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1. 发明申请

US20120190625A1 NOVEL PEPTIDE AND USE THEREOF 有权
标题翻译：新肽及其用途
公开(公告)号：US20120190625A1
公开(公告)日：2012-07-26
申请号：US13389051
申请日：2010-02-12
申请人： Hae Jin Kim , Eun Joung Moon , Yang Seon Kim , Young Joon Kwon
发明人： Hae Jin Kim , Eun Joung Moon , Yang Seon Kim , Young Joon Kwon
IPC分类号： A61K38/08 , A61P19/04 , A61P35/00 , C07K7/06 , A61P13/12
CPC分类号： C07K7/06 , A61K38/00
摘要： The present invention provides a peptide comprising an amino acid sequence of SEQ ID NO: 1, a variant thereof and a pharmaceutically acceptable salt thereof.A novel peptide of the present invention, a variant thereof and a pharmaceutically acceptable salt thereof are effective for treating and/or preventing degenerative disc diseases, treating body organ fibrosis, treating cancer and/or treating glomerulosclerosis, and are effective for the inhibition of TGF-beta1 signaling.
摘要翻译：本发明提供了包含SEQ ID NO：1的氨基酸序列，其变体和其药学上可接受的盐的肽。本发明的新型肽，其变体及其药学上可接受的盐对于治疗和/或预防退行性椎间盘疾病，治疗身体器官纤维化，治疗癌症和/或治疗肾小球硬化症是有效的，并且对于抑制TGF -beta1信号。

2. 发明授权

US08691749B2 Peptide and use thereof 有权
标题翻译：肽及其用途
公开(公告)号：US08691749B2
公开(公告)日：2014-04-08
申请号：US13389051
申请日：2010-02-12
申请人： Hae Jin Kim , Eun Joung Moon , Yang Seon Kim , Young Joon Kwon
发明人： Hae Jin Kim , Eun Joung Moon , Yang Seon Kim , Young Joon Kwon
IPC分类号： A61K38/00 , A61P35/00 , A61K38/08
CPC分类号： C07K7/06 , A61K38/00
摘要： The present invention provides a peptide comprising an amino acid sequence of SEQ ID NO: 1 and a pharmaceutically acceptable salt thereof effective for treating degenerative disc diseases, treating body organ fibrosis, treating cancer and/or treating glomerulosclerosis, and effective for the inhibition of TGF-beta 1 signaling.
摘要翻译：本发明提供一种肽，其包含SEQ ID NO：1的氨基酸序列及其药学上可接受的盐，其有效治疗退行性椎间盘疾病，治疗身体器官纤维化，治疗癌症和/或治疗肾小球硬化，并且有效抑制TGF -beta 1信号。

3. 发明授权

US08772241B2 Peptide and use thereof 有权
标题翻译：肽及其用途
公开(公告)号：US08772241B2
公开(公告)日：2014-07-08
申请号：US13701465
申请日：2011-06-22
申请人： Hae Jin Kim , Je Wook Lee , Young Joon Kwon , Eun Joung Moon
发明人： Hae Jin Kim , Je Wook Lee , Young Joon Kwon , Eun Joung Moon
IPC分类号： A61K38/08 , A61K38/18 , C07K7/06 , C07K14/495
CPC分类号： C07K7/06 , A61K38/08 , A61K38/1841 , A61K2300/00
摘要： The present invention provides a peptide represented by formula (I) of X1-Leu-X2-Leu-X3 wherein X1 represents Glu or Asp, X2 represents His, Lys or Arg, X3 represents Asp or Glu, with Glu, Asp, Leu, His, Lys and Arg being respectively glutamic acid, aspartic acid, leucine, histidine, lysine and arginine; or a pharmaceutically acceptable salt thereof; a composition for the treatment or prevention of at least one selected from cartilage damage and arthritis, containing the same peptide or a pharmaceutically acceptable salt thereof as an active ingredient; and a composition containing the same peptide or a pharmaceutically acceptable salt thereof and TGFβ1. The above-mentioned peptide or a pharmaceutically acceptable salt thereof is effective for the treatment and/or prevention of cartilage damage and/or arthritis and is capable of exhibiting effects of the regeneration of cartilage tissue, the inhibition of the expression of cartilage tissue matrix degrading enzyme and/or the inhibition of cartilage tissue ossification.
摘要翻译：本发明提供了X1-Leu-X2-Leu-X3的式（I）所示的肽，其中X1表示Glu或Asp，X2表示His，Lys或Arg，X3表示Asp或Glu，Glu，Asp，Leu，他的Lys和Arg分别是谷氨酸，天冬氨酸，亮氨酸，组氨酸，赖氨酸和精氨酸; 或其药学上可接受的盐; 用于治疗或预防选自软骨损伤和关节炎的至少一种的组合物，其含有相同的肽或其药学上可接受的盐作为活性成分; 和含有相同肽或其药学上可接受的盐和TGFβ的组合物。上述肽或其药学上可接受的盐对于治疗和/或预防软骨损伤和/或关节炎是有效的，并且能够表现出软骨组织再生的作用，抑制软骨组织基质降解的表达酶和/或抑制软骨组织骨化。

4. 发明申请

US20130109626A1 NOVEL PEPTIDE AND USE THEREOF 有权
标题翻译：新肽及其用途
公开(公告)号：US20130109626A1
公开(公告)日：2013-05-02
申请号：US13701465
申请日：2011-06-22
申请人： Hae Jin Kim , Je Wook Lee , Young Joon Kwon , Eun Joung Moon
发明人： Hae Jin Kim , Je Wook Lee , Young Joon Kwon , Eun Joung Moon
IPC分类号： C07K7/06 , A61K38/18 , A61K38/08
CPC分类号： C07K7/06 , A61K38/08 , A61K38/1841 , A61K2300/00
摘要： The present invention provides a peptide represented by formula (I) of X1-Leu-X2-Leu-X3 wherein X1 represents Glu or Asp, X2 represents His, Lys or Arg, X3 represents Asp or Glu, with Glu, Asp, Leu, His, Lys and Arg being respectively glutamic acid, aspartic acid, leucine, histidine, lysine and arginine; or a pharmaceutically acceptable salt thereof; a composition for the treatment or prevention of at least one selected from cartilage damage and arthritis, containing the same peptide or a pharmaceutically acceptable salt thereof as an active ingredient; and a composition containing the same peptide or a pharmaceutically acceptable salt thereof and TGFβ1. The above-mentioned peptide or a pharmaceutically acceptable salt thereof is effective for the treatment and/or prevention of cartilage damage and/or arthritis and is capable of exhibiting effects of the regeneration of cartilage tissue, the inhibition of the expression of cartilage tissue matrix degrading enzyme and/or the inhibition of cartilage tissue ossification.
摘要翻译：本发明提供了X1-Leu-X2-Leu-X3的式（I）所示的肽，其中X1表示Glu或Asp，X2表示His，Lys或Arg，X3表示Asp或Glu，Glu，Asp，Leu，他的Lys和Arg分别是谷氨酸，天冬氨酸，亮氨酸，组氨酸，赖氨酸和精氨酸; 或其药学上可接受的盐; 用于治疗或预防选自软骨损伤和关节炎的至少一种的组合物，其含有相同的肽或其药学上可接受的盐作为活性成分; 和含有相同肽或其药学上可接受的盐和TGFbeta1的组合物。上述肽或其药学上可接受的盐对于治疗和/或预防软骨损伤和/或关节炎是有效的，并且能够表现出软骨组织再生的作用，抑制软骨组织基质降解的表达酶和/或抑制软骨组织骨化。

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