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1. 发明授权

US08868166B2 Arrhythmia detection based on active muscle noise detection 有权
标题翻译：基于主动肌肉噪声检测的心律失常检测
公开(公告)号：US08868166B2
公开(公告)日：2014-10-21
申请号：US13455131
申请日：2012-04-25
申请人： Dirk Muessig , J. Christopher Moulder , Hannes Kraetschmer , Jeffrey A. Von Arx , Larry Stotts
发明人： Dirk Muessig , J. Christopher Moulder , Hannes Kraetschmer , Jeffrey A. Von Arx , Larry Stotts
IPC分类号： A61N5/04 , A61B5/00 , A61B5/0452 , A61N1/05 , A61B5/0464 , A61B5/046
CPC分类号： A61N1/05 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/721
摘要： Implantable electromedical device or loop recorders or ILRs that solve the problem of very low arrhythmia detection specificities in, i.e., high number of false positives, based on detection and analysis of external noise, specifically muscle noise surrounding the electromedical device. Embodiments generally employ active detection of lead or device movement that induces signal artifacts indicative of external noise. One or more embodiments may detect lead or device movement through use of a piezoelectric transducer, for example located proximally to the device or in the lead of the electromedical.
摘要翻译：基于外部噪声的检测和分析，特别是电动医疗装置周围的肌肉噪声，可植入的电疗装置或回路记录器或ILR，其解决非常低的心律失常检测特性（即，高数量的假阳性）的问题。实施例通常采用引导或器件移动的主动检测，其引起指示外部噪声的信号伪影。一个或多个实施例可以通过使用压电换能器来检测引线或器件的移动，例如位于设备的近侧或电子医疗的引线。

2. 发明授权

US08849425B2 Implantable apparatus for detection of external noise using motion sensor signal 有权
标题翻译：用于使用运动传感器信号检测外部噪声的可植入装置
公开(公告)号：US08849425B2
公开(公告)日：2014-09-30
申请号：US13455136
申请日：2012-04-25
申请人： Hannes Kraetschmer , Dirk Muessig , Jeffrey A. Von Arx , Larry Stotts
发明人： Hannes Kraetschmer , Dirk Muessig , Jeffrey A. Von Arx , Larry Stotts
IPC分类号： A61N1/00 , A61B5/11 , A61N1/05 , A61B5/00 , A61B5/024 , A61B5/0452 , A61B5/04
CPC分类号： A61N1/0504 , A61B5/02405 , A61B5/0452 , A61B5/11 , A61B5/686 , A61B5/6867 , A61B5/721 , A61B2562/0219
摘要： Detects external noise using a motion sensor signal for example to increase the specificity of arrhythmia detections based on active muscle noise detection. Whenever a motion signal is present that is below or above a certain frequency, for example 5 Hz, or within a certain frequency range, for example 1 to 10 Hz, and/or above a certain amplitude, for example greater than 1 mg, or close to a known motion pattern, then the detection of fast ventricular arrhythmia is suspended. For the detection of slow arrhythmia, for example asystole or syncope, an episode is confirmed when a short lasting motion sensor signal occurs. Uses a motion sensor based signal, for example as obtained from an accelerometer on an implantable electrode lead and/or implantable device.
摘要翻译：使用运动传感器信号检测外部噪声，例如以增加基于主动肌肉噪声检测的心律失常检测的特异性。每当存在低于或高于某一频率（例如5Hz）或在一定频率范围内（例如1至10Hz）和/或高于某一幅度（例如大于1mg）的运动信号时，或接近已知的运动模式，然后暂停检测快速心室心律失常。为了检测慢性心律不齐，例如心搏停止或晕厥，当发生短暂的持续运动传感器信号时，确认发作。使用基于运动传感器的信号，例如从可植入电极引线和/或可植入装置上的加速度计获得。

