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    • 8. 发明授权
    • Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same
    • 通过磷酸盐,组合物,制品和制造和使用它们的方法延伸的可生物降解的聚合物
    • US06376644B1
    • 2002-04-23
    • US09654326
    • 2000-09-01
    • Hai-Quan MaoKam W. LeongZhong ZhaoJames P. English
    • Hai-Quan MaoKam W. LeongZhong ZhaoJames P. English
    • C08G7904
    • A61K9/0024A61K9/1647A61L17/12A61L26/0019A61L27/18C08G63/6922C08G63/912Y10S623/924C08L85/02
    • Biodegradable polymers are described comprising the recurring monomeric units shown in formula I or II: wherein X is —O— or —NR′—, where R′ is H or alkyl; L is a branched or straight chain aliphatic group having from 1-20 carbon atoms; M1 and M2 are each independently (1) a branched or straight chain aliphatic group having from 1-20 carbon atoms; or (2) a branched or straight chain, oxy-, carboxy- or amino-aliphatic group having from 1-20 carbon atoms; Y is —O—, —S— or —NR′—, where R′ is H or alkyl; R is H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; the molar ratio of x:y is about 1; the molar ratio n:(x or y) is between about 200:1 and 1:200; and the molar ratio q:r is between about 1:99 and 99:1; wherein said biodegradable polymer is biocompatible before and upon biodegradat. Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.
    • 描述包含式I或II所示的重复单体单元的生物可降解聚合物:其中X是-O-或-NR'-,其中R'是H或烷基; L是具有1-20个碳原子的支链或直链脂族基团; M1和M2各自独立地为(1)具有1-20个碳原子的支链或直链脂族基团; 或(2)具有1-20个碳原子的支链或直链,氧基,羧基或氨基 - 脂族基团; Y是-O - , - S-或-NR'-,其中R'是H或烷基; R是H,烷基,烷氧基,芳基,芳氧基,杂环或杂环氧基; x:y的摩尔比为约1; 摩尔比n:(x或y)在约200:1和1:200之间; 并且摩尔比q:r在约1:99和99:1之间; 其中所述可生物降解聚合物在生物降解之前和之后是生物相容的。 还描述了制备聚合物的方法,含有聚合物和生物活性物质的组合物,用于植入或注射到由组合物制造的身体中的制品,以及使用该聚合物可控地释放生物活性物质的方法。