US06905875B2
公开(公告)日：2005-06-14
申请号：US10398957
申请日：2001-10-12
申请人： Hanry Yu , Kam W. Leong , Ser-Mien Chia
发明人： Hanry Yu , Kam W. Leong , Ser-Mien Chia
IPC分类号： A61K35/12 , C12N5/00 , C12N5/071 , C12N11/00 , C12N11/02 , C12N11/10
CPC分类号： C12N5/0062 , A61K2035/128 , C12N5/0012 , C12N5/0671 , C12N2533/30 , C12N2533/54 , C12N2533/72 , Y10S514/963 , Y10S514/97
摘要： A non-disruptive three-dimensional culture system allows cell growth and proliferation in three dimensions, permitting cell splitting without subjecting cells to disruptive conditions that affect cell structure and functions. An extracellular matrix provides a good environment for culturing or co-culturing anchorage-dependent cells. The cells cultured this manner can be readily used in such applications as cell transplantation, tissue engineering seeding of cells on scaffolds, and other applications that require immediate availability of functioning cells.
摘要翻译：无破坏性的三维培养系统允许三维细胞生长和增殖，允许细胞分裂而不使细胞受到影响细胞结构和功能的破坏性条件。细胞外基质提供培养或共培养锚定依赖性细胞的良好环境。以这种方式培养的细胞可以容易地用于诸如细胞移植，在支架上细胞的组织工程接种以及需要立即获得功能性细胞的其它应用的应用。

4. 发明申请

US20090286278A1 MULTI-LAYER CELL ENCAPSULATION FOR TISSUE ENGINEERING 失效
标题翻译：用于组织工程的多层细胞浸润
公开(公告)号：US20090286278A1
公开(公告)日：2009-11-19
申请号：US12507900
申请日：2009-07-23
申请人： Hanry Yu , Kam W. Leong , Ser-Mien Chia , Andrew C.A. Wan
发明人： Hanry Yu , Kam W. Leong , Ser-Mien Chia , Andrew C.A. Wan
IPC分类号： C12Q1/02 , C12N11/08 , C12N11/14 , C12N11/10
CPC分类号： C12N5/0062 , A61K2035/128 , C12N5/0012 , C12N5/0671 , C12N2533/30 , C12N2533/54 , C12N2533/72 , Y10S514/963 , Y10S514/97
摘要： A multi-layered microcapsule has an inner extracellular matrix and an outer shell. The inner extracellular matrix includes a first inner layer of biopolymer and a second intermediate layer of polymer that provides partial immune-protection and holds the first layer in place. The outer shell can form an exoskeleton to provide mechanical stability. Each of the individual layers can be varied to optimize mechanical stability, cell function, and immuno-protection.
摘要翻译：多层微胶囊具有内细胞外基质和外壳。内部细胞外基质包括生物聚合物的第一内层和聚合物的第二中间层，其提供部分免疫保护并将第一层保持在适当位置。外壳可以形成外骨骼以提供机械稳定性。每个单独的层可以变化以优化机械稳定性，细胞功能和免疫保护。

5. 发明申请

US20050220891A1 Multi-layer cell encapsulation for tissue engineering 审中-公开
公开(公告)号：US20050220891A1
公开(公告)日：2005-10-06
申请号：US11137483
申请日：2005-05-26
申请人： Hanry Yu , Kam Leong , Ser-Mien Chia , Andrew Wan
发明人： Hanry Yu , Kam Leong , Ser-Mien Chia , Andrew Wan
IPC分类号： A61K35/12 , C12N5/00 , C12N5/071 , A61K9/16 , A61K9/50
CPC分类号： C12N5/0062 , A61K2035/128 , C12N5/0012 , C12N5/0671 , C12N2533/30 , C12N2533/54 , C12N2533/72 , Y10S514/963 , Y10S514/97
摘要： A multi-layered microcapsule has an inner extracellular matrix and an outer shell. The inner extracellular matrix includes a first inner layer of biopolymer and a second intermediate layer of polymer that provides partial immune-protection and holds the first layer in place. The outer shell can form an exoskeleton to provide mechanical stability. Each of the individual layers can be varied to optimize mechanical stability, cell function, and immuno-protection.