3. 发明申请

US20120283589A1 ARRHYTHMIA DETECTION BASED ON ACTIVE MUSCLE NOISE DETECTION 有权
标题翻译：基于主动肌肉噪声检测的ARRHYTHMIA检测
公开(公告)号：US20120283589A1
公开(公告)日：2012-11-08
申请号：US13455131
申请日：2012-04-25
申请人： Dirk Muessig , J. Christopher Moulder , Hannes Kraetschmer , Jeffrey A. Von Arx , Larry Stotts
发明人： Dirk Muessig , J. Christopher Moulder , Hannes Kraetschmer , Jeffrey A. Von Arx , Larry Stotts
IPC分类号： A61B5/0452
CPC分类号： A61N1/05 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/721
摘要： Implantable electromedical device or loop recorders or ILRs that solve the problem of very low arrhythmia detection specificities in, i.e., high number of false positives, based on detection and analysis of external noise, specifically muscle noise surrounding the electromedical device. Embodiments generally employ active detection of lead or device movement that induces signal artifacts indicative of external noise. One or more embodiments may detect lead or device movement through use of a piezoelectric transducer, for example located proximally to the device or in the lead of the electromedical.
摘要翻译：基于外部噪声的检测和分析，特别是电动医疗装置周围的肌肉噪声，可植入的电疗装置或回路记录器或ILR，其解决非常低的心律失常检测特性（即，高数量的假阳性）的问题。实施例通常采用引导或器件移动的主动检测，其引起指示外部噪声的信号伪影。一个或多个实施例可以通过使用压电换能器来检测引线或器件的移动，例如位于设备的近侧或电子医疗的引线。

4. 发明申请

US20130079839A1 APPARATUS AND METHOD TO OPTIMIZE PACING PARAMETERS 有权
标题翻译：优化PAC参数的装置和方法
公开(公告)号：US20130079839A1
公开(公告)日：2013-03-28
申请号：US13603418
申请日：2012-09-05
申请人： Jie Lian , Volker Lang , Hannes Kraetschmer , Dirk Muessig
发明人： Jie Lian , Volker Lang , Hannes Kraetschmer , Dirk Muessig
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0402 , A61N1/36521 , A61N1/3682 , A61N1/3684 , A61N1/3686
摘要： The present disclosure refers to a heart stimulator comprising a stimulation control unit, a stimulation unit, an impedance measurement unit and an impedance evaluation unit. The stimulation control unit is operatively connected to the stimulation unit to control timing of stimulation pulses by said stimulation unit. The impedance measurement unit is configured to determine an impedance signal reflecting intracardiac impedance. The impedance evaluation unit is operatively connected to the impedance measurement unit and to the stimulation control unit and is configured to evaluate the impedance signal so as to determine an isovolumic contraction time, an isovolumic relaxation time, an ejection time and a filling time from said impedance signal. The stimulation control unit is further configured to control timing of stimulation pulses depending on a performance index.
摘要翻译：本公开涉及包括刺激控制单元，刺激单元，阻抗测量单元和阻抗评估单元的心脏刺激器。刺激控制单元可操作地连接到刺激单元以控制所述刺激单元的刺激脉冲的定时。阻抗测量单元被配置为确定反映心内阻抗的阻抗信号。阻抗评估单元可操作地连接到阻抗测量单元和刺激控制单元，并被配置为评估阻抗信号，以便确定等容收缩时间，等容弛豫时间，喷射时间和来自所述阻抗的填充时间信号。刺激控制单元还被配置为根据性能指标来控制刺激脉冲的定时。

