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1. 发明公开

EP2255797A2 COMPOSITE PREPARATION 审中-公开
标题翻译： KOMPOSIT-HERSTELLUNG
公开(公告)号：EP2255797A2
公开(公告)日：2010-12-01
申请号：EP09713514.9
申请日：2009-02-21
申请人： HanAll Biopharma Co., Ltd.
发明人： KIM, Sung Wuk , JUN, Sung Soo , JO, Young Gwan , KOO, Ja Seong , SUN, Sang Ouk , BAE, Jung-won
IPC分类号： A61K9/52 , A61K9/00 , A61K9/20 , A61K9/22 , A61K47/00
CPC分类号： A61K9/2077 , A61K9/2009 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2059 , A61K9/2081 , A61K9/209 , A61K9/2866 , A61K9/4808 , A61K9/5078 , A61K9/5084 , A61K31/4365 , A61K31/60 , A61K31/616 , A61K2300/00
摘要： The present invention provides a combination preparation which comprises: a prior-release section comprising aspirin or a pharmaceutically acceptable salt thereof as a pharmacologically active component; and a delayed-release section comprising clopidogrel, an isomer thereof or a pharmaceutically acceptable salt thereof as a pharmacologically active component. The combination preparation of the present invention exhibits a far better effect in preventing platelet aggregation than does simultaneous oral therapy or treatment with the respective single preparations, and not only can it improve the patient's drug-taking compliance by administration once a day but it can also reduce the adverse reactions which follow long-term administration of aspirin. The combination preparation of the present invention is also advantageous in that it exhibits an outstanding effect in inhibiting blood platelet aggregation despite a reduction in the amount of aspirin ingested, and in that it converts clopidogrel resistance into susceptibility and prevents serious adverse reactions caused by clopidogrel resistance and in that it can be stored over the longer term since it is stable under common storage conditions.
摘要翻译：本发明提供了一种组合制剂，其包含：包含阿司匹林或其药学上可接受的盐作为药理活性成分的先前释放部分; 以及包含氯吡格雷，其异构体或其药学上可接受的盐作为药理活性成分的延迟释放部分。本发明的组合制剂与单独使用的制剂同时进行口服治疗或治疗相比，具有更好的预防血小板聚集的效果，并且不仅可以通过一天一次的给药来改善患者的药物依从性，而且还可以减少长期服用阿司匹林后的不良反应。本发明的组合制剂的优点还在于尽管阿司匹林摄入量减少，但其表现出抑制血小板聚集的突出效果，并且将氯吡格雷耐药性转化为易感性并防止由氯吡格雷耐药引起的严重不良反应并且由于它在常见的储存条件下是稳定的，因此可以长期储存。

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