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1. 发明申请

US20110117606A1 NRPS-PKS Gene Cluster and its Manipulation and Utility 有权
标题翻译： NRPS-PKS基因簇及其操作和实用性
公开(公告)号：US20110117606A1
公开(公告)日：2011-05-19
申请号：US12922718
申请日：2009-03-20
申请人： Hanne Jørgensen , Trond Erling Ellingsen , Kristin Fløgstad Degnes , Per Bruheim , Håvard Sletta , Espen Fjaervik , Geir Klinkenberg , Sergey Zotchev
发明人： Hanne Jørgensen , Trond Erling Ellingsen , Kristin Fløgstad Degnes , Per Bruheim , Håvard Sletta , Espen Fjaervik , Geir Klinkenberg , Sergey Zotchev
IPC分类号： C12P19/34 , C07H21/04 , C12N9/00 , C12P7/26 , C12P17/10 , C12N1/00 , C12N1/21 , C12N1/20
CPC分类号： C12N15/52 , C07D225/02 , C07K14/36 , C12P17/10 , C12P19/62 , C12R1/465
摘要： The present invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 1; or (b) a nucleotide sequence which is the complement of SEQ ID No. 1; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 1; or (d) a nucleotide sequence having at least 85% sequence identity (preferably at least 87%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% sequence identity) with SEQ ID No. 1; or (e) a part of any one of (a) to (d), wherein said nucleic acid molecule encodes or is a complementary to a nucleic acid molecule encoding one or more polypeptides, or comprises or is complementary to a nucleic acid molecule comprising one or more genetic elements, having functional activity in the synthesis of a polyketide-based or macrolactam molecule. Particularly the invention contemplates the modification of the nucleic acid of the invention, encoding the biosynthetic machinery for the synthesis of the polyketide macrolactam BE-14106, including expressing in a microorganism the modified nucleic acid molecule. In certain aspects the modification includes introducing, mutating, deleting, replacing or inactivating a sequence encoding one or more activities or proteins encoded by said nucleic acid molecule. Other aspects of the invention include a microorganism containing the modified and unmodified nucleic acid and recovering the polyketide-based or macrolactam molecule from said mircoorganism.
摘要翻译：本发明提供了一种核酸分子，其包含：（a）SEQ ID No.1所示的核苷酸序列; 或（b）作为SEQ ID No.1的互补序列的核苷酸序列; 或（c）与SEQ ID No.1退行的核苷酸序列; 或（d）具有至少85％序列同一性（优选至少87％，90％，91％，92％，93％，94％，95％，96％，97％，98％或99％序列同一性）; 或（e）（a）至（d）中任一项的一部分，其中所述核酸分子编码或与编码一种或多种多肽的核酸分子互补，或包含或互补于包含一种或多种在合成聚酮化合物或大内酰胺分子中具有功能活性的遗传元件。特别地，本发明考虑了本发明的核酸的修饰，其编码用于合成聚酮化物大内酰胺BE-14106的生物合成机理，包括在微生物中表达经修饰的核酸分子。在某些方面，修饰包括引入，突变，缺失，替换或失活编码由所述核酸分子编码的一种或多种活性或蛋白质的序列。本发明的其它方面包括含有经修饰和未修饰的核酸的微生物，并从所述微生物中回收聚酮化合物或大环内酰胺分子。

2. 发明授权

US09217150B2 NRPS-PKS gene cluster and its manipulation and utility 有权
标题翻译： NRPS-PKS基因簇及其操作和实用性
公开(公告)号：US09217150B2
公开(公告)日：2015-12-22
申请号：US12922718
申请日：2009-03-20
申请人： Hanne Jørgensen , Trond Erling Ellingsen , Kristin Fløgstad Degnes , Per Bruheim , Håvard Sletta , Espen Fjærvik , Geir Klinkenberg , Sergey Zotchev
发明人： Hanne Jørgensen , Trond Erling Ellingsen , Kristin Fløgstad Degnes , Per Bruheim , Håvard Sletta , Espen Fjærvik , Geir Klinkenberg , Sergey Zotchev
IPC分类号： C07H21/04 , C12P7/26 , C12N9/00 , C12N15/52 , C07K14/36 , C12P17/10 , C12R1/465 , C12P19/62
CPC分类号： C12N15/52 , C07D225/02 , C07K14/36 , C12P17/10 , C12P19/62 , C12R1/465
摘要： The present invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 1; or (b) a nucleotide sequence which is the complement of SEQ ID No. 1; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 1; or (d) a nucleotide sequence having at least 85% sequence identity (preferably at least 87%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% sequence identity) with SEQ ID No. 1; or (e) a part of any one of (a) to (d), wherein said nucleic acid molecule encodes or is a complementary to a nucleic acid molecule encoding one or more polypeptides, or comprises or is complementary to a nucleic acid molecule comprising one or more genetic elements, having functional activity in the synthesis of a polyketide-based or macrolactam molecule. Particularly the invention contemplates the modification of the nucleic acid of the invention, encoding the biosynthetic machinery for the synthesis of the polyketide macrolactam BE-14106, including expressing in a microorganism the modified nucleic acid molecule. In certain aspects the modification includes introducing, mutating, deleting, replacing or inactivating a sequence encoding one or more activities or proteins encoded by said nucleic acid molecule. Other aspects of the invention include a microorganism containing the modified and unmodified nucleic acid and recovering the polyketide-based or macrolactam molecule from said microorganism.
摘要翻译：本发明提供了一种核酸分子，其包含：（a）SEQ ID No.1所示的核苷酸序列; 或（b）作为SEQ ID No.1的互补序列的核苷酸序列; 或（c）与SEQ ID No.1退行的核苷酸序列; 或（d）具有至少85％序列同一性（优选至少87％，90％，91％，92％，93％，94％，95％，96％，97％，98％或99％序列同一性）; 或（e）（a）至（d）中任一项的一部分，其中所述核酸分子编码或与编码一种或多种多肽的核酸分子互补，或包含或互补于包含一种或多种在合成聚酮化合物或大内酰胺分子中具有功能活性的遗传元件。特别地，本发明考虑了本发明的核酸的修饰，其编码用于合成聚酮化物大内酰胺BE-14106的生物合成机理，包括在微生物中表达经修饰的核酸分子。在某些方面，修饰包括引入，突变，缺失，替换或失活编码由所述核酸分子编码的一种或多种活性或蛋白质的序列。本发明的其它方面包括含有修饰和未修饰的核酸的微生物，并从所述微生物中回收聚酮化物或大环内酰胺分子。