6. 发明授权

US08343742B2 Encapsulation of cells in biologic compatible scaffolds by coacervation of charged polymers 失效
标题翻译：通过凝聚电荷聚合物将细胞封装在生物相容的支架中
公开(公告)号：US08343742B2
公开(公告)日：2013-01-01
申请号：US12693300
申请日：2010-01-25
申请人： Hanry Yu , Yi Chin Toh
发明人： Hanry Yu , Yi Chin Toh
IPC分类号： C12N11/02 , C12N5/02
CPC分类号： C12N5/0068 , A61L27/165 , A61L27/24 , A61L27/38 , A61L27/44 , A61L27/56 , A61L27/58 , C12N11/04 , C12N2533/30 , C08L33/12
摘要： This invention relates to a method for the encapsulation of cells in biologic compatible three dimensional scaffolds and the use of such cells encapsulated in a scaffold. The cells are embedded in a charged polymer that is complex coacervating with an oppositely charged polymer within biologic compatible scaffolds. The polymer complex embedding the cells is forming an ultra thin membrane on the surface of the three dimensional scaffold.
摘要翻译：本发明涉及一种在生物相容的三维支架中包封细胞的方法以及封装在支架中的这种细胞的使用。将细胞嵌入带电的聚合物中，其与生物相容的支架内的带相反电荷的聚合物复合凝聚。嵌入细胞的聚合物复合物在三维支架的表面上形成超薄膜。

7. 发明申请

US20110256574A1 Microfluidic Continuous Flow Device 有权
标题翻译：微流控连续流量装置
公开(公告)号：US20110256574A1
公开(公告)日：2011-10-20
申请号：US13058079
申请日：2008-08-08
申请人： Chi Zhang , Danny van Noort , Hanry Yu
发明人： Chi Zhang , Danny van Noort , Hanry Yu
IPC分类号： C12Q1/02 , C12N5/071 , C12M3/00 , C12M1/00
CPC分类号： C12N1/04 , B01L3/502761 , B01L2200/0668 , B01L2300/0877 , B01L2400/0487 , B01L2400/086 , C12M23/16 , C12M23/34 , C12M25/00 , C12M29/10 , C12N5/0653 , C12N5/067 , C12N5/0686 , C12N5/0688
摘要： A microfluidic continuous flow device comprising a channel which comprises a first and a second area wherein the first area of the channel is a compartment which is defined by partitioning elements and the second area of the channel is a space outside the compartment; wherein through passages which are formed between the partitioning elements are dimensioned such as to retain a biological material and optionally a sustained release composition which can be comprised in the compartment within the compartment; wherein the channel has a first inlet to the compartment through which biological material can be introduced into the compartment; a second inlet for introducing a cultivation medium into a space of the channel arranged outside of the compartment, and an outlet. The present invention further refers to methods of using the devices of the present invention and kits comprising the microfluidic continuous flow devices of the present invention.
摘要翻译：一种微流体连续流动装置，其包括通道，该通道包括第一和第二区域，其中通道的第一区域是由分隔元件限定的隔室，并且通道的第二区域是隔室外部的空间; 其中形成在分隔元件之间的通过通道的尺寸被设计成保持生物材料和任选的可以包含在隔室内的隔室中的缓释组合物; 其中所述通道具有到所述隔室的第一入口，生物材料可以通过所述第一入口引入所述隔间; 用于将培养介质引入布置在隔室外部的通道的空间中的第二入口和出口。本发明还涉及使用本发明的装置和包含本发明的微流体连续流动装置的试剂盒的方法。