5. 发明授权

US08175709B2 Heart monitoring system and method 有权
标题翻译：心脏监测系统及方法
公开(公告)号：US08175709B2
公开(公告)日：2012-05-08
申请号：US11668491
申请日：2007-01-30
申请人： Jie Lian , Hannes Kraetschmer , Dirk Muessig
发明人： Jie Lian , Hannes Kraetschmer , Dirk Muessig
IPC分类号： A61N1/362
CPC分类号： A61B5/04017 , A61B5/0402 , A61B5/04525 , A61B5/7232
摘要： A system for heart monitoring comprises an IEGM input for an intracardiac electrocardiogram (IEGM) that is connected to an active filtering stage that is adapted to transform an incoming IEGM into an output ECG signal. The active filtering stage is connected to a filter characterization stage that is adapted to process a recorded, patient specific IEGM template and a corresponding SECG template and to adapt the filter characteristics of said active filtering stage such that the filter characteristics best characterize the input-output relationship between the IEGM template and the corresponding SECG template. As a consequence, the active filtering stage is adapted to transform an incoming IEGM such that the output ECG signal closely resembles a morphology of a corresponding SECG.
摘要翻译：用于心脏监测的系统包括用于心内心电图（IEGM）的IEGM输入，其连接到适用于将输入的IEGM变换为输出ECG信号的有源滤波级。有源滤波级连接到滤波器表征阶段，其适于处理记录的，患者特异性IEGM模板和对应的SECG模板，并适应所述有源滤波级的滤波器特性，使得滤波器特性最好地表征输入 - 输出 IEGM模板与相应的SECG模板之间的关系。因此，有源滤波阶段适于变换输入的IEGM，使得输出的ECG信号非常类似于对应的SECG的形态。

6. 发明申请

US20070288063A1 Atrial heart stimulator apparatus and method 有权
标题翻译：心房心脏刺激装置及方法
公开(公告)号：US20070288063A1
公开(公告)日：2007-12-13
申请号：US11451138
申请日：2006-06-12
申请人： Christopher S. de Voir , Jie Lian , Richard A. Schomburg , Duane Patterson , Hannes Kraetschmer , Dirk Muessig
发明人： Christopher S. de Voir , Jie Lian , Richard A. Schomburg , Duane Patterson , Hannes Kraetschmer , Dirk Muessig
IPC分类号： A61N1/00
CPC分类号： A61N1/3712 , A61N1/3622 , A61N1/3714
摘要： The invention relates to heart stimulators and implantable atrial pacemakers which utilize a rhythm based atrial capture threshold test wherein in a ventricle based DDI mode a predetermined number of ventricle started atrial and ventricular escape intervals are triggered with an overdrive rate about 20% higher than an intrinsic heart rate. The number of atrial sense events during atrial capture threshold test is counted. Too high of a number of atrial sense events indicates loss of capture due to too small of a pulse strength of the atrial stimulation pulses.
摘要翻译：本发明涉及心脏刺激器和可植入心房起搏器，其利用基于心律的心房采集阈值测试，其中在基于心室的DDI模式中，预定数量的心室开始心房和心室逃逸间隔被触发，超速率比内在的心率。在心房采集阈值测试期间心房感觉事件的数量被计数。许多心房感觉事件的太高表示由于心房刺激脉冲的脉冲强度太小而导致的捕获损失。