3. 发明申请

US20150126467A1 USE OF ALGINATE OLIGOMERS TO ENHANCE THE EFFECTS OF ANTIFUNGAL AGENTS 审中-公开
标题翻译：使用低聚物来增强抗真菌药物的作用
公开(公告)号：US20150126467A1
公开(公告)日：2015-05-07
申请号：US14345224
申请日：2012-09-14
申请人： Edvar Onsøyen , Arne Dessen , David William Thomas , Katja Etel Hill , Hàvard Sletta , Anne Tøndervik , Geir Klinkenberg , Rolf Myrvold
发明人： Edvar Onsøyen , Arne Dessen , David William Thomas , Katja Etel Hill , Hàvard Sletta , Anne Tøndervik , Geir Klinkenberg , Rolf Myrvold
IPC分类号： A61K31/7048 , A01N43/653 , A01N33/04 , A61K31/506 , A61K31/4196 , A61K31/137 , A61K31/4174 , A01N43/16 , A01N43/50
CPC分类号： A61K31/7048 , A01N33/04 , A01N43/16 , A01N43/50 , A01N43/653 , A61K31/137 , A61K31/4174 , A61K31/4196 , A61K31/506 , A61K31/734 , A61K45/06 , Y02A50/492 , A01N43/90 , A01N2300/00 , A61K2300/00
摘要： The disclosure relates to use of alginate oligomers to enhance the effects of antifungal agents. The invention provides a method to improve the efficacy of an antifungal agent against a fungus, said method comprising using said antifungal agent together with an alginate oligomer. The fungus may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use together with at least one antifungal agent in treating a subject infected, suspected to be infected, or at risk of infection, with a fungus. In another aspect the method can be used to combat fungal contamination of a site e.g., for disinfection and cleaning purposes.
摘要翻译：本公开涉及使用藻酸盐低聚物来增强抗真菌剂的作用。本发明提供了一种改善抗真菌剂对真菌的功效的方法，所述方法包括将所述抗真菌剂与藻酸盐低聚物一起使用。真菌可能是生动的或无生命的表面，并提供医疗和非医疗用途和方法。在一个方面，本发明提供了一种与至少一种抗真菌剂一起使用的藻酸盐低聚物，用一种真菌来治疗受感染的，疑似感染的或有感染风险的受试者。在另一方面，该方法可用于抵抗现场的真菌污染，例如用于消毒和清洁目的。

4. 发明授权

US08178130B2 Preservation and controlled delivery / release of spermatozoa 有权
标题翻译：保存和控制精子的释放/释放
公开(公告)号：US08178130B2
公开(公告)日：2012-05-15
申请号：US12305654
申请日：2007-07-03
申请人： Elisabeth Kommisrud , Peer Ola Hofmo , Geir Klinkenberg
发明人： Elisabeth Kommisrud , Peer Ola Hofmo , Geir Klinkenberg
IPC分类号： A61K35/52
CPC分类号： A01N1/02 , A01N1/0231
摘要： The present invention relates to biopolymer particles for preservation of spermatozoa, wherein the spermatozoa are embedded within the biopolymer particle. The present invention also regards a method for preservation, storage and controlled delivery/release of spermatozoa, and the use of the biopolymer particles according to the present invention in breeding.
摘要翻译：本发明涉及用于保存精子的生物聚合物颗粒，其中精子嵌入生物聚合物颗粒内。本发明还涉及精子的保存，储存和控制递送/释放的方法，以及根据本发明的生物聚合物颗粒在育种中的用途。

5. 发明申请

US20100041941A1 Preservation and Controlled Delivery / Release of Spermatozoa 有权
标题翻译：保存和控制递送/释放精子
公开(公告)号：US20100041941A1
公开(公告)日：2010-02-18
申请号：US12305654
申请日：2007-07-03
申请人： Elisabeth Kommisrud , Per Ola Hofmo , Geir Klinkenberg
发明人： Elisabeth Kommisrud , Per Ola Hofmo , Geir Klinkenberg
IPC分类号： A61B17/43 , A01N1/02
CPC分类号： A01N1/02 , A01N1/0231
摘要： The present invention relates to biopolymer particles for preservation of spermatozoa, wherein the spermatozoa are embedded within the biopolymer particle. The present invention also regards a method for preservation, storage and controlled delivery/release of spermatozoa, and the use of the biopolymer particles according to the present invention in breeding.
摘要翻译：本发明涉及用于保存精子的生物聚合物颗粒，其中精子嵌入生物聚合物颗粒内。本发明还涉及精子的保存，储存和控制递送/释放的方法，以及根据本发明的生物聚合物颗粒在育种中的用途。

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