8. 发明申请

US20050202096A1 Microcapsules for encapsulation of bioactive substances 审中-公开
标题翻译：用于包封生物活性物质的微胶囊
公开(公告)号：US20050202096A1
公开(公告)日：2005-09-15
申请号：US10796902
申请日：2004-03-09
申请人： Jun Li , Chai Quek , Leong Gan , Hanry Yu , Kam Leong
发明人： Jun Li , Chai Quek , Leong Gan , Hanry Yu , Kam Leong
IPC分类号： A61K9/16 , A61K9/50
CPC分类号： A61K9/5026
摘要： The invention relates to photo-crosslinkable microcapsules with enhanced properties for encapsulation of bioactive substances. The present invention also relates to a microencapsulation composition and to a method of manufacturing microcapsules. The microcapsule comprise bioactive substances that are encapsulated by a selectively permeable polymeric membrane. The selectively permeable membrane is impermeable to immune system components associated with immune rejection in an animal. A monomer of the selectively permeable polymeric membrane includes a photosensitive cross-linking agent having a cinnamoyl moiety.
摘要翻译：本发明涉及具有增强的生物活性物质包封性能的光交联性微胶囊。本发明还涉及一种微囊化组合物和一种制造微胶囊的方法。微胶囊包含被选择性渗透性聚合物膜封装的生物活性物质。选择性渗透膜对于与动物中的免疫排斥相关的免疫系统组分是不可渗透的。选择性渗透性聚合物膜的单体包括具有肉桂酰基部分的光敏交联剂。

9. 发明授权

US09670462B2 Bioactive surface for hepatocyte-based applications 有权
公开(公告)号：US09670462B2
公开(公告)日：2017-06-06
申请号：US12301890
申请日：2007-05-24
申请人： Yanan Du , Rongbin Han , Hanry Yu
发明人： Yanan Du , Rongbin Han , Hanry Yu
IPC分类号： C40B30/00 , C12Q1/00 , C12N11/08 , C12N5/071 , C12N5/00 , C12M1/00
CPC分类号： C12N5/0677 , C12N5/0068 , C12N5/0671 , C12N2533/20 , C12N2533/30 , C12N2533/50 , C12N2533/52 , C12N2533/54
摘要： The invention provides a surface, wherein said surface comprises (i) a polymer substrate and (ii) sugar groups and peptide groups coupled to said substrate suitable for culturing hepatocytes.

10. 发明授权

US08993537B2 Forming porous scaffold from cellulose derivatives 有权
标题翻译：从纤维素衍生物形成多孔支架
公开(公告)号：US08993537B2
公开(公告)日：2015-03-31
申请号：US13611339
申请日：2012-09-12
申请人： Zhilian Yue , Feng Wen , Hanry Yu
发明人： Zhilian Yue , Feng Wen , Hanry Yu
IPC分类号： A61K31/717 , A61L27/20 , A61L27/56 , C08B11/20 , C08J9/28 , C08L1/14
CPC分类号： B32B3/26 , A61L27/20 , A61L27/56 , C08B11/20 , C08J9/28 , C08J2201/024 , C08J2201/026 , C08J2201/0484 , C08J2201/0524 , C08J2205/044 , C08J2207/10 , C08J2301/28 , C08L1/14 , Y10T428/249921 , Y10T428/249978 , Y10T428/249979 , C08L1/28
摘要： Scaffold comprises a polymer defining macropores and comprising hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, which is crosslinked through the self-crosslinkable group. The macropores have an average pore size larger than 50 microns and are at least partially interconnected. In one method, bicontinuous emulsion comprising a continuous aqueous phase and a continuous polymer phase is formed. The polymer phase comprises hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, and is crosslinked through the self-crosslinkable group to form a polymer defining at least partially interconnected pores. In another method, phase separation is induced in a solution comprising a polymer precursor and water to form a bicontinuous emulsion comprising a continuous polymer phase and a continuous aqueous phase. The polymer precursor comprises a self-crosslinkable group and is crosslinked through the self-crosslinkable group in the emulsion to form a polymer defining at least partially interconnected macropores.
摘要翻译：脚手架包含限定大孔的聚合物，并且包含部分由包含自交联基团的取代基取代的羟丙基纤维素，所述取代基通过自交联基团交联。大孔具有大于50微米的平均孔径并且至少部分互连。在一种方法中，形成包含连续水相和连续聚合物相的双连续乳液。聚合物相包含部分由包含自交联基团的取代基取代的羟丙基纤维素，并且通过自交联基团交联以形成限定至少部分互连的孔的聚合物。在另一种方法中，在包含聚合物前体和水的溶液中诱导相分离以形成包含连续聚合物相和连续水相的双连续乳液。聚合物前体包含自交联基团，并且通过乳液中的自交联基团交联以形成限定至少部分互连的大孔的聚合物。

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