7. 发明授权

US08843198B2 Apparatus and method to optimize pacing parameters 有权
标题翻译：优化起搏参数的装置和方法
公开(公告)号：US08843198B2
公开(公告)日：2014-09-23
申请号：US13603418
申请日：2012-09-05
申请人： Jie Lian , Volker Lang , Hannes Kraetschmer , Dirk Muessig
发明人： Jie Lian , Volker Lang , Hannes Kraetschmer , Dirk Muessig
IPC分类号： A61N1/368 , A61B5/04 , A61N1/365 , A61N1/362 , A61B5/0402
CPC分类号： A61N1/3627 , A61B5/0402 , A61N1/36521 , A61N1/3682 , A61N1/3684 , A61N1/3686
摘要： The present disclosure refers to a heart stimulator comprising a stimulation control unit, a stimulation unit, an impedance measurement unit and an impedance evaluation unit. The stimulation control unit is operatively connected to the stimulation unit to control timing of stimulation pulses by said stimulation unit. The impedance measurement unit is configured to determine an impedance signal reflecting intracardiac impedance. The impedance evaluation unit is operatively connected to the impedance measurement unit and to the stimulation control unit and is configured to evaluate the impedance signal so as to determine an isovolumic contraction time, an isovolumic relaxation time, an ejection time and a filling time from said impedance signal. The stimulation control unit is further configured to control timing of stimulation pulses depending on a performance index.
摘要翻译：本公开涉及包括刺激控制单元，刺激单元，阻抗测量单元和阻抗评估单元的心脏刺激器。刺激控制单元可操作地连接到刺激单元以控制所述刺激单元的刺激脉冲的定时。阻抗测量单元被配置为确定反映心内阻抗的阻抗信号。阻抗评估单元可操作地连接到阻抗测量单元和刺激控制单元，并被配置为评估阻抗信号，以便确定等容收缩时间，等容弛豫时间，喷射时间和来自所述阻抗的填充时间信号。刺激控制单元还被配置为根据性能指标来控制刺激脉冲的定时。

8. 发明授权

US08064998B2 Heart stimulating system 有权
标题翻译：心脏刺激系统
公开(公告)号：US08064998B2
公开(公告)日：2011-11-22
申请号：US11863375
申请日：2007-09-28
申请人： Xin Good , David F. Hastings , Hannes Kraetschmer , Dirk Muessig
发明人： Xin Good , David F. Hastings , Hannes Kraetschmer , Dirk Muessig
IPC分类号： A61N1/00
CPC分类号： A61N1/3702 , A61B5/0422 , A61B5/0452 , A61B5/053 , A61B5/0816 , A61B5/11 , A61B5/145 , A61N1/368 , A61N1/3682
摘要： Heart stimulating system for stimulating at least a ventricle of a heart including: stimulation pulse generator adapted to generate stimulation pulses and connected to a ventricular stimulation electrode for delivering stimulation pulses, atrial sensing stage connected to an electrode for picking up potentials inside an atrium and adapted to sense an excitation or contraction of atrial myocardium, ventricular sensing stage connected to an electrode for picking up potentials inside a ventricle and adapted to sense an excitation or contraction of ventricular myocardium, memory for AV-delay values, a control unit adapted to trigger said stimulation pulse generator to generate ventricular stimulation pulses timed based on AV-delay values stored in said memory and to acquire atrioventricular interval samples, and atrioventricular interval timing analyzing unit for receiving atrioventricular interval samples from said control unit and adapted to generate at least one histogram based on said atrioventricular interval samples and analyze said histograms.
摘要翻译：用于刺激至少一个心脏心室的心脏刺激系统，包括：刺激脉冲发生器，其适于产生刺激脉冲并连接到心室刺激电极以传递刺激脉冲，心房感测级连接到电极，用于拾取心房内的电位并适应感测心房心肌的激发或收缩，心室感测阶段连接到电极，用于拾取心室内的电位并且适于感测心室心肌的激发或收缩，用于AV延迟值的记忆，适于触发所述刺激脉冲发生器，以产生基于存储在所述存储器中的AV延迟值定时并获取房室间隔样本的心室刺激脉冲，以及房室间隔定时分析单元，用于从所述控制单元接收房室间隔样本，并适于生成至少一个基于直方图就说房室间隔采样并分析所述直方图。

9. 发明授权

US07970462B2 Implantable medical devices evaluating thorax impedance 有权
标题翻译：评估胸部阻抗的植入式医疗器械
公开(公告)号：US07970462B2
公开(公告)日：2011-06-28
申请号：US11754973
申请日：2007-05-29
申请人： Sharon Lefkov , David F. Hastings , Christopher S. de Voir , Garth Garner , Dirk Muessig , Hannes Kraetschmer
发明人： Sharon Lefkov , David F. Hastings , Christopher S. de Voir , Garth Garner , Dirk Muessig , Hannes Kraetschmer
IPC分类号： A61B5/02 , A61B5/08 , A61B5/05 , A61N1/00
CPC分类号： A61B5/053 , A61B5/0538 , A61B5/0809 , A61B5/4878 , A61B5/6846 , A61B5/7285 , A61N1/36521 , A61N1/36585
摘要： Implantable medical device with an impedance determination unit with constant current/voltage source having current feed terminals connected to electrodes for intracorporal placement which generates measuring current pulses having constant current/voltage, for causing a current through a body via intracorporally placed electrodes, a measuring unit for measuring voltage/current strength of voltage/current fed through body, an impedance value determination unit connected to the current/voltage source and adapted to determine an impedance value for each measuring current pulse, and an impedance measuring control and evaluation unit connected to the impedance determination unit which controls the unit and evaluates a sequence of consecutive impedance values, the impedance determination unit further adapted to determine at least intrathoracic and intracardiac impedance values for same period of time, the intrathoracic values sampled with a lower sampling rate than the intracardiac values.
摘要翻译：具有恒定电流/电压源的阻抗确定单元的植入式医疗装置，其具有连接到用于体内放置的电极的电流馈电端子，其产生具有恒定电流/电压的测量电流脉冲，用于通过体内放置的电极使电流通过身体，测量单元用于测量通过本体馈送的电压/电流的电压/电流强度，阻抗值确定单元，连接到电流/电压源并适于确定每个测量电流脉冲的阻抗值，以及阻抗测量控制和评估单元，连接到阻抗确定单元，其控制所述单元并评估连续阻抗值的序列，所述阻抗确定单元还适于在相同时间段内至少确定胸内和心内阻抗值，以比心脏内值更低的采样率采样的胸内值。

10. 发明授权

US08718751B2 Monitoring system for sleep disordered breathing 有权
标题翻译：睡眠呼吸障碍监测系统
公开(公告)号：US08718751B2
公开(公告)日：2014-05-06
申请号：US11746156
申请日：2007-05-09
申请人： David F. Hastings , Xin Good , Hannes Kraetschmer , Dirk Muessig
发明人： David F. Hastings , Xin Good , Hannes Kraetschmer , Dirk Muessig
IPC分类号： A61B5/08 , A61B5/04 , A61B5/053 , A61B5/085
CPC分类号： A61N1/36521 , A61B5/0535 , A61B5/0809 , A61B5/4818 , A61N1/36114 , A61N1/36542 , A61N1/36585
摘要： A heart monitoring system comprises a ventricular sensing stage sensing excitation or contraction of ventricular myocardium, an activity sensor unit determining a signal reflecting a patient's physical activity, a ventricular impedance or conductance measuring module, said modules comprising a current source unit adapted to provide a sub-threshold excitation current to the myocardium and comprising an impedance or conductance measurement unit for measuring the resulting voltage on said electrode at the myocardium, a signal generator module, a filter module, a memory, a control unit adapted to derive single measures |ΣZ| of magnitude of impedance or conductance change over a preset sample time interval, determine the variability TARVI in the impedance or conductance change, compare this variability and the activity sensor output signal with a threshold and recent history, determine if sleep disturbed breathing (SDB) is present, and log the SDB episode in the memory device.
摘要翻译：心脏监测系统包括心室感测阶段感测心室心肌的激发或收缩，活动传感器单元确定反映患者身体活动的信号，心室阻抗或电导测量模块，所述模块包括电流源单元，其适于提供子并且包括用于测量心肌上的所述电极上产生的电压的阻抗或电导测量单元，信号发生器模块，滤波器模块，存储器，适于导出单个测量的控制单元。 Z | 在预设的采样时间间隔内测量阻抗或电导变化的大小，确定阻抗或电导变化中的变异性TARVI，将该变异性和活动传感器输出信号与阈值和最近历史进行比较，确定睡眠扰动呼吸（SDB）是否为呈现并记录SDB剧集在内存设备中。